Projects per year
Personal profile
Expertise
The main objective of my research is to develop and investigate the applicability of human adult stem cells and their hepatic differentiated progeny as an alternative in vitro model for toxicity testing and liver disease modelling. My current focus lays on the application of in vitro cell systems to study non-alcoholic fatty liver diseases (NAFLD) and more specific non-alcoholic steatohepatitis (NASH). Using alternative aproaches to animal experimentation, we aim at elucidating NAFLD-specific mechanisms and evaluate the anti-NASH properties of novel pharmacological compounds.
This reserach is conducted within a postdoctoral fellowship funded by the Research Foundation Flanders - FWO as well as an assistant professorship (10%) position within the faculty of Pharmacy and Medicine of the VUB.
Education/Academic qualification
Pharmacological Sciences, PhD
Award Date: 22 May 2015
External positions
Visiting Postdoctoral Researcher, National Institutes of Health
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EUAR35: H2020: CSA: TWINALT: Twinning towards excellence in alternative methods for toxicity assessment
Vanhaecke, T., De Kock, J., Marcelino Rodrigues, R. & Rogiers, V.
1/09/20 → 31/08/23
Project: Applied
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HERC45: FWO Hercules MZW: Light sheet fluorescence microscopy in life sciences and medical research
Sermon, K., Van De Velde, H., Goossens, E., Baeyens, L., Van Ginderachter, J., De Bundel, D., Hernot, S., De Kock, J., Vinken, M., Vanhaecke, T., Marcelino Rodrigues, R. & van Grunsven, L.
1/05/18 → 30/04/22
Project: Fundamental
Research output
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An updated adverse outcome pathway network for chemical-induced liver steatosis
Verhoeven, A., van Ertvelde, J., Boeckmans, J., Gatzios, A., Jover, R., Lindeman, B., Lopez Soop, G., Rodrigues, R., Rapisarda, A., Stinckens, M., Sepehri, S., Vinken, M., Jiang, J. & Vanhaecke, T., 2022, p. 1-1. 1 p.Research output: Unpublished contribution to conference › Poster
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E-Selectin-Dependent Inflammation and Lipolysis in Adipose Tissue Exacerbate Steatosis-to-NASH Progression via S100A8/9
Rodrigues, R. M., He, Y., Hwang, S., Bertola, A., Mackowiak, B., Ait-Ahmed, Y., Seo, W., Ma, J., Wang, X., Park, S. H., Guan, Y., Fu, Y., Vanhaecke, T., Feng, D. & Gao, B., Jan 2022, In: Cellular and molecular gastroenterology and hepatology. 13, 1, p. 151-171 21 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus) -
From NAFLD to MAFLD: Aligning translational in vitro research to clinical insights
Gatzios, A., Rombaut, M., Buyl, K., De Kock, J., Rodrigues, R., Rogiers, V., Vanhaecke, T. & Boeckmans, J., 13 Jan 2022, In: Biomedicines. 10, 1, 19 p., 161.Research output: Contribution to journal › Article › peer-review
Open AccessFile39 Downloads (Pure) -
Resmetirom reduces lipid load, restores THRB expression and prevents cell damage in a human stem cell based in vitro MAFLD model.
Gatzios, A., Rodrigues, R., De Kock, J., Verhoeven, A., Sepehri, S., Buyl, K., Rombaut, M., Rogiers, V., Boeckmans, J. & Vanhaecke, T., 10 Jun 2022, Resmetirom reduces lipid load, restores THRB expression and prevents cell damage in a human stem cell based in vitro MAFLD model.. 3rd European Fatty Liver Conference, p. 49-49 1 p.Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book)
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Resmetirom reduces lipid load, restores THRB expression and prevents cell damage in a human stem cell based in vitro MAFLD model.
