Projects per year
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Dive into the research topics where Nico De Leu is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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OZR4463: Brussels Metabolism Core (BruMet): an Integrated Platform for In Vitro, Ex Vivo and In Vivo Metabolic Profiling
Massie, A. (Administrative Promotor), De Ridder, M. (CoI (Co-Promotor)), De Leu, N. (CoI (Co-Promotor)), Hernot, S. (CoI (Co-Promotor)), Verhulst, S. (CoI (Co-Promotor)) & Staels, W. (CoI (Co-Promotor))
1/05/26 → 30/04/30
Project: Fundamental
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OZR4465: Decoding cellular landscapes in health and disease: building the Spatial Proteomics And Transcriptomics Alliance (SPArTA)
Rooman, I. (Administrative Promotor), De Leu, N. (CoI (Co-Promotor)), Forsyth, R. (CoI (Co-Promotor)), Janssen, T. (CoI (Co-Promotor)), Staels, W. (CoI (Co-Promotor)), Waelput, W. (CoI (Co-Promotor)) & Van Laere, S. (CoI (Co-Promotor))
1/05/26 → 30/04/30
Project: Fundamental
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FWOTM1255: MACBETh: Uncovering the role of MACrophages in BETa cell (re)generation.
Willems, L. (Mandate), De Leu, N. (Administrative Promotor), Staels, W. (CoI (Co-Promotor)) & Van Ginderachter, J. (CoI (Co-Promotor))
1/11/24 → 31/10/28
Project: Fundamental
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HERC66: 3D-CELLMAP: Unveiling complex cellular interactions in tissues through 3D super-resolution protein multiplex imaging
Movahedi, K. (Administrative Promotor), Rooman, I. (CoI (Co-Promotor)), Sermon, K. (CoI (Co-Promotor)), De Bundel, D. (CoI (Co-Promotor)), Fioravanti, A. (CoI (Co-Promotor)), Staels, W. (CoI (Co-Promotor)), Magez, S. (CoI (Co-Promotor)), Breckpot, K. (CoI (Co-Promotor)), De Kock, J. (CoI (Co-Promotor)), Laoui, D. (CoI (Co-Promotor)), Goyvaerts, C. (CoI (Co-Promotor)), Smolders, I. (CoI (Co-Promotor)), Van Ginderachter, J. (CoI (Co-Promotor)), Marcelino Rodrigues, R. (CoI (Co-Promotor)), De Leu, N. (CoI (Co-Promotor)), van Grunsven, L. (CoI (Co-Promotor)), Hernot, S. (CoI (Co-Promotor)), Peeters, E. (CoI (Co-Promotor)), Vanhaecke, T. (CoI (Co-Promotor)), De Veirman, K. (CoI (Co-Promotor)), Ruytinx, J. (CoI (Co-Promotor)), Van Schependom, J. (CoI (Co-Promotor)), Kortekaas, I. (CoI (Co-Promotor)) & Goossens, E. (CoI (Co-Promotor))
1/05/24 → 31/05/28
Project: Fundamental
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FWOAL1090: Exploiting vascular signals to improve the functional maturation of iPSC-derived beta-like cells
De Leu, N. (Administrative Promotor)
1/01/23 → 31/12/26
Project: Fundamental
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Beyond islets: compartment-specific endocrine responses to immune and beta-cell-targeted therapy in NOD mice revealed by spatial transcriptomics
Chrzanowski, J., Lemaitre, P. (Contributor), Degroote, L. (Contributor), Packbier, M. (Contributor), Viaene, M. (Contributor), Roelandt, R. (Contributor), Naert, R. (Contributor), Michalak, A. (Contributor), Fendler, W. (Contributor), Staels, W. (Contributor), De Leu, N. (Contributor), van Damme, N. (Contributor), Mathieu, C. (Contributor) & Gysemans, C. (Contributor), 23 Jun 2026, (Unpublished).Research output: Unpublished contribution to conference › Poster
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GLP1-E2 therapy delays autoimmune diabetes in late-stage prediabetic NOD mice and potentiates low-dose anti-CD3 therapy for enhanced disease protection
Degroote, L., Chrzanowski, J. (Contributor), Lemaitre, P. (Contributor), Wouters, A. (Contributor), Bourgeois, S. (Contributor), Van Mulders, A. (Contributor), Pierreux, J. (Contributor), Coenen, S. (Contributor), Willems, L. (Contributor), Leuckx, G. (Contributor), Viaene, M. (Contributor), Packbier, M. (Contributor), Douros, J. D. (Contributor), Yang, B. (Contributor), Heremans, Y. (Contributor), Mathieu, C. (Contributor), Staels, W. (Contributor), Gysemans, C. (Contributor) & De Leu, N. (Contributor), 17 Jun 2026, (Unpublished). 1 p.Research output: Unpublished contribution to conference › Poster
