Projects per year
Personal profile
Expertise
Research focus: mRNA technology, development and manufacturing of mRNA-based therapeutics.
- Improving stability and biological activity of mRNA vaccines;
- Individualised Neoantigen-based cancer therapy;
- Automatised mRNA production pipeline for research grade/ GMP
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Dive into the research topics where Lorenzo Franceschini is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Projects
- 2 Active
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FWOTM1309: COLORNA: Colorectal cancer mRNA therapy focusing on the immune checkpoint ST2
Marco Aragon, M. (Mandate), Breckpot, K. (Administrative Promotor) & Franceschini, L. (CoI (Co-Promotor))
1/11/25 → 31/10/29
Project: Fundamental
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IOF3036: INTEGRAL - Integrating a multimodal approach to address current challenges in immunotherapy
Van Ginderachter, J. (Administrative Promotor), Laoui, D. (CoI (Co-Promotor)), Movahedi, K. (CoI (Co-Promotor)), Hadadi, E. (CoI (Co-Promotor)), Stijlemans, B. (CoI (Co-Promotor)), Raes, G. (CoI (Co-Promotor)), Devoogdt, N. (CoI (Co-Promotor)), Lahoutte, T. (CoI (Co-Promotor)), De Groof, T. (CoI (Co-Promotor)), Goyvaerts, C. (CoI (Co-Promotor)), D'Huyvetter, M. (CoI (Co-Promotor)), Debacker, J. (CoI (Co-Promotor)), Breckpot, K. (CoI (Co-Promotor)), Franceschini, L. (CoI (Co-Promotor)), Raes, G. (Mandate) & Revets, H. (Mandate)
1/01/25 → 31/12/29
Project: Applied
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A novel pentavalent mRNA-LNP vaccine developed using immunopeptidomics-driven antigen identification protects against Mycobacterium tuberculosis
Ferrel, K., Van Moortel, L. (Contributor), Willems, P. (Contributor), Aernout, I. (Contributor), Franceschini, L. (Contributor), Mwangi, K. (Contributor), Verbeke, R. (Contributor), Gul, A. (Contributor), Veront, C. (Contributor), Cobanoglu, Ö. (Contributor), Breckpot, K. (Contributor), Lentacker, I. (Contributor), Demangel, C. (Contributor) & Impens, F. (Contributor), 12 Oct 2026, (Unpublished). 1 p.Research output: Unpublished contribution to conference › Unpublished abstract
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Beyond iNKT Activation: α-GalCer–adjuvanted mRNA-LNP Vaccines Elicit Broader Unconventional T-Cell Responses
Mwangi, K., Aernout, I. (Contributor), Ehourne, T. (Contributor), De Velder, M. (Contributor), Swinnen, J. (Contributor), Verplancke, A. (Contributor), De Geest, B. (Contributor), Franceschini, L. (Contributor), Breckpot, K. (Contributor), De Smet, S. (Contributor), Verbeke, R. (Contributor) & Lentacker, I. (Contributor), 12 Oct 2026, (Unpublished). 1 p.Research output: Unpublished contribution to conference › Unpublished abstract
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Immunopeptidomics-identified and mRNA-encoded Mycobacterium tuberculosis antigens elicit functional human T cells with antimycobacterial activity
Marco Aragon, M., Autaers, D., Boel, E. (Contributor), Mwangi, K. (Contributor), Aernout, I. (Contributor), Van Moortel, L. (Contributor), Willems, P. (Contributor), Kovalchuke, L. (Contributor), Franceschini, L. (Contributor), Lentacker, I. (Contributor), Impens, F. (Contributor) & Breckpot, K. (Contributor), 12 Oct 2026. 1 p.Research output: Unpublished contribution to conference › Unpublished abstract
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An mRNA-based workflow validating neo-epitope presentation through HLA-I/peptide affinity purification
Esprit, A., Autaers, D., Thielemans, K., Pepermans, E., Boonen, K., Baggerman, G., Franceschini, L. & Breckpot, K., 4 Jun 2025, In: Frontiers In Immunology. 16, p. 1-10 10 p., 1566461.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)8 Downloads (Pure) -
B7-H3 nanobody-based CAR T cells control multiple myeloma growth, while dual BCMA/B7-H3 CAR T cells overcome antigen escape
van der Vreken, A., Meeus, F., Tu, C., van den Broecke, L., Raimondi, V., Vescovini, R., Hanssens, H., Watté, F., Autaers, D., Aragon, M., Billiau, J., De Veirman, K., Vanderkerken, K., De Vlaeminck, Y., Franceschini, L., Lee, H., Neri, P., De Bruyne, E., Storti, P. & Giuliani, N. & 2 others, , 14 Nov 2025, In: Journal of Hematology & Oncology. 18, 17 p., 103.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)15 Downloads (Pure)
Datasets
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Sequence simplification of antigen coding IVT mRNA allows accelerated synthetic DNA template generation and epitope immunogenicity validation
Breckpot, K. (Creator), Esprit, A. (Creator), Autaers, D. (Creator), Franceschini, L. (Creator), Lentacker, I. (Creator) & Aernout, I. (Creator), VUB Institutional Data Repository, 11 Aug 2025
Dataset
Prizes
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FWO travel grant
Franceschini, L. (Recipient) & Breckpot, K. (Recipient), 7 Dec 2023
Prize: Prize (including medals and awards)
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Developing synthetic RNA for the rapid selection of next-generation personalized therapeutics.
Franceschini, L. (Speaker)
4 Jun 2026Activity: Talk or presentation › Talk or presentation at a conference
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Developing personalized synthetic RNA for the rapid selection of next-generation therapeutics
Franceschini, L. (Speaker)
2 Oct 2025Activity: Talk or presentation › Talk or presentation at a conference
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Developing personalized synthetic RNA for the rapid selection of next-generation therapeutics
Franceschini, L. (Speaker)
8 May 2025Activity: Talk or presentation › Talk or presentation at a conference
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CHIMERNA
Franceschini, L. (Speaker)
29 May 2025Activity: Talk or presentation › Talk or presentation at a conference
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Sequence simplification of antigen coding IVT mRNA allows accelerated synthetic DNA template generation and epitope immunogenicity validation
Franceschini, L. (Speaker)
10 Jun 2025Activity: Talk or presentation › Talk or presentation at a conference
Thesis
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Plasmid engineering to enhance stability and translatability for MRNA-based immunotherapy
Cappelle, C. A. ((PhD) Student), Thielemans, K. (Promotor) & Franceschini, L. (Co-promotor), 2019Student thesis: Master's Thesis