Projects per year
Personal profile
Expertise
BIO: Joris Messens is since 2012 group leader of the Redox Signaling Lab within the VIB Center for Structural Biology and professor at the Vrije Universiteit Brussel. After several years in Biotech-industry as an Engineer in Biochemistry, he obtained his PhD from the John Moores University of Liverpool (UK, 2003) with structural and functional work on arsenate reductase from Staphyloccocus aureus. In 2006, he created together with Jean-Francois Collet (de Duve Institute, UCL) the Brussels Center for Redox Biology (http://redox.vub.ac.be/) as a platform to stimulate redox and oxidative protein folding research. Joris Messens is frequently invited speaker, session leader, chair and co-chair on international meetings, like GRC, ESF, EMBO, and he is member of the reviewing board for the DFG priority program ‘Dynamics of thiol-based switches in cellular physiology’. As a protein biochemist, he has authored more than 100 peer-reviewed publications (h-index = 40). Most of his studies focus on protein conformational changes induced by thiol-based reaction mechanisms, and the identification of redox-sensitive proteins.
MISSION: The mission of the Redox Signaling Lab is to decipher how cells sense and respond to redox metabolites. The importance of redox signaling for the proper functioning of the cell is being increasingly recognized, and the elucidation of its precise mechanisms and players is becoming critical, as it will allow us to manipulate these pathways with a wide variety of implications, ranging from increasing stress resistance in plants to identifying therapeutic targets in diseases where aberrant redox signaling plays a role.
MORE INFO: http://redox.vub.ac.be and https://messenslab.sites.vib.be/en
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Network
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OZR3941: Cofinanciering OZR FWO Hercules MZW: SPECY-SORT: SPEctral flow CYtometer and cell SORTer
Laoui, D., Van Ginderachter, J., Movahedi, K., De Veirman, K., Magez, S., De Trez, C., Stijlemans, B., Raes, G., Devoogdt, N., Messens, J., Brunner, J., Remaut, H. K., Fioravanti, A., Peeters, E. & Van der Henst, C.
16/03/22 → 16/03/25
Project: Fundamental
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FWOTM1074: Molecular and structural aspects controlling the Prdx2 redox-relay
Malo Pueyo, J., Messens, J. & Bolduc, J.
1/11/21 → 31/10/23
Project: Fundamental
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OZR3906: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - ULB, PEREZ CHAVEZ Israel
1/10/21 → 30/09/25
Project: Fundamental
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OZR3904: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - ULB, SHEN Tzu-Keng
30/07/21 → 29/07/25
Project: Fundamental
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OZR3586: Financiering FWO Hercules: SPIDER-FLOW: State-of-the-art high-Parameter Immunology and DEvelopmental biology Research FLOW cytometer
Van Ginderachter, J., Messens, J., Raes, G., Devoogdt, N., Magez, S., Leyns, L., Aerts, J., Movahedi, K., De Trez, C. & Laoui, D.