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GLP1-E2 therapy delays autoimmune diabetes in late-stage prediabetic NOD mice and potentiates low-dose anti-CD3 therapy for enhanced disease protection
Degroote, L., Chrzanowski, J., Lemaitre, P., Wouters, A., Bourgeois, S., Mulders, A. V., Pierreux, J., Coenen, S., Willems, L., Leuckx, G., Viaene, M., Packbier, M., Douros, J. D., Yang, B., Heremans, Y., Mathieu, C., Staels, W., Gysemans, C. & Leu, N. D., 18 May 2026, In: Diabetologia. 69, 8, p. 2307-2322 16 p.Research output: Contribution to journal › Article › peer-review
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GLP1-E2 therapy delays autoimmune diabetes in late-stage prediabetic NOD mice and potentiates low-dose anti-CD3 therapy for enhanced disease protection
Degroote, L., Chrzanowski, J. (Contributor), Lemaitre, P. (Contributor), Wouters, A. (Contributor), Bourgeois, S. (Contributor), Van Mulders, A. (Contributor), Pierreux, J. (Contributor), Coenen, S. (Contributor), Willems, L. (Contributor), Leuckx, G. (Contributor), Viaene, M. (Contributor), Packbier, M. (Contributor), Douros, J. D. (Contributor), Yang, B. (Contributor), Heremans, Y. (Contributor), Mathieu, C. (Contributor), Staels, W. (Contributor), Gysemans, C. (Contributor) & De Leu, N. (Contributor), 18 Jun 2026, (Unpublished). 1 p.Research output: Unpublished contribution to conference › Unpublished abstract
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Iron deficiency induces maturation-dependent loss of pancreatic β-cells
Van Mulders, A., Willems, L., Coenen, S., Bourgeois, S., Yi, X., Tong, Y., Leuckx, G., Heremans, Y., Pierreux, J., Degroote, L., Sawatani, T., Vinci, C., Ates, G., Massie, A., Carlotti, F., de Koning, E., Mandrup-Poulsen, T., Zelinsky, C., Goderis, S. & Ghesquière, B. & 4 others, , 16 Feb 2026, In: NATURE COMMUNICATIONS. 17, 1, 21 p., 2826.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus)
Prizes
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Belgian Endocrine Society, annual lecture
De Leu, N. (Recipient), 2015
Prize: National/international honour
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Belgian Endocrine Society Annual Lecture Award
De Leu, N. (Recipient), 2015
Prize: Prize (including medals and awards)
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McKinsey and Company Scientific Award
De Leu, N. (Recipient), 2015
Prize: Prize (including medals and awards)
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Novo Nordisk prijs voor Diabetologie
De Leu, N. (Recipient), 2018
Prize: National/international honour
Activities
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GLP1-E2 therapy delays autoimmune diabetes in late-stage prediabetic NOD mice and potentiates low-dose anti-CD3 therapy for enhanced disease protection
Degroote, L. (Speaker), Chrzanowski, J. (Contributor), Lemaitre, P. (Contributor), Wouters, A. (Contributor), Bourgeois, S. (Contributor), Van Mulders, A. (Contributor), Pierreux, J. (Contributor), Coenen, S. (Contributor), Willems, L. (Contributor), Leuckx, G. (Contributor), Viaene, M. (Contributor), Packbier, M. (Contributor), Douros, J. D. (Contributor), Yang, B. (Contributor), Heremans, Y. (Contributor), Mathieu, C. (Contributor), Staels, W. (Contributor), Gysemans, C. (Contributor) & De Leu, N. (Contributor)
18 Jun 2026Activity: Talk or presentation › Talk or presentation at a conference
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Movub Lentesymposium 2026
