Projects per year
Personal profile
Expertise
Marleen Keyaerts obtained her PhD in preclinical research about molecular imaging and therapy at the ICMI lab of the VUB. She obtained a senior clinical investigator scholarship of the Research Foundation Flanders in 2013. Marleen now combines her clinical work as a nuclear medicine physician with basic and translational research at the ICMI lab. One of her major goals is the clinical translation of new radiopharmaceuticals for imaging and therapy. She also focuses on cancer immunotherapy, with a special interest in immune checkpoint blockade therapy and targeted radionuclide therapy.
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FWOSB80: Combining targeted radionuclide therapy and cancer immunotherapy to advance precision medicine through innovation.
Breckpot, K., Devoogdt, N., D'Huyvetter, M., Keyaerts, M. & Ertveldt, T.
1/11/19 → 31/10/21
Project: Fundamental
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EUAR14: H2020: Immune-Image: Specific Imaging of Immune Cell Dynamics Using Novel Tracer Strategies
Lahoutte, T., Devoogdt, N. & Keyaerts, M.
1/10/19 → 30/09/24
Project: Applied
Research output
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68Ga-Labeling: Laying the Foundation for an Anti-Radiolytic Formulation for NOTA-sdAb PET Tracers
Baudhuin, H., Cousaert, J., Vanwolleghem, P., Raes, G., Caveliers, V., Keyaerts, M., Lahoutte, T. & Xavier, C., 1 Jan 2021, In : Pharmaceuticals. 14, 5, 16 p., 448.Research output: Contribution to journal › Article
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A Comprehensive Analysis of Baseline Clinical Characteristics and Biomarkers Associated with Outcome in Advanced Melanoma Patients Treated with Pembrolizumab
Awada, G., Jansen, Y., Schwarze, J. K., Tijtgat, J., Hellinckx, L., Gondry, O., Vermeulen, S., Warren, S., Schats, K., van Dam, P-J., Kockx, M., Keyaerts, M., Everaert, H., Seremet, T., Rogiers, A. & Neyns, B., 2 Jan 2021, In : Cancers. 13, 2, p. 1-18 18 p., 168.Research output: Contribution to journal › Article
1 Citation (Scopus) -
Early Reassessment of Total Metabolic Tumor Volume on FDG-PET/CT in Advanced Melanoma Patients Treated with Pembrolizumab Predicts Long-Term Outcome
Vermeulen, S., Awada, G., Keyaerts, M., Neyns, B. & Everaert, H., 27 Apr 2021, In : Current Oncology (Toronto, Ont.). 28, 3, p. 1630-1640 11 p.Research output: Contribution to journal › Article
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Formatting and gene-based delivery of a human PD-L1 single domain antibody for immune checkpoint blockade
Awad, R. M., Lecocq, Q., Zeven, K., Ertveldt, T., De Beck, L., Ceuppens, H., Broos, K., De Vlaeminck, Y., Goyvaerts, C., Verdonck, M., Raes, G., Van Parys, A., Cauwels, A., Keyaerts, M., Devoogdt, N. & Breckpot, K., 10 Sep 2021, In : Molecular Therapy: Methods & Clinical Development. 22, 9, p. 172-182 11 p., 10.Research output: Contribution to journal › Article
Open AccessFile12 Downloads (Pure) -
Gene-based delivery of human PD-L1 single domain antibody formats for immune checkpoint blockade
Awad, R. M., Lecocq, Q., Zeven, K., Ertveldt, T., De Beck, L., Ceuppens, H., Broos, K., De Vlaeminck, Y., Goyvaerts, C., Verdonck, M., Raes, G., Van Parys, A., Cauwels, A., Keyaerts, M., Devoogdt, N. & Breckpot, K., 22 Feb 2021.Research output: Unpublished contribution to conference › Poster
File19 Downloads (Pure)
Prizes
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Alavi-Mandell Award from Journal of Nuclear Medicine
Ahmet Krasniqi (Recipient), Matthias D'Huyvetter (Recipient), Nick Devoogdt (Recipient) & Marleen Keyaerts (Recipient), 16 Apr 2019
Prize: Prize (including medals and awards)
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Best Poster Award
Gil Awada (Recipient), Ibrahim Özdemir (Recipient), Julia Katharina Schwarze (Recipient), Emma Daeninck (Recipient), Odrade Gondry (Recipient), Yanina Jansen (Recipient), Teofila Seremet (Recipient), Marleen Keyaerts (Recipient), Hendrik Everaert (Recipient) & Bart Neyns (Recipient), 15 Dec 2018
Prize: Prize (including medals and awards)
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Certificat of Young Speaker Award
Quentin Lecocq (Recipient), Katrijn Broos (Recipient), Jessica Bridoux (Recipient), Geert Raes (Recipient), Catarina Xavier (Recipient), Nick Devoogdt (Recipient), Marleen Keyaerts (Recipient) & Karine Breckpot (Recipient), 1 Feb 2019
Prize: Prize (including medals and awards)
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ESMI presentation award for best oral presentation
Jessica Bridoux (Recipient), Katrijn Broos (Recipient), Quentin Lecocq (Recipient), Maxine Crauwels (Recipient), Charlotte Martin (Recipient), Frederik Cleeren (Recipient), Mikhail Kondrashov (Recipient), Steven Ballet (Recipient), G. Bormans (Recipient), Magnus Schou (Recipient), Chad Elmore (Recipient), Geert Raes (Recipient), Karine Breckpot (Recipient), Serge Muyldermans (Recipient), Nick Devoogdt (Recipient), Marleen Keyaerts (Recipient), Vicky Caveliers (Recipient) & Catarina Xavier (Recipient), 17 Jan 2020
