Projects per year
Personal profile
Expertise
BIO: Joris Messens is since 2012 group leader of the Redox Signaling Lab within the VIB Center for Structural Biology and professor at the Vrije Universiteit Brussel. After several years in Biotech-industry as an Engineer in Biochemistry, he obtained his PhD from the John Moores University of Liverpool (UK, 2003) with structural and functional work on arsenate reductase from Staphyloccocus aureus. In 2006, he created together with Jean-Francois Collet (de Duve Institute, UCL) the Brussels Center for Redox Biology (http://redox.vub.ac.be/) as a platform to stimulate redox and oxidative protein folding research. Joris Messens is frequently invited speaker, session leader, chair and co-chair on international meetings, like GRC, ESF, EMBO, and he was member of the reviewing board for the DFG priority program ‘Dynamics of thiol-based switches in cellular physiology’. As a protein biochemist, he has authored more than 100 peer-reviewed publications (h-index > 40). Most of his studies focus on protein conformational changes induced by thiol-based reaction mechanisms, and the identification of redox-sensitive proteins.
MISSION: The mission of the Redox Signaling Lab is to decipher how cells sense and respond to redox metabolites. The importance of redox signaling for the proper functioning of the cell is being increasingly recognized, and the elucidation of its precise mechanisms and players is becoming critical, as it will allow us to manipulate these pathways with a wide variety of implications, ranging from increasing stress resistance in plants to identifying therapeutic targets in diseases where aberrant redox signaling plays a role.
MORE INFO: http://redox.vub.ac.be and https://messenslab.sites.vib.be/en
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Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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HERC58: SPECY-SORT: SPEctral flow CYtometer and cell SORTer
Laoui, D., De Veirman, K., Van der Henst, C., Brunner, J., Messens, J., Raes, G., Van Ginderachter, J., Devoogdt, N., Magez, S., Remaut, H. K., Stijlemans, B., Movahedi, K., Peeters, E. & De Trez, C.
1/05/22 → 30/04/26
Project: Fundamental
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OZR3941: Cofinanciering OZR FWO Hercules MZW: SPECY-SORT: SPEctral flow CYtometer and cell SORTer
Laoui, D., Van Ginderachter, J., Movahedi, K., De Veirman, K., Magez, S., De Trez, C., Stijlemans, B., Raes, G., Devoogdt, N., Messens, J., Brunner, J., Remaut, H. K., Fioravanti, A., Peeters, E. & Van der Henst, C.
16/03/22 → 16/03/25
Project: Fundamental
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FWOTM1074: Molecular and structural aspects controlling the Prdx2 redox-relay
Malo Pueyo, J., Messens, J. & Bolduc, J.
1/11/21 → 31/10/23
Project: Fundamental
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OZR3906: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - ULB, PEREZ CHAVEZ Israel
1/10/21 → 30/09/25
Project: Fundamental
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OZR3904: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - ULB, SHEN Tzu-Keng
30/07/21 → 29/07/25
Project: Fundamental
Research output
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Functionally annotating cysteine disulfides and metal binding sites in the plant kingdom using AlphaFold2 predicted structures
Willems, P., Huang, J., Messens, J. & Van Breusegem, F., 17 Oct 2022Research output: Other contribution
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Functionally annotating cysteine disulfides and metal binding sites in the plant kingdom using AlphaFold2 predicted structures
Willems, P., Huang, J., Messens, J. & Van Breusegem, F., Dec 2022, In: Free Radical Biology & Medicine. 194, p. 220-229 10 p.Research output: Contribution to journal › Article › peer-review
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Hypocrates is a genetically encoded fluorescent biosensor for (pseudo)hypohalous acids and their derivatives
Kostyuk, A. I., Tossounian, M-A., Panova, A. S., Thauvin, M., Raevskii, R. I., Ezeriņa, D., Wahni, K., Van Molle, I., Sergeeva, A. D., Vertommen, D., Gorokhovatsky, A. Y., Baranov, M. S., Vriz, S., Messens, J., Bilan, D. S. & Belousov, V. V., 10 Jan 2022, In: Nature Communications. 13, 1, 17 p., 171.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus) -
Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators
Johanns, M., Corbet, C., Jacobs, R., Drappier, M., Bommer, G. T., Herinckx, G., Vertommen, D., Tajeddine, N., Young, D., Messens, J., Feron, O., Steinberg, G. R., Hue, L. & Rider, M. H., 30 Jun 2022, In: Biochemical Journal. 479, 12, p. 1317-1336 20 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Member of the editorial board of Redox Biochemistry and Chemistry
Messens, J. (ed.), 2022, Elsevier.Research output: Other contribution
Prizes
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Winner of the ‘European contest for young scientists on protein purification’, Paris (1999)
Messens, Joris (Recipient), 1999
Prize: Prize (including medals and awards)
Activities
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Making the invisible visible – Mechanistical insights on biosensor functioning
Joris Messens (Speaker)
9 Oct 2022Activity: Talk or presentation › Talk or presentation at a conference
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Department of Bio-engineering Sciences (Organisational unit)
Joris Messens (Member)
2022Activity: Membership › Member of PhD committee
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Summerschool research internship
Joris Messens (Supervisor)
16 Aug 2022 → 19 Aug 2022Activity: Participating in or organising an event › Participation in workshop, seminar
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SFRR-E conference
Joris Messens (Chair)
26 Aug 2022Activity: Participating in or organising an event › Participation in conference
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Redox Biochemistry and Chemistry (Journal)
Joris Messens (Editorial board member)
2022 → …Activity: Publication peer-review and editorial work › Publication peer-review
Press/Media
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'Misisng link' ontdekt in verdedigingsmechanisme van de tuberculoseverwekker
1/12/12
1 Media contribution
Press/Media: Other
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Vlaamse biologen stap dichter bij bestrijding tuberculose
14/11/12
1 Media contribution
Press/Media: Other
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Vlaamse biologen stap dichter bij bestrijding tuberculose
14/11/12
1 Media contribution
Press/Media: Other
Thesis
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Analysis of in silico designed calpain inhibitors
Author: Nguyen, H. H., Tompa, P., Pauwels, K. & Messens, J., 2013Supervisor: Pauwels, K. (Promotor)
Student thesis: Master's Thesis
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Aqueous size-exclusion chromatography of intact proteins at ultra-high pressures: effect on selectivity and efficiency
Author: Peten, F., Eeltink, S., Messens, J. & De Vos, J., 2016Student thesis: Master's Thesis
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Biochemical and structural characterisation of arsenate reductase from Staphylococcus aureus
Author: Messens, J., Wyns, L. & Reynolds, C., Apr 2003Supervisor: Wyns, L. (Promotor) & Reynolds, C. (External person) (Promotor)
Student thesis: Doctoral Thesis
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Characterisation of the bacterial GTPase Obg, a novel target for drug development
Author: Berna, S., Versées, W. & Messens, J., 2014Student thesis: Master's Thesis
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Characterization of a small heat shock protein from rice proteome for putative chaperone activity in vitro
Author: Ali, M. M., Tompa, P., Kovacs, S. D. & Messens, J., 2015Student thesis: Master's Thesis