Gatzios, A., Rodrigues, R., De Kock, J., Verhoeven, A., Sepehri, S., Buyl, K., Rombaut, M., Rogiers, V., Boeckmans, J. & Vanhaecke, T., 21 Sep 2022.Research output: Unpublished contribution to conference › Poster
Prizes
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33. Forschungspreises zur Förderung methodischer Arbeiten mit dem Ziel der Einschränkung und des Ersatzes von Tierversuchen
De Kock, Joery (Recipient), Marcelino Rodrigues, Robim (Recipient), Vanhaecke, Tamara (Recipient) & Rogiers, Vera (Recipient), 2014
Prize: Prize (including medals and awards)
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Fellows Award for Research Excellence (FARE)
Marcelino Rodrigues, Robim (Recipient), 2020
Prize: Prize (including medals and awards)
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Postdoctoral Fellow Research Award
Marcelino Rodrigues, Robim (Recipient), 2020
Prize: Prize (including medals and awards)
Activities
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The Innovation Centre 3Rs (IC-3Rs) in Belgium
Mieke Van Mulders (Invited speaker), Birgit Mertens (Contributor), Robim Marcelino Rodrigues (Contributor), Joery De Kock (Contributor), Tamara Vanhaecke (Contributor) & Vera Rogiers (Contributor)
28 Sep 2022Activity: Talk or presentation › Talk or presentation at a conference
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Resmetirom reduces lipid load, restores THRB expression and prevents cell damage in a human stem cell based in vitro MAFLD model.
Alexandra Gatzios (Speaker), Robim Marcelino Rodrigues (Contributor), Joery De Kock (Contributor), Anouk Verhoeven (Contributor), Sara Sepehri (Contributor), Karolien Buyl (Contributor), Matthias Rombaut (Contributor), Vera Rogiers (Contributor), Joost Boeckmans (Contributor) & Tamara Vanhaecke (Contributor)
10 Jun 2022Activity: Talk or presentation › Talk or presentation at a conference
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A human hepatocyte-like cell based In Vitro model for hepatic insulin-driven De Novo Lipogenesis
Karolien Buyl (Speaker), Martine Vrints (Speaker), Ruani Fernando (Speaker), Thomas Van Eeckhoute (Speaker), Mia Jans (Speaker), Joost Boeckmans (Speaker), Robim Marcelino Rodrigues (Speaker), Vera Rogiers (Speaker), Jan Van Der Schueren (Speaker), Joery De Kock (Speaker), Tamara Vanhaecke (Speaker) & Filip Beirinckx (Speaker)
2020 → …Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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In vitro investigation of the anti-NASH properties of elafibranor and lanifibranor using a human stem cell-derived disease model
Joost Boeckmans (Speaker), Vera Rogiers (Contributor), Tamara Vanhaecke (Contributor) & Robim Marcelino Rodrigues (Contributor)
25 Feb 2019 → 26 Feb 2019Activity: Talk or presentation › Talk or presentation at a conference
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Untargeted in vitro metabolomics to identify hepatotoxic modes of action
Matthias Cuykx (Speaker), C Beirnaert (Speaker), Robim Marcelino Rodrigues (Speaker), K Laukens (Speaker), Tamara Vanhaecke (Speaker) & Adrian Covaci (Speaker)
19 Sep 2018Activity: Talk or presentation › Talk or presentation at a conference
Thesis
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Bijdrage tot de ontwikkeling van een in vitro ziektemodel voor rhepatische steatose door gebruik te maken van huidafgeleide stamcellen
Author: Declerck, E., Vanhaecke, T., Marcelino Rodrigues, R. & Hernot, S., 7 Sep 2017Student thesis: Master's Thesis
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Human skin-derived precursors as a novel cell source for the in vitro prediction of drug-induced liver injury.
Author: Marcelino Rodrigues, R. & Vander Heyden, Y., 22 May 2015Supervisor: Rogiers, V. (Promotor), Vanhaecke, T. (Promotor), De Kock, J. (Promotor), De Bundel, D. (Jury), Martens, G. (Jury), Vander Heyden, Y. (Jury), Maria José, G. (External person) (Jury) & Van Gompel, J. (External person) (Jury)
Student thesis: Doctoral Thesis
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Influence of pro-inflammatory cytokines on lipogenesis in hepatocyte-like cells derived from human skin precursors.
Author: Vlerick, L., Boeckmans, J., Vanhaecke, T. & Marcelino Rodrigues, R., 2018Student thesis: Master's Thesis