Projects per year
Personal profile
Expertise
- In vitro and in vivo models to induce islet regeneration or islet cell neogenesis and in which the effect of soluble growth factors, hormones, cytokines or pharmacological substances can be studied
- Regenerative medicine for diabetes
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OZR3588: Financiering FWO hercules: ERA platform: Extended RNA Analysis platform - version 2.0
Rooman, I., Bouwens, L., Heimberg, H., Neyns, B., Vranken, W., Vanhaecke, T., Massie, A., van Grunsven, L., De Bruyne, E., De Bundel, D., Forsyth, R., Breckpot, K., Van Dooren, S., De Kock, J., Njemini, R. & Laoui, D.
1/05/20 → 30/04/24
Project: Fundamental
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HERC44: FWO Hercules MZW: ERA platform: Extended RNA Analysis platform
Rooman, I., Baeyens, L., Goossens, E., Vanhaecke, T., van Grunsven, L., Bouwens, L., De Bundel, D., Bautmans, I., Massie, A., Van Riet, I., De Bruyne, E., De Kock, J. & Forsyth, R.
1/05/18 → 30/04/22
Project: Fundamental
Research output
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In vitro comparison of various antioxidants and flavonoids from Rooibos as beta cell protectants against lipotoxicity and oxidative stress-induced cell death
Moens, C., Muller, C. J. F. & Bouwens, L., 2022, In : PLOS ONE. 17, 5, 16 p., e0268551.Research output: Contribution to journal › Article
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Discovery and 3D imaging of a novel ΔNp63-expressing basal cell type in human pancreatic ducts with implications in disease
Martens, S., Coolens, K., Van Bulck, M., Arsenijevic, T., Casamitjana, J., Fernandez Ruiz, A., El Kaoutari, A., Martinez de Villareal, J., Madhloum, H., Esni, F., Heremans, Y., Leuckx, G., Heimberg, H., Bouwens, L., Jacquemin, P., De Paep, D. L., In't Veld, P., D'Haene, N., Bouchart, C., Dusetti, N. & 6 others, , 30 Jul 2021, In : Gut.Research output: Contribution to journal › Article
Open AccessFile2 Citations (Scopus) -
Dynamic regulation of expression of KRAS and its effectors determines the ability to initiate tumorigenesis in pancreatic acinar cells
Assi, M., Achouri, Y., Loriot, A., Dauguet, N., Dahou, H., Baldan, J., Libert, M., Fain, J. S., Guerra, C., Bouwens, L., Barbacid, M., Lemaigre, F. P. & Jacquemin, P., May 2021, In : Cancer Research. 81, 10, p. 2679-2689 11 p.Research output: Contribution to journal › Article
5 Citations (Scopus) -
Fractionated Radiation Severely Reduces the Number of CD8+ T Cells and Mature Antigen Presenting Cells Within Lung Tumors
Reijmen, E., De Mey, S., De Mey, W., Gevaert, T., De Ridder, K., Locy, H., Martens, S., De Blay, E., Bouwens, L., Debie, P., Breckpot, K., De Grève, J., De Ridder, M. & Goyvaerts, C., 1 Sep 2021, In : International Journal of Radiation Oncology, Biology, Physics. 111, 1, p. 272-283 12 p.Research output: Contribution to journal › Article
8 Citations (Scopus) -
MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions
Backx, E., Wauters, E., Baldan, J., Van Bulck, M., Michiels, E., Heremans, Y., De Paep, D. L., Kurokawa, M., Goyama, S., Bouwens, L., Jacquemin, P., Houbracken, I. & Rooman, I., Sep 2021, In : Cell Death and Differentiation. 28, 9, p. 2601-2615 15 p.Research output: Contribution to journal › Article
Open AccessFile7 Citations (Scopus)29 Downloads (Pure)
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DPP6 as a new biomarker suitable for human islet in vivo imaging
Nick Devoogdt (Contributor), Rita Sofia Garcia Ribeiro (Speaker), Stéphane Demine (Contributor), Julie Kerr-Conte (Contributor), Julien Thévenet (Contributor), Alexander Balhuizen (Contributor), Davide Pacetti (Contributor), Raphael Scharfmann (Contributor), Piero Marchetti (Contributor), Serge Goldman (Contributor), Tony Lahoutte (Contributor), Luc Bouwens (Contributor), Decio Eizirik (Contributor)4 Jun 2018Activity: Talk or presentation › Talk or presentation at a conference
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DPP6 as a new biomarker suitable for human islet in vivo imaging
