Research output per year
Research output per year
Research output
- 1 - 50 out of 401 results
Search results
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2024
Accessible methods and tools to estimate chemical exposure in humans to support risk assessment: a systematic scoping review
Kalyva, M. E., Vist, G. E., Diemar, M., Lopez Soop, G., Bozada, TJ., Luechtefeld, T., Roggen, E., Dirven, H., Vinken, M. & Husoy, T., 1 Jul 2024, In: Environmental Pollution. 352, 11 p., 124109.Research output: Contribution to journal › Article › peer-review
50 Downloads (Pure) -
A comprehensive item bank of internal validity issues of relevance to in vitro toxicology studies
Vist, G. E., Ames, H. M., Mathisen, G. H., Husoy, T., Svendsen, C., Beronius, A., Di Consiglio, E., Druwe, I. L., Hartung, T., Hoffmann, S., Hooijmans, C. R., Machera, K., Prieto, P., Robinson, J. F., Roggen, E., Rooney, A., Roth, N., Spilioti, E., Spyropoulou, A., Tcheremenskaia, O. & 2 others, , 14 Oct 2024, (Accepted/In press) In: Evidence-Based Toxicology.Research output: Contribution to journal › Article › peer-review
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Adverse outcome pathway networks as the basis for the development of new approach methodologies: liver toxicity as a case study.
Vinken, M., Dec 2024, In: Current Opinion in Toxicology. 40, 6 p., 100504.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Downloads (Pure) -
Adverse outcome pathways mechanistically describing hepatotoxicity
Callewaert, E., Louisse, J., Kramer, N., Sanz-Serrano, J. & Vinken, M., 25 Sep 2024, In: Computational Toxicology. Methods in Molecular Biology.. 2834, 2, p. 249–273 25 p.Research output: Contribution to journal › Article › peer-review
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A quantitative weight-of-evidence method for confidence assessment of adverse outcome pathway networks: a case study on chemical-induced liver steatosis
Verhoeven, A., van Ertvelde, J., Boeckmans, J., Gatzios, A., Rover, R., Lindeman, B., Lopze Soop, G., Rodrigues, R., Rapisarda, A., Sanz-Serrano, J., Stinckens, M., Sepehri, S., Teunis, M., Vinken, M., Jiang, J. & Vanhaecke, T., Jun 2024, In: Toxicology. 505, 11 p., 153814.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus)18 Downloads (Pure) -
Assessment of connexin43 hemichannel functionality based on cytosolic uptake of Yo-Pro1
Van Campenhout, R., Sanz-Serrano, J., Cooreman, A., De Vlaeminck, Y., Breckpot, K., Kadam, P., Tabernilla Garcia, A. & Vinken, M., 6 Apr 2024, In: Methods in Molecular Biology. 2801, p. 75-85 11 p., 6.Research output: Contribution to journal › Article
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Assessment of connexin43 hemichannel functionality based on cytosolic uptake of Yo-Pro1
Van Campenhout, R., Sanz-Serrano, J., Cooreman, A., De Vlaeminck, Y., Breckpot, K., Kadam, P., Tabernilla Garcia, A. & Vinken, M., 2024, Assessment of connexin43 hemichannel functionality based on cytosolic uptake of Yo-Pro1. Mammano, F. & Retamal, M. (eds.). Methods in Molecular Biology, Vol. 2801. p. 75-85Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Building disease ontology maps: in silico tools for applications in toxicology
Staumont, B., Ladeira, L. C. M., Gamba, A., Verhoeven, A., Sanz-Serrano, J., Kuchovska, E., Berkhout, J., Barnes, D. A., Teunis, M., Luechtefeld, T., Hartung, T., Jover, R., Vanhaecke, T., Fritsche, E., Heusinkveld, H. J., Piersma, A., Masereeuw, R., Vinken, M. & Geris, L., 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Chemical-induced liver cancer: an adverse outcome pathway perspective
Sanz-Serrano, J., Callewaert, E., De Boever, S., Drees, A. H., Verhoeven, A. & Vinken, M., 4 Apr 2024, In: Expert Opinion on Drug Safety. 23, 4, p. 425-438 19 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Corrigendum to “Novel clinical phenotypes, drug categorization, and outcome prediction in drug-induced cholestasis: Analysis of a database of 432 patients developed by literature review and machine learning support” [Biomed. Pharmacother. 174 (2024) 116530]
Moreno-Torres, M., López, E., Rapisarda, A., Quintás, G., Drees, A. H., Steffensen, I-L., Luechtefeld, T., Serrano-Candelas, E., Garcia de Lomana, M., Gadaleta, D., Dirven, H., Vinken, M. & Jover, R., 1 Jun 2024, In: Biomedicine & Pharmacotherapy. 175, 1 p., 116813.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Downloads (Pure) -
Cross-mapping of terms used in chemical risk assessment with those used in systematic review: research protocol
Svendsen, C., Mathisen, G. H., Vist, G. E., Husoy, T., Ames, H. M., Beronius, A., Di Consiglio, E., Druwe, I. L., Hartung, T., Hoffmann, S., Hooijmans, C. R., Machera, K., Robinson, J. F., Roggen, E., Rooney, A., Roth, N., Spilioti, E., Spyropoulou, A., Tcheremenskaia, O., Testai, E. & 2 others, , 7 Sep 2024, In: Evidence-Based Toxicology. 2, 1, 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Dataset on transcriptomic profiling of parenteral nutrition-induced hepatotoxicity in a human liver in vitro model
Mihajlovic, M. & Vinken, M., 28 Jul 2024, In: Data in Brief. 55, 7 p., 110653.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
Development of a hepatic spheroid co-culture model for prediction of cholestatic drug-induced liver injury
Sanz-Serrano, J., Drees, A. H., Rodrigues, P., Olaizola, P., Banales, J. M. & Vinken, M., 10 Sep 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Development of an adverse outcome pathway network for nephrotoxicity
Barnes, D. A., Firman, J., Belfield, S., Cronin, M., Vinken, M., Janssen, M. & Masereeuw, R., Mar 2024, In: Archives of Toxicology. 98, 3, p. 929-942 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)24 Downloads (Pure) -
Development of a test battery for the detection of induction of molecular initiating events of cholestatic liver toxicity induced by chemical compounds
Sanz-Serrano, J., Benfenati, E., Drees, A. H., Gadaleta, D., Garcia de Lomana, M., Geci, R., Gozalbes, R., Kramer, N., Maerten, A., Ortega, R., Paini, A., Proença, S., Serrano-Candelas, E., Verhoeven, A. & Vinken, M., 21 Mar 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Development of a test battery for the detection of induction of molecular initiating events of cholestatic liver toxicity induced by chemical compounds
Sanz-Serrano, J., Benfenati, E., Drees, A. H., Gadaleta, D., Garcia de Lomana, M., Geci, R., Gozalbes, R., Kramer, N., Maerten, A., Ortega, R., Paini, A., Proença, S., Serrano-Candelas, E., Verhoeven, A. & Vinken, M., 24 Mar 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Distribution Kinetics of Azole Fungicides in an In Vitro Liver Steatosis Model
Adam, S., Bakker, W., Proença, S., Sotiriou, A., Verhoeven, A., Vinken, M. & Kramer, N., 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Distribution Kinetics of Triazole Fungicides in an In Vitro Liver Steatosis Model
Adam, S., Anagnostaki, M., Bakker, W., Proença, S., Sotiriou, A., Verhoeven, A., Vinken, M. & Kramer, N., Mar 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Effects of altered gravity on the liver
Cools, B. & Vinken, M., 8 Jan 2024, (Accepted/In press) Fundamentals of Space Medicine and Clinical Technology. Elsevier, 12 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Effects of per- and polyfluoroalkyl substances on the liver: human-relevant mechanisms of toxicity
Maerten, A., Callewaert, E., Sanz-Serrano, J., Devisscher, L. & Vinken, M., 1 Dec 2024, In: Science of the Total Environment. 954, 21 p., 176717.Research output: Contribution to journal › Article › peer-review
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E-waste: mechanisms of toxicity and safety testing
Eze, C. T. & Vinken, M., 9 Sep 2024, In: FEBS Open Bio. 14, 9, p. 1420-1440 21 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)1 Downloads (Pure) -
From physiological maps to disease ontology maps using a systems biology approach
Staumont, B., Ladeira, L. C. M., Gamba, A., Verhoeven, A., Sanz-Serrano, J., Kuchovska, E., Berkhout, J., Barnes, D. A., Teunis, M., Luechtefeld, T., Hartung, T., Jover, R., Vanhaecke, T., Fritsche, E., Heusinkveld, H. J., Piersma, A., Masereeuw, R., Vinken, M. & Geris, L., Mar 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Hepatic cell junctions: pulling a double-duty
Van Campenhout, R. & Vinken, M., 23 Oct 2024, In: Liver International. 44, 11, p. 2873-2889 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
Hepatology during spaceflight
Cools, B., Helvacıoğlu Akyüz, S. & Vinken, M., 6 Dec 2024, Precision Medicine in Space.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Investigation of parenteral nutrition-induced hepatotoxicity using human liver spheroid co-cultures
Mihajlovic, M., De Boever, S., Tabernilla Garcia, A., Callewaert, E., Sanz-Serrano, J., Verhoeven, A., Maerten, A., Rosseel, Z., De Waele, E. & Vinken, M., Sep 2024, In: Archives of Toxicology. 98, 9, p. 3109-3126 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)1 Downloads (Pure) -
Mapping Physiology As A Basis For Building Disease Ontology Maps
Staumont, B., Ladeira, L. C. M., Gamba, A., Verhoeven, A., Sanz-Serrano, J., Kuchovska, E., Berkhout, J., Barnes, D. A., Janssen, M. J., Teunis, M., Luechtefeld, T. H., Hartung, T., Jover, R., Vanhaecke, T., Fritsche, E., Heusinkveld, H. J., Piersma, A., Masereeuw, R., Vinken, M. & Geris, L., 1 Mar 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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NAM to identify (low, medium, high) concern of carboxylic acid-induced hepatic steatosis
Jover, R., Soluyanova, P., del Pozo, M., Verhoeven, A., Vanhaecke, T., Vinken, M., Ortega‐Vallbona, R., Serrano‐Candelas, E., Gozalbes, R., Geci, R. & Proença, S., Mar 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Novel clinical phenotypes, drug categorization, and outcome prediction in drug-induced cholestasis: analysis of a database of 432 patients developed by literature review and machine learning support
Moreno-Torres, M., López, E., Rapisarda, A., Quintás, G., Drees, A. H., Luechtefeld, T., Serrano-Candelas, E., Garcia de Lomana, M., Gadaleta, D., Dirven, H., Steffensen, I-L., Vinken, M. & Jover, R., May 2024, In: Biomedicine & Pharmacotherapy. 174, 12 p., 116530.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Downloads (Pure) -
Optimization of predictive liver toxicity modeling based on the drug-induced cholestasis index.
Drees, A. H., Nassiri, V., Tabernilla Garcia, A., Serroyen, J., Gustin, E., dos Santos Rodrigues, B., Moss, D. M., De Smedt, A., Vinken, M., Van Goethem, F. & Sanz-Serrano, J., 9 Sep 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Osteopontin expression characterizes bile duct associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis.
De Muynck, K., Heyerick, L., De Ponti, F. F., Vanderborght, B., Meese, T., Van Campenhout, S., Baudonck, L., Gijbels, E., Rodrigues, P. M., Banales, J. M., Vesterhuus, M., Karlsen, T. H., Scott, C. L., Vinken, M., Van der Linden, M., Hoorens, A., Van Dorpe, J., Lefere, S., Geerts, A., Van Nieuwerburgh, F. & 3 others, , 1 Feb 2024, In: Hepatology. 79, 2, p. 269-288 20 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)23 Downloads (Pure) -
Parenteral nutrition-associated liver injury: clinical relevance and mechanistic insights
Mihajlovic, M., Rosseel, Z., De Waele, E. & Vinken, M., 1 May 2024, In: Toxicological Sciences. 199, 1, p. 1-11 11 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus) -
Precision Medicine for Long and Safe Permanence of Humans in Space: Hepatology during spaceflight
Cools, B., Helvacıoğlu Akyüz, S. & Vinken, M., 30 Nov 2024, Academic Press. Krittanawong, C. (ed.). 1 ed. Elsevier, p. 593-600Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Qualitative and quantitative concentration-response modelling of gene co-expression networks to unlock hepatotoxic mechanisms for next generation chemical safety asssessment
Kunnen, S. J., Arnesdotter, E., Willenbockel, C. T., Vinken, M. & Van De Water, B., 17 Apr 2024, In: ALTEX. 41, 2, p. 213-232 20 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Downloads (Pure) -
Report of the first ONTOX Hackathon: hack to save lives and avoid animal suffering: artificial Intelligence (AI) in toxicology-a potential driver for reducing/replacing laboratory animals in the future
Diemar, M., Krul, C., Teunis, M., Busquet, F., Kandarova, H., Zajac, J. D., Vinken, M. & Roggen, E., 27 Oct 2024, (Accepted/In press) In: ATLA. Alternatives to Laboratory Animals.Research output: Contribution to journal › Article › peer-review
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Report of the first ONTOX Stakeholder Network meeting: digging under the surface of ONTOX together with the stakeholders
Diemar, M., Vinken, M., Teunis, M., Krul, C., Busquet, F., Zajac, J. D., Kandarova, H., Corvi, R., Russo, M. Z., Kharina, A., Bryndum, L., Santillo, M., Bloch, D., Kucheryavenko, O., Panagiotakos, D., Rogiers, V., Beekhuijzen, M., Giusti, A., Najjar, A., Courage, C. & 27 others, , 14 Mar 2024, In: ATLA. Alternatives to Laboratory Animals. 52, 2, p. 117-131 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)30 Downloads (Pure) -
Semi-automated workflow to accelerate AOP network construction using SBGN elements: a pilot study.
Ladeira, L. C. M., Mazein, A., Ostaszewski, M., Verhoeven, A., Sanz-Serrano, J., Drees, A. H., Vanhaecke, T., Vinken, M., Geris, L. & Staumont, B., 24 Mar 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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The ability of a human stem cell-based in vitro model to detect liver steatotic potential of chemicals from various application domains
Verhoeven, A., Gatzios, A., Rodrigues, R., Sanz-Serrano, J., Tabernilla Garcia, A., De Kock, J., Vinken, M. & Vanhaecke, T., Mar 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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The application of natural language processing for the extraction of mechanistic information in toxicology
Corradi, M., Luechtefeld, T., de Haan, A., Pieters, R., Freedman, J. H., Vanhaecke, T., Vinken, M. & Teunis, M., 27 May 2024, In: Frontiers in toxicology. 6, 10 p., 1393662.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Downloads (Pure) -
Unraveling the micro- and nanoplastic predicament: a human-centric insight
De Boever, S., Devisscher, L. & Vinken, M., 15 Mar 2024, In: Science of the Total Environment. 916, 17 p., 170262.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
2023
Connexin and pannexin signaling in health and disease 3.0
Vinken, M. (Guest ed.), 31 Aug 2023, In: International Journal of Molecular Sciences. 24Research output: Contribution to journal › Special issue › peer-review
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DETERMINATION AND DIFFERENTIATING THE IMPACT OF PARENTERAL NUTRITION, SEPSIS, ACUTE HEART FAILURE AND HEPATOTOXIC DRUGS ON LIVER TESTS IN ICU PATIENTS: A RETROSPECTIVE STUDY.
Rosseel, Z., De Waele, E., Reynaert, H., Vinken, M., Cools, W., Jonckheer, J. & Cortoos, P-J., 13 Sep 2023.Research output: Unpublished contribution to conference › Poster
File15 Downloads (Pure) -
Determination of structural features that underpin the pannexin1 channel inhibitory activity of the peptide 10Panx1
Caufriez, A., Lamouroux, A., Martin, C., Iaculli, D., Ince Ergüç, E., Gozalbes, R., Mayán Santos, M. D., Kwak, B. R., Tabernilla Garcia, A., Vinken, M. & Ballet, S., Sep 2023, In: Bioorganic Chemistry. 138, 8 p., 106612.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)53 Downloads (Pure) -
Development of human liver cancer 3D spheroid cultures for assessment of nanoplastic toxicity
De Boever, S., Leroy, K., Devisscher, L. & Vinken, M., 19 Sep 2023.Research output: Unpublished contribution to conference › Poster
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Effects of acute and chronic disease on cell junctions in mouse liver
Van Campenhout, R., Cogliati, B. & Vinken, M., 3 Jan 2023, In: EXCLI Journal. 22, 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)27 Downloads (Pure) -
Effects of bile duct ligation on cell junctions in mouse liver
Van Campenhout, R., Cooreman, A., Cogliati, B. & Vinken, M., 21 Sep 2023.Research output: Unpublished contribution to conference › Poster
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Effects of glyphosate exposure on western diet-induced non-alcoholic fatty liver disease in mice
Romualdo, G. R., Cardoso Valente, L., Sprocatti dos Santos, A. C., Alves Grandini, N., Correa Camacho, C. R., Vinken, M., Cogliati, B., Hou, D-X. & Barbisan, L. F., Nov 2023, In: Environmental Toxicology & Pharmacology. 104, 11 p., 104286.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)2 Downloads (Pure) -
Elucidation of molecular initiating events in PFAS-mediated cholestatic liver disease
Maerten, A., Sanz-Serrano, J., Vinken, M. & Devisscher, L., 2023, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Evaluation of functional candidate biomarkers of non-genotoxic hepatocarcinogenicity in human liver spheroid co-cultures
dos Santos Rodrigues, B., Leroy, K., Mihajlovic, M., De Boever, S., Vanbellingen, S., Cogliati, B., Aerts, J. & Vinken, M., 15 May 2023, In: Archives of Toxicology. 97, 6, p. 1739-1751 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)15 Downloads (Pure) -
High-content imaging of human hepatic spheroids for studying compounds with cholestatic liability
dos Santos Rodrigues, B., Cendoya Garmendia, X., Steemans, M., Gustin, E., Van Goethem, F. & Vinken, M., 15 Jun 2023, (Accepted/In press) Abstracts of the 57th Congress of the European Societies of Toxicology (EUROTOX 2023): TOXICOLOGY - MULTIDISCIPLINARY SCIENCE LEADING TO SAFER AND SUSTAINABLE LIFE. Elsevier, Vol. 384. p. S182-S182 1 p. P16-06. (TOXICOLOGY - MULTIDISCIPLINARY SCIENCE LEADING TO SAFER AND SUSTAINABLE LIFE; vol. 384).Research output: Chapter in Book/Report/Conference proceeding › Conference paper
Open Access -
Kupffer Cells Contested as Early Drivers in the Pathogenesis of Primary Sclerosing Cholangitis
De Muynck, K., Vanderborght, B., De Ponti, F. F., Gijbels, E., Van Welden, S., Guilliams, M., Scott, C. L., Beschin, A., Vinken, M., Lefere, S., Geerts, A., Verhelst, X., Van Vlierberghe, H. & Devisscher, L., Apr 2023, In: The American Journal of Pathology. 193, 4, p. 366-379 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)52 Downloads (Pure)