Research output per year
Research output per year
Research output
- 1 - 50 out of 132 results
Search results
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2024
Efficient α and β- radionuclide therapy targeting fibroblast activation protein-α in an aggressive preclinical mouse tumour model
Ceuppens, H., Pombo Antunes, A. R., Navarro, L., Ertveldt, T., Berdal, M., Nagachinta, S., De Ridder, K., Lahoutte, T., Keyaerts, M., Devoogdt, N., Goyvaerts, C., D'Huyvetter, M. & Breckpot, K., 6 Sep 2024, (E-pub ahead of print) In: European Journal of Nuclear Medicine and Molecular Imaging.Research output: Contribution to journal › Article › peer-review
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Generic semi-automated radiofluorination strategy for single domain antibodies: [18F]FB-labelled single domain antibodies for PET imaging of fibroblast activation protein-α or folate receptor-α overexpression in cancer
Dierick, H., Navarro, L., Ceuppens, H., Ertveldt, T., Pombo Antunes, A. R., Keyaerts, M., Devoogdt, N., Breckpot, K., D'Huyvetter, M., Lahoutte, T., Caveliers, V. & Bridoux, J., Dec 2024, In: EJNMMI Radiopharmacy and Chemistry. 9, 1, 14 p., 54.Research output: Contribution to journal › Article › peer-review
Open Access -
Optimised solid-phase extraction of 211At:Activity balance of 211At, 210At and 210Po after wet chemistry target dissolution
Sevenois, M. B., Jensen, H. J., Haddad, F., Bäck, T., D'Huyvetter, M., Navarro, L. & Covens, P., Dec 2024, In: Radiation Physics and Chemistry. 225, 7 p., 112146.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Accepted poster session at ImmunoRad 2023: Targeted alpha therapy using Actinium-225 radiolabeled single domain antibodies induces antigen-specific immune responses and instills immunomodulation both systemically and at the tumor microenvironment
Ertveldt, T., Krasniqi, A., Ceuppens, H., Puttemans, J., Dekempeneer, Y., De Jonghe, K., de Mey, W., Lecocq, Q., De Vlaeminck, Y., Awad, R. M., Goyvaerts, C., De Veirman, K., Morgenstern, A., Bruchertseifer, F., Keyaerts, M., Devoogdt, N., D'Huyvetter, M. & Breckpot, K., 27 Sep 2023.Research output: Unpublished contribution to conference › Poster
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A realistic multiregion mouse kidney dosimetry model to support the preclinical evaluation of potential nephrotoxicity of radiopharmaceutical therapy
Vargas, C. S., Struelens, L., D'Huyvetter, M., Caveliers, V. & Covens, P., 1 Mar 2023, In: Journal of Nuclear Medicine. 64, 3, p. 493-499 7 p., 264453.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus) -
Case Study #3: Antibody Fragments in Radiopharmaceutical Therapy
Funeh, C. N., Asiabi, P., D'Huyvetter, M. & Devoogdt, N., 1 Jan 2023, Radiopharmaceutical Therapy. springer link, p. 253-273 21 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
1 Citation (Scopus) -
Optimized cyclotron production of 211At: The challenge of 210Po-characterization
Sevenois, M. B. C., Miller, B. WM., Jensen, H. J., D'Huyvetter, M. & Covens, P., Nov 2023, In: Radiation Physics and Chemistry. 212, 7 p., 111155.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)5 Downloads (Pure) -
Optimizing the Safety and Efficacy of Bio-Radiopharmaceuticals for Cancer Therapy
Funeh, C. N., Devoogdt, N., Chigoho, D. M., De Groof, T., Bridoux, J., Ertveldt, T., Covens, P. & D'Huyvetter, M., May 2023, In: Pharmaceutics. 15, 5, 31 p., 1378.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)61 Downloads (Pure) -
Optimizing the yield of At-211
Sevenois, M., Jensen, H., Haddad, F., Koumeir, C., D'Huyvetter, M. & Covens, P., 2023.Research output: Unpublished contribution to conference › Poster
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Preclinical Evaluation of a Radiotheranostic Single-Domain Antibody Against Fibroblast Activation Protein α
