Projects per year
Personal profile
Expertise
Marius Regin graduated in Biomedical Sciences at the VUB in june 2018 with great distinction. During his master thesis at REGE he validated and implemented simultaneous genomic and transcriptomic sequencing of single human embryonic stem cells. Immediately after obtaining his master degree he started his PhD project under supervision of Prof. Sermon and Prof. Spits on the search for the origin of chromosomal abnormalities in human preimplantation embryos. Furthermore, he has ongoing collaborations with the KU Leuven and the Karolinska Institutet (Sweden).
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Collaborations and top research areas from the last five years
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Projects
- 1 Finished
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FWOTM968: The search for the origin of chromosomal abnormalities in human preimplantation embryos
Sermon, K., Spits, C. & Regin, M.
1/10/19 → 31/10/23
Project: Fundamental
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Loss of 18q Alters TGFβ Signalling Affecting Anteroposterior Neuroectodermal Fate in Human Embryonic Stem Cells
lei, Y., Duong, C. M., Krivec, N., Janssens, C., Regin, M., Huyghebaert, A., Deckersberg, E. C. D., Sermon, K., Delbany, D. A. & Spits, C., 5 Feb 2025, In: Cell Proliferation. 12 p., e13813.Research output: Contribution to journal › Article › peer-review
Open Access -
The interplay between mitochondrial DNA genotypes, female infertility, ovarian response and mutagenesis in oocytes
Van Der Kelen, A., Li Piani, L., Mertens, J., Regin, M., Couvreu De Deckersberg, E., Van De Velde, H., Sermon, K., Tournaye, H., Verpoest, W., Hes, F. J., Blockeel, C. & Spits, C., 2025, In: Human reproduction open. 2025, 1, 13 p., hoae074.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Children born after assisted reproduction more commonly carry a mitochondrial genotype associating with low birthweight
Spits, C., Mertens, J., Belva, F., van Montfoort, A. PA., Regin, M., Zambelli, F., Seneca, S., Couvreu De Deckersberg, E., Bonduelle, M-L., Tournaye, H., Stouffs, K., Barbé, K., Smeets, B., Van De Velde, H., Sermon, K. & Blockeel, C., 9 Feb 2024, In: Nature Communications. 15, 1, p. 1232 16 p., 1232 .Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)28 Downloads (Pure) -
Complex aneuploidy triggers autophagy and p53-mediated apoptosis and impairs the second lineage segregation in human preimplantation embryos
Regin, M., Lei, Y., Couvreu De Deckersberg, E., Janssens, C., Huyghebaert, A., Guns, Y., Verdyck, P., Verheyen, G., Van de Velde, H., Sermon, K. & Spits, C., 9 Dec 2024, In: eLife. 12, 24 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus) -
De Novo Cancer Mutations Frequently Associate with Recurrent Chromosomal Abnormalities during Long-Term Human Pluripotent Stem Cell Culture
Delbany, D. A., Ghosh, M. S., Krivec, N., Huyghebaert, A., Regin, M., Duong, M. C., Lei, Y., Sermon, K., Olsen, C. & Spits, C., 21 Aug 2024, In: Cells. 13, 16, p. 1-14 14 p., 1395.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)27 Downloads (Pure)
Datasets
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De Novo Cancer Mutations Frequently Associate with Recurrent Chromosomal Abnormalities during Long-Term Human Pluripotent Stem Cell Culture
Al Delbany, D. (Creator), Ghosh, M. (Creator), Krivec, N. (Creator), Huyghebaert, A. (Creator), Regin, M. (Creator), Duong, C. M. (Creator), Lei, Y. (Creator), Sermon, K. (Creator), Olsen, C. (Creator) & Spits, C. (Creator), OSF, 2024
Dataset
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Gain of 1q confers an MDM4-driven growth advantage to undifferentiated and differentiating hESC while altering their differentiation capacity
Spits, C. (Creator), Krivec, N. (Creator), Al Delbany, D. (Creator), Regin, M. (Creator), Lei, Y. (Creator), Sermon, K. (Creator), Couvreu De Deckersberg, E. (Creator), van Grunsven, L. (Creator) & Verhulst, S. (Creator), VUB Institutional Data Repository, 9 May 2025
Dataset
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Lineage segregation in human pre-implantation embryos is specified by YAP1 and TEAD1
Spits, C. (Creator), Regin, M. (Creator), Essahib, W. (Creator), Demtschenko, A. (Creator), Dewandre, D. (Creator), David, L. (Creator), Gerri, C. (Creator), Niakan, K. K. (Creator), Verheyen, G. (Creator), Tournaye, H. (Creator), Sterckx, J. (Creator), Sermon, K. (Creator), Van De Velde, H. (Creator) & Verloes, A. (Creator), VUB Institutional Data Repository, 16 May 2025
DOI: 10.17605/OSF.IO/NUHZM, https://osf.io/nuhzm/
Dataset
Activities
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Regulators of cell fate decisions in human pre-implantation embryos (Event)
Luc Leyns (Jury), Marius Regin (Presenter), Karen Sermon (Supervisor) & Claudia Spits (Supervisor)
28 Mar 2024Activity: Membership › Member of PhD committee
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Aneuploidy induces proteotoxic stress and autophagy-mediated apoptosis in human preimplantation embryos
Marius Regin (Speaker), Edouard Couvreu De Deckersberg (Contributor), Yves Guns (Contributor), Pieter Verdyck (Contributor), Greta Verheyen (Contributor), Hilde Van De Velde (Contributor), Claudia Spits (Contributor) & Karen Sermon (Contributor)
1 Jul 2021Activity: Talk or presentation › Talk or presentation at a conference
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Aneuploidy induces proteotoxic stress and autophagy-mediated apoptosis in human preimplantation embryos
Marius Regin (Speaker), Yingnan Lei (Contributor), Edouard Couvreu De Deckersberg (Contributor), Yves Guns (Contributor), Pieter Verdyck (Contributor), Greta Verheyen (Contributor), Hilde Van De Velde (Contributor), Claudia Spits (Contributor) & Karen Sermon (Contributor)
26 Nov 2021 → 27 Nov 2021Activity: Talk or presentation › Talk or presentation at a conference
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Mitochondrial DNA mosaicism in early human development
Joke Mertens (Speaker), Marius Regin (Contributor), Neelke De Munck (Contributor), Edouard Couvreu De Deckersberg (Contributor), Christophe Blockeel (Contributor), Herman Tournaye (Contributor), Hilde Van De Velde (Contributor), Karen Sermon (Contributor) & Claudia Spits (Contributor)
17 Sept 2021Activity: Talk or presentation › Talk or presentation at a conference
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Mitochondrial DNA mosaicism in early human development
Joke Mertens (Speaker), Marius Regin (Contributor), Neelke De Munck (Contributor), Hilde Van De Velde (Contributor), Karen Sermon (Contributor) & Claudia Spits (Contributor)
25 Jun 2019Activity: Talk or presentation › Talk or presentation at a conference