Personal profile
Expertise
- Protein crystallography
- Biophysics
- Bio-SAXS (Small angle X-ray diffraction on biological molecules)
- Structural biology
- Persistence
- Bacterial stress response
- Intrinsically disordered proteins
- Transcription factors
- Liquid-liquid phase separation
External positions
Group Leader, Flanders Institute for Biotechnology
1 Jan 2012 → …
Expert scientist, Flanders Institute for Biotechnology
1 Jan 2009 → 31 Dec 2011
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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HERC68: High-resolution low-cost 100 kV electron cryogenic microscope for near-atomic protein structure determination
Efremov, R. (Administrative Promotor), Messens, J. (CoI (Co-Promotor)), Vorobieva, A. A. (CoI (Co-Promotor)), Remaut, H. K. (CoI (Co-Promotor)), Van der Henst, C. (CoI (Co-Promotor)), Steyaert, J. (CoI (Co-Promotor)), Versées, W. (CoI (Co-Promotor)), Loris, R. (CoI (Co-Promotor)) & Brunner, J. (CoI (Co-Promotor))
1/05/24 → 30/04/28
Project: Fundamental
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OZR4290: Financiering MZW OZR: High-resolution low-cost 100 kV electron cryogenic microscope for near-atomic protein structure determination
Efremov, R. (Administrative Promotor), Messens, J. (CoI (Co-Promotor)), Vorobieva, A. A. (CoI (Co-Promotor)), Remaut, H. K. (CoI (Co-Promotor)), Van der Henst, C. (CoI (Co-Promotor)), Steyaert, J. (CoI (Co-Promotor)), Versées, W. (CoI (Co-Promotor)), Loris, R. (CoI (Co-Promotor)) & Brunner, J. (CoI (Co-Promotor))
24/04/24 → 24/04/28
Project: Fundamental
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OZR4292: Financiering MZW OZR: Biolayer interferometry to study protein-protein and protein-ligand interactions
Versées, W. (Administrative Promotor), Loris, R. (CoI (Co-Promotor)), Rooman, I. (CoI (Co-Promotor)), Laoui, D. (CoI (Co-Promotor)), Messens, J. (CoI (Co-Promotor)), Brunner, J. (CoI (Co-Promotor)), Stijlemans, B. (CoI (Co-Promotor)) & Ballet, S. (CoI (Co-Promotor))
24/04/24 → 24/04/28
Project: Fundamental
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OZRMANSRF25: Senior Research Fellowship: Structural flexibility and disorder in protein function - 5nd term
Loris, R. (Administrative Promotor)
1/10/23 → 30/09/28
Project: Fundamental
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FWOTM1124: Uncovering the effect of long non-coding RNAs on liquid-liquid phase separation of androgen receptor in prostate cancer
Tompa, P. (Administrative Promotor), Loris, R. (Co-Promotor) & Farahi, N. (Mandate)
1/11/22 → 31/10/26
Project: Fundamental
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DNA binding and dimerization of the SOG1 NAC domain are functionally linked with its ability to undergo liquid-liquid phase separation.
Mignon, K., Van der Eecken, R., Galle, M., Demulder, M., Van Lindt, J., De Veylder, L., De Greve, H. & Loris, R., 20 Jan 2026, In: Nucleic Acids Res.. 54, 2, 16 p., gkaf1522.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Downloads (Pure) -
Expression, purification, and biophysical characterization of liquid-liquid phase separation of full-length hnRNPA2B1
Durán-Armenta, L. F., Meszaros, A., Malo Pueyo, J., Janvier, S., Lazar, T., Maes, D., Loris, R. & Tompa, P., Mar 2026, In: Prot. Express. Purif.. 239, 11 p., 106861.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Isolation and characterization of bacteriophages from clinical enterohemorrhagic Escherichia coli strains
Vandierendonck, J., Valcek, A., Nguyen, V.-S., Vertommen, D., Malhotra-Kumar, S., De Greve, H. & Loris, R., 7 Oct 2025, In: Microbiology spectrum. 13, 10, 16 p., e0059725.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Purification and characterization of the intrinsically disordered Arabidopsis thaliana protein SOG1
Mignon, K., Galle, M., Van der Eecken, R., Demulder, M., Haesaerts, S., De Greve, H., De Veylder, L. & Loris, R., May 2025, In: Prot. Express. Purif.. 229, 13 p., 106678.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Downloads (Pure) -
Putting bacteria in alarm: Toxin–antitoxin systems
Loris, R., Feb 2025, In: Nat. Chem. Biol.. 21, 2, p. 158-159 2 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Downloads (Pure)
Datasets
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Proteomics analysis of bacteriophages from clinical enterohemorrhagic E. coli strains
Loris, R. (Creator), Vandierendonck, J. (Data Collector), Vertommen, D. (Data Collector) & De Greve, H. (Project Leader), EMBL-EBI, 2025
https://www.ebi.ac.uk/pride/archive/projects/PXD061229
Dataset
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Arabidopsis thaliana Phosphoenolpyruvate carboxylase PPC1 free form
Loris, R. (Creator), Prolic Kalinsek, M. (Creator) & Haesaerts, S. (Creator), Protein Data Bank, 12 Apr 2023
DOI: 10.2210/pdb8OJ9/pdb
Dataset