Rita Sofia Garcia Ribeiro (Speaker), Stephane Demine (Contributor), Julie Kerr-Conte (Contributor), Francois Pattou (Contributor), Davide Pacitte (Contributor), Raphael Scharfmann (Contributor), Piero Marchetti (Contributor), Serge Goldman (Contributor), Tony Lahoutte (Contributor), Luc Bouwens (Contributor), Decio Eizirik (Contributor), Nick Devoogdt (Contributor)4 Oct 2018Activity: Talk or presentation › Talk or presentation at a conference
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Acinar cells in the neonatal pancreas grow by self-duplication and not by neogenesis from duct cells
Isabelle Houbracken (Speaker), Luc Bouwens (Contributor)6 Oct 2018Activity: Talk or presentation › Talk or presentation at a conference
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A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic islets
Alexander Balhuizen (Contributor), Iris Mathijs (Contributor), Sam Massa (Contributor), Jean-Valery Turatsinze (Contributor), Jens De Vos (Contributor), Stéphane Demine (Contributor), Catarina Xavier (Contributor), Olatz Villate (Contributor), Isabelle Millard (Contributor), Dominique Egrise (Contributor), Carmen Capito (Contributor), Raphael Scharfmann (Contributor), Peter In't Veld (Contributor), Piero Marchetti (Contributor), Serge Muyldermans (Contributor), Serge Goldman (Contributor), Tony Lahoutte (Contributor), Luc Bouwens (Contributor), Decio Eizirik (Contributor), Nick Devoogdt (Speaker)5 Apr 2017 → 7 Apr 2017Activity: Talk or presentation › Talk or presentation at a conference
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A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic islets
Alexander Balhuizen (Contributor), Iris Mathijs (Contributor), Sam Massa (Contributor), Jean-Valery Turatsinze (Contributor), Jens De Vos (Contributor), Stéphane Demine (Contributor), Catarina Xavier (Contributor), Olatz Villate (Contributor), Isabelle Millard (Contributor), Dominique Egrise (Contributor), Carmen Capito (Contributor), Raphael Scharfmann (Contributor), Peter In't Veld (Contributor), Piero Marchetti (Contributor), Serge Muyldermans (Contributor), Serge Goldman (Contributor), Tony Lahoutte (Contributor), Luc Bouwens (Contributor), Decio Eizirik (Contributor), Nick Devoogdt (Speaker)13 Sep 2017 → 16 Sep 2017Activity: Talk or presentation › Talk or presentation at a conference
Thesis
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Assessment of Functional Beta Cell Mass in the Rodent Pancreas
Author: Chintinne, M., Pipeleers, D., Marichal, M., Ling, Z., Van Schravendijk, C., Lahoutte, T., Bouwens, L., Lenmark, A. & Roels, F., 7 Sep 2012Supervisor: Pipeleers, D. (Promotor), Marichal, M. (Co-promotor), Ling, Z. (Co-promotor), Van Schravendijk, C. (Jury), Lahoutte, T. (Jury), Bouwens, L. (Jury), Lernmark, A. (External person) (Jury) & Roels, F. (External person) (Jury)
Student thesis: Doctoral Thesis
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Characterisation of ciliary neurotrophic factor and ciliary neurotrophic factor receptor expression in adult rat pancreas
Author: Desimmie, B., Jun 2008Supervisor: Houbracken, I. (Co-promotor) & Bouwens, L. (Promotor)
Student thesis: Master's Thesis
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De rol van neogenine in de morfogenese en regeneratie van de pancreas.
Author: De Breuck, S. & Bouwens, L., 2001Supervisor: Bouwens, L. (Promotor)
Student thesis: Master's Thesis
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Determining the effects of Aspalathin on INS-1E cells using in vitro experiments: Master thesis of Science in Molecular Biology (Interuniversity Program Molecular Biology)
Author: Fualefac, A., Aug 2016Supervisor: Bouwens, L. (Promotor), Himpe, E. (Co-promotor) & Houbracken, I. (Jury)
Student thesis: Master's Thesis
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Evaluation of antioxidants and flavonoids as beta-cell protectants
Author: Moens, C. & Rosseel, F., 2020Supervisor: Bouwens, L. (Promotor)
Student thesis: Master's Thesis