Projects per year
Personal profile
Expertise
BIO: Joris Messens is since 2012 group leader of the Redox Signaling Lab within the VIB Center for Structural Biology and professor at the Vrije Universiteit Brussel. After several years in Biotech-industry as an Engineer in Biochemistry, he obtained his PhD from the John Moores University of Liverpool (UK, 2003) with structural and functional work on arsenate reductase from Staphyloccocus aureus. In 2006, he created together with Jean-Francois Collet (de Duve Institute, UCL) the Brussels Center for Redox Biology (http://redox.vub.ac.be/) as a platform to stimulate redox and oxidative protein folding research. Joris Messens is frequently invited speaker, session leader, chair and co-chair on international meetings, like GRC, ESF, EMBO, and he was member of the reviewing board for the DFG priority program ‘Dynamics of thiol-based switches in cellular physiology’. As a protein biochemist, he has authored more than 100 peer-reviewed publications (h-index > 40). Most of his studies focus on protein conformational changes induced by thiol-based reaction mechanisms, and the identification of redox-sensitive proteins.
MISSION: The mission of the Redox Signaling Lab is to decipher how cells sense and respond to redox metabolites. The importance of redox signaling for the proper functioning of the cell is being increasingly recognized, and the elucidation of its precise mechanisms and players is becoming critical, as it will allow us to manipulate these pathways with a wide variety of implications, ranging from increasing stress resistance in plants to identifying therapeutic targets in diseases where aberrant redox signaling plays a role.
MORE INFO: http://redox.vub.ac.be and https://messenslab.sites.vib.be/en
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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FWOTM1074: Molecular and structural aspects controlling the Prdx2 redox-relay
Malo Pueyo, J., Messens, J. & Bolduc, J.
1/11/21 → 31/10/25
Project: Fundamental
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OZR3906: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - ULB, PEREZ CHAVEZ Israel
1/10/21 → 30/09/25
Project: Fundamental
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OZR3904: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - ULB, SHEN Tzu-Keng
30/07/21 → 29/07/25
Project: Fundamental
Research output
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Examining Arginase-1 Trimerization Uncovers a Promising Allosteric Site for Inhibition
Dechenne, J., Wierzbicka, M., Krimou, R., El Aakchioui, A., Malo Pueyo, J., Messens, J., Fillet, M., Spillier, Q. & Frédérick, R., 23 Jan 2025, In: Journal of medicinal chemistry. 68, 2, p. 1433-1445 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Downloads (Pure) -
A family of NADPH/NADP+ biosensors reveals in vivo dynamics of central redox metabolism across eukaryotes
Scherschel, M., Niemeier, J-O., Jacobs, L., Hoffmann, M. D. A., Diederich, A., Bell, C., Höhne, P., Raetz, S., Kroll, J. B., Steinbeck, J., Lichtenauer, S., Multhoff, J., Zimmermann, J., Sadhanasatish, T., Rothemann, R. A. U., Grashoff, C., Messens, J., Ampofo, E., Laschke, M. W., Riemer, J. & 3 others, , 19 Dec 2024, In: Nature communications. 15, 10704.Research output: Contribution to journal › Article › peer-review
Open Access -
A novel approach to pH-Responsive targeted cancer Therapy: Inhibition of FaDu cancer cell proliferation with a pH low insertion Peptide-Conjugated DGAT1 inhibitor
Deskeuvre, M., Lan, J., Messens, J., Riant, O., Feron, O. & Frédérick, R., 25 May 2024, In: International Journal of Pharmaceutics. 657, 124132.Research output: Contribution to journal › Article › peer-review
Open Access -
APX2 Is an Ascorbate Peroxidase-Related Protein that Regulates the Levels of Plastocyanin in Chlamydomonas
Caccamo, A., Vega de Luna, F., Misztak, A. E., Pyr Dit Ruys, S., Vertommen, D., Cardol, P., Messens, J. & Remacle, C., 2024, In: Plant & Cell Physiology. 65, 4, p. 644-656 13 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Arsenate reductase of Rufibacter tibetensis is a metallophosphoesterase evolved to catalyze redox reactions
Shen, J., Song, XW., Bickel, D., Rosen, B. P., Zhao, FJ., Messens, J. & Zhang, J., Aug 2024, In: Molecular Microbiology. 122, 2, p. 201-212 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)11 Downloads (Pure)
Prizes
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Winner of the ‘European contest for young scientists on protein purification’, Paris (1999)
Messens, Joris (Recipient), 1999
Prize: Prize (including medals and awards)
Activities
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Department of Bio-engineering Sciences (Organisational unit)
Joris Messens (Member)
30 Aug 2024Activity: Membership › Member of PhD committee
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Department of Bio-engineering Sciences (Organisational unit)
Joris Messens (Member)
4 Jul 2024Activity: Membership › Member of PhD committee
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Université catholique de Louvain (External organisation)
Joris Messens (Member)
12 Jan 2024Activity: Membership › Member of PhD committee
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GRC Thiol-Based Redox Regulation and Signaling
Joris Messens (Participant)
14 Jul 2024 → 19 Jul 2024Activity: Participating in or organising an event › Participation in conference
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Department of Bio-engineering Sciences (Organisational unit)
Joris Messens (Member)
22 Nov 2024Activity: Membership › Member of PhD committee
Press/Media
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'Misisng link' ontdekt in verdedigingsmechanisme van de tuberculoseverwekker
1/12/12
1 Media contribution
Press/Media: Other
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'Missing Link' Discovered in Defense Mechanism of Tuberculosis Pathogen
14/11/12
1 Media contribution
Press/Media: Other
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Vlaamse biologen stap dichter bij bestrijding tuberculose
14/11/12
1 Media contribution
Press/Media: Other
Thesis
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Analysis of in silico designed calpain inhibitors
Author: Nguyen, H. H., Tompa, P., Pauwels, K. & Messens, J., 2013Supervisor: Pauwels, K. (Promotor)
Student thesis: Master's Thesis
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Aqueous size-exclusion chromatography of intact proteins at ultra-high pressures: effect on selectivity and efficiency
Author: Peten, F., Eeltink, S., Messens, J. & De Vos, J., 2016Student thesis: Master's Thesis
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Characterisation of the bacterial GTPase Obg, a novel target for drug development
Author: Berna, S., Versées, W. & Messens, J., 2014Student thesis: Master's Thesis
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Characterization of a small heat shock protein from rice proteome for putative chaperone activity in vitro
Author: Ali, M. M., Tompa, P., Kovacs, S. D. & Messens, J., 2015Student thesis: Master's Thesis
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Characterization of dipeptyl peptidase 4 (DPP-4) and bacterial collagenase
Author: Benachour, N., Vanderheyden, P. & Messens, J., 2017Supervisor: Vanderheyden, P. (Promotor)
Student thesis: Master's Thesis