Personal profile
Expertise
Stem cell biology. Stem cell in vitro culture, qPCR, immunostaining, microscopy
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
Projects
- 1 Finished
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FWOTM1016: The impact of recurrent chromosomal abnormalities on growth advantage and differentiation capacity of human pluripotent stem cells
Krivec, N. (Mandate), Spits, C. (Administrative Promotor) & Sermon, K. (Co-Promotor)
1/11/20 → 31/10/24
Project: Fundamental
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1q gain bypasses the selective barrier against aneuploidy in RPE differentiation via wild-type co-culture rescue
Couvreu De Deckersberg, E., Lei, Y., Krivec, N., Huyghebaert, A., Duong, M. C., Janssens, C., Regin, M., Tsuiko, O., Movahedi, K., Verhulst, S., van Grunsven, L. A., Sermon, K., Al Delbany, D. & Spits, C., 25 Nov 2025, In: Nature Communications. 16, 1, 15 p., 11627.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
Aneuploidy as a first genetic hit that enhances the tumorigenic capacity of differentiated human pluripotent stem cells
Al Delbany, D., Mampay, M., Srinivasan, A. N., Krivec, N., Huyghebaert, A., Movahedi, K. & Spits, C., 12 Jun 2025.Research output: Unpublished contribution to conference › Poster
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Aneuploidy as a first genetic hit that enhances the tumorigenic capacity of differentiated human pluripotent stem cells
Al Delbany, D., Mampay, M., Srinivasan, A. N., Krivec, N., Huyghebaert, A., Duong, M. C., Sarkar, A., Brock, S., Movahedi, K. & Spits, C., 28 Nov 2025.Research output: Unpublished contribution to conference › Poster
Open Access -
Aneuploidy as a first genetic hit that enhances the tumorigenic capacity of differentiated human pluripotent stem cells
Al Delbany, D., Mampay, M., Srinivasan, A. N., Krivec, N., Huyghebaert, A., Movahedi, K. & Spits, C., 11 Apr 2025, (Unpublished).Research output: Unpublished contribution to conference › Poster
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A novel liver organoid model using directed mutagenesis to study the oncogenic potential of human pluripotent stem cell-derived hepatocytes
Huyghebaert, A., Al Delbany, D., Krivec, N., van Grunsven, L. A. & Spits, C., 11 Apr 2025, (Unpublished).Research output: Unpublished contribution to conference › Poster
Datasets
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SALL3 mediates the loss of neuroectodermal differentiation potential in human embryonic stem cells with chromosome 18q loss (RESTRICTED)
Spits, C. (Creator), Lei, Y. (Creator), Al Delbany, D. (Creator), Krivec, N. (Creator), Regin, M. (Creator), Couvreu De Deckersberg, E. (Creator), Janssens, C. (Creator), Ghosh, M. (Creator) & Sermon, K. (Creator), VUB Institutional Data Repository, 10 Oct 2025
Dataset
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De Novo Cancer Mutations Frequently Associate with Recurrent Chromosomal Abnormalities during Long-Term Human Pluripotent Stem Cell Culture
Spits, C. (Creator), Al Delbany, D. (Creator), Ghosh, M. (Creator), Krivec, N. (Creator), Huyghebaert, A. (Creator), Regin, M. (Creator), Duong, C. M. (Creator), Lei, Y. (Creator), Sermon, K. (Creator) & Olsen, C. (Creator), VUB Institutional Data Repository, 15 Oct 2025
Dataset
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Gain of 1q confers an MDM4-driven growth advantage to undifferentiated and differentiating hESC while altering their differentiation capacity
Spits, C. (Creator), Krivec, N. (Creator), Al Delbany, D. (Creator), Regin, M. (Creator), Lei, Y. (Creator), Sermon, K. (Creator), Couvreu De Deckersberg, E. (Creator), van Grunsven, L. (Creator) & Verhulst, S. (Creator), VUB Institutional Data Repository, 9 May 2025
Dataset
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SALL3 mediates the loss of neuroectodermal differentiation potential in human embryonic stem cells with chromosome 18q loss (OPEN)
Spits, C. (Creator), Lei, Y. (Creator), Al Delbany, D. (Creator), Krivec, N. (Creator), Regin, M. (Creator), Couvreu De Deckersberg, E. (Creator), Janssens, C. (Creator), Ghosh, M. (Creator) & Sermon, K. (Creator), VUB Institutional Data Repository, 10 Oct 2025
Dataset
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Loss of 18q Alters TGFβ Signalling Affecting Anteroposterior Neuroectodermal Fate in Human Embryonic Stem Cells
Spits, C. (Creator), Lei, Y. (Creator), Regin, M. (Creator), Krivec, N. (Creator), Huyghebaert, A. (Creator), Couvreu De Deckersberg, E. (Creator), Sermon, K. (Creator), Al Delbany, D. (Creator), Duong, C. M. (Creator) & Janssens, C. (Creator), VUB Institutional Data Repository, 10 Oct 2025
Dataset
Activities
- 1 Talk or presentation at a conference
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SALL3 drives selective growth advantage and modulates pluripotency in hPSCs with chromosome 18q loss
Duong, C. M. (Presenter), Krivec, N. (Contributor), Al Delbany, D. (Contributor), Huyghebaert, A. (Contributor) & Spits, C. (Contributor)
28 Nov 2025Activity: Talk or presentation › Talk or presentation at a conference
Thesis
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Study the effect of chromosomal abnormalities on the neuroectoderm differentiation of hESCs in two and three-dimensional culture systems
Asadi, R. ((PhD) Student), Al Delbany, D. (Co-promotor), Krivec, N. (Co-promotor) & Spits, C. (Promotor), 28 Jul 2024Student thesis: Master's Thesis