Projects per year
Personal profile
Expertise
Design of innovative immunotherapy strategies. The strategies under development include ex vivo and in vivo engineering of (1) dendritic cells for immune activation and (2) T-cells for cancer cell rejection, and (3) engineering of the tumor microenvironment to facilitate antitumor immune responses. Technologies such as mRNA, lentiviral vectors and single domain antibodies (better known as nanobodies) are employed for these purposes. Strategies under development are extensively tested in preclinical in vitro models using cells of human and mouse origin as well as in mouse cancer models. Successful strategies are translated towards clinical applications in phase I/II trials.
Research interests
Cancer immunology and immunotherapy:
- Cancer vaccination
- T-cell therapy
- Immune checkpoint therapy
Education/Academic qualification
Education, Educational Professionalisation Pathway for Teaching Staff, Vrije Universiteit Brussel
Award Date: 3 Nov 2015
Languages, Certificate CEFR level C1 (Academic English), Ghent University
Award Date: 14 Sep 2013
Medical Sciences, PhD, Vrije Universiteit Brussel
Award Date: 7 Jul 2004
Biomedical Sciences, Master, Vrije Universiteit Brussel
Award Date: 3 Jul 1998
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Collaborations and top research areas from the last five years
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ANI397: Colorectal cancer mRNA therapy focusing on the immune checkpoint ST2
Breckpot, K. & Marco Aragon, M.
1/11/24 → 31/10/25
Project: Fundamental
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FWOTM1257: CATCH - CAR-T cell immunotherapy against Chronic liver disease and Hepatocellular carcinoma
De Wolf, R., van Grunsven, L. & Breckpot, K.
1/11/24 → 31/10/28
Project: Fundamental
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ANI389: Development of a B7-H3 nanoCAR-T cell therapy for recurrent glioblastoma (GlioCAR)
Neyns, B., Geeraerts, X., Tuyaerts, S., Breckpot, K., Duerinck, J. & Smolders, I.
1/10/24 → 30/09/28
Project: Fundamental
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HERC66: 3D-CELLMAP: Unveiling complex cellular interactions in tissues through 3D super-resolution protein multiplex imaging
Movahedi, K., Rooman, I., Sermon, K., De Bundel, D., Fioravanti, A., Staels, W., Magez, S., Breckpot, K., De Kock, J., Laoui, D., Goyvaerts, C., Smolders, I., Van Ginderachter, J., Marcelino Rodrigues, R., De Leu, N., van Grunsven, L., Hernot, S., Peeters, E., Vanhaecke, T., De Veirman, K., Ruytinx, J., Van Schependom, J., Kortekaas, I. & Goossens, E.
1/05/24 → 31/05/28
Project: Fundamental
Research output
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Efficient α and β- radionuclide therapy targeting fibroblast activation protein-α in an aggressive preclinical mouse tumour model
Ceuppens, H., Pombo Antunes, A. R., Navarro, L., Ertveldt, T., Berdal, M., Nagachinta, S., De Ridder, K., Lahoutte, T., Keyaerts, M., Devoogdt, N., Goyvaerts, C., D'Huyvetter, M. & Breckpot, K., Jan 2025, In: European Journal of Nuclear Medicine and Molecular Imaging. 52, p. 444-457 14 p.Research output: Contribution to journal › Article › peer-review
File2 Downloads (Pure) -
Activation of PD-1K78A CAR transduced T-cells via clinical grade anti-PD-1 monoclonal antibodies
Schaukens, J., De Vlaeminck, Y., Geeraerts, X., Stevens, L., Breckpot, K., Neyns, B. & Tuyaerts, S., 15 May 2024.Research output: Unpublished contribution to conference › Poster
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Alpha-galactosylceramide improves the potency of mRNA LNP vaccines against cancer and intracellular bacteria
Meulewaeter, S., Aernout, I., Deprez, J., Engelen, Y., De Velder, M., Franceschini, L., Breckpot, K., Van Calenbergh, S., Asselman, C., Boucher, K., Impens, F., De Smedt, S. C., Verbeke, R. & Lentacker, I., Jun 2024, In: Journal of Controlled Release. 370, p. 379-391 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)5 Downloads (Pure) -
Anti-Idiotypic VHHs and VHH-CAR-T Cells to Tackle Multiple Myeloma: Different Applications Call for Different Antigen-Binding Moieties
Hanssens, H., Meeus, F., Gesquiere, E. L., Puttemans, J., Vlaeminck, Y. D., Veirman, K. D., Breckpot, K. & Devoogdt, N., 22 May 2024, In: International Journal of Molecular Sciences. 25, 11, 16 p., 5634.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
Assessment of connexin43 hemichannel functionality based on cytosolic uptake of Yo-Pro1
Van Campenhout, R., Sanz-Serrano, J., Cooreman, A., De Vlaeminck, Y., Breckpot, K., Kadam, P., Tabernilla Garcia, A. & Vinken, M., 6 Apr 2024, In: Methods in Molecular Biology. 2801, p. 75-85 11 p., 6.Research output: Contribution to journal › Article
File
Datasets
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Targeted Radionuclide Therapy with Low and High-Dose Lutetium-177-Labeled Single Domain Antibodies Induces Distinct Immune Signatures in a Mouse Melanoma Model
Breckpot, K. (Creator) & Ertveldt, T. (Creator), Molecular Cancer Therapy, 16 Dec 2024
DOI: https://doi.org/10.1158/1535-7163.c.6543403.v1
Dataset
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Nanobody-mediated SPECT/CT imaging reveals the spatiotemporal expression of programmed death-ligand 1 in response to a CD8+ T cell and iNKT cell activating mRNA vaccine
Breckpot, K. (Creator) & Ertveldt, T. (Creator), Journal of Nuclear Medicine, 16 Dec 2024
