Projects per year
Personal profile
Expertise
The main objective of my research is to develop and investigate the applicability of human adult stem cells and their hepatic differentiated progeny as an alternative in vitro model for toxicity testing and liver disease modelling. My current focus lays on the application of in vitro cell systems to study non-alcoholic fatty liver diseases (NAFLD) and more specific non-alcoholic steatohepatitis (NASH). Using alternative aproaches to animal experimentation, we aim at elucidating NAFLD-specific mechanisms and evaluate the anti-NASH properties of novel pharmacological compounds.
This reserach is conducted within a postdoctoral fellowship funded by the Research Foundation Flanders - FWO as well as an assistant professorship (10%) position within the faculty of Pharmacy and Medicine of the VUB.
Education/Academic qualification
Pharmacological Sciences, PhD
Award Date: 22 May 2015
External positions
Visiting Postdoctoral Researcher, National Institutes of Health
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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HERC66: 3D-CELLMAP: Unveiling complex cellular interactions in tissues through 3D super-resolution protein multiplex imaging
Movahedi, K., Rooman, I., Sermon, K., De Bundel, D., Fioravanti, A., Staels, W., Magez, S., Breckpot, K., De Kock, J., Laoui, D., Goyvaerts, C., Smolders, I., Van Ginderachter, J., Marcelino Rodrigues, R., De Leu, N., van Grunsven, L., Hernot, S., Peeters, E., Vanhaecke, T., De Veirman, K., Ruytinx, J., Van Schependom, J., Kortekaas, I. & Goossens, E.
1/05/24 → 31/05/28
Project: Fundamental
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EUAR35: H2020: CSA: TWINALT: Twinning towards excellence in alternative methods for toxicity assessment
Vanhaecke, T., De Kock, J., Marcelino Rodrigues, R. & Rogiers, V.
1/09/20 → 31/08/23
Project: Applied
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HERC45: FWO Hercules MZW: Light sheet fluorescence microscopy in life sciences and medical research
Sermon, K., Van De Velde, H., Goossens, E., Baeyens, L., Van Ginderachter, J., De Bundel, D., Hernot, S., De Kock, J., Vinken, M., Vanhaecke, T., Marcelino Rodrigues, R. & van Grunsven, L.
1/05/18 → 30/04/22
Project: Fundamental
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A human liver-based in vitro test battery to detect liver steatogenic potential of chemicals from various applicability domains
Verhoeven, A., Drees, A. H., Rodrigues, R., Sanz-Serrano, J., Vanhaecke, T. & Vinken, M., 2025, (Unpublished).Research output: Unpublished contribution to conference › Poster
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A human liver-based in vitro test battery to detect liver steatogenic potential of chemicals from various applicability domains
Verhoeven, A., Drees, A. H., Rodrigues, R., Sanz-Serrano, J., Vanhaecke, T. & Vinken, M., May 2025, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Genetic predisposition for hepatic fat accumulation impacts the uptake of fatty acids through fatty acid translocase in a human stem cell-based in vitro model
Gatzios, A., Rombaut, M., De Kock, J., Verhoeven, A., De Win, D., Heymans, A., Rogiers, V., Rodrigues, R., Boeckmans, J. & Vanhaecke, T., May 2025, Abstract Book of EASL Congress 2025. Elsevier, Vol. 82(S1). p. S585-S586 2 p. FRI-338Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book)
Open Access -
Genetic predisposition for hepatic fat accumulation impacts the uptake of fatty acids through fatty acid translocase in a human stem cell-based in vitro model
Gatzios, A., Rombaut, M., De Kock, J., Verhoeven, A., De Win, D., Heymans, A., Rogiers, V., Rodrigues, R., Boeckmans, J. & Vanhaecke, T., 9 May 2025, (Unpublished). 1 p.Research output: Unpublished contribution to conference › Poster
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Next Generation Risk Assessment of Hair Dye HC Yellow No. 13: Ensuring Protection From Liver Steatogenic Effects
Sepehri, S., De Win, D., Heymans, A., Van Goethem, F., Rodrigues, R. M., Rogiers, V. & Vanhaecke, T., Jun 2025, In: Regulatory Toxicology and Pharmacology. 159, p. 1-14 14 p., 105794.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Neutral Red uptake in HepG2
Marcelino Rodrigues, R. (Creator), Zenodo, 2023
DOI: https://doi.org/10.5281/zenodo.14903041
Dataset
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"Transcriptomics analysis of in vitro NASH models unveils potential adverse effect of elafibranor"
Marcelino Rodrigues, R. (Creator), NCBI Gene Expression Omnibus, 22 Mar 2022
DOI: doi:10.3390/cells11050893
Dataset
Prizes
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33. Forschungspreises zur Förderung methodischer Arbeiten mit dem Ziel der Einschränkung und des Ersatzes von Tierversuchen
De Kock, Joery (Recipient), Marcelino Rodrigues, Robim (Recipient), Vanhaecke, Tamara (Recipient) & Rogiers, Vera (Recipient), 2014