Dekempeneer, Y., Massa, S., Santens, F., Navarro, L., Berdal, M., Miranda Lucero, M., Pombo Antunes, A. R., Lahoutte, T., Van Ginderachter, J. A., Devoogdt, N. & D'Huyvetter, M., Dec 2023, In: Journal of Nuclear Medicine. 64, 12, p. 1941-1948 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)15 Downloads (Pure) -
Targeted α-Therapy Using 225Ac Radiolabeled Single-Domain Antibodies Induces Antigen-Specific Immune Responses and Instills Immunomodulation Both Systemically and at the Tumor Microenvironment
Ertveldt, T., Krasniqi, A., Ceuppens, H., Puttemans, J., Dekempeneer, Y., De Jonghe, K., de Mey, W., Lecocq, Q., De Vlaeminck, Y., Awad, R. M., Goyvaerts, C., De Veirman, K., Morgenstern, A., Bruchertseifer, F., Keyaerts, M., Devoogdt, N., D'Huyvetter, M. & Breckpot, K., 1 May 2023, In: Journal of Nuclear Medicine. 64, 5, p. 751-758 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)28 Downloads (Pure) -
2022
A multi-region model of a mouse kidney for preclinical internal dosimetry of beta- and alpha-particle emitting radionuclides
Saldarriaga Vargas, C., Struelens, L., D'Huyvetter, M., Caveliers, V. & Covens, P., 22 Sep 2022, In: European Journal of Nuclear Medicine and Molecular Imaging. 49, SUPPL 1, p. 208-208 1 p., OP-623.Research output: Contribution to journal › Meeting abstract (Journal)
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Anti-cd38 single-domain antibodies in disease monitoring and treatment
Caers, J., Duray, E., Dumoulin, M., D'Huyvetter, M. & Karlström, A. E., 2022, Patent No. WO2022242892Research output: Patent
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Assessment of mouse-specific pharmacokinetics in kidneys based on I-131 activity measurements using micro-SPECT
Saldarriaga Vargas, C., Struelens, L., D'Huyvetter, M., Caveliers, V. & Covens, P., Dec 2022, In: EJNMMI Physics. 9, 1, p. 13 21 p., 13.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)82 Downloads (Pure) -
Emerging applications of nanobodies in cancer therapy
Awad, R. M., Meeus, F., Ceuppens, H., Ertveldt, T., Hanssens, H., Lecocq, Q., Mateusiak, L., Zeven, K., Valenta, H., De Groof, T. W. M., De Vlaeminck, Y., Krasniqi, A., De Veirman, K., Goyvaerts, C., D'Huyvetter, M., Hernot, S., Devoogdt, N. & Breckpot, K., 2022, In: International review of cell and molecular biology. 369, p. 143-199 57 p.Research output: Contribution to journal › Scientific review › peer-review
Open AccessFile12 Citations (Scopus)410 Downloads (Pure) -
Optimizing the yield of 211At
Sevenois, M., Jensen, H., D'Huyvetter, M. & Covens, P., Sep 2022, In: European Journal of Nuclear Medicine and Molecular Imaging. 49, p. S35-S35Research output: Contribution to journal › Meeting abstract (Journal)
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Optimizing the yield of 211At - first results of the RASTA project
Sevenois, M., Jensen, H., D'Huyvetter, M. & Covens, P., 2022.Research output: Unpublished contribution to conference › Poster
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Preclinical evaluation of 225Ac-labeled single-domain antibody for the treatment of HER2pos cancer
Rodak, M., Dekempeneer, Y., Wojewódzka, M., Caveliers, V., Covens, P., Miller, B. W., Sevenois, M. B., Bruchertseifer, F., Morgenstern, A., Lahoutte, T., D'Huyvetter, M. & Pruszynski, M., 1 Dec 2022, In: Molecular Cancer Therapeutics. 21, 12, p. 1835-1845 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)15 Downloads (Pure) -
Radio-labelled antibody fragments for use in the prevention and/or treatment of cancer
Lahoutte, T., Devoogdt, N., D'Huyvetter, M. & De Vos, J., 2022, Patent No. EP3174559Research output: Patent
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Radiolabelled antibody fragments for use in treating cancer
Lahoutte, T., D'Huyvetter, M., De Vos, J. & Devoogdt, N., 2022, Patent No. US11298433Research output: Patent
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Radiolabelled antibody fragments for use in treating cancer
Lahoutte, T., D'Huyvetter, M., De Vos, J. & Devoogdt, N., 2022, Patent No. EP3325020Research output: Patent