Prize: Prize (including medals and awards)
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Knowledge for Growth 2018 Ghent - poster award
Katrijn Broos (Recipient), Quentin Lecocq (Recipient), Jessica Bridoux (Recipient), Geert Raes (Recipient), Catarina Xavier (Recipient), Marleen Keyaerts (Recipient), Nick Devoogdt (Recipient) & Karine Breckpot (Recipient), 18 May 2018
Prize: Prize (including medals and awards)
Activities
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Nanobody-mediated molecular imaging provides spatiotemporal insight in mRNA-vaccine-induced PD-L1 upregulation
Thomas Ertveldt (Speaker), Sofie Meulewaeter (Speaker), Ine Lentacker (Contributor), Rein Verbeke (Contributor), Stefaan De Smedt (Contributor), Oscar Javier Olarte Rodriguez (Contributor), Kurt Barbé (Contributor), Nick Devoogdt (Contributor), Marleen Keyaerts (Contributor), Heleen Dewitte (Contributor), Karine Breckpot (Contributor)19 Apr 2021Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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Noninvasive imaging and inhibition of human programmed death ligand 1 (PD-L1) using nanobody K2 to improve cancer immunotherapy
Robin Maximilian Awad (Contributor), Dora Mugoli Chigoho (Contributor), Katrijn Broos (Contributor), Quentin Lecocq (Contributor), Katty Zeven (Contributor), Thomas Ertveldt (Contributor), Lien De Beck (Contributor), Hannelore Ceuppens (Contributor), Yannick De Vlaeminck (Contributor), Cleo Goyvaerts (Contributor), Steve Schoonooghe (Contributor), Vicky Caveliers (Contributor), Catarina Xavier (Contributor), Jessica Bridoux (Contributor), Geert Raes (Contributor), Marleen Keyaerts (Contributor), Nick Devoogdt (Contributor), Karine Breckpot (Speaker)25 Oct 2021 → 26 Oct 2021Activity: Talk or presentation › Talk or presentation at a conference
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2020-69
Marleen Keyaerts (Supervisor), Ahmet Krasniqi (Contributor), Cindy Peleman (Contributor), Kevin De Jonghe (Contributor), Yoline Lauwers (Contributor)2020Activity: Other
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2020-78
Nick Devoogdt (Supervisor), Marleen Keyaerts (Supervisor), Ahmet Krasniqi (Contributor)2020 → …Activity: Other
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2020-20
Tony Lahoutte (Supervisor), Isabel Remory (Contributor), Henri Vincent Baudhuin (Contributor), Marleen Keyaerts (Contributor), Odrade Gondry (Contributor)2020Activity: Other
Press / Media
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Nanobodies in de strijd tegen kanker
Tony Lahoutte & Marleen Keyaerts
1/09/17
1 Media contribution
Press/Media: Research
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VUB-onderzoek naar immuumtherapie voor melanoom ondersteund door Melanoma Research Alliance
Karine Breckpot & Marleen Keyaerts
30/06/17
1 item of Media coverage
Press/Media: Research
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Team K - De helden in de strijd tegen kanker
Marleen Keyaerts & Kris Thielemans
26/12/15
1 item of Media coverage
Press/Media: Research
Thesis
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123I-2-Iodo-Tyrosine, a new tumour imaging agent: biodistribution, dosimetry and initial clinical evaluation in brain tumours
Author: Keyaerts, M., Bossuyt, A. & Lahoutte, T., 7 Jul 2005Supervisor: Bossuyt, A. (Promotor) & Lahoutte, T. (Advisor)
Student thesis: Master's Thesis
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Camelid reporter gene imaging: A generic method for in vivo cell tracking of GFP or YFP transfected cell lines
Author: Allemeersch, G., Lahoutte, T., Goethals, L. & Keyaerts, M., 21 Jun 2013Supervisor: Lahoutte, T. (Promotor), Goethals, L. (Co-promotor) & Keyaerts, M. (Jury)
Student thesis: Master's Thesis
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Development of a circulating tumor cell model in mice
Author: Vandereycken, J., Lahoutte, T., Goethals, L. & Keyaerts, M., 10 Jun 2015Student thesis: Master's Thesis
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Effectiveness of the implementation of insertion and maintenance bundles in prevention of central line associated bloodstream infections (CLABSI) in patients admitted in a neonatal intensive care unit
Author: Leeman, M., Cools, F. & Keyaerts, M., 22 Jun 2018Student thesis: Master's Thesis
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Evaluating single domain antibodies specific for PD-L1 as cancer nuclear imaging and therapy agents
Author: Broos, K., Breckpot, K., Devoogdt, N., Keyaerts, M., De Gruijl, T., Vermaelen, K., Everaert, H., Menu, E. & Neyns, B., 11 Oct 2019Supervisor: Breckpot, K. (Promotor), Devoogdt, N. (Promotor), Keyaerts, M. (Promotor), De Gruijl, T. (External person) (Jury), Vermaelen, K. (External person) (Jury), Everaert, H. (Jury), Menu, E. (Jury) & Neyns, B. (Jury)
Student thesis: Doctoral Thesis