Serge Muyldermans

PhD

Emeritus, Vriendenkring VUB

https://orcid.org/0000-0002-3678-3575

Pleinlaan 2
1050 Brussels
Belgium

Source: Scopus
Calculated based on no. of publications stored in Pure and citations from Scopus

Research activity per year

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Personal profile

Expertise

Fundamental Research in Eukaryotic Gene Expression. Protein-DNA interaction. Protein Structure and Action. (X-ray crystallography) Antibody Engineering. Protein engineering. (Site directed mutagenesis/Enzym kinetics).
Cloning and production of recombinant antibody fragments derived from camelidae

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2 Active
48 Finished

SRP50: SRP-Onderzoekszwaartepunt: Exploiting Peptides: Protein Binders, Modulators and Inhibitors for Imaging and Therapy [Exploit-PeptIT]
Ballet, S., Caveliers, V., Hernot, S., Versées, W., Vinken, M., Muyldermans, S. & Devoogdt, N.
1/03/19 → 29/02/24
Project: Fundamental
FWOAL879: Nanobody-based inhibitors of connexin hemichannels and pannexin channels as novel therapeutics for the treatment of inflammatory hepatic and cardiovascular diseases.
Vinken, M., Muyldermans, S. & Kwak, B. R.
1/01/18 → 31/12/21
Project: Fundamental
ANI192: Evaluation of the theranostic potential of Nanobodies against Acute Myeloid Leukemia Stem Cell Markers
Muyldermans, S., Romao, E. & Devoogdt, N.
1/10/17 → 14/11/18
Project: Fundamental
FWOAL856: ERA-NET NEURON cofund JTC 2016: 'Spinal cord repair by endogenous stem cells from the spinal niche'
Muyldermans, S.
1/07/17 → 30/06/19
Project: Fundamental
OZR3125: Bilateral cooperation ikv joint research project: Bench Fee for Joint PhD VUB Tianjin University, Hu Yaozhong
Muyldermans, S.
21/09/16 → 31/12/17
Project: Fundamental

Direct Immobilization of Engineered Nanobodies on Gold Sensors
Simões, B., Guedens, W. J., Keene, C., Kubiak-Ossowska, K., Mulheran, P., Kotowska, A. M., Scurr, D. J., Alexander, M. R., Broisat, A., Johnson, S., Muyldermans, S., Devoogdt, N., Adriaensens, P. & Mendes, P. M., 12 Apr 2021, In : ACS Applied Materials and Interfaces.
Research output: Contribution to journal › Article
Immunogenicity Risk Profile of Nanobodies
Ackaert, C., Smiejkowska, N., Xavier, C., Sterckx, Y. G. J., Denies, S., Stijlemans, B., Elkrim, Y., Devoogdt, N., Caveliers, V., Lahoutte, T., Muyldermans, S., Breckpot, K. & Keyaerts, M., 9 Mar 2021, In : Frontiers in Immunology. 12, 15 p., 632687.
Research output: Contribution to journal › Article
1 Citation (Scopus)
Mechanisms underlying connexin hemichannel activation in disease
Van Campenhout, R., Coelho Gomes, A. R., De Groof, T., Muyldermans, S., Devoogdt, N. & Vinken, M., 28 Mar 2021, In : International Journal of Molecular Sciences. 22, p. 1-13 13 p., 3503.
Research output: Contribution to journal › Article

Open Access
File
Therapeutic Nanobodies Targeting Cell Plasma Membrane Transport Proteins: A High-Risk/High-Gain Endeavor
Van Campenhout, R., Muyldermans, S., Vinken, M., Devoogdt, N. & De Groof, T., 6 Jan 2021, In : Biomolecules. 11, 1, p. 1-19 19 p., 63.
Research output: Contribution to journal › Article

Open Access
File
1 Citation (Scopus)

10 Downloads (Pure)
The Therapeutic and Diagnostic Potential of Nanobodies
Devoogdt, N. (Guest ed.), De Groof, T. (Guest ed.), Muyldermans, S. (Guest ed.) & Hernot, S. (Guest ed.), 2021, In : Biomolecules.
Research output: Contribution to journal › Special issue

ESMI presentation award for best oral presentation
Jessica Bridoux (Recipient), Katrijn Broos (Recipient), Quentin Lecocq (Recipient), Maxine Crauwels (Recipient), Charlotte Martin (Recipient), Frederik Cleeren (Recipient), Mikhail Kondrashov (Recipient), Steven Ballet (Recipient), G. Bormans (Recipient), Magnus Schou (Recipient), Chad Elmore (Recipient), Geert Raes (Recipient), Karine Breckpot (Recipient), Serge Muyldermans (Recipient), Nick Devoogdt (Recipient), Marleen Keyaerts (Recipient), Vicky Caveliers (Recipient) & Catarina Xavier (Recipient), 17 Jan 2020
Prize: Prize (including medals and awards)