Raeymaeckers, S. (Chair), Allemeersch, G.-J. (Participant), Al-Ani, A. (Participant), Al-Awa, A. (Participant), Al-Janabi, M. J. M. (Participant), Al Saadi, M. (Participant), Belsack, D. (Participant), Blockeel, C. (Participant), Bollineni, V. R. (Participant), Boulet, C. (Participant), Breugelmans, M. (Participant), Brussaard, C. (Chair), Bhutia, J. T. (Participant), Cammu, H. (Organiser), Colsoul, O. (Participant), Da'meh, A. (Participant), David, K. (Participant), De Backer, A. (Participant), De Boe, V. R. J. (Participant), De Bondt, A. (Participant), De Leu, N. (Participant), de Mey, J. (Participant), De Mey, J. (Participant), De Munck, F. (Participant), De Ridder, M. (Participant), Devos, H. (Participant), Devroey, D. (Participant), Dewilde, D. (Participant), D'Haese, J. M. G. (Participant), Dhooge, E. (Participant), Diltoer, M. (Participant), Döring, S. (Participant), du Maine, C. M. (Participant), Dumarey, A. (Participant), Engels, B. (Participant), Ernst, C. (Participant), Everaert, H. (Participant), Garkalne, I. (Participant), Goethals, L. (Participant), Gungor, B. (Participant), Hasaerts, D. (Participant), Hubloux, G. (Participant), Hulstaert, T. (Participant), Ilsen, B. (Participant), Janssens, W. P. M. (Participant), Jonckheere, J. (Participant), Kichouh, M. (Participant), Kindt, S. (Participant), Kubincova, M. (Participant), Kumba, C. (Participant), Leeman, M. (Participant), Liebaers, I. (Participant), Leunen, M. (Participant), Leus, A. (Participant), Marchand, J. U. M. (Participant), Marcinkowski, I. (Participant), Marynen, F. (Participant), Mwewa, T. B. (Participant), Neyns, B. (Participant), Nieboer, K. (Participant), Orinx, E. (Participant), Osipowska, E. M. (Participant), Pauwels, A. (Participant), Pauwels, F. (Participant), Poortmans, N. K. N. (Participant), Pouliart, N. (Participant), Raeymaeckers, S. (Chair), Rabbachin, N. (Participant), Reynaert, H. (Participant), Roelandt, T. (Participant), Schiettecatte, A. (Participant), Schoneveld, M. (Participant), Schots, H. (Participant), Siffain, J. (Participant), Smets, D. (Participant), Stadnik, T. (Participant), Stas, A. (Participant), Stevens, G. (Participant), Stijns, J. (Participant), Szucs, E. (Participant), Tanaka, K. (Participant), Thielemans, K. (Participant), Vanbinst, A. (Participant), Van Der Niepen, P. (Participant), Van Eetvelde, E. (Participant), Vanfleteren, P. S. V. (Participant), Vanhoeij, M. (Participant), Van Royen, K. (Participant), Van Vaerenbergh, K. (Participant), Vandenbroucke, F. (Participant), Vanderhasselt, T. (Participant), Vanderlinden, K. (Participant), Vansintejan, J. (Participant), Vercauteren, C. (Participant), Verdam, M. (Participant), Ver Eecke, G. (Participant), Vermoesen, C. (Participant), Verstappen, G. (Participant), Violon, S. (Participant), Tosi, M. (Participant), Scholliers, A. (Participant), von Kemp, K. (Participant), Welch, A. (Participant), Willekens, I. (Participant), Vorsselmans, A. (Participant) & Zeeuws, D. (Participant)
21 Mar 2026Activity: Participating in or organising an event › Participation in conference
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Duct cells in development, regeneration, and transplantation:charting a path to new islets (Event)
Balak, J. (Presenter) & De Leu, N. (Jury)
16 May 2025Activity: Membership › Membership of peer-review panel or committee
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Biomarkers of beta cell loss, dysglycemia and responsiveness to immune intervention in (a)symptomatic type 1 diabetes (Event)
Desouter, A. (Presenter) & De Leu, N. (Jury)
23 Sept 2025Activity: Membership › Membership of peer-review panel or committee
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Targeting system xc- to simultaneously tackle the metabolic and neurological comorbidities of diet-induced obesity
Walckiers, J. (Speaker), Dalmas, E. (Contributor), Vanonckelen, O. (Contributor), Mackens, L. (Contributor), Van Mulders, A. (Contributor), Dreessen, T. (Contributor), Staels, W. (Contributor), De Leu, N. (Contributor), Ates, G. (Contributor) & Massie, A. (Contributor)
20 Oct 2025Activity: Talk or presentation › Talk or presentation at a conference
Thesis
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Can beta cell injury induce homing of an intravenous injected stem cell line, seRM26, to pancreas?
De Leu, N. ((PhD) Student) & Heimberg, H. (Promotor), Heimberg, H. (Promotor), 2005Student thesis: Master's Thesis
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Exploring the effect of estradiol on murine pancreatic beta cell proliferation
Noé, T. B. ((PhD) Student), Degroote, L. (Advisor), De Leu, N. (Promotor) & Staels, W. (Co-promotor), 2023Student thesis: Master's Thesis