Prize: Prize (including medals and awards)
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Fellows Award for Research Excellence (FARE)
Marcelino Rodrigues, Robim (Recipient), 2020
Prize: Prize (including medals and awards)
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Postdoctoral Fellow Research Award
Marcelino Rodrigues, Robim (Recipient), 2020
Prize: Prize (including medals and awards)
Activities
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Genetic predisposition for anti-MASH drug response: a population-based in vitro study
Alexandra Gatzios (Speaker), Matthias Rombaut (Contributor), Joery De Kock (Contributor), Dinja De Win (Contributor), Anja Heymans (Contributor), Vera Rogiers (Contributor), Robim Marcelino Rodrigues (Contributor), Joost Boeckmans (Contributor) & Tamara Vanhaecke (Contributor)
5 Jun 2024Activity: Talk or presentation › Talk or presentation at a conference
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A stem cell-based in vitro test battery to predict liver steatotic potential of diverse chemicals
Anouk Verhoeven (Speaker), Alexandra Gatzios (Contributor), Robim Marcelino Rodrigues (Contributor), Julen Sanz Serrano (Contributor), Andres Tabernilla Garcia (Contributor), Joery De Kock (Contributor), Mathieu Vinken (Contributor) & Tamara Vanhaecke (Contributor)
4 Jun 2024Activity: Talk or presentation › Talk or presentation at a conference
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The development of a human liver-based in vitro test battery to detect liver steatotic potential of chemicals from various applicability domains
Anouk Verhoeven (Invited speaker), Annika Hanna Drees (Contributor), Alexandra Gatzios (Contributor), Robim Marcelino Rodrigues (Contributor), Julen Sanz Serrano (Contributor), Andres Tabernilla Garcia (Contributor), Tamara Vanhaecke (Contributor) & Mathieu Vinken (Contributor)
9 Sept 2024Activity: Talk or presentation › Talk or presentation at a conference
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Genetic predisposition for anti-MASH drug response: a population-based in vitro study
Alexandra Gatzios (Speaker), Matthias Rombaut (Contributor), Joery De Kock (Contributor), Dinja De Win (Contributor), Anja Heymans (Contributor), Vera Rogiers (Contributor), Robim Marcelino Rodrigues (Contributor), Joost Boeckmans (Contributor) & Tamara Vanhaecke (Contributor)
25 Jun 2024Activity: Talk or presentation › Talk or presentation at a conference
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An optimized adverse outcome pathway network for chemical-induced liver steatosis.
Anouk Verhoeven (Speaker), Jonas van Ertvelde (Contributor), Joost Boeckmans (Contributor), Alexandra Gatzios (Contributor), Ramiro Jover (Contributor), Birgitte Lindeman (Contributor), Graciela Lopez (Contributor), Robim Marcelino Rodrigues (Contributor), Anna Rapisarda (Contributor), Julen Sanz Serrano (Contributor), Marth Stinckens (Contributor), Sara Sepehri (Contributor), Mathieu Vinken (Contributor), Jian Jiang (Contributor) & Tamara Vanhaecke (Contributor)
29 Nov 2024Activity: Talk or presentation › Talk or presentation at a conference
Thesis
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Bijdrage tot de ontwikkeling van een in vitro ziektemodel voor rhepatische steatose door gebruik te maken van huidafgeleide stamcellen
Author: Declerck, E., Vanhaecke, T., Marcelino Rodrigues, R. & Hernot, S., 7 Sept 2017Student thesis: Master's Thesis
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Evaluation of stem cell characteristics of reaggregated human skin-derived precursors
Author: Wulffaert, E., Vanhaecke, T., Rodrigues, R. & Natale, A., 2019Student thesis: Master's Thesis
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Human skin-derived precursors as a novel cell source for the in vitro prediction of drug-induced liver injury.
Author: Marcelino Rodrigues, R. & Vander Heyden, Y., 22 May 2015Supervisor: Rogiers, V. (Promotor), Vanhaecke, T. (Promotor), De Kock, J. (Promotor), De Bundel, D. (Jury), Martens, G. (Jury), Vander Heyden, Y. (Jury), Maria José, G. (External person) (Jury) & Van Gompel, J. (External person) (Jury)
Student thesis: Doctoral Thesis
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Influence of pro-inflammatory cytokines on lipogenesis in hepatocyte-like cells derived from human skin precursors.
Author: Vlerick, L., Boeckmans, J., Vanhaecke, T. & Marcelino Rodrigues, R., 2018Supervisor: Vanhaecke, T. (Promotor)
Student thesis: Master's Thesis
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In vitro evaluation of the anti-NASH properties of Seladelpar and its anti-fibrotic properties versus other PPAR-agonists.
Author: Vandenberghen, E. L., Vanhaecke, T. & Rodrigues, R., 2020Supervisor: Vanhaecke, T. (Promotor)
Student thesis: Master's Thesis