Projects per year
Personal profile
Expertise
Marleen Keyaerts obtained her PhD in preclinical research about molecular imaging and therapy at the ICMI lab of the VUB. She obtained a senior clinical investigator scholarship of the Research Foundation Flanders in 2013. Marleen now combines her clinical work as a nuclear medicine physician with basic and translational research at the ICMI lab. One of her major goals is the clinical translation of new radiopharmaceuticals for imaging and therapy. She also focuses on cancer immunotherapy, with a special interest in immune checkpoint blockade therapy and targeted radionuclide therapy.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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OZR4288: Financiering MZW OZR: RAPTOR: Rapid Analysis and production of Proteins for clinical Translation using biacORe and bioreactOR systems.
Devoogdt, N. (Administrative Promotor), Hernot, S. (CoI (Co-Promotor)), De Groof, T. (CoI (Co-Promotor)), Ballet, S. (CoI (Co-Promotor)), Stijlemans, B. (CoI (Co-Promotor)), Massie, A. (CoI (Co-Promotor)), Rooman, I. (CoI (Co-Promotor)), Keyaerts, M. (CoI (Co-Promotor)), Raes, G. (CoI (Co-Promotor)), De Kock, J. (CoI (Co-Promotor)), Breckpot, K. (CoI (Co-Promotor)), De Veirman, K. (CoI (Co-Promotor)) & Caveliers, V. (CoI (Co-Promotor))
24/04/24 → 24/04/28
Project: Fundamental
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EUAR14: H2020: Immune-Image: Specific Imaging of Immune Cell Dynamics Using Novel Tracer Strategies.
Lahoutte, T. (Administrative Promotor), Devoogdt, N. (Co-Promotor), Keyaerts, M. (Administrative Promotor) & De Jonge, J. (Collaborator)
1/10/19 → 31/03/27
Project: Applied
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IOFACC9B: IOF Accelerator:Integrating a multimodal approach to address current challenges in immunotherapy (INTEGRAL)
Lahoutte, T. (Administrative Promotor), Devoogdt, N. (Co-Promotor), Keyaerts, M. (Co-Promotor), Van Ginderachter, J. (Co-Promotor), Laoui, D. (Co-Promotor), Raes, G. (Co-Promotor), Breckpot, K. (Co-Promotor) & Goyvaerts, C. (Co-Promotor)
1/10/22 → 31/03/24
Project: Applied
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HERC59: CASA PETIt: CAmera for Small Animal PET-Imaging
Devoogdt, N. (Administrative Promotor), Raes, G. (Co-Promotor), Lahoutte, T. (Co-Promotor), Van Ginderachter, J. (Co-Promotor), Caveliers, V. (Co-Promotor), Keyaerts, M. (Co-Promotor), Hernot, S. (Co-Promotor) & D'Huyvetter, M. (Co-Promotor)
1/05/22 → 30/04/26
Project: Fundamental
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BRGRD44: Joint R&D 2020: "IMPACT: Invigorating precision Medicine by Predictive imaging of sdAb-based anti-Cancer Theranostics"
Lahoutte, T. (Administrative Promotor), Keyaerts, M. (Administrative Promotor), Krasniqi, A. (CoI (Co-Promotor)), Breckpot, K. (Administrative Promotor) & Goyvaerts, C. (CoI (Co-Promotor))
1/07/20 → 30/06/24
Project: Applied
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Efficient α and β- radionuclide therapy targeting fibroblast activation protein-α in an aggressive preclinical mouse tumour model
Ceuppens, H., Pombo Antunes, A. R., Navarro, L., Ertveldt, T., Berdal, M., Nagachinta, S., De Ridder, K., Lahoutte, T., Keyaerts, M., Devoogdt, N., Goyvaerts, C., D'Huyvetter, M. & Breckpot, K., Jan 2025, In: European Journal of Nuclear Medicine and Molecular Imaging. 52, 2, p. 444-457 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)18 Downloads (Pure) -
Immune modulation following α and β- radionuclide therapy targeting fibroblast activation protein-α in a preclinical tumor model
Ceuppens, H., De Ridder, K., Ertveldt, T., Zeven, K., de Mey, W., Pombo Antunes, A. R., Navarro, L., Dumauthioz, N., Lahoutte, T., Debacker, J., Devoogdt, N., Keyaerts, M., D'Huyvetter, M., Goyvaerts, C. & Breckpot, K., 1 Dec 2025, In: Oncoimmunology. 14, 1, 16 p., 2540054.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)8 Downloads (Pure) -
[68Ga]Ga-NOTA-anti-HER2-VHH1PET/CT Imaging of brain metastasis: first clinical results in patients with HER2 positive and HER2 negative breast cancer.
