Projects per year
Personal profile
Expertise
The main objective of my research is to develop and investigate the applicability of human adult stem cells and their hepatic differentiated progeny as an alternative in vitro model for toxicity testing and liver disease modelling. My current focus lays on the application of in vitro cell systems to study non-alcoholic fatty liver diseases (NAFLD) and more specific non-alcoholic steatohepatitis (NASH). Using alternative aproaches to animal experimentation, we aim at elucidating NAFLD-specific mechanisms and evaluate the anti-NASH properties of novel pharmacological compounds.
This reserach is conducted within a postdoctoral fellowship funded by the Research Foundation Flanders - FWO as well as an assistant professorship (10%) position within the faculty of Pharmacy and Medicine of the VUB.
Education/Academic qualification
Pharmacological Sciences, PhD
External positions
Visiting Postdoctoral Researcher, National Institutes of Health
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Projects
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HERC45: FWO Hercules MZW: Light sheet fluorescence microscopy in life sciences and medical research
Sermon, K., Van De Velde, H., Goossens, E., Baeyens, L., Van Ginderachter, J., De Bundel, D., Hernot, S., De Kock, J., Vinken, M., Vanhaecke, T., Marcelino Rodrigues, R. & van Grunsven, L.
1/05/18 → 30/04/22
Project: Fundamental
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AIIFUND24: HSI Grant: Roadmaps to human biology-based disease research
1/08/17 → 31/12/17
Project: Fundamental
Research output
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Differentiation of multipotent human skin-derived precursors towards hepatic stellate cell-like cells for modelling liver fibrosis in vitro
Gatzios, A., Rodrigues, R., De Kock, J., Rombaut, M., Rogiers, V., Boeckmans, J. & Vanhaecke, T., 28 Apr 2021.Research output: Unpublished contribution to conference › Poster
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Human hepatic in vitro models reveal distinct anti-NASH potencies of PPAR agonists
Boeckmans, J., Natale, A., Rombaut, M., Buyl, K., Cami, B., De Boe, V., Heymans, A., Rogiers, V., De Kock, J., Vanhaecke, T. & Rodrigues, R. M., Apr 2021, In : Cell Biology and Toxicology. 37, 2, p. 293-311 19 p.Research output: Contribution to journal › Article
2 Citations (Scopus) -
COVID-19 and drug-induced liver injury: a problem of plenty or a petty point?
Boeckmans, J., Rodrigues, R., Demuyser, T., Pierard, D., Vanhaecke, T. & Rogiers, V., 8 Apr 2020, In : Archives of dairy research and technology. 94, 4, p. 1367-1369 3 p., 21.Research output: Contribution to journal › Article
39 Citations (Scopus) -
Flow cytometric quantification of neutral lipids in a human skin stem cell-derived model of NASH
Boeckmans, J., Natale, A., Rombaut, M., Buyl, K., Vanhaecke, T., Rogiers, V., Rodrigues, R. M. & De Kock, J., 2020, In : MethodsX. 7, 7 p., 101068.Research output: Contribution to journal › Article
1 Citation (Scopus) -
Inflammation Alters the Secretome and Immunomodulatory Properties of Human Skin-Derived Precursor Cells
De Kock, J., Rodrigues, R. M., Branson, S., Verhoye, L., Colemonts-Vroninks, H., Rombaut, M., Boeckmans, J., Neuckermans, J., Lequeue, S., Buyl, K., Merimi, M., Moussa Agha, D., De Boe, V., Lagneaux, L., Meuleman, P., Vanhaecke, T. & Najar, M., 8 Apr 2020, In : Cells. 9, 4, 914.Research output: Contribution to journal › Article
2 Citations (Scopus)
Activities
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A human hepatocyte-like cell based In Vitro model for hepatic insulin-driven De Novo Lipogenesis
