Projects per year
Personal profile
Expertise
- Fundamental Research in Eukaryotic Gene Expression. Protein-DNA interaction. Protein Structure and Action. (X-ray crystallography) Antibody Engineering. Protein engineering. (Site directed mutagenesis/Enzym kinetics).
- Cloning and production of recombinant antibody fragments derived from camelidae
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Network
Projects
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FWOAL879: Nanobody-based inhibitors of connexin hemichannels and pannexin channels as novel therapeutics for the treatment of inflammatory hepatic and cardiovascular diseases.
Vinken, M., Muyldermans, S. & Kwak, B. R.
1/01/18 → 31/12/21
Project: Fundamental
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ANI192: Evaluation of the theranostic potential of Nanobodies against Acute Myeloid Leukemia Stem Cell Markers
Muyldermans, S., Romao, E. & Devoogdt, N.
1/10/17 → 14/11/18
Project: Fundamental
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FWOAL856: ERA-NET NEURON cofund JTC 2016: 'Spinal cord repair by endogenous stem cells from the spinal niche'
1/07/17 → 30/06/19
Project: Fundamental
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OZR3125: Bilateral cooperation ikv joint research project: Bench Fee for Joint PhD VUB Tianjin University, Hu Yaozhong
21/09/16 → 31/12/17
Project: Fundamental
Research output
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Direct Immobilization of Engineered Nanobodies on Gold Sensors
Simões, B., Guedens, W. J., Keene, C., Kubiak-Ossowska, K., Mulheran, P., Kotowska, A. M., Scurr, D. J., Alexander, M. R., Broisat, A., Johnson, S., Muyldermans, S., Devoogdt, N., Adriaensens, P. & Mendes, P. M., 12 Apr 2021, In : ACS Applied Materials and Interfaces.Research output: Contribution to journal › Article
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Immunogenicity Risk Profile of Nanobodies
Ackaert, C., Smiejkowska, N., Xavier, C., Sterckx, Y. G. J., Denies, S., Stijlemans, B., Elkrim, Y., Devoogdt, N., Caveliers, V., Lahoutte, T., Muyldermans, S., Breckpot, K. & Keyaerts, M., 9 Mar 2021, In : Frontiers in Immunology. 12, 15 p., 632687.Research output: Contribution to journal › Article
1 Citation (Scopus) -
Mechanisms underlying connexin hemichannel activation in disease
Van Campenhout, R., Coelho Gomes, A. R., De Groof, T., Muyldermans, S., Devoogdt, N. & Vinken, M., 28 Mar 2021, In : International Journal of Molecular Sciences. 22, p. 1-13 13 p., 3503.Research output: Contribution to journal › Article
Open AccessFile -
Therapeutic Nanobodies Targeting Cell Plasma Membrane Transport Proteins: A High-Risk/High-Gain Endeavor
Van Campenhout, R., Muyldermans, S., Vinken, M., Devoogdt, N. & De Groof, T., 6 Jan 2021, In : Biomolecules. 11, 1, p. 1-19 19 p., 63.Research output: Contribution to journal › Article
Open AccessFile1 Citation (Scopus)10 Downloads (Pure) -
The Therapeutic and Diagnostic Potential of Nanobodies
Devoogdt, N. (Guest ed.), De Groof, T. (Guest ed.), Muyldermans, S. (Guest ed.) & Hernot, S. (Guest ed.), 2021, In : Biomolecules.Research output: Contribution to journal › Special issue
Prizes
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ESMI presentation award for best oral presentation
Jessica Bridoux (Recipient), Katrijn Broos (Recipient), Quentin Lecocq (Recipient), Maxine Crauwels (Recipient), Charlotte Martin (Recipient), Frederik Cleeren (Recipient), Mikhail Kondrashov (Recipient), Steven Ballet (Recipient), G. Bormans (Recipient), Magnus Schou (Recipient), Chad Elmore (Recipient), Geert Raes (Recipient), Karine Breckpot (Recipient), Serge Muyldermans (Recipient), Nick Devoogdt (Recipient), Marleen Keyaerts (Recipient), Vicky Caveliers (Recipient) & Catarina Xavier (Recipient), 17 Jan 2020
Prize: Prize (including medals and awards)
Activities
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Biomolecules (Journal)