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Chemical shift data for Vibrio cholerae HigA2
Loris, R. (Project Leader) & Hadzi, S. (Creator), BMRB - Biological magnetic resonance data bank, 20 Jun 2022
DOI: 10.13018/BMR51448
Dataset
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Human ganglioside-induced differentiation-associated protein 1 (GDAP1) missense mutant R120W, construct GDAP1∆302-358
Loris, R. (Supervisor) & Muruganandam, G. (Creator), Small Angle Scattering Biological Data Bank, 2022
https://www.sasbdb.org/data/SASDNE6/
Dataset
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Human ganglioside-induced differentiation-associated protein 1 (GDAP1) missense mutant H123R, construct GDAP1∆302-358
Loris, R. (Creator) & Muruganandam, G. (Creator), Small Angle Scattering Biological Data Bank, 2022
https://www.sasbdb.org/data/SASDND6/
Dataset
Activities
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PhD Defense Zala Zivic - The regulation of toxin-antitoxin systems in in vivo (Event)
Loris, R. (Jury), Zivic, Z. (Speaker), Lah, J. (Supervisor) & Hadzi, S. (Chair)
7 Oct 2025Activity: Membership › Member of PhD committee
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PhD defense Kim Mignon - Molecular basis of DNA recognition by Arabidopsis thaliana SOG1: the master regulator for DNA damage control in plants (Event)
Mignon, K. (Speaker), Loris, R. (Supervisor), Messens, J. (Chair), Ruytinx, J. (Jury), Versées, W. (Jury), Ezerina, D. (Jury), Hadzi, S. (Jury) & Hendrix, J. (Jury)
3 Dec 2025Activity: Membership › Member of PhD committee
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PhD Defense Yana Girardin - Exploring the interaction landscape of the Vibrio cholerae toxin ParE2: gyrase inhibition and neutralization by ParD2 (Event)
Girardin, Y. (Speaker), Loris, R. (Supervisor), Peeters, E. (Chair), Van Molle, I. (Member), De Proft, F. (Member), Sterckx, Y. (Member) & Dunham, C. (Member)
4 Aug 2025Activity: Membership › Member of PhD committee
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PhD Defense Jessie Vandierendonck - Isolation, characterization and genetic modification of toxin-bearing bacteriophages from enterohemorhaggic E. coli (Event)
Vandierendonck, J. (Speaker), Loris, R. (Supervisor), De Greve, H. (Supervisor), Van der Henst, C. (Chair), Peeters, E. (Member), Roelants, K. (Member), Rob, L. (Member) & Tamman, H. (Member)
31 Oct 2025Activity: Membership › Member of PhD committee
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Gordon Research Conference on Intrinsically Disordered Proteins 2024
Loris, R. (Participant)
23 Jun 2024 → 28 Jun 2024Activity: Participating in or organising an event › Participation in conference
Press/Media
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Press release: Toppublicatie dankzij gloednieuw NMR-centrum: Vlaamse onderzoekers leveren eerste experimenteel bewijs van dynamische allosterie in eiwitregulatie
9/07/10
1 Media contribution
Press/Media: Other
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Thesis
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Advances in methodology for the analysis of DNA interacting proteins by native ion mobility mass spectrometry
Kotter, A. ((PhD) Student), Sobott, F. (Promotor), Lemiere, F. (Jury), Dewilde, S. (Jury), Loris, R. (Jury), Devreese, B. (Jury), Lambeir, A.-M. (Jury) & Dillingham, M. (Jury), 21 Mar 2016Student thesis: Doctoral Thesis
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Characterization of activity-modulating nanobodies against the translation-inhibiting proteins Doc and MazF
Oyet, A. ((PhD) Student), Loris, R. (Promotor), De Greve, H. (Promotor), Sterckx, Y. (Jury), Beeckmans, S. (Jury) & Van Driessche, E. ((PhD) Student), 2 Sept 2014Student thesis: Master's Thesis
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Generation of a megabody toolkit for crystallization and performing cryo-EM of the SOG1 NAC domain
Aoude, L. ((PhD) Student), Messens, J. (Jury), Stijlemans, B. (Jury), Mignon, K. (Advisor) & Loris, R. (Promotor), 25 Jun 2024Student thesis: Master's Thesis
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Mechanisms of transcription regulation in prokaryotic toxin-antitoxin modules
Vandervelde, A. ((PhD) Student), Loris, R. (Promotor), Danckaert, J. (Promotor), De Greve, H. (Promotor), Muyldermans, S. (Jury), Garcia-Pino, A. (Jury), Kaldalu, N. (Jury), Leyns, L. (Jury) & Peeters, E. (Jury), 26 Sept 2016Student thesis: Doctoral Thesis
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Methionine sulfoxide reductase A (MsrA) in the repair of oxidized proteins in the pathogenic Actinomycete Corynebacterium diphtheriae
Tossounian, M.-A. ((PhD) Student), Messens, J. (Promotor), Van Molle, I. (Co-promotor), Loris, R. (Jury) & Beeckmans, S. (Jury), Messens, J. (Promotor) & Van Molle, I. (Co-promotor), 5 Sept 2014Student thesis: Master's Thesis