1/05/20 → 30/04/24
Project: Fundamental
Research output
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Hypocrates is a genetically encoded fluorescent biosensor for (pseudo)hypohalous acids and their derivatives
Kostyuk, A. I., Tossounian, M-A., Panova, A. S., Thauvin, M., Raevskii, R. I., Ezeriņa, D., Wahni, K., Van Molle, I., Sergeeva, A. D., Vertommen, D., Gorokhovatsky, A. Y., Baranov, M. S., Vriz, S., Messens, J., Bilan, D. S. & Belousov, V. V., 10 Jan 2022, In : Nature Communications. 13, 1, 17 p., 171.Research output: Contribution to journal › Article
Open Access1 Citation (Scopus) -
Arabidopsis APx-R Is a Plastidial Ascorbate-Independent Peroxidase Regulated by Photomorphogenesis
Lazzarotto, F., Wahni, K., Piovesana, M., Maraschin, F., Messens, J. & Margis-Pinheiro, M., 7 Jan 2021, In : Antioxidants. 10, 1, p. 1-15 15 p., 65.Research output: Contribution to journal › Article
Open Access1 Citation (Scopus) -
Charge Interactions in a Highly Charge-Depleted Protein
Hervø-Hansen, S., Højgaard, C., Johansson, K. E., Wang, Y., Wahni, K., Young, D., Messens, J., Teilum, K., Lindorff-Larsen, K. & Winther, J. R., 17 Feb 2021, In : Journal of the American Chemical Society. 143, 6, p. 2500-2508 9 p.Research output: Contribution to journal › Article
4 Citations (Scopus) -
Discovery of a novel lactate dehydrogenase tetramerization domain using epitope mapping and peptides
Thabault, L., Liberelle, M., Koruza, K., Yildiz, E., Joudiou, N., Messens, J., Brisson, L., Wouters, J., Sonveaux, P. & Frédérick, R., 2021, In : Journal of Biological Chemistry. 296, 100422.Research output: Contribution to journal › Article
Open Access4 Citations (Scopus) -
Monitoring oxidative inflammatory processes in live cells and tissue with Hypocrates, a genetically encoded biosensor for hypochlorite
Kostyuk, A. I., Tossounian, M-A., Panova, A. S., Thauvin, M., Wahni, K., Molle, I. V., Raevskii, R. I., Baranov, M. S., Vriz, S., Messens, J., Bilan, D. S. & Belousov, V. V., 22 Feb 2021, 38 p. (BIORXIV).Research output: Working paper › Preprint
Prizes
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Winner of the ‘European contest for young scientists on protein purification’, Paris (1999)
Joris Messens (Recipient), 1999
Prize: Prize (including medals and awards)
Activities
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The dynamic redox language of the cell – peroxiredoxin mediated signaling
Joris Messens (Speaker)15 Jun 2021Activity: Talk or presentation › Talk or presentation at a conference
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Redox in motion
Joris Messens (Speaker)29 Mar 2021Activity: Talk or presentation › Talk or presentation at a conference
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Tools to probe for subcellular oxidative and metabolic events
Joris Messens (Speaker)2 Feb 2020 → 7 Feb 2020Activity: Talk or presentation › Talk or presentation at a conference
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The peroxidatic mechanism of H2O2 sensing
Joris Messens (Speaker)1 Jul 2019 → 3 Jul 2019Activity: Talk or presentation › Talk or presentation at a conference
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The redox language of the cell
Joris Messens (Speaker)27 Mar 2019Activity: Talk or presentation › Talk or presentation at a workshop/seminar
Press / Media
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'Misisng link' ontdekt in verdedigingsmechanisme van de tuberculoseverwekker
1/12/12
1 Media contribution
Press/Media: Other
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'Missing Link' Discovered in Defense Mechanism of Tuberculosis Pathogen
14/11/12
1 Media contribution
Press/Media: Other
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Vlaamse biologen stap dichter bij bestrijding tuberculose
14/11/12
1 Media contribution
Press/Media: Other
Thesis
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Analysis of in silico designed calpain inhibitors
Author: Nguyen, H. H., Tompa, P., Pauwels, K. & Messens, J., 2013Supervisor: Pauwels, K. (Promotor)
Student thesis: Master's Thesis
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Approches globales de l’état redox du résidu cystéine
Author: Le Moan, N., Toledano, M. & Messens, J., 26 Sep 2007Supervisor: Messens, J. (Jury) & Toledano, M. (External person) (Promotor)
Student thesis: Doctoral Thesis
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Aqueous size-exclusion chromatography of intact proteins at ultra-high pressures: effect on selectivity and efficiency
Author: Peten, F., Eeltink, S., Messens, J. & De Vos, J., 2016Student thesis: Master's Thesis
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Arabidopsis thaliana serpin1, a potent insecticide that inhibits both serine and cysteine proteases
Author: Van Den Wijngaert, G., Messens, J. & Wyns, L., 2009Supervisor: Messens, J. (Promotor) & Wyns, L. (Promotor)
Student thesis: Master's Thesis
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Arsenate reductase thioredoxin interactions in Staphylococcus aureus
Author: Limbourg, M., Messens, J. & Wyns, L., 2001Supervisor: Messens, J. (Promotor) & Wyns, L. (Promotor)
Student thesis: Master's Thesis