Projects per year
Personal profile
Expertise
Leo van Grunsven is a developmental biologist (Utrecht, NL) and obtained his PhD in life sciences from the Ecole Normale Supérieure de Lyon (France, 1996). He had his postdoctoral training at the NINDS/NIH (Bethesda, USA, ’96-‘98) and the KU Leuven (Belgium, ’98-‘06) before he moved to the Vrije Universiteit Brussel and became head of the Liver Cell Biology research group in 2009.
His group studies molecular mechanisms that drive liver homeostasis, fibrosis, and regeneration, with a particular focus on hepatic stellate cells. He also specialized in developing in vitro models for studying chronic liver disease. His group was the first to identify autophagy, AGE- and Hippo-signaling as key mechanisms involved in hepatic stellate cell activation during liver fibrogenesis. His team also reported on the transcriptional changes that are associated with the activation of mouse and human hepatic stellate cells and established the first hepatocyte-injury dependent in vitro liver fibrosis model by using organoid cultures of human hepatocytes and primary or iPSC-derived hepatic stellate cells. The group currently invests in refining and applying their in vitro models of liver fibrosis and investigates the regulation of stress pathways in hepatic stellate cells and other sinusoidal liver cells during an acute and chronic liver injury in mouse models.
Fingerprint
Dive into the research topics where Leo van Grunsven is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
EUAR78: Long-term Microphysiological Sample Imaging for Evaluation of Polypharmacy in Liver : DeLIVERY
1/05/22 → 30/04/26
Project: Applied
-
OZR3913: Cofinancing OZR FWO Hercules MZW - High-parametric single-cell protein profiling in intact tissues
Movahedi, K., van Grunsven, L., Rooman, I., Van Ginderachter, J., Smolders, I., Neyns, B., Vanhaecke, T., Laoui, D., Breckpot, K., De Veirman, K., Stijlemans, B., Van Schependom, J., Magez, S., Goyvaerts, C., De Kock, J., De Leu, N., Massie, A., Hellemans, K., Spits, C., De Bundel, D., De Trez, C., Hernot, S., Van Dooren, S., Aerts, J., Staels, W. & Tuyaerts, S.
25/02/22 → 25/02/26
Project: Fundamental
-
-
iBOF/21/083: Synthetic organogenesis: the role of blood vessels in orchestrating the development and morphogenesis of ectopic miniorgans
van Grunsven, L., Halder, G. & Van Oosterwyck, H.
1/01/21 → 31/12/24
Project: Fundamental
-
FWOSB98: Development of a human induced pluripotent stem cell-derived 3D liver NAFLD culture model.
Kazemzadeh Dastjerd, M. & van Grunsven, L.
1/11/20 → 31/10/22
Project: Fundamental
Research output
-
Assessing Tumor-Infiltrating Lymphocytes in Breast Cancer: A Proposal for Combining Immunohistochemistry and Gene Expression Analysis to Refine Scoring
Locy, H., Verhulst, S., Cools, W., Waelput, W., Brock, S., Cras, L., Schiettecatte, A., Jonckheere, J., van Grunsven, L. A., Vanhoeij, M., Thielemans, K. & Breckpot, K., 11 Feb 2022, In : Frontiers in Immunology. 13, 794175.Research output: Contribution to journal › Article
Open AccessFile23 Downloads (Pure) -
Editorial: Roles of Liver Sinusoidal Endothelial Cells in Liver Homeostasis and Disease
Lalor, P., Huser, T. & van Grunsven, L. A., 2022, In : Frontiers in Physiology. 13, 3 p., 869473.Research output: Contribution to journal › Editorial
File -
Extension of the Virtual Cell Based Assay from a 2-D to a 3-D Cell Culture Model
Bednarczyk, E., Lu, Y., Paini, A., Batista Leite, S., van Grunsven, L. A., Worth, A. & Whelan, M., Jan 2022, In : ATLA. Alternatives to Laboratory Animals. 50, 1, p. 45-56 12 p.Research output: Contribution to journal › Article
1 Citation (Scopus) -
Improved Precision-Cut Liver Slice Cultures for Testing Drug-Induced Liver Fibrosis
Dewyse, L., De Smet, V., Verhulst, S., Eysackers, N., Kunda, R., Messaoudi, N., Reynaert, H. & van Grunsven, L. A., 30 Mar 2022, In : Frontiers in Medicine. 9, 11 p., 862185.Research output: Contribution to journal › Article
Open Access -
A fully defined matrix to support a pluripotent stem cell derived multi-cell-liver steatohepatitis and fibrosis model
Kumar, M., Toprakhisar, B., Van Haele, M., Antoranz, A., Boon, R., Chesnais, F., De Smedt, J., Tricot, T., Idoype, T. I., Canella, M., Tilliole, P., De Boeck, J., Bajaj, M., Ranga, A., Bosisio, F. M., Roskams, T., van Grunsven, L. A. & Verfaillie, C. M., Sep 2021, In : Biomaterials. 276, 121006.Research output: Contribution to journal › Article
Open Access3 Citations (Scopus)
Activities
-
OZR ZAP selection (Event)
Aldo Scafoglieri (Contributor), Eva Swinnen (Contributor), Koen Putman (Chair), Debby Mangelings (Contributor), Leo van Grunsven (Contributor)8 Jun 2022Activity: Membership › Membership of peer-review panel or committee
-
LSECs in chronic liver disease- Willy Gepts, UZ brussel
Elise Van Os (Recipient), Leo van Grunsven (Contributor)1 Jan 2021 → 1 Jan 2022Activity: Other › Written proposal
-
Multicellular primary mouse liver spheroids for DILI, NAFLD, NASH and fibrosis studies.
