Projects per year
Personal profile
Expertise
Leo van Grunsven is a developmental biologist (Utrecht, NL) and obtained his PhD in life sciences from the Ecole Normale Supérieure de Lyon (France, 1996). He had his postdoctoral training at the NINDS/NIH (Bethesda, USA, ’96-‘98) and the KU Leuven (Belgium, ’98-‘06) before he moved to the Vrije Universiteit Brussel and became head of the Liver Cell Biology research group in 2009.
His group studies molecular mechanisms that drive liver homeostasis, fibrosis, and regeneration, with a particular focus on hepatic stellate cells. He also specialized in developing in vitro models for studying chronic liver disease. His group was the first to identify autophagy, AGE- and Hippo-signaling as key mechanisms involved in hepatic stellate cell activation during liver fibrogenesis. His team also reported on the transcriptional changes that are associated with the activation of mouse and human hepatic stellate cells and established the first hepatocyte-injury dependent in vitro liver fibrosis model by using organoid cultures of human hepatocytes and primary or iPSC-derived hepatic stellate cells. The group currently invests in refining and applying their in vitro models of liver fibrosis and investigates the regulation of stress pathways in hepatic stellate cells and other sinusoidal liver cells during an acute and chronic liver injury in mouse models.
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iBOF/21/083: Synthetic organogenesis: the role of blood vessels in orchestrating the development and morphogenesis of ectopic miniorgans
van Grunsven, L., Halder, G. & Van Oosterwyck, H.
1/01/21 → 31/12/24
Project: Fundamental
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FWOSB98: Development of a human induced pluripotent stem cell-derived 3D liver NAFLD culture model.
Kazemzadeh Dastjerd, M. & van Grunsven, L.
1/11/20 → 31/10/22
Project: Fundamental
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OZR3588: Financiering FWO hercules: ERA platform: Extended RNA Analysis platform - version 2.0
Rooman, I., Bouwens, L., Heimberg, H., Neyns, B., Vranken, W., Vanhaecke, T., Massie, A., van Grunsven, L., De Bruyne, E., De Bundel, D., Forsyth, R., Breckpot, K., Van Dooren, S., De Kock, J., Njemini, R. & Laoui, D.
1/05/20 → 30/04/24
Project: Fundamental
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IOF3013: GEAR: Brussels Liver Research to Valorisation Alliance (B-Liver): Valorisation of VUB’s liver cell biology and toxicology expertise via a consortium focused on liver therapeutics, patient and consumer safety.
Vanhaecke, T., van Grunsven, L., De Kock, J., Vinken, M. & Reynaert, H.
1/01/20 → 31/12/24
Project: Applied
Research output
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A fully defined matrix to support a pluripotent stem cell derived multi-cell-liver steatohepatitis and fibrosis model
Kumar, M., Toprakhisar, B., Van Haele, M., Antoranz, A., Boon, R., Chesnais, F., De Smedt, J., Tricot, T., Idoype, T. I., Canella, M., Tilliole, P., De Boeck, J., Bajaj, M., Ranga, A., Bosisio, F. M., Roskams, T., van Grunsven, L. A. & Verfaillie, C. M., Sep 2021, In : Biomaterials. 276, 121006.Research output: Contribution to journal › Article
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Best Practices and Progress in Precision-Cut Liver Slice Cultures
Dewyse, L., Reynaert, H. & van Grunsven, L. A., 1 Jul 2021, In : International Journal of Molecular Sciences. 22, 13, 18 p., 7137.Research output: Contribution to journal › Article
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Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis
Vandewalle, J., Timmermans, S., Paakinaho, V., Vancraeynest, L., Dewyse, L., Vanderhaeghen, T., Wallaeys, C., Van Wyngene, L., Van Looveren, K., Nuyttens, L., Eggermont, M., Dewaele, S., Velho, T. R., Moita, L. F., Weis, S., Sponholz, C., van Grunsven, L. A., Dewerchin, M., Carmeliet, P., De Bosscher, K. & 3 others, , 7 Sep 2021, In : Cell Metabolism. 33, 9, p. 1763-1776.e5 14 p.Research output: Contribution to journal › Article
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Directed differentiation of human induced pluripotent stem cells to hepatic stellate cells
Vallverdú, J., Martínez García de la Torre, R. A., Mannaerts, I., Verhulst, S., Smout, A., Coll, M., Ariño, S., Rubio-Tomás, T., Aguilar-Bravo, B., Martínez-Sánchez, C., Blaya, D., Verfaillie, C. M., van Grunsven, L. A. & Sancho-Bru, P., May 2021, In : Nature Protocols. 16, 5, p. 2542-2563 22 p.Research output: Contribution to journal › Article
2 Citations (Scopus) -
Direct reprogramming of somatic cells into induced hepatocytes: Cracking the Enigma code
Rombaut, M., Boeckmans, J., Rodrigues, R. M., van Grunsven, L. A., Vanhaecke, T. & De Kock, J., Sep 2021, In : Journal of Hepatology. 75, 3, p. 690-705 16 p.Research output: Contribution to journal › Article
Open AccessFile10 Downloads (Pure)
Activities
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PLoS ONE (Journal)
Leo A Van Grunsven (Editor)1 Sep 2014 → …Activity: Publication peer-review and editorial work › Editorial activity
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Epigen meeting
Leo A Van Grunsven (Participant)27 Feb 2014Activity: Participating in or organising an event › Participation in workshop, seminar
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European Association for the Study of the Liver (External organisation)
Leo A Van Grunsven (Member)1 Jan 2007 → 1 Jan 2030Activity: Membership › Membership of external research organisation
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Chromatin Dynamics and Epigenetics
Leo A Van Grunsven (Participant)10 Mar 2007Activity: Participating in or organising an event › Participation in workshop, seminar
Thesis
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ASPIRE: adjuvant-driven induction of cancer Specific Immune Responses
Author: Van Der Jeught, K., Breckpot, K., Thielemans, K., Vanderkerken, K., Menu, E., van Grunsven, L. A., Pascolo, S. & Raemdonck, K., 20 Oct 2016Supervisor: Breckpot, K. (Promotor), Thielemans, K. (Promotor), Vanderkerken, K. (Jury), Van Grunsven, L. A. (Jury), Menu, E. (Jury), Van Raemdonck, K. (External person) (Jury) & Pascolo, S. (External person) (Jury)
Student thesis: Doctoral Thesis
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Balancing between totipotency and differentiation in human embryos.
Author: Krivega, M., Van De Velde, H., Geens, M., Van Schravendijk, C., van Grunsven, L. A., Mateizel, I., Viville, S. & Tilleman, K., 3 Sep 2015Supervisor: Van De Velde, H. (Promotor), Geens, M. (Promotor), Van Schravendijk, C. (Jury), Van Grunsven, L. A. (Jury), Mateizel, I. (Jury), Viville, S. (External person) (Jury) & Tilleman, K. (External person) (Jury)
Student thesis: Doctoral Thesis
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Characterization of hepcidin-inducing cytokines in multiple myeloma.
Author: Maes, K., Vanderkerken, K., Van Grunsven, L., Van Den Branden, C. & Kooijman, R., 28 Jan 2010Supervisor: Vanderkerken, K. (Promotor), Van Grunsven, L. A. (Jury), Van Den Branden, C. (Jury) & Kooijman, R. (Jury)
Student thesis: Master's Thesis
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Characterization of human quiescent, activated and inactivated hepatic stellate cells
Author: El Taghdouini, A., van Grunsven, L. A., Van Schravendijk, C., Vanderkerken, K., Heimberg, H., Laleman, W. & Trautwein, C., 3 May 2016Supervisor: Van Grunsven, L. A. (Promotor), Van Schravendijk, C. (Jury), Vanderkerken, K. (Jury), Heimberg, H. (Jury), Trautwein, C. (External person) (Jury) & Wim, L. (External person) (Jury)
Student thesis: Doctoral Thesis
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Contribution to the isolation and hepatic differentiation of postnatal stem/progenitor cells from human adipose tissue
Author: Albattah, F., Rogiers, V., van Grunsven, L. A., Vanhaecke, T., Smolders, I., Mangelings, D., Massie, A., Leclercq, I. & Roskams, T., 15 Dec 2011Supervisor: Rogiers, V. (Promotor), Van Grunsven, L. A. (Co-promotor), Vanhaecke, T. (Co-promotor), Smolders, I. (Jury), Mangelings, D. (Jury), Massie, A. (Jury), Leclercq, I. (External person) (Jury) & Roskams, T. (External person) (Jury)
Student thesis: Doctoral Thesis