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Radiotheranostic Agents in Hematological Malignancies
Caers, J., Duray, E., Vrancken, L., Marcion, G., Bocuzzi, V., De Veirman, K., Krasniqi, A., Lejeune, M., Withofs, N., Devoogdt, N., Dumoulin, M., Karlström, A. E. & D'Huyvetter, M., 5 Jul 2022, In: Frontiers in Immunology. 13, 18 p., 911080.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)26 Downloads (Pure) -
Targeted radionuclide therapy with low and high-dose Lutetium-177 labeled single domain antibodies induces distinct immune signatures in a mouse melanoma model
Ertveldt, T., De Beck, L., De Ridder, K., Locy, H., De Mey, W., Goyvaerts, C., Lecocq, Q., Ceuppens, H., De Vlaeminck, Y., Awad, R. M., Keyaerts, M., Devoogdt, N., D'Huyvetter, M., Breckpot, K. & Krasniqi, A., Jul 2022, In: Molecular Cancer Therapeutics. 21, 7, p. 1136-1148 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)47 Downloads (Pure) -
The road to personalized myeloma medicine: Patient-specific single-domain antibodies for anti-idiotypic radionuclide therapy
Puttemans, J., Stijlemans, B., Keyaerts, M., Vander Meeren, S., Renmans, W., Fostier, K., Debie, P., Hanssens, H., Rodak, M., Pruszynski, M., De Veirman, K., Vanderkerken, K., Lahoutte, T., Morgenstern, A., Bruchertseifer, F., Devoogdt, N. & D'Huyvetter, M., Jan 2022, In: Molecular Cancer Therapeutics. 21, 1, p. 159-169 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)171 Downloads (Pure) -
2021
A non-internalised CD38-binding radiolabelled single-domain antibody fragment to monitor and treat multiple myeloma
Duray, E., Lejeune, M., Baron, F., Beguin, Y., Devoogdt, N., Krasniqi, A., Lauwers, Y., Zhao, Y. J., D'Huyvetter, M., Dumoulin, M. & Caers, J., 2 Nov 2021, In: Journal of Hematology & Oncology. 14, 1, 13 p., 183.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)34 Downloads (Pure) -
Anti-cd38 single-domain antibodies in disease monitoring and treatment
Caers, J., Duray, E., Dumoulin, M. & D'Huyvetter, M., 2021, Patent No. WO2021229104Research output: Patent
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CS1-specific single-domain antibodies labeled with Actinium-225 prolong survival and increase CD8+ T cells and PD-L1 expression in Multiple Myeloma
De Veirman, K., Puttemans, J., Krasniqi, A., Ertveldt, T., Hanssens, H., Romao, E., Hose, D., Goyvaert, C., Vlummens, P., Muyldermans, S., Breckpot, K., Bruchertseifer, F., Morgenstern, A., D'Huyvetter, M. & Devoogdt, N., 2021, In: Oncoimmunology. 10, 1, 11 p., 2000699.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)14 Downloads (Pure) -
Phase I trial of 131I-GMIB-Anti-HER2-VHH1, a new promising candidate for HER2-targeted radionuclide therapy in breast cancer patients
D'Huyvetter, M., De Vos, J., Caveliers, V., Vaneycken, I., Heemskerk, J., Duhoux, F. P., Fontaine, C., Vanhoeij, M., Windhorst, A. D., van der Aa, F., Hendrikse, N. H., Eersels, J. L. E., Everaert, H., Gykiere, P., Devoogdt, N., Raes, G., Lahoutte, T. & Keyaerts, M., 1 Aug 2021, In: Journal of Nuclear Medicine. 62, 8, p. 1097-1105 9 p.Research output: Contribution to journal › Article › peer-review
Open Access67 Citations (Scopus) -
The therapeutic potential of Actinium-225-labeled CS1-specific single-domain antibodies for the treatment of Multiple Myeloma
De Veirman, K., Puttemans, J., Krasniqi, A., Hanssens, H., Romao, E., Vlummens, P., Breckpot, K., Hose, D., Bruchertseifer, F., Morgenstern, A., D'Huyvetter, M. & Devoogdt, N., 8 Sep 2021, p. 79-79. 1 p.Research output: Unpublished contribution to conference › Unpublished abstract
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2020
Investigating immune activation upon beta targeted radionuclide therapy using anti-CD20 single domain antibody fragments in melanoma
Ertveldt, T., Dekempeneer, Y., De Beck, L., Goyvaerts, C., Lecocq, Q., De Vlaeminck, Y., Awad, R. M., Devoogdt, N., Keyaerts, M., D'Huyvetter, M., Breckpot, K. & Krasniqi, A., 7 Feb 2020, p. page 79. 1 p.Research output: Unpublished contribution to conference › Poster