Laura Cools (Speaker), Elise Van Os (Speaker), Nathalie Eysackers (Contributor), Ayla Smout (Contributor), Stefaan Verhulst (Contributor), Hendrik Reynaert (Contributor), Inge Mannaerts (Contributor), Leo van Grunsven (Contributor)4 Mar 2021Activity: Talk or presentation › Talk or presentation at a conference
-
Multicellular primary mouse liver spheroids for DILI, NAFLD, NASH and fibrosis studies.
Laura Cools (Speaker), Elise Van Os (Speaker), Nathalie Eysackers (Contributor), Ayla Smout (Contributor), Stefaan Verhulst (Contributor), Hendrik Reynaert (Contributor), Inge Mannaerts (Contributor), Leo van Grunsven (Contributor)28 Sep 2021Activity: Talk or presentation › Talk or presentation at a conference
-
Multicellular primary mouse liver spheroids for DILI, NAFLD, NASH and fibrosis studies.
Laura Cools (Speaker), Elise Van Os (Speaker), Nathalie Eysackers (Contributor), Ayla Smout (Contributor), Stefaan Verhulst (Contributor), Hendrik Reynaert (Contributor), Inge Mannaerts (Contributor), Leo van Grunsven (Contributor)24 Jun 2021Activity: Talk or presentation › Talk or presentation at a conference
Thesis
-
ASPIRE: adjuvant-driven induction of cancer Specific Immune Responses
Author: Van Der Jeught, K., Breckpot, K., Thielemans, K., Vanderkerken, K., Menu, E., van Grunsven, L. A., Pascolo, S. & Raemdonck, K., 20 Oct 2016Supervisor: Breckpot, K. (Promotor), Thielemans, K. (Promotor), Vanderkerken, K. (Jury), Van Grunsven, L. A. (Jury), Menu, E. (Jury), Van Raemdonck, K. (External person) (Jury) & Pascolo, S. (External person) (Jury)
Student thesis: Doctoral Thesis
-
Balancing between totipotency and differentiation in human embryos.
Author: Krivega, M., Van De Velde, H., Geens, M., Van Schravendijk, C., van Grunsven, L. A., Mateizel, I., Viville, S. & Tilleman, K., 3 Sep 2015Supervisor: Van De Velde, H. (Promotor), Geens, M. (Promotor), Van Schravendijk, C. (Jury), Van Grunsven, L. A. (Jury), Mateizel, I. (Jury), Viville, S. (External person) (Jury) & Tilleman, K. (External person) (Jury)
Student thesis: Doctoral Thesis
-
Characterization of hepcidin-inducing cytokines in multiple myeloma.
Author: Maes, K., Vanderkerken, K., Van Grunsven, L., Van Den Branden, C. & Kooijman, R., 28 Jan 2010Supervisor: Vanderkerken, K. (Promotor), Van Grunsven, L. A. (Jury), Van Den Branden, C. (Jury) & Kooijman, R. (Jury)
Student thesis: Master's Thesis
-
Characterization of human quiescent, activated and inactivated hepatic stellate cells
Author: El Taghdouini, A., van Grunsven, L. A., Van Schravendijk, C., Vanderkerken, K., Heimberg, H., Laleman, W. & Trautwein, C., 3 May 2016Supervisor: Van Grunsven, L. A. (Promotor), Van Schravendijk, C. (Jury), Vanderkerken, K. (Jury), Heimberg, H. (Jury), Trautwein, C. (External person) (Jury) & Wim, L. (External person) (Jury)
Student thesis: Doctoral Thesis
-
Contribution to the isolation and hepatic differentiation of postnatal stem/progenitor cells from human adipose tissue
Author: Albattah, F., Rogiers, V., van Grunsven, L. A., Vanhaecke, T., Smolders, I., Mangelings, D., Massie, A., Leclercq, I. & Roskams, T., 15 Dec 2011Supervisor: Rogiers, V. (Promotor), Van Grunsven, L. A. (Co-promotor), Vanhaecke, T. (Co-promotor), Smolders, I. (Jury), Mangelings, D. (Jury), Massie, A. (Jury), Leclercq, I. (External person) (Jury) & Roskams, T. (External person) (Jury)
Student thesis: Doctoral Thesis