Projects per year
Personal profile
Expertise
BIO: Joris Messens is since 2012 group leader of the Redox Signaling Lab within the VIB Center for Structural Biology and professor at the Vrije Universiteit Brussel. After several years in Biotech-industry as an Engineer in Biochemistry, he obtained his PhD from the John Moores University of Liverpool (UK, 2003) with structural and functional work on arsenate reductase from Staphyloccocus aureus. In 2006, he created together with Jean-Francois Collet (de Duve Institute, UCL) the Brussels Center for Redox Biology (http://redox.vub.ac.be/) as a platform to stimulate redox and oxidative protein folding research. Joris Messens is frequently invited speaker, session leader, chair and co-chair on international meetings, like GRC, ESF, EMBO, and he was member of the reviewing board for the DFG priority program ‘Dynamics of thiol-based switches in cellular physiology’. As a protein biochemist, he has authored more than 100 peer-reviewed publications (h-index > 40). Most of his studies focus on protein conformational changes induced by thiol-based reaction mechanisms, and the identification of redox-sensitive proteins.
MISSION: The mission of the Redox Signaling Lab is to decipher how cells sense and respond to redox metabolites. The importance of redox signaling for the proper functioning of the cell is being increasingly recognized, and the elucidation of its precise mechanisms and players is becoming critical, as it will allow us to manipulate these pathways with a wide variety of implications, ranging from increasing stress resistance in plants to identifying therapeutic targets in diseases where aberrant redox signaling plays a role.
MORE INFO: http://redox.vub.ac.be and https://messenslab.sites.vib.be/en
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Collaborations and top research areas from the last five years
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FWOAL1204: The role of reactive sulfur species in plants' epic struggle against environmental oxidative stress
Messens, J. (Administrative Promotor)
1/01/26 → 31/12/29
Project: Fundamental
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HERC68: High-resolution low-cost 100 kV electron cryogenic microscope for near-atomic protein structure determination
Efremov, R. (Administrative Promotor), Messens, J. (CoI (Co-Promotor)), Vorobieva, A. A. (CoI (Co-Promotor)), Remaut, H. K. (CoI (Co-Promotor)), Van der Henst, C. (CoI (Co-Promotor)), Steyaert, J. (CoI (Co-Promotor)), Versées, W. (CoI (Co-Promotor)), Loris, R. (CoI (Co-Promotor)) & Brunner, J. (CoI (Co-Promotor))
1/05/24 → 30/04/28
Project: Fundamental
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SRP97: Microfluidic cell handling and optical detection to gain insights in subcellular dynamics and metabolite communication (SUBCELLDYNAMITE)
De Malsche, W. (Administrative Promotor), Maes, D. (CoI (Co-Promotor)) & Messens, J. (CoI (Co-Promotor))
1/03/24 → 28/02/29
Project: Fundamental
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OZR2206: The Interaction Proteome of Oxidative Stress Signalling in Plants
Messens, J. (Administrative Promotor) & Messens, J. (Scientific Promotor)
22/11/10 → …
Project: Fundamental
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FWOTM1074: Molecular and structural aspects controlling the Prdx2 redox-relay
Malo Pueyo, J. (Mandate), Messens, J. (Administrative Promotor) & Bolduc, J. (Co-Promotor)
1/11/21 → 31/10/25
Project: Fundamental
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A color-tailored fluorogenic sensor for hydrogen peroxide
Potekhina, E. S., Bass, D. I., Ezeriņa, D., Fleckenstein, D. D., Chebotarev, A. S., Sysoeva, V. A., Maltsev, D. I., Pak, V. V., Moshchenko, A. A., Sokolov, A. I., Myasnyanko, I. N., Baranov, M. S., Fedotov, A. B., Zheltikov, A. M., Lanin, A. A., Messens, J. & Belousov, V. V., Apr 2026, In: Nature Chemical Biology. 22, 4, p. 568-579 12 p.Research output: Contribution to journal › Article › peer-review
File11 Citations (Scopus)17 Downloads (Pure) -
Acoustophoretic buffer exchange in microfluidics: quantifying radiation-driven migration, streaming, and flow effects
Gyimah, N., Maisto, A., Amanatchi, N., Gómez Piedrafita, E., Ezeriņa, D., Messens, J., Hellemans, K. H. & De Malsche, W., 8 Jul 2026, In: Lab on a Chip. 26, 17, p. 4661-4678 18 p.Research output: Contribution to journal › Article › peer-review
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Challenges in reconstituting the peroxiredoxin 2:STAT3 transient redox-relay complex in vitro
Malo Pueyo, J., Baranova, E., Wahni, K., Dubach, V. R., Janvier, S., Vertommen, D., Murphy, B., Ezerina, D. & Messens, J., 6 Jul 2026, Biorxiv, 12 p.Research output: Working paper › Preprint
Open Access -