Karolien Buyl (Speaker), Martine Vrints (Speaker), Ruani Fernando (Speaker), Thomas Van Eeckhoute (Speaker), Mia Jans (Speaker), Joost Boeckmans (Speaker), Robim Marcelino Rodrigues (Speaker), Vera Rogiers (Speaker), Jan Van Der Schueren (Speaker), Joery De Kock (Speaker), Tamara Vanhaecke (Speaker), Filip Beirinckx (Speaker)2020 → …Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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In vitro investigation of the anti-NASH properties of elafibranor and lanifibranor using a human stem cell-derived disease model
Joost Boeckmans (Speaker), Vera Rogiers (Contributor), Tamara Vanhaecke (Contributor), Robim Marcelino Rodrigues (Contributor)25 Feb 2019 → 26 Feb 2019Activity: Talk or presentation › Talk or presentation at a conference
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Untargeted in vitro metabolomics to identify hepatotoxic modes of action
Matthias Cuykx (Speaker), Charlie Beirnaert (Contributor), Robim Marcelino Rodrigues (Contributor), Kris Laukens (Speaker), Tamara Vanhaecke (Contributor), Adrian Covaci (Speaker)20 Sep 2018Activity: Talk or presentation › Talk or presentation at a conference
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The investigation of drug-induced cholestasis in HepaRG cells using untargeted LC-MS cholestasis
Matthias Cuykx (Speaker), C Beirnaert (Speaker), Robim Marcelino Rodrigues (Speaker), K Laukens (Speaker), Tamara Vanhaecke (Speaker), Adrian Covaci (Speaker)2 Sep 2018 → 5 Sep 2018Activity: Talk or presentation › Talk at an external academic organisation
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Untargeted in vitro metabolomics to identify hepatotoxic modes of action
Matthias Cuykx (Speaker), C Beirnaert (Speaker), Robim Marcelino Rodrigues (Speaker), K Laukens (Speaker), Tamara Vanhaecke (Speaker), Adrian Covaci (Speaker)19 Sep 2018Activity: Talk or presentation › Talk or presentation at a conference
Thesis
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Bijdrage tot de ontwikkeling van een in vitro ziektemodel voor rhepatische steatose door gebruik te maken van huidafgeleide stamcellen
Author: Declerck, E., Vanhaecke, T., Marcelino Rodrigues, R. & Hernot, S., 7 Sep 2017Student thesis: Master's Thesis
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Development and application of in vitro toxicology methods.
Author: Larrosa Flor, M., Vanhaecke, T., Rogiers, V. & Marcelino Rodrigues, R., 1 Feb 2012Supervisor: Vanhaecke, T. (Promotor), Rogiers, V. (Promotor) & Marcelino Rodrigues, R. (Co-promotor)
Student thesis: Master's Thesis
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Development and characterization of a human stem cell-based in vitro model for anti-nash drug testing
Author: Boeckmans, J., Rodrigues, R., Vanhaecke, T., Rogiers, V., De Kock, J., Vander Heyden, Y., De Paepe, K., Reynaert, H., Leclercq, I. & Jover, R., 8 Jul 2020Supervisor: Marcelino Rodrigues, R. (Promotor), Vanhaecke, T. (Promotor), Rogiers, V. (Promotor), De Kock, J. (Co-promotor), Vander Heyden, Y. (Jury), De Paepe, K. (Jury), Reynaert, H. (Jury), Leclercq, I. (External person) (Promotor) & Jover, R. (External person) (Promotor)
Student thesis: Doctoral Thesis
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Evaluatie van het gebruik van humane huid-afgeleide precursoren voor de bepaling van in vitro-geïnduceerde steatose door geneesmiddelen
Author: Hasaert, S., Vanhaecke, T., Rogiers, V., De Kock, J. & Marcelino Rodrigues, R., 2015Supervisor: Vanhaecke, T. (Promotor), Rogiers, V. (Promotor), De Kock, J. (Promotor) & Marcelino Rodrigues, R. (Co-promotor)
Student thesis: Master's Thesis
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Evaluation of human and rat in vitro cellular models for toxicity screening
Author: Garcia Barbazan, I., Vanhaecke, T., Rogiers, V. & Marcelino Rodrigues, R., 1 Jul 2012Supervisor: Vanhaecke, T. (Promotor), Rogiers, V. (Promotor) & Marcelino Rodrigues, R. (Co-promotor)
Student thesis: Master's Thesis