Projects per year
Personal profile
Expertise
The main objective of my research is to develop and investigate the applicability of human adult stem cells and their hepatic differentiated progeny as an alternative in vitro model for toxicity testing and liver disease modelling. My current focus lays on the application of in vitro cell systems to study non-alcoholic fatty liver diseases (NAFLD) and more specific non-alcoholic steatohepatitis (NASH). Using alternative aproaches to animal experimentation, we aim at elucidating NAFLD-specific mechanisms and evaluate the anti-NASH properties of novel pharmacological compounds.
This reserach is conducted within a postdoctoral fellowship funded by the Research Foundation Flanders - FWO as well as an assistant professorship (10%) position within the faculty of Pharmacy and Medicine of the VUB.
Education/Academic qualification
Pharmacological Sciences, PhD
Award Date: 22 May 2015
External positions
Visiting Postdoctoral Researcher, National Institutes of Health
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Collaborations and top research areas from the last five years
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EUAR35: H2020: CSA: TWINALT: Twinning towards excellence in alternative methods for toxicity assessment
Vanhaecke, T., De Kock, J., Marcelino Rodrigues, R. & Rogiers, V.
1/09/20 → 31/08/23
Project: Applied
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HERC45: FWO Hercules MZW: Light sheet fluorescence microscopy in life sciences and medical research
Sermon, K., Van De Velde, H., Goossens, E., Baeyens, L., Van Ginderachter, J., De Bundel, D., Hernot, S., De Kock, J., Vinken, M., Vanhaecke, T., Marcelino Rodrigues, R. & van Grunsven, L.
1/05/18 → 30/04/22
Project: Fundamental
Research output
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Gene-occupation interactions: A review of the literature on bladder and prostate cancer.
Wieczorek, E., Wolbiakowska, A., Roszak, J., Rodrigues, R., Vanhaecke, T. & Reszka, E., 19 May 2023, In: Medycyna Pracy. 74, 2, p. 127-144 18 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Genetically engineering human skin-derived precursor cells into functional hepatocyte-like cells as a novel liver-based in vitro model.
Stinckens, M., Rombaut, M., Gatzios, A., Rodrigues, R., Vanhaecke, T. & De Kock, J., 19 Sep 2023.Research output: Unpublished contribution to conference › Poster
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Human skin stem cell-derived hepatic cells as in vitro drug discovery model for insulin-driven de novo lipogenesis
Buyl, K., Vrints, M., Fernando, R., Desmae, T., Van Eeckhoutte, T., Jans, M., Van Der Schueren, J., Boeckmans, J., Rodrigues, R. M., De Boe, V., Rogiers, V., De Kock, J., Beirinckx, F. & Vanhaecke, T., 15 Oct 2023, In: European Journal of Pharmacology. 957, 175989.Research output: Contribution to journal › Article › peer-review
Open Access -
Human skin stem cell-derived hepatic cells with genetic predisposition for liver fat accumulation mimic susceptibility to develop metabolic dysfunction-associated fatty liver disease
Gatzios, A., Rodrigues, R., De Kock, J., Rombaut, M., De Win, D., Rogiers, V., Boeckmans, J. & Vanhaecke, T., Jun 2023, Abstract Book of EASL Congress 2023: 21-24 June 2023, Vienna, Austria. Elsevier, Vol. 78(S1). p. S775-S776 2 p. WED-465. (Poster presentations; vol. 78(S1)).Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book) › Research
Open AccessFile4 Downloads (Pure) -
Human skin stem cell-derived hepatic cells with genetic predisposition for liver fat accumulation mimic susceptibility to develop metabolic dysfunction-associated fatty liver disease
Gatzios, A., Rodrigues, R., De Kock, J., Rombaut, M., De Win, D., Rogiers, V., Boeckmans, J. & Vanhaecke, T., 21 Jun 2023.Research output: Unpublished contribution to conference › Poster
Prizes
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33. Forschungspreises zur Förderung methodischer Arbeiten mit dem Ziel der Einschränkung und des Ersatzes von Tierversuchen
De Kock, Joery (Recipient), Marcelino Rodrigues, Robim (Recipient), Vanhaecke, Tamara (Recipient) & Rogiers, Vera (Recipient), 2014
Prize: Prize (including medals and awards)
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Fellows Award for Research Excellence (FARE)
Marcelino Rodrigues, Robim (Recipient), 2020
Prize: Prize (including medals and awards)
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Postdoctoral Fellow Research Award
Marcelino Rodrigues, Robim (Recipient), 2020
Prize: Prize (including medals and awards)
Activities
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An updated adverse outcome pathway network on chemical-induced liver steatosis
Anouk Verhoeven (Presenter), Jonas van Ertvelde (Contributor), Joost Boeckmans (Contributor), Alexandra Gatzios (Contributor), Ramiro Jover (Contributor), Birgitte Lindeman (Contributor), Graciela Lopez Soop (Contributor), Robim Marcelino Rodrigues (Contributor), Anna Rapisarda (Contributor), Marth Stinckens (Contributor), Sara Sepehri (Contributor), Mathieu Vinken (Contributor), Jian Jiang (Contributor) & Tamara Vanhaecke (Contributor)
10 Sep 2023 → 13 Sep 2023Activity: Talk or presentation › Talk or presentation at a conference
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An updated adverse outcome pathway network on chemical-induced liver steatosis
Anouk Verhoeven (Speaker), Jonas van Ertvelde (Contributor), Joost Boeckmans (Contributor), Alexandra Gatzios (Contributor), Ramiro Rover (Contributor), Birgitte Lindeman (Contributor), Graciela Lopze Soop (Contributor), Robim Marcelino Rodrigues (Contributor), Anna Rapisarda (Contributor), Marth Stinckens (Contributor), Sara Sepehri (Contributor), Mathieu Vinken (Contributor), Jian Jiang (Contributor) & Tamara Vanhaecke (Contributor)
14 Sep 2023 → 15 Sep 2023Activity: Talk or presentation › Talk or presentation at a conference
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An updated adverse outcome pathway network for chemical-induced liver steatosis
Anouk Verhoeven (Presenter), Jonas van Ertvelde (Contributor), Joost Boeckmans (Contributor), Alexandra Gatzios (Contributor), Ramiro Rover (Contributor), Birgitte Lindeman (Contributor), Garciala Lopze Soop (Contributor), Robim Marcelino Rodrigues (Contributor), Anna Rapisarda (Contributor), Marth Stinckens (Contributor), Sara Sepehri (Contributor), Mathieu Vinken (Contributor), Jian Jiang (Contributor) & Tamara Vanhaecke (Speaker)
27 Aug 2023 → 31 Aug 2023Activity: Talk or presentation › Talk or presentation at a conference
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TWINNING TOWARDS EXCELLENCE IN ALTERNATIVE METHODS FOR TOXICITY ASSESSMENT
Sara Sepehri (Chair), Robim Marcelino Rodrigues (Chair) & Tamara Vanhaecke (Chair)
22 Aug 2022 → 16 Sep 2022Activity: Participating in or organising an event › Participation in workshop, seminar
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FWOSB134: Development and application of a human stem cell-derived, etiology-based anti-MAFLD drug discovery platform targeting the thyroid hormone receptor axis
Alexandra Gatzios (Recipient), Tamara Vanhaecke (Supervisor), Joost Boeckmans (Supervisor) & Robim Marcelino Rodrigues (Supervisor)
1 Nov 2022 → 31 Oct 2026Activity: Other › Written proposal
Thesis
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Bijdrage tot de ontwikkeling van een in vitro ziektemodel voor rhepatische steatose door gebruik te maken van huidafgeleide stamcellen
Author: Declerck, E., Vanhaecke, T., Marcelino Rodrigues, R. & Hernot, S., 7 Sep 2017Student thesis: Master's Thesis
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Human skin-derived precursors as a novel cell source for the in vitro prediction of drug-induced liver injury.
Author: Marcelino Rodrigues, R. & Vander Heyden, Y., 22 May 2015Supervisor: Rogiers, V. (Promotor), Vanhaecke, T. (Promotor), De Kock, J. (Promotor), De Bundel, D. (Jury), Martens, G. (Jury), Vander Heyden, Y. (Jury), Maria José, G. (External person) (Jury) & Van Gompel, J. (External person) (Jury)
Student thesis: Doctoral Thesis
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Influence of pro-inflammatory cytokines on lipogenesis in hepatocyte-like cells derived from human skin precursors.
Author: Vlerick, L., Boeckmans, J., Vanhaecke, T. & Marcelino Rodrigues, R., 2018Supervisor: Vanhaecke, T. (Promotor)
Student thesis: Master's Thesis
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In vitro evaluation of the anti-NASH properties of Seladelpar and its anti-fibrotic properties versus other PPAR-agonists.
Author: Vandenberghen, E. L., Vanhaecke, T. & Rodrigues, R., 2020Supervisor: Vanhaecke, T. (Promotor)
Student thesis: Master's Thesis