Projects per year
Personal profile
Expertise
Leo van Grunsven is a developmental biologist (Utrecht, NL) and obtained his PhD in life sciences from the Ecole Normale Supérieure de Lyon (France, 1996). He had his postdoctoral training at the NINDS/NIH (Bethesda, USA, ’96-‘98) and the KU Leuven (Belgium, ’98-‘06) before he moved to the Vrije Universiteit Brussel and became head of the Liver Cell Biology research group in 2009.
His group studies molecular mechanisms that drive liver homeostasis, fibrosis, and regeneration, with a particular focus on hepatic stellate cells. He also specialized in developing in vitro models for studying chronic liver disease. His group was the first to identify autophagy, AGE- and Hippo-signaling as key mechanisms involved in hepatic stellate cell activation during liver fibrogenesis. His team also reported on the transcriptional changes that are associated with the activation of mouse and human hepatic stellate cells and established the first hepatocyte-injury dependent in vitro liver fibrosis model by using organoid cultures of human hepatocytes and primary or iPSC-derived hepatic stellate cells. The group currently invests in refining and applying their in vitro models of liver fibrosis and investigates the regulation of stress pathways in hepatic stellate cells and other sinusoidal liver cells during an acute and chronic liver injury in mouse models.
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FWOTM1107: Exploring the initiation and progression of NASH in a stem cell derived liver coculture model by revealing cellular stress activation pathways in real time
Toprakhisar, B. & van Grunsven, L.
1/10/22 → 6/10/25
Project: Fundamental
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EUAR78: Long-term Microphysiological Sample Imaging for Evaluation of Polypharmacy in Liver : DeLIVERY
1/05/22 → 30/04/26
Project: Applied
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OZR4059: Long-term Microphysiological Sample Imaging for Evaluation of Polypharmacy in Liver : DeLIVERY (EU BONUS OZR)
1/05/22 → 30/04/26
Project: Fundamental
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OZR3913: Cofinancing OZR FWO Hercules MZW - High-parametric single-cell protein profiling in intact tissues
Movahedi, K., van Grunsven, L., Rooman, I., Van Ginderachter, J., Smolders, I., Neyns, B., Vanhaecke, T., Laoui, D., Breckpot, K., De Veirman, K., Stijlemans, B., Van Schependom, J., Magez, S., Goyvaerts, C., De Kock, J., De Leu, N., Massie, A., Hellemans, K., Spits, C., De Bundel, D., De Trez, C., Hernot, S., Van Dooren, S., Aerts, J., Staels, W. & Tuyaerts, S.
25/02/22 → 25/02/26
Project: Fundamental
Research output
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Assessing Tumor-Infiltrating Lymphocytes in Breast Cancer: A Proposal for Combining Immunohistochemistry and Gene Expression Analysis to Refine Scoring
Locy, H., Verhulst, S., Cools, W., Waelput, W., Brock, S., Cras, L., Schiettecatte, A., Jonckheere, J., van Grunsven, L. A., Vanhoeij, M., Thielemans, K. & Breckpot, K., 11 Feb 2022, In: Frontiers in Immunology. 13, 794175.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)44 Downloads (Pure) -
Development and comparison of novel prediction models for genotoxicity based on biomarker genes in HepaRGTM cells
Thienpont, A., Verhulst, S., van Grunsven, L. A., Rogiers, V., Vanhaecke, T. & Mertens, B., 16 May 2022, (Unpublished).Research output: Unpublished contribution to conference › Unpublished abstract
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Editorial: Roles of Liver Sinusoidal Endothelial Cells in Liver Homeostasis and Disease
Lalor, P., Huser, T. & van Grunsven, L. A., 8 Mar 2022, In: Frontiers in Physiology. 13, 3 p., 869473.Research output: Contribution to journal › Editorial
Open AccessFile8 Downloads (Pure) -
Extension of the Virtual Cell Based Assay from a 2-D to a 3-D Cell Culture Model
Bednarczyk, E., Lu, Y., Paini, A., Batista Leite, S., van Grunsven, L. A., Worth, A. & Whelan, M., Jan 2022, In: ATLA. Alternatives to Laboratory Animals. 50, 1, p. 45-56 12 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
GENOMARK, a promising new approach methodology for genotoxicity testing in the cosmetic industry.
Thienpont, A., Verhulst, S., van Grunsven, L. A., Vanhaecke, T., Mertens, B. & Rogiers, V., 3 Dec 2022, (Unpublished).Research output: Unpublished contribution to conference › Unpublished abstract
Activities
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OZR ZAP selection (Event)
Aldo Scafoglieri (Contributor), Eva Swinnen (Contributor), Koen Putman (Chair), Debby Mangelings (Contributor) & Leo van Grunsven (Contributor)
8 Jun 2022Activity: Membership › Membership of peer-review panel or committee
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LSECs in chronic liver disease- Willy Gepts, UZ brussel
Elise Van Os (Recipient) & Leo van Grunsven (Contributor)
1 Jan 2021 → 1 Jan 2022Activity: Other › Written proposal
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Multicellular primary mouse liver spheroids for DILI, NAFLD, NASH and fibrosis studies.
Laura Cools (Speaker), Elise Van Os (Speaker), Nathalie Eysackers (Contributor), Ayla Smout (Contributor), Stefaan Verhulst (Contributor), Hendrik Reynaert (Contributor), Inge Mannaerts (Contributor) & Leo van Grunsven (Contributor)
4 Mar 2021Activity: Talk or presentation › Talk or presentation at a conference
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Multicellular primary mouse liver spheroids for DILI, NAFLD, NASH and fibrosis studies.
Laura Cools (Speaker), Elise Van Os (Speaker), Nathalie Eysackers (Contributor), Ayla Smout (Contributor), Stefaan Verhulst (Contributor), Hendrik Reynaert (Contributor), Inge Mannaerts (Contributor) & Leo van Grunsven (Contributor)
24 Jun 2021Activity: Talk or presentation › Talk or presentation at a conference
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Multicellular primary mouse liver spheroids for DILI, NAFLD, NASH and fibrosis studies.
Laura Cools (Speaker), Elise Van Os (Speaker), Nathalie Eysackers (Contributor), Ayla Smout (Contributor), Stefaan Verhulst (Contributor), Hendrik Reynaert (Contributor), Inge Mannaerts (Contributor) & Leo van Grunsven (Contributor)
28 Sep 2021Activity: Talk or presentation › Talk or presentation at a conference
Thesis
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Real-Time in vitro Toxicity Monitoring in a Microfluidic Bioreactor for Drug and Chemical Safety Assessment
Author: van Grunsven, L. A. & Prill, S., 7 Jul 2015Student thesis: Doctoral Thesis
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Real-time in vitro toxicity monitoring in a microfluidic bioreactor for drug and chemical safety assessment.
Author: van Grunsven, L. A. & Prill, S., 4 Mar 2015Student thesis: Doctoral Thesis
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The Functional Role of Furin in the Liver during Homeostasis and Pathological Conditions: A Journey of Challenges and Pitfalls in Transgene Technology
Author: van Grunsven, L. A. & Pruniau, V., Nov 2015Student thesis: Doctoral Thesis