Open AccessFile22 Downloads (Pure) -
Multi-regional dosimetry of mouse kidneys for beta-emitters
Saldarriaga Vargas, C., Covens, P., D'Huyvetter, M., Caveliers, V., Miller, B. W. & Struelens, L., Sep 2020, In: European Journal of Nuclear Medicine and Molecular Imaging. 47, SUPPL 1, p. 57-57 1 p.Research output: Contribution to journal › Meeting abstract (Journal)
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Preclinical Targeted α- and β−-Radionuclide Therapy in HER2-Positive Brain Metastasis Using Camelid Single-Domain Antibodies
Puttemans, J., Dekempeneer, Y., Eersels, J. L., Hanssens, H., Debie, P., Keyaerts, M., Breckpot, K., Lecocq, Q., Lahoutte, T., Windhorst, A. D., Van Der Aa, F., Morgenstern, A., Bruchertseifer, F., Devoogdt, N. & D'Huyvetter, M., 21 Apr 2020, In: Cancers. 12, 4, 1017.Research output: Contribution to journal › Article › peer-review
Open AccessFile51 Citations (Scopus)200 Downloads (Pure) -
Reshaping nanobodies for affinity purification on protein a
Crauwels, M., Van Vaerenbergh, N., Kulaya, N. B., Vincke, C., D'Huyvetter, M., Devoogdt, N., Muyldermans, S. & Xavier, C., 25 Jul 2020, In: New Biotechnology. 57, p. 20-28 9 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Citations (Scopus) -
Size and affinity kinetics of nanobodies influence targeting and penetration of solid tumours
Debie, P., Lafont, C., Defrise, M., Hansen, I., van Willigen, D. M., van Leeuwen, F. WB., Gijsbers, R., D'Huyvetter, M., Devoogdt, N., Lahoutte, T., Mollard, P. & Hernot, S., 10 Jan 2020, In: Journal of Controlled Release. 317, p. 34-42 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile124 Citations (Scopus)360 Downloads (Pure) -
Therapeutic Efficacy of 213Bi-labeled sdAbs in a Preclinical Model of Ovarian Cancer.
Dekempeneer, Y., Caveliers, V., Ooms, M., Maertens, D., Gysemans, M., Lahoutte, T., Xavier, C., Lecocq, Q., Maes, K., Covens, P., Miller, B. W., Bruchertseifer, F., Morgenstern, A., Cardinaels, T. & D'Huyvetter, M., 8 Sep 2020, In: Molecular Pharmaceutics. 17, 9, p. 3553-3566 14 p.Research output: Contribution to journal › Article › peer-review
37 Citations (Scopus) -
2019
Beyond the Barrier: Targeted Radionuclide Therapy in Brain Tumors and Metastases
Puttemans, J., Lahoutte, T., D'Huyvetter, M. & Devoogdt, N., 1 Aug 2019, In: Pharmaceutics. 11, 8, 23 p., 376.Research output: Contribution to journal › Article › peer-review
Open Access19 Citations (Scopus) -
CAM-H2 effectively targets and treats HER2 positive brain lesions: A comparative preclinical study with trastuzumab
Puttemans, J., D'Huyvetter, M., Windhorst, B., Lahoutte, T. & Devoogdt, N., May 2019, In: Annals of Oncology. 30Research output: Contribution to journal › Meeting abstract (Journal)
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CAM-H2 effectively targets and treats HER2 positive brain lesions: a comparative preclinical study with Trastuzumab.
Puttemans, J., D'Huyvetter, M., Windhorst, AD., Lahoutte, T. & Devoogdt, N., 2 May 2019.Research output: Unpublished contribution to conference › Poster
Open Access -
Cd20 binding agents and uses thereof
Tavernier, J., Van Der Heyden, J., Devoogdt, N., D'Huyvetter, M. & Krasniqi, A., 2019, Patent No. EP3426687Research output: Patent
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Combining Bismuth-213 with Nanobodies: Finding the Perfect Match for Targeted Alpha Therapy
Dekempeneer, Y., Caveliers, V., D'Huyvetter, M., Maertens, D., Gysemans, M., Ooms, M., Lahoutte, T., Xavier, C., Bruchertseifer, F., Morgenstern, A. & Cardinaels, T., 23 Mar 2019, Journal of Medical Imaging and Radiation Sciences. 1 ed. Elsevier, Vol. 50. p. S7-S8 2 p.Research output: Chapter in Book/Report/Conference proceeding › Conference paper
Open Access -
Does targeted radionuclide therapy using 177Lutetium induce immune activation upon treatment?
