Projects per year
Personal profile
Expertise
- Manufacturing and screening of monoclonal antibodies against human cell membranes and proteins. Sorting cells on FACS-sorter. DNA analysis using gen probes for clinical purposes. Orders for third parties have been executed. Delays may be discussed and depend on the demand.
- Hematology & Immunobiology
- Generation of mouse and human dendritic cells Genetic modification of dendritic cells
- Gene transfer technology (adenovirus, retrovirus, lentivirus) Non viral transfer techniques (RNA electroporation)
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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SRP48: Strategic Research Programme: Cancer Cell Targeting in Myeloma and Melanoma (MyMe)
Vanderkerken, K., Thielemans, K., Vanderkerken, K. & Breckpot, K.
1/11/17 → 31/10/24
Project: Fundamental
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VOPPU95: VOPPU95 - Prijs kankeronderzoek - Wout De Mey
Breckpot, K., Thielemans, K. & de Mey, W.
1/01/21 → 30/06/21
Project: Fundamental
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Research output
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An mRNA mix redirects dendritic cells towards an antiviral program, inducing anticancer cytotoxic stem cell and central memory CD8+ T cells
de Mey, W., Locy, H., De Ridder, K., De Schrijver, P., Autaers, D., Lakdimi, A., Esprit, A., Franceschini, L., Thielemans, K., Verdonck, M. & Breckpot, K., 4 Mar 2023, In: Frontiers in Immunology. 14, 10 p., 1111523.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)29 Downloads (Pure) -
Assessment of Human SARS CoV-2-Specific T-Cell Responses Elicited In Vitro by New Computationally Designed mRNA Immunogens: COVARNA
Esteban, I., Pastor-Quinones, C., Usero, L., Aurrecoechea, E., Franceschini, L., Esprit, A., Gelpi, J. L., Martinez-Jimenez, F., Lopez-Biga, N., Breckpot, K., Thielemans, K., Leal, L., Gomez, C. E., Sistere-Oro, M., Meyerhans, A., Esteban, M., Alonso, M. J., Garcia, F. & Plana, M., 22 Dec 2023, In: Vaccines. 12, 1, p. 15-30 16 p., 15.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Downloads (Pure) -
Challenges in neoantigen-directed therapeutics
Lybaert, L., Lefever, S., Fant, B., Smits, E., De Geest, B., Breckpot, K., Dirix, L., Feldman, S. A., van Criekinge, W., Thielemans, K., van der Burg, S. H., Ott, P. A. & Bogaert, C., 9 Jan 2023, In: Cancer Cell. 41, 1, p. 15-40 26 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile45 Citations (Scopus)96 Downloads (Pure) -
Assessing Tumor-Infiltrating Lymphocytes in Breast Cancer: A Proposal for Combining Immunohistochemistry and Gene Expression Analysis to Refine Scoring
Locy, H., Verhulst, S., Cools, W., Waelput, W., Brock, S., Cras, L., Schiettecatte, A., Jonckheere, J., van Grunsven, L. A., Vanhoeij, M., Thielemans, K. & Breckpot, K., 11 Feb 2022, In: Frontiers in Immunology. 13, p. 1-13 13 p., 794175.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)62 Downloads (Pure) -
A synthetic DNA template for fast manufacturing of versatile single epitope mRNA
de Mey, W., De Schrijver, P., Autaers, D., Pfitzer, L., Fant, B., Locy, H., Esprit, A., Lybaert, L., Bogaert, C., Verdonck, M., Thielemans, K., Breckpot, K. & Franceschini, L., 13 Sep 2022, In: Molecular Therapy Nucleic Acids. 29, p. 943-954 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)44 Downloads (Pure)
Datasets
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MOESM2 of Intranodal administration of mRNA encoding nucleoprotein provides cross-strain immunity against influenza in mice
Saelens, X. (Creator), Ysenbaert, T. (Creator), Schepens, B. (Creator), Heirman, C. (Creator), Thielemans, K. (Creator), Christopoulou, I. (Creator), Van Hoecke, L. (Creator) & Aerts, J. L. (Creator), Springer, 1 Jan 2019
DOI: 10.6084/m9.figshare.9109040, http://10.1186/s12967-019-1991-3
Dataset
Activities
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Unknown (External organisation)
Kris Thielemans (Member)
2012 → 2015Activity: Membership › Membership of external research organisation
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Unknown (External organisation)
Kris Thielemans (Member)
10 Oct 2010 → …Activity: Membership › Membership of external research organisation
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Unknown (External organisation)
Kris Thielemans (Member)
2009 → …Activity: Membership › Membership of external research organisation
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Unknown (External organisation)
Kris Thielemans (Member)
2009Activity: Membership › Membership of external research organisation
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Stanford University (External organisation)
Kris Thielemans (Member)
2008 → …Activity: Membership › Membership of external research organisation
Press/Media
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Sanofi Podcast: Therapeutic RNA vaccines in cancer immunotherapy
Karine Breckpot & Kris Thielemans
29/03/23
1 Media contribution
Press/Media: Public Engagement Activities
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Vlaamse overheid pompt 2 miljoen euro in darmkankervaccin
Karine Breckpot & Kris Thielemans
21/02/20
1 item of Media coverage
Press/Media: Other
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Vlaamse overheid pompt 2 miljoen euro in darmkankervaccin
Karine Breckpot & Kris Thielemans
21/02/20
1 item of Media coverage
Press/Media: Other
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Darmkanker - Vlaanderen injecteert 2 miljoen euro
Karine Breckpot & Kris Thielemans
20/02/20
1 item of Media coverage
Press/Media: Other
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Darmkanker: Vlaanderen injecteert 2 miljoen euro
Karine Breckpot & Kris Thielemans
20/02/20
1 item of Media coverage
Press/Media: Other
Thesis
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Plasmid engineering to enhance stability and translatability for MRNA-based immunotherapy
Author: Cappelle, C. A., Thielemans, K. & Franceschini, L., 2019Student thesis: Master's Thesis