Dataset
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Nanobody-mediated SPECT/CT imaging reveals the spatiotemporal expression of programmed death-ligand 1 in response to a CD8+ T cell and iNKT cell activating mRNA vaccine
Breckpot, K. (Creator) & Ertveldt, T. (Creator), Theranostics, 16 Dec 2024
Dataset
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Histochemistry and immunohistochemistry stainings
Verhulst, S. (Creator), Locy, H. (Creator) & Breckpot, K. (Creator), Zenodo, 11 Feb 2022
DOI: 10.3389/fimmu.2022.794175
Dataset
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B7-H3-targeting nanobody-based CAR-T cells
Breckpot, K. (Creator) & Meeus, F. (Creator), VUB Institutional Data Repository, 20 Jan 2025
Dataset
Prizes
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Award "Dr. Karel-Lodewijk Verleysen ter bekroning van medisch onderzoekswerk aan Vlaamse universiteiten (2005-2010)"
Breckpot, Karine (Recipient), 7 Mar 2011
Prize: Prize (including medals and awards)
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Best Oral Presentation - MOSA conference 2021
Janssens, E. M. (Recipient), De Beck, L. (Recipient), Verbeke, R. (Recipient), Lentacker, I. (Recipient), Dewitte, H. (Recipient), Menu, Eline (Recipient) & Breckpot, Karine (Recipient), 23 Jun 2021
Prize: Prize (including medals and awards)
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Best Poster Presentation
Vandewalle, Niels (Recipient), Menu, Eline (Recipient), De Bruyne, Elke (Recipient), De Veirman, Kim (Recipient), Breckpot, Karine (Recipient) & Devoogdt, Nick (Recipient), 2 Feb 2024
Prize: Prize (including medals and awards)
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Certificat of Young Speaker Award
Lecocq, Q. (Recipient), Broos, K. (Recipient), Bridoux, Jessica (Recipient), Raes, Geert (Recipient), Xavier, C. (Recipient), Devoogdt, Nick (Recipient), Keyaerts, Marleen (Recipient) & Breckpot, Karine (Recipient), 1 Feb 2019
Prize: Prize (including medals and awards)
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Development of a nanoCAR-T cell approach for the treatment of multiple myeloma
Hanssens, Heleen (Recipient), Devoogdt, Nick (Recipient), De Veirman, Kim (Recipient) & Breckpot, Karine (Recipient), 15 Dec 2021
Prize: Fellowship awarded competitively
Activities
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ESGCT 2025 (Event)
Karine Breckpot (Chair)
1 Jan 2025 → 31 Dec 2025Activity: Membership › Membership of peer-review panel or committee
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ESGCT 2024 (Event)
Karine Breckpot (Chair)
1 Jan 2024 → 31 Dec 2024Activity: Membership › Membership of peer-review panel or committee
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Faculty of Medicine and Pharmacy (Organisational unit)
Karine Breckpot (Chair)
16 Sep 2024 → 21 Sep 2025Activity: Membership › Work on academic committees and working groups
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Efficient α and β- radionuclide therapy targeting fibroblast activation protein-α in an aggressive preclinical mouse tumour model.
Hannelore Ceuppens (Speaker), Ana Rita Pombo Antunes (Contributor), Laurent Navarro (Contributor), Thomas Ertveldt (Contributor), Marion Berdal (Contributor), Surasa Nagachinta (Contributor), Kirsten De Ridder (Contributor), Marleen Keyaerts (Contributor), Nick Devoogdt (Contributor), Cleo Goyvaerts (Contributor), Matthias D'Huyvetter (Contributor) & Karine Breckpot (Contributor)
23 Oct 2024Activity: Talk or presentation › Talk or presentation at a conference
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Fonds Wetenschapelijk Onderzoek - FWO (External organisation)
Karine Breckpot (Chair)
1 Jan 2024 → 31 Dec 2024Activity: Membership › Membership of peer-review panel or committee
Press/Media
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LinkedIn Coverage - Gen Webinar on mRNA (Thermo Fisher)
22/08/23
1 Media contribution
Press/Media: Other
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Thesis
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Combining the Strengths of Cytotoxic T Cells and nanomedicines for Cancer Immunotherapy
Author: Wayteck, L. & Breckpot, K., 15 Jun 2016Supervisor: Stefaan C., D. S. (External person) (Promotor) & Van Raemdonck, K. (External person) (Promotor)
Student thesis: Doctoral Thesis
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Creation of a 3D Crime scene to unravel cytotoxicity resistance mechanisms in non-small cell lung cancer
Author: Schaukens, J., Goyvaerts, C., Breckpot, K. & De Ridder, K., Jul 2022Student thesis: Master's Thesis
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Design and evaluation of immunotherapeutic imaging for cancer vaccination
Author: Dewitte, H., Lentacker, I., Breckpot, K. & Stefaan C., D. S., 26 Feb 2015Student thesis: Doctoral Thesis
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Development of a NanoCAR approach for the treatment of multiple myeloma
Author: Devoogdt, N., Breckpot, K., De Veirman, K. & Hanssens, H., 10 Sep 2024Student thesis: Doctoral Thesis
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Differentiële genexpressie in een humane stroma-dependente myeloom cellijn en haar stroma-independente variant.
Author: Breckpot, K. & Van Camp, B., 1998Supervisor: Van Camp, B. (Promotor)
Student thesis: Master's Thesis