Nick Devoogdt (Editor), Serge Muyldermans (Editor), Timo De Groof (Editor), Sophie Hernot (Editor)2021 → …Activity: Publication peer-review and editorial work › Editorial activity
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Immuno-PET imaging using the hPD-L1 Nanobody: Radiolabelling strategies
Jessica Bridoux (Speaker), Katrijn Broos (Contributor), Quentin Lecocq (Contributor), Maxine Crauwels (Contributor), Charlotte Martin (Contributor), Frederik Cleeren (Contributor), Mikhail Krivoshapov (Speaker), Steven Ballet (Speaker), G. Bormans (Speaker), Geert Raes (Speaker), Karine Breckpot (Speaker), Serge Muyldermans (Speaker), Magnus Schou (Speaker), Chad Elmore (Speaker), Nick Devoogdt (Speaker), Vicky Caveliers (Speaker), Marleen Keyaerts (Speaker), Catarina Xavier (Speaker)14 Jan 2020Activity: Talk or presentation › Talk or presentation at a conference
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Human PD-L1 Nanobody for PET imaging: A site-specific radiolabeling strategy
Jessica Bridoux (Speaker), Katrijn Broos (Contributor), Maxine Crauwels (Contributor), Quentin Lecocq (Contributor), C Martin (Contributor), Frederik Cleeren (Contributor), Guy Bormans (Contributor), Steven Ballet (Contributor), Vicky Caveliers (Contributor), Geert Raes (Contributor), Karine Breckpot (Contributor), Serge Muyldermans (Contributor), Nick Devoogdt (Contributor), Marleen Keyaerts (Contributor), Catarina Xavier (Contributor)21 Mar 2018Activity: Talk or presentation › Talk or presentation at a conference
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Targeted radionuclide therapy of Non-Hodgkin lymphoma with 177Lu-radiolabeled anti-hCD20 Nb
Ahmet Krasniqi (Speaker), Matthias D'Huyvetter (Contributor), Catarina Xavier (Contributor), Kevin Van Der Jeught (Contributor), Serge Muyldermans (Contributor), Tony Lahoutte (Contributor), Jan Tavernier (Contributor), Nick Devoogdt (Contributor)16 May 2017Activity: Talk or presentation › Talk or presentation at a conference
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Targeted radionuclide therapy of Non-Hodgkin lymphoma with theranostic anti-hCD20 Nb
Ahmet Krasniqi (Speaker), Matthias D'Huyvetter (Contributor), Catarina Xavier (Contributor), Kevin Van Der Jeught (Contributor), Serge Muyldermans (Contributor), Tony Lahoutte (Contributor), Jan Tavernier (Contributor), Nick Devoogdt (Contributor)28 Mar 2017Activity: Talk or presentation › Talk or presentation at a conference
Thesis
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Affiniteits bepaling van single domain kameel antilichaam fragmenten
Author: De Genst, E. & Muyldermans, S., 1996Supervisor: Muyldermans, S. (Promotor)
Student thesis: Master's Thesis
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Affiniteitsmaturatie van Camelus dromedarius enkel-domein antilichaamfragment, bepaald door in vitro mutagenese, affiniteits- en stabiliteitsmetingen.
Author: Van Meirhaeghe, A., Muyldermans, S. & Wyns, L., 1998Supervisor: Muyldermans, S. (Promotor) & Wyns, L. (Co-promotor)
Student thesis: Master's Thesis
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Anti hapten heavy chain antibodies from camelidae
Author: Serrao, M., Wyns, L. & Muyldermans, S., 2004Supervisor: Wyns, L. (Promotor) & Muyldermans, S. (Co-promotor)
Student thesis: Doctoral Thesis
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Anti-schistoma single-domain antibody-nanoparticles conjugate : a novel tool for diagnostic and therapeutic applications.
Author: Sallam, M., Zada, S., Ramadan, A. & Muyldermans, S., Sep 2012Supervisor: Muyldermans, S. (Co-promotor), Zada, S. (External person) (Promotor) & Ramadan, A. (External person) (Co-promotor)
Student thesis: Master's Thesis
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Application of nanobodies as probes in proximity ligation assay
Author: Ayalefac, D., Muyldermans, S. & DE PAUW, P., 10 Sep 2012Supervisor: Muyldermans, S. (Promotor) & De Pauw, P. (External person) (Advisor)
Student thesis: Master's Thesis