Projects per year
Personal profile
Expertise
- Fundamental Research in Eukaryotic Gene Expression. Protein Structure and Action (X-ray crystallography). Protein engineering (Site directed mutagenesis/Enzym kinetics).
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Dive into the research topics where Lode Wyns is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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CONO272: Study day on synchrotron and neutron radiation DD. 23 april 2009.
20/02/09 → …
Project: Fundamental
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AIIESA11: PRODEX 8 : Influence of mass transport and surface growth processes on protein crystal perfection.+ PRODEX 9, PRODEX10.
1/01/06 → 31/12/22
Project: Fundamental
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Research output
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Epitope tag for affinity-based applications
Pardon, E., Steyaert, J. & Wyns, L., 18 Oct 2018, IPC No. C07K14/47, C07K5/10, EPO, Patent No. EP2576609B, 25 May 2011, Priority date 25 May 2010, Priority No. GB1008682.5Research output: Patent
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Study of the structural and dynamic effects in the FimH adhesin upon α-D-heptyl mannose binding
Vanwetswinkel, S., Volkov, O., Sterckx, Y., Garcia Pino, A., Buts, L., Vranken, W., Bouckaert, J., Roy, R., Wyns, L. & Van Nuland, N., 29 Jan 2014, In : Journal of Medicinal Chemistry. 57, p. 1416-1427 12 p.Research output: Contribution to journal › Article
36 Citations (Scopus) -
A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation.
De Genst, E., Chan, P., Pardon, E., Hsu, S-T. D., Kumita, J., Christodoulou, J., Menzer, L., Dimitri, C., Robinson, C. V., Muyldermans, S., Matagne, A., Wyns, L., Dobson, C. M. & Dumoulin, M., 6 Aug 2013, In : Journal of Physical Chemistry B. Special Issue:Peter G. Wolynes Festschrift, p. 13245-13258 14 p.Research output: Contribution to journal › Article
35 Citations (Scopus) -
Nanobodies Raised against Monomeric alpha-Synuclein Distinguish between Fibrils at Different Maturation Stages
Guilliams, T., El-Turk, F., Buell, A. K., O'Day, E. M., Aprile, F. A., Esbjoerner, E. K., Vendruscolo, M., Cremades, N., Pardon, E., Wyns, L., Welland, M. E., Steyaert, J., Christodoulou, J., Dobson, C. M. & De Genst, E., 24 Jul 2013, In : Journal of Molecular Biology. 425, 14, p. 2397-2411 15 p.Research output: Contribution to journal › Article
Open AccessFile65 Citations (Scopus)135 Downloads (Pure) -
Validation of reactivity descriptors to assess the aromatic stacking within the tyrosine gate of FimH
Roos, G., Wellens, A., Touaibia, M., Yamakawa, N., Geerlings, P., Roy, R., Wyns, L. & Bouckaert, J., 1 Nov 2013, In : ACS Medicinal Chemistry Letters. 4, 11, p. 1085-1090 6 p.Research output: Contribution to journal › Article
27 Citations (Scopus)
Prizes
Activities
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23rd Solvay Conference on Chemistry: new chemistry and new opportunities from the expanding protein universe
Lode Wyns (Keynote speaker)16 Oct 2013 → 20 Oct 2013Activity: Talk or presentation › Talk or presentation at a conference
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Solvay workshop on "Design Principles and hardware of biological circuits"
Lode Wyns (Organiser)15 Feb 2012 → 17 Feb 2012Activity: Participating in or organising an event › Participation in workshop, seminar
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Discussion day "Large European Infrastructures"
Lode Wyns (Organiser)Feb 2007Activity: Participating in or organising an event › Participation in conference
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University of Southern Denmark (External organisation)
Lode Wyns (Member)1 Jan 2007 → …Activity: Membership › Membership of external research organisation
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V.R.W.B. (External organisation)
Lode Wyns (Host)1 Jan 2006 → 31 Dec 2006Activity: Membership › Work on advisory panel to industry or government or non-government organisation
Thesis
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Affiniteitsmaturatie van Camelus dromedarius enkel-domein antilichaamfragment, bepaald door in vitro mutagenese, affiniteits- en stabiliteitsmetingen.
Author: Van Meirhaeghe, A., Muyldermans, S. & Wyns, L., 1998Supervisor: Muyldermans, S. (Promotor) & Wyns, L. (Co-promotor)
Student thesis: Master's Thesis
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Align-m, a platform for sensitive and higly specific multiple sequence alignment.
Author: Van Walle, I., Wyns, L. & Lasters, I., 2005Supervisor: Wyns, L. (Promotor) & Lasters, I. (External person) (Co-promotor)
Student thesis: Doctoral Thesis
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Analysis of protein-carbohydrate interactions using macromolecular crystallography and biophysical affinity measurements
Author: Buts, L., Wyns, L., Abbaspour Tehrani, K., Loris, R., Willem, R., Cunin, R., Imberty, A. & Kamerling, H., 2004Supervisor: Wyns, L. (Promotor), Abbaspour Tehrani, K. (Jury), Loris, R. (Co-promotor), Willem, R. (Jury), Cunin, R. (Jury), Imberty, A. (External person) (Jury) & Kamerling, H. (External person) (Jury)
Student thesis: Doctoral Thesis
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An integrative structural bioinformatics approach for the study of human genetic variation underlying conformational disease
Author: Reumers, J., Rousseau, F., Wyns, L., Maes, D., Serrano, L. & Van De Peer, Y., 23 Jun 2008Supervisor: Rousseau, F. (Promotor), Wyns, L. (Jury), Maes, D. (Jury), Serrano, L. (External person) (Jury) & Van De Peer, Y. (External person) (Jury)
Student thesis: Doctoral Thesis
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Anti hapten heavy chain antibodies from camelidae
Author: Serrao, M., Wyns, L. & Muyldermans, S., 2004Supervisor: Wyns, L. (Promotor) & Muyldermans, S. (Co-promotor)
Student thesis: Doctoral Thesis