Personal profile
Expertise
- Fundamental Research in Eukaryotic Gene Expression. Protein-DNA interaction. Protein Structure and Action. (X-ray crystallography) Antibody Engineering. Protein engineering. (Site directed mutagenesis/Enzym kinetics).
- Cloning and production of