Hetero-oligomerization drives structural plasticity of eukaryotic peroxiredoxins
Zimmermann, J., Lang, L., Malo Pueyo, J., Riedel, M., Wahni, K., Stobbe, D., Leiskau, L., Aref, E., Lux, C., Janvier, S., Vertommen, D., Lenhard, S., Hannemann, F., Thangamuragan, S., Castro, H., Helms, V., Tomas, A. M., Herrmann, J. M., Salvador, A. & Mühlhaus, T. & 4 others, , 10 Mar 2026, In: Nature Chemical Biology. 22, 4, p. 580-592 25 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Sung, H.-M., Bickel, D., Krause, L. C. M., Ezeriņa, D., Ickes, C., Wojtachnia, J., Gibhardt, C. S., Shumanska, M., Wahni, K., Paluschkiwitz, A., Malo Pueyo, J., Baranova, E., Vranken, W., Stanisz, H., Stejerean-Todoran, I., Schön, M. P., Messens, J. & Bogeski, I., May 2026, In: Molecular Oncology. 20, 5, p. 1161-1184 24 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus)
Datasets
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Dataset of a color-tailored fluorogenic sensor for hydrogen peroxide
Potekhina, E. S. (Creator), Bass, D. I. (Creator), Ezerina, D. (Creator), Messens, J. (Supervisor) & Belousov, V. (Project Manager), Nature Chemical Biology, 16 Oct 2025
DOI: 10.1038/s41589-025-02036-6
Dataset
Prizes
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Winner of the ‘European contest for young scientists on protein purification’, Paris (1999)
Messens, J. (Recipient), 1999
Prize: Prize (including medals and awards)
Activities
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Department of Bio-engineering Sciences (Organisational unit)
Radonicic, V. (Speaker), Messens, J. (Chair), Willaert, R. (Supervisor), Devreese, B. (Supervisor), Torino, S. (Jury), De Malsche, W. (Jury), Kasas, S. (Jury), Wendland, J. (Jury), Van Damme, P. (Jury) & Audenaert, K. (Jury)
16 Feb 2026Activity: Membership › Member of PhD committee
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UNIVERSITE CATHOLIQUE DE LOUVAIN (External organisation)
Messens, J. (Member)
2 Jul 2025Activity: Membership › Member of PhD committee
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Redox in motion: Mechanistic insights into cellular signaling
Messens, J. (Speaker)
14 Nov 2025Activity: Talk or presentation › Talk or presentation at a conference
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PhD defense Kim Mignon - Molecular basis of DNA recognition by Arabidopsis thaliana SOG1: the master regulator for DNA damage control in plants (Event)
Mignon, K. (Speaker), Loris, R. (Supervisor), Messens, J. (Chair), Ruytinx, J. (Jury), Versées, W. (Jury), Ezerina, D. (Jury), Hadzi, S. (Jury) & Hendrix, J. (Jury)
3 Dec 2025Activity: Membership › Member of PhD committee
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Department of Bio-engineering Sciences (Organisational unit)
Messens, J. (Member)
4 Jul 2024Activity: Membership › Member of PhD committee
Press/Media
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Cells build diversity like Lego®: scientists uncover new behavior of antioxidant enzymes
10/03/26
2 Media contributions
Press/Media: Research
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'Misisng link' ontdekt in verdedigingsmechanisme van de tuberculoseverwekker
1/12/12
1 Media contribution
Press/Media: Other
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Vlaamse biologen stap dichter bij bestrijding tuberculose
14/11/12
1 Media contribution
Press/Media: Other
Thesis
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Analysis of in silico designed calpain inhibitors
Nguyen, H. H. ((PhD) Student), Tompa, P. (Promotor), Pauwels, K. (Promotor) & Messens, J. (Jury), Pauwels, K. (Promotor), 2013Student thesis: Master's Thesis
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Aqueous size-exclusion chromatography of intact proteins at ultra-high pressures: effect on selectivity and efficiency
Peten, F. ((PhD) Student), Eeltink, S. (Promotor), Messens, J. (Jury) & De Vos, J. (Advisor), 2016Student thesis: Master's Thesis
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Characterization of a small heat shock protein from rice proteome for putative chaperone activity in vitro
Ali, M. M. ((PhD) Student), Tompa, P. (Promotor), Kovacs, S. D. (Promotor) & Messens, J. (Jury), 2015Student thesis: Master's Thesis
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Characterization of dipeptyl peptidase 4 (DPP-4) and bacterial collagenase
Benachour, N. ((PhD) Student), Vanderheyden, P. (Promotor) & Messens, J. (Jury), Vanderheyden, P. (Promotor), 2017Student thesis: Master's Thesis
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Charcterization of the transcription regulator PhaR in the polyhydroxyalkanoate producer Caldimonas thermodepolymerans
Hira, N. T. ((PhD) Student), Messens, J. (Jury), Weckx, S. (Jury) & Peeters, E. (Promotor), 30 Jun 2025Student thesis: Master's Thesis