De Mey, L., Gondry, O. (Editor), Bourgeois, S. (Editor), Bracke, A. (Editor), Everaert, H. (Editor), Goethals, L. (Editor), Raes, L. (Editor), Caveliers, V. (Editor), Van den Block, S. (Editor), Decoster, L. (Editor), Fontaine, C. (Editor), Devoogdt, N. (Editor), Dierick, H. (Editor), Cousaert, J. (Editor), Lahoutte, T. (Editor) & Keyaerts, M. (Editor), 2024.Research output: Unpublished contribution to conference › Poster
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An interpretable deep learning approach for lesion detection and segmentation on whole-body [18F]FDG PET/CT
Dirks, I., Keyaerts, M., Neyns, B. & Vandemeulebroucke, J., 2 Apr 2024, Proc. SPIE 12926, Medical Imaging 2024: Image Processing. SPIE, Vol. 12926. 10 p. 1292617. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 12926).Research output: Chapter in Book/Report/Conference proceeding › Conference paper
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Clinicopathological and molecular predictors of [<SUP>18</SUP>F]FDG-PET disease detection in HER2-positive early breast cancer: RESPONSE, a substudy of the randomized PHERGain trial
Llombart-Cussac, A., Prat, A., Perez-Garcia, J. M., Mateos, J., Pascual, T., Escriva-de-Romani, S., Stradella, A., Ruiz-Borrego, M., de las Heras, B. B., Keyaerts, M., Galvan, P., Braso-Maristany, F., Garcia-Mosquera, J. J., Guiot, T., Gion, M., Sampayo-Cordero, M., Di Cosimo, S., Perez-Escuredo, J., de Frutos, M. A. & Cortes, J. & 1 others, , Jul 2024, In: European Journal of Nuclear Medicine and Molecular Imaging. 51, 9, p. 2733-2743 11 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (Scopus)
Datasets
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DataSet-Targeted Radionuclide Therapy with Low and High-Dose Lutetium-177-Labeled Single Domain Antibodies Induces Distinct Immune Signatures in a Mouse Melanoma Model
Ertveldt, T. (Creator), De Beck, L. (Creator), De Ridder, K. (Creator), Locy, H. (Creator), de Mey, W. (Creator), Goyvaerts, C. (Creator), Lecocq, Q. (Creator), Ceuppens, H. (Creator), De Vlaeminck, Y. (Creator), Awad, R. M. (Creator), Keyaerts, M. (Creator), Devoogdt, N. (Creator), D'Huyvetter, M. (Creator), Breckpot, K. (Creator) & Krasniqi, A. (Creator), Zenodo, 16 Dec 2024
Dataset
Prizes
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Alavi-Mandell Award from Journal of Nuclear Medicine
Krasniqi, A. (Recipient), D'Huyvetter, M. (Recipient), Devoogdt, N. (Recipient) & Keyaerts, M. (Recipient), 16 Apr 2019
Prize: Prize (including medals and awards)
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Best Poster Award
Awada, G. (Recipient), Özdemir, I. (Recipient), Schwarze, J. K. (Recipient), Daeninck, E. (Recipient), Gondry, O. (Recipient), Jansen, Y. (Recipient), Seremet, T. (Recipient), Keyaerts, M. (Recipient), Everaert, H. (Recipient) & Neyns, B. (Recipient), 15 Dec 2018
Prize: Prize (including medals and awards)
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Certificat of Young Speaker Award
Lecocq, Q. (Recipient), Broos, K. (Recipient), Bridoux, J. (Recipient), Raes, G. (Recipient), Xavier, C. (Recipient), Devoogdt, N. (Recipient), Keyaerts, M. (Recipient) & Breckpot, K. (Recipient), 1 Feb 2019
Prize: Prize (including medals and awards)
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ESMI presentation award for best oral presentation
Bridoux, J. (Recipient), Broos, K. (Recipient), Lecocq, Q. (Recipient), Crauwels, M. (Recipient), Martin, C. (Recipient), Cleeren, F. (Recipient), Kondrashov, M. (Recipient), Ballet, S. (Recipient), Bormans, G. (Recipient), Schou, M. (Recipient), Elmore, C. (Recipient), Raes, G. (Recipient), Breckpot, K. (Recipient), Muyldermans, S. (Recipient), Devoogdt, N. (Recipient), Keyaerts, M. (Recipient), Caveliers, V. (Recipient) & Xavier, C. (Recipient), 17 Jan 2020
Prize: Prize (including medals and awards)
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Knowledge for Growth 2018 Ghent - poster award
Broos, K. (Recipient), Lecocq, Q. (Recipient), Bridoux, J. (Recipient), Raes, G. (Recipient), Xavier, C. (Recipient), Keyaerts, M. (Recipient), Devoogdt, N. (Recipient) & Breckpot, K. (Recipient), 18 May 2018
Prize: Prize (including medals and awards)
Activities
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Nanobody-based tracers in image-guided surgery applications
Keyaerts, M. (Invited speaker), Debacker, J. (Invited speaker) & Hernot, S. (Invited speaker)
17 May 2025Activity: Talk or presentation › Talk or presentation at a conference
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PET/CT imaging of high mannose receptor expressing macrophages with [68Ga]Ga-NOTA -Anti-MMR-VHH2: an overview of the clinical results
De Mey, L. (Speaker), Bourgeois, S. (Contributor), Bracke, A. (Contributor), Gondry, O. (Contributor), Everaert, H. (Contributor), Goethals, L. (Contributor), Debacker, J. (Contributor), Keyaerts, M. (Contributor), Devoogdt, N. (Contributor), Raes, L. (Contributor), Caveliers, V. (Contributor), Van den Block, S. (Contributor), Vaneycken, I. (Contributor), Cousaert, J. (Contributor), De Beule, N. (Contributor), Kerselaers, L. A. A. (Contributor), Forsyth, R. (Contributor), Locy, H. (Contributor) & Lahoutte, T. (Contributor)
11 Oct 2024Activity: Talk or presentation › Talk or presentation at a conference
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PET/CT imaging with [68Ga]Ga-NOTA-anti-HER2-VHH1 in cancer patients with potential HER2 expression: first clinical results.
De Mey, L. (Speaker), Gondry, O. (Contributor), Bourgeois, S. (Contributor), Bracke, A. (Contributor), Everaert, H. (Contributor), Goethals, L. (Contributor), Raes, L. (Contributor), Caveliers, V. (Contributor), Van den Block, S. (Contributor), Joris, S. (Contributor), de Haar-Holleman, A. (Contributor), Fontaine, C. (Contributor), Devoogdt, N. (Contributor), Dierick, H. (Contributor), Cousaert, J. (Contributor), Lahoutte, T. (Contributor) & Keyaerts, M. (Contributor)
22 Oct 2024Activity: Talk or presentation › Talk or presentation at a conference
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PET/CT imaging of high mannose receptor expressing macrophages: first clinical results in cancer and inflammatory disease
De Mey, L. (Speaker), Gondry, O. (Contributor), Bracke, A. (Contributor), Bourgeois, S. (Contributor), Everaert, H. (Contributor), Goethals, L. (Contributor), Raes, L. (Contributor), Gebruers, J. (Contributor), Waelput, W. (Contributor), Caveliers, V. (Contributor), Debacker, J. (Contributor), Devoogdt, N. (Contributor), Dierick, H. (Contributor), Cousaert, J. (Contributor), De Beule, N. (Contributor), Kerselaers, L. A. A. (Contributor), Keyaerts, M. (Contributor) & Lahoutte, T. (Contributor)
12 Mar 2024Activity: Talk or presentation › Talk or presentation at a conference
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Efficient α and β- radionuclide therapy targeting fibroblast activation protein-α in an aggressive preclinical mouse tumour model.
Ceuppens, H. (Speaker), Pombo Antunes, A. R. (Contributor), Navarro, L. (Contributor), Ertveldt, T. (Contributor), Berdal, M. (Contributor), Nagachinta, S. (Contributor), De Ridder, K. (Contributor), Keyaerts, M. (Contributor), Devoogdt, N. (Contributor), Goyvaerts, C. (Contributor), D'Huyvetter, M. (Contributor) & Breckpot, K. (Contributor)
23 Oct 2024Activity: Talk or presentation › Talk or presentation at a conference
Press/Media
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VUB-onderzoek naar immuumtherapie voor melanoom ondersteund door Melanoma Research Alliance
30/06/17
1 item of Media coverage
Press/Media: Research
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Thesis
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123I-2-Iodo-Tyrosine, a new tumour imaging agent: biodistribution, dosimetry and initial clinical evaluation in brain tumours
Keyaerts, M. ((PhD) Student), Bossuyt, A. (Promotor) & Lahoutte, T. (Advisor), Bossuyt, A. (Promotor) & Lahoutte, T. (Advisor), 7 Jul 2005Student thesis: Master's Thesis
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Development of a circulating tumor cell model in mice
Vandereycken, J. ((PhD) Student), Lahoutte, T. (Promotor), Goethals, L. (Co-promotor) & Keyaerts, M. (Jury), 10 Jun 2015Student thesis: Master's Thesis
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Effectiveness of the implementation of insertion and maintenance bundles in prevention of central line associated bloodstream infections (CLABSI) in patients admitted in a neonatal intensive care unit
Leeman, M. ((PhD) Student), Cools, F. (Promotor) & Keyaerts, M. (Jury), 22 Jun 2018Student thesis: Master's Thesis
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FDG PET/CT parameters voor de voorspelling van algemene en progressievrije overleving na pembrolizumab-behandeling bij melanoompatienten
Özdemir, I. ((PhD) Student), Keyaerts, M. (Promotor), Neyns, B. (Promotor) & Everaert, H. (Promotor), 20 Jun 2018Student thesis: Master's Thesis
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Fractional flow reserve and coronary computed tomography angiography in the noninvasive assessment of coronary artery disease
Delariviere, E. ((PhD) Student) & Keyaerts, M. (Jury), Jun 2018Student thesis: Master's Thesis