Projects per year
Personal profile
Expertise
Leo van Grunsven is a developmental biologist (Utrecht, NL) and obtained his PhD in life sciences from the Ecole Normale Supérieure de Lyon (France, 1996). He had his postdoctoral training at the NINDS/NIH (Bethesda, USA, ’96-‘98) and the KU Leuven (Belgium, ’98-‘06) before he moved to the Vrije Universiteit Brussel and became head of the Liver Cell Biology research group in 2009.
His group studies molecular mechanisms that drive liver homeostasis, fibrosis, and regeneration, with a particular focus on hepatic stellate cells. He also specialized in developing in vitro models for studying chronic liver disease. His group was the first to identify autophagy, AGE- and Hippo-signaling as key mechanisms involved in hepatic stellate cell activation during liver fibrogenesis. His team also reported on the transcriptional changes that are associated with the activation of mouse and human hepatic stellate cells and established the first hepatocyte-injury dependent in vitro liver fibrosis model by using organoid cultures of human hepatocytes and primary or iPSC-derived hepatic stellate cells. The group currently invests in refining and applying their in vitro models of liver fibrosis and investigates the regulation of stress pathways in hepatic stellate cells and other sinusoidal liver cells during an acute and chronic liver injury in mouse models.
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Collaborations and top research areas from the last five years
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FWOTM1257: CATCH - CAR-T cell immunotherapy against Chronic liver disease and Hepatocellular carcinoma
De Wolf, R., van Grunsven, L. & Breckpot, K.
1/11/24 → 31/10/28
Project: Fundamental
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HERC66: 3D-CELLMAP: Unveiling complex cellular interactions in tissues through 3D super-resolution protein multiplex imaging
Movahedi, K., Rooman, I., Sermon, K., De Bundel, D., Fioravanti, A., Staels, W., Magez, S., Breckpot, K., De Kock, J., Laoui, D., Goyvaerts, C., Smolders, I., Van Ginderachter, J., Marcelino Rodrigues, R., De Leu, N., van Grunsven, L., Hernot, S., Peeters, E., Vanhaecke, T., De Veirman, K., Ruytinx, J., Van Schependom, J., Kortekaas, I. & Goossens, E.
1/05/24 → 31/05/28
Project: Fundamental
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OZR4233: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - KU Leuven, KIMPS Laurens
20/10/23 → 19/10/27
Project: Fundamental
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EU667: Imaging Ageing Endothelium at the nanoscale - Doctorates
1/10/23 → 30/09/27
Project: Fundamental
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Research output
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An opto-acousto-fluidic microchip for efficient Raman spectroscopy of microparticles in aqueous environment
Lotfi Choobbari, M., Vandermotten, M., Chalyan, T., Bihi, I., Gelin, P. P., De Malsche, W., Meulebroeck, W., van Grunsven, L. A., Thienpont, H. & Ottevaere, P. D. I. H., 1 Nov 2024, In: Sensors and Actuators. B, Chemical. 418, p. 1-10 10 p., 136300.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
Early detection of liver fibrosis through hepatic stellate cell activation monitoring using Raman spectroscopy and machine learning
Vandermotten, M., Knetemann, E., Chalyan, T., Meulebroeck, W., van Grunsven, L. A. & Ottevaere, P. D. I. H., 2024, Early detection of liver fibrosis through hepatic stellate cell activation monitoring using Raman spectroscopy and machine learning. SPIE, Vol. 13006. p. 1-6 6 p. 1300603Research output: Chapter in Book/Report/Conference proceeding › Conference paper
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Gain of 1q confers an MDM4-driven growth advantage to undifferentiated and differentiating hESC while altering their differentiation capacity
Krivec, N., Couvreu De Deckersberg, E., Lei, Y., Al Delbany, D., Regin, M., Verhulst, S., van Grunsven, L. A., Sermon, K. & Spits, C., 21 Nov 2024, In: Cell Death and Disease. 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
GPR176 Expression Correlates With Hepatic Stellate Cell Activation In Metabolic Dysfunction-Associated Steatotic Liver Disease And Chronic Viral Hepatitis
De Smet, V., Gürbüz, E., Eysackers, N., Smout, A., Lefesvre, P., Messaoudi, N., Mannaerts, I., Verhulst, S. & van Grunsven, L. A., 2024, In: Acta Gastro-Enterologica Belgica. Vol 87 (S1), 1 p., A04.Research output: Contribution to journal › Meeting abstract (Journal)
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Human iPSC-derived liver co-culture spheroids to model liver fibrosis
Cools, L., Kazemzadeh Dastjerd, M., Smout, A., Merens, V., Yang, Y., Reynaert, H., Messaoudi, N., De Smet, V., Kumar, M., Verhulst, S., Verfaillie, C. & van Grunsven, L. A., 28 Jun 2024, In: Biofabrication. 16, 3, p. 1-18 18 p., 035032.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Activities
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OZR ZAP selection (Event)
Aldo Scafoglieri (Contributor), Eva Swinnen (Contributor), Koen Putman (Chair), Debby Mangelings (Contributor) & Leo van Grunsven (Contributor)
8 Jun 2022Activity: Membership › Membership of peer-review panel or committee
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Multicellular primary mouse liver spheroids for DILI, NAFLD, NASH and fibrosis studies.
Laura Cools (Speaker), Elise Van Os (Speaker), Nathalie Eysackers (Contributor), Ayla Smout (Contributor), Stefaan Verhulst (Contributor), Hendrik Reynaert (Contributor), Inge Mannaerts (Contributor) & Leo van Grunsven (Contributor)
24 Jun 2021Activity: Talk or presentation › Talk or presentation at a conference
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Multicellular primary mouse liver spheroids for DILI, NAFLD, NASH and fibrosis studies.
Laura Cools (Speaker), Elise Van Os (Speaker), Nathalie Eysackers (Contributor), Ayla Smout (Contributor), Stefaan Verhulst (Contributor), Hendrik Reynaert (Contributor), Inge Mannaerts (Contributor) & Leo van Grunsven (Contributor)
28 Sep 2021Activity: Talk or presentation › Talk or presentation at a conference
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Multicellular primary mouse liver spheroids for DILI, NAFLD, NASH and fibrosis studies.
Laura Cools (Speaker), Elise Van Os (Speaker), Nathalie Eysackers (Contributor), Ayla Smout (Contributor), Stefaan Verhulst (Contributor), Hendrik Reynaert (Contributor), Inge Mannaerts (Contributor) & Leo van Grunsven (Contributor)
4 Mar 2021Activity: Talk or presentation › Talk or presentation at a conference
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LSECs in chronic liver disease- Willy Gepts, UZ brussel
Elise Van Os (Recipient) & Leo van Grunsven (Contributor)
1 Jan 2021 → 1 Jan 2022Activity: Other › Written proposal
Thesis
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Real-Time in vitro Toxicity Monitoring in a Microfluidic Bioreactor for Drug and Chemical Safety Assessment
Author: van Grunsven, L. A. & Prill, S., 7 Jul 2015Student thesis: Doctoral Thesis
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Real-time in vitro toxicity monitoring in a microfluidic bioreactor for drug and chemical safety assessment.
Author: van Grunsven, L. A. & Prill, S., 4 Mar 2015Student thesis: Doctoral Thesis
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The Functional Role of Furin in the Liver during Homeostasis and Pathological Conditions: A Journey of Challenges and Pitfalls in Transgene Technology
Author: van Grunsven, L. A. & Pruniau, V., Nov 2015Student thesis: Doctoral Thesis