13 Talk or presentation at a conference
10 Talk or presentation at a workshop/seminar
8 Membership of peer-review panel or committee
4 Talk at a public lecture/debate
More

Biomolecules (Journal)
Nick Devoogdt (Editor), Serge Muyldermans (Editor), Timo De Groof (Editor), Sophie Hernot (Editor)
2021 → …
Activity: Publication peer-review and editorial work › Editorial activity
Immuno-PET imaging using the hPD-L1 Nanobody: Radiolabelling strategies
Jessica Bridoux (Speaker), Katrijn Broos (Contributor), Quentin Lecocq (Contributor), Maxine Crauwels (Contributor), Charlotte Martin (Contributor), Frederik Cleeren (Contributor), Mikhail Krivoshapov (Speaker), Steven Ballet (Speaker), G. Bormans (Speaker), Geert Raes (Speaker), Karine Breckpot (Speaker), Serge Muyldermans (Speaker), Magnus Schou (Speaker), Chad Elmore (Speaker), Nick Devoogdt (Speaker), Vicky Caveliers (Speaker), Marleen Keyaerts (Speaker), Catarina Xavier (Speaker)
14 Jan 2020
Activity: Talk or presentation › Talk or presentation at a conference
Human PD-L1 Nanobody for PET imaging: A site-specific radiolabeling strategy
Jessica Bridoux (Speaker), Katrijn Broos (Contributor), Maxine Crauwels (Contributor), Quentin Lecocq (Contributor), C Martin (Contributor), Frederik Cleeren (Contributor), Guy Bormans (Contributor), Steven Ballet (Contributor), Vicky Caveliers (Contributor), Geert Raes (Contributor), Karine Breckpot (Contributor), Serge Muyldermans (Contributor), Nick Devoogdt (Contributor), Marleen Keyaerts (Contributor), Catarina Xavier (Contributor)
21 Mar 2018
Activity: Talk or presentation › Talk or presentation at a conference
Targeted radionuclide therapy of Non-Hodgkin lymphoma with 177Lu-radiolabeled anti-hCD20 Nb
Ahmet Krasniqi (Speaker), Matthias D'Huyvetter (Contributor), Catarina Xavier (Contributor), Kevin Van Der Jeught (Contributor), Serge Muyldermans (Contributor), Tony Lahoutte (Contributor), Jan Tavernier (Contributor), Nick Devoogdt (Contributor)
16 May 2017
Activity: Talk or presentation › Talk or presentation at a conference
Targeted radionuclide therapy of Non-Hodgkin lymphoma with theranostic anti-hCD20 Nb
Ahmet Krasniqi (Speaker), Matthias D'Huyvetter (Contributor), Catarina Xavier (Contributor), Kevin Van Der Jeught (Contributor), Serge Muyldermans (Contributor), Tony Lahoutte (Contributor), Jan Tavernier (Contributor), Nick Devoogdt (Contributor)
28 Mar 2017
Activity: Talk or presentation › Talk or presentation at a conference

Affiniteits bepaling van single domain kameel antilichaam fragmenten
Author: De Genst, E. & Muyldermans, S., 1996
Supervisor: Muyldermans, S. (Promotor)
Student thesis: Master's Thesis
Affiniteitsmaturatie van Camelus dromedarius enkel-domein antilichaamfragment, bepaald door in vitro mutagenese, affiniteits- en stabiliteitsmetingen.
Author: Van Meirhaeghe, A., Muyldermans, S. & Wyns, L., 1998
Supervisor: Muyldermans, S. (Promotor) & Wyns, L. (Co-promotor)
Student thesis: Master's Thesis
Anti hapten heavy chain antibodies from camelidae
Author: Serrao, M., Wyns, L. & Muyldermans, S., 2004
Supervisor: Wyns, L. (Promotor) & Muyldermans, S. (Co-promotor)
Student thesis: Doctoral Thesis
Anti-schistoma single-domain antibody-nanoparticles conjugate : a novel tool for diagnostic and therapeutic applications.
Author: Sallam, M., Zada, S., Ramadan, A. & Muyldermans, S., Sep 2012
Supervisor: Muyldermans, S. (Co-promotor), Zada, S. (External person) (Promotor) & Ramadan, A. (External person) (Co-promotor)
Student thesis: Master's Thesis
Application of nanobodies as probes in proximity ligation assay
Author: Ayalefac, D., Muyldermans, S. & DE PAUW, P., 10 Sep 2012
Supervisor: Muyldermans, S. (Promotor) & De Pauw, P. (External person) (Advisor)
Student thesis: Master's Thesis