Ertveldt, T., Krasniqi, A., Keyaerts, M., Goyvaerts, C., Lecocq, Q., De Vlaeminck, Y., Awad, R. M., De Beck, L., Dekempeneer, Y., Devoogdt, N., D'Huyvetter, M. & Breckpot, K., 7 Jun 2019.Research output: Unpublished contribution to conference › Poster
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Effect of charges of radiolabeled Nanobodies on kidney retention
Crauwels, M., Massa, S., Martin, C., Ballet, S., Caveliers, V., Lahoutte, T., D'Huyvetter, M., Hernot, S., Devoogdt, N., Xavier, C. & Muyldermans, S., 11 Mar 2019.Research output: Unpublished contribution to conference › Poster
File62 Downloads (Pure) -
Immunogenic effect of targeted radionuclide therapy-induced tumor cell death
Ertveldt, T., Krasniqi, A., D'Huyvetter, M., Goyvaerts, C., Lecocq, Q., De Vlaeminck, Y., Awad, R. M., De Beck, L., Devoogdt, N., Keyaerts, M. & Breckpot, K., 25 Jun 2019.Research output: Unpublished contribution to conference › Poster
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Iodinated anti-HER2 sdAb effectively targets and treats HER2 positive brain lesions
Puttemans, J., D'Huyvetter, M., Lahoutte, T. & Devoogdt, N., 5 Sep 2019.Research output: Unpublished contribution to conference › Poster
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Labeling of Anti-HER2 Nanobodies with Astatine-211: Optimization and the Effect of Different Coupling Reagents on Their in Vivo Behavior
Dekempeneer, Y., Back, T., Aneheim, E., Jensen, H., Puttemans, J., Xavier, C., Keyaerts, M., Palm, S., Albertsson, P., Lahoutte, T., Caveliers, V., Lindegren, S. & D'Huyvetter, M., Jun 2019, In: Molecular Pharmaceutics. 16, 8, p. 3524-3533 10 p.Research output: Contribution to journal › Article › peer-review
Open Access44 Citations (Scopus) -
Quantification of 131I activity in mouse kidneys using kidneys using micro-SPECT and ex vivo gamma counting: experimental evaluation of uncertainties
Saldarriaga Vargas, C., Struelens, L., D'Huyvetter, M., Eersels, J. L., Caveliers, V. & Covens, P., 13 Oct 2019.Research output: Unpublished contribution to conference › Poster
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Quantification of I-131 activity in mouse kidneys using micro-SPECT and ex vivo gamma counting: experimental evaluation of uncertainties
Vargas, C. S., Struelens, L., D'Huyvetter, M., Eersels, J. L., Caveliers, V. & Covens, P., Oct 2019, In: European Journal of Nuclear Medicine and Molecular Imaging. 46, SUPPL 1, p. S483-S483Research output: Contribution to journal › Meeting abstract (Journal)
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Size And Affinity Kinetics Of Nanobodies Influence Penetration And Targeting Of Solid Tumours
Debie, P., Lafont, C., Defrise, M., Hansen, I., van Willigen, D. M., van Leeuwen, F. WB., Gijsbers, R., D'Huyvetter, M., Devoogdt, N., Mollard, P. & Hernot, S., 5 Sep 2019.Research output: Unpublished contribution to conference › Poster
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Stromal-targeting radioimmunotherapy mitigates the progression of therapy-resistant tumors
Bolli, E., D'Huyvetter, M., Murgaski, A., Berus, D., Stangé, G., Clappaert, E. J., Arnouk, S., Pombo Antunes, A. R., Krasniqi, A., Lahoutte, T., Gonçalves, A., Vuylsteke, M., Raes, G., Devoogdt, N., Movahedi, K. & Van Ginderachter, J. A., 28 Nov 2019, In: Journal of Controlled Release. 314, p. 1-11 11 p.Research output: Contribution to journal › Article › peer-review
23 Citations (Scopus) -
Targeted radionuclide therapy using anti-CD20 sdAbs: assessment of immune-activation post treatment with beta-emitting radionuclides
Ertveldt, T., Krasniqi, A., Keyaerts, M., Goyvaerts, C., Lecocq, Q., De Vlaeminck, Y., Awad, R. M., De Beck, L., Dekempeneer, Y., Devoogdt, N., D'Huyvetter, M. & Breckpot, K., 18 Oct 2019.Research output: Unpublished contribution to conference › Poster