Projects per year
Personal profile
Expertise
Marleen Keyaerts obtained her PhD in preclinical research about molecular imaging and therapy at the ICMI lab of the VUB. She obtained a senior clinical investigator scholarship of the Research Foundation Flanders in 2013. Marleen now combines her clinical work as a nuclear medicine physician with basic and translational research at the ICMI lab. One of her major goals is the clinical translation of new radiopharmaceuticals for imaging and therapy. She also focuses on cancer immunotherapy, with a special interest in immune checkpoint blockade therapy and targeted radionuclide therapy.
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Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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HERC59: CASA PETIt: CAmera for Small Animal PET-Imaging
Devoogdt, N., Raes, G., Lahoutte, T., Van Ginderachter, J., Caveliers, V., Keyaerts, M., Hernot, S. & D'Huyvetter, M.
1/05/22 → 30/04/26
Project: Fundamental
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EUAR14: H2020: Immune-Image: Specific Imaging of Immune Cell Dynamics Using Novel Tracer Strategies.
Lahoutte, T., Devoogdt, N. & Keyaerts, M.
1/10/19 → 30/09/24
Project: Applied
Research output
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Assessment of repeatability and uptake quantification of (68)GaNOTA-anti-HER2 sdAb PET/CT in patients with locally advanced or metastatic breast cancer
Gondry, O., Xavier, C., Waelput, W., Al Dabssi, O., Vanhoeij, M., Aspeslagh, S., Joris, S., Fontaine, C., Verfaillie, G., De Greve, J., Glorieus, K., Luyten, I., Vandenbroucke, F., Bourgeois, S., Raes, L., Thyparambil, S., Devoogdt, N., Vaneycken, I., Cousaert, J., Caveliers, V. & 3 others, , 15 Feb 2022, In: Cancer Research. 82, 4Research output: Contribution to journal › Meeting abstract (Journal)
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Computer-aided detection and segmentation of malignant melanoma lesions on whole-body 18F-FDG PET/CT using an interpretable deep learning approach
Dirks, I., Keyaerts, M., Neyns, B. & Vandemeulebroucke, J., Jun 2022, In: Computer Methods and Programs in Biomedicine. 221, 106902.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Preclinical validation of [18F]-FB-(Anti Human PD-L1) Nanobody for PET imaging
Dierick, H., Breckpot, K., Devoogdt, N., Keyaerts, M., Caveliers, V., Lahoutte, T. & Bridoux, J., 22 May 2022.Research output: Unpublished contribution to conference › Poster
Open Access -
Targeted radionuclide therapy with low and high-dose Lutetium-177 labeled single domain antibodies induces distinct immune signatures in a mouse melanoma model
Ertveldt, T., De Beck, L., De Ridder, K., Locy, H., De Mey, W., Goyvaerts, C., Lecocq, Q., Ceuppens, H., De Vlaeminck, Y., Awad, R. M., Keyaerts, M., Devoogdt, N., D'Huyvetter, M., Breckpot, K. & Krasniqi, A., Jul 2022, In: Molecular Cancer Therapeutics. 21, 7, p. 1136-1148 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The road to personalized myeloma medicine: Patient-specific single-domain antibodies for anti-idiotypic radionuclide therapy
Puttemans, J., Stijlemans, B., Keyaerts, M., Vander Meeren, S., Renmans, W., Fostier, K., Debie, P., Hanssens, H., Rodak, M., Pruszynski, M., De Veirman, K., Vanderkerken, K., Lahoutte, T., Morgenstern, A., Bruchertseifer, F., Devoogdt, N. & D'Huyvetter, M., Jan 2022, In: Molecular Cancer Therapeutics. 21, 1, p. 159-169 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)75 Downloads (Pure)
Prizes
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Alavi-Mandell Award from Journal of Nuclear Medicine
Krasniqi, Ahmet (Recipient), D'Huyvetter, Matthias (Recipient), Devoogdt, Nick (Recipient) & Keyaerts, Marleen (Recipient), 16 Apr 2019
Prize: Prize (including medals and awards)
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Best Poster Award
Awada, Gil (Recipient), Özdemir, Ibrahim (Recipient), Schwarze, Julia Katharina (Recipient), Daeninck, E. (Recipient), Gondry, Odrade (Recipient), Jansen, Y. (Recipient), Seremet, T. (Recipient), Keyaerts, Marleen (Recipient), Everaert, Hendrik (Recipient) & Neyns, Bart (Recipient), 15 Dec 2018
Prize: Prize (including medals and awards)
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Certificat of Young Speaker Award
Lecocq, Quentin (Recipient), Broos, K. (Recipient), Bridoux, Jessica (Recipient), Raes, Geert (Recipient), Xavier, Catarina (Recipient), Devoogdt, Nick (Recipient), Keyaerts, Marleen (Recipient) & Breckpot, Karine (Recipient), 1 Feb 2019
Prize: Prize (including medals and awards)
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ESMI presentation award for best oral presentation
Bridoux, Jessica (Recipient), Broos, K. (Recipient), Lecocq, Quentin (Recipient), Crauwels, M. (Recipient), Martin, Charlotte (Recipient), Cleeren, F. (Recipient), Kondrashov, M. (Recipient), Ballet, Steven (Recipient), Bormans, G. (Recipient), Schou, M. (Recipient), Elmore, C. (Recipient), Raes, Geert (Recipient), Breckpot, Karine (Recipient), Muyldermans, Serge (Recipient), Devoogdt, Nick (Recipient), Keyaerts, Marleen (Recipient), Caveliers, Vicky (Recipient) & Xavier, Catarina (Recipient), 17 Jan 2020
Prize: Prize (including medals and awards)
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Knowledge for Growth 2018 Ghent - poster award
Broos, K. (Recipient), Lecocq, Quentin (Recipient), Bridoux, Jessica (Recipient), Raes, Geert (Recipient), Xavier, Catarina (Recipient), Keyaerts, Marleen (Recipient), Devoogdt, Nick (Recipient) & Breckpot, Karine (Recipient), 18 May 2018
Prize: Prize (including medals and awards)
Activities
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Using the site-specific radiolabeling of a PD-L1 nanobody via maleimide–cysteine chemistry to develop a PET-tracer as screening tool for personalized oncology treatment
Dora Mugoli Chigoho (Speaker), Jessica Bridoux (Speaker), Catarina Xavier (Speaker), Vicky Caveliers (Speaker), Marleen Keyaerts (Speaker), Nick Devoogdt (Speaker), Karine Breckpot (Speaker), Robin Maximilian Awad (Speaker) & Quentin Lecocq (Speaker)
7 May 2022Activity: Talk or presentation › Talk or presentation at a conference
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Preclinical validation of [18F]-FB-(Anti Human PD-L1) Nanobody for PET imaging
Herlinde Dierick (Speaker), Karine Breckpot (Contributor), Nick Devoogdt (Contributor), Marleen Keyaerts (Contributor), Vicky Caveliers (Contributor), Tony Lahoutte (Contributor) & Jessica Bridoux (Contributor)
7 May 2022Activity: Talk or presentation › Talk or presentation at a conference
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Noninvasive imaging and inhibition of human programmed death ligand 1 (PD-L1) using nanobody K2 to improve cancer immunotherapy
Robin Maximilian Awad (Contributor), Dora Mugoli Chigoho (Contributor), Katrijn Broos (Contributor), Quentin Lecocq (Contributor), Katty Zeven (Contributor), Thomas Ertveldt (Contributor), Lien De Beck (Contributor), Hannelore Ceuppens (Contributor), Yannick De Vlaeminck (Contributor), Cleo Goyvaerts (Contributor), Steve Schoonooghe (Contributor), Vicky Caveliers (Contributor), Catarina Xavier (Contributor), Jessica Bridoux (Contributor), Geert Raes (Contributor), Marleen Keyaerts (Contributor), Nick Devoogdt (Contributor) & Karine Breckpot (Speaker)
25 Oct 2021 → 26 Oct 2021Activity: Talk or presentation › Talk or presentation at a conference
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Nanobody-mediated molecular imaging provides spatiotemporal insight in mRNA-vaccine-induced PD-L1 upregulation
Thomas Ertveldt (Speaker), Sofie Meulewaeter (Speaker), Ine Lentacker (Contributor), Rein Verbeke (Contributor), Stefaan De Smedt (Contributor), Oscar Javier Olarte Rodriguez (Contributor), Kurt Barbé (Contributor), Nick Devoogdt (Contributor), Marleen Keyaerts (Contributor), Heleen Dewitte (Contributor) & Karine Breckpot (Contributor)
19 Apr 2021Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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2020-20
Tony Lahoutte (Supervisor), Isabel Remory (Contributor), Henri Vincent Baudhuin (Contributor), Marleen Keyaerts (Contributor) & Odrade Gondry (Contributor)
2020Activity: Other
Press / Media
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Nanobodies in de strijd tegen kanker
Tony Lahoutte & Marleen Keyaerts
1/09/17
1 Media contribution
Press/Media: Research
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VUB-onderzoek naar immuumtherapie voor melanoom ondersteund door Melanoma Research Alliance
Karine Breckpot & Marleen Keyaerts
30/06/17
1 item of Media coverage
Press/Media: Research
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Team K - De helden in de strijd tegen kanker
Marleen Keyaerts & Kris Thielemans
26/12/15
1 item of Media coverage
Press/Media: Research
Thesis
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123I-2-Iodo-Tyrosine, a new tumour imaging agent: biodistribution, dosimetry and initial clinical evaluation in brain tumours
Author: Keyaerts, M., Bossuyt, A. & Lahoutte, T., 7 Jul 2005Supervisor: Bossuyt, A. (Promotor) & Lahoutte, T. (Advisor)
Student thesis: Master's Thesis
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Development of a circulating tumor cell model in mice
Author: Vandereycken, J., Lahoutte, T., Goethals, L. & Keyaerts, M., 10 Jun 2015Student thesis: Master's Thesis
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Effectiveness of the implementation of insertion and maintenance bundles in prevention of central line associated bloodstream infections (CLABSI) in patients admitted in a neonatal intensive care unit
Author: Leeman, M., Cools, F. & Keyaerts, M., 22 Jun 2018Student thesis: Master's Thesis
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FDG PET/CT parameters voor de voorspelling van algemene en progressievrije overleving na pembrolizumab-behandeling bij melanoompatienten
Author: Özdemir, I., Keyaerts, M., Neyns, B. & Everaert, H., 20 Jun 2018Student thesis: Master's Thesis
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Fractional flow reserve and coronary computed tomography angiography in the noninvasive assessment of coronary artery disease
Author: Delariviere, E. & Keyaerts, M., Jun 2018Student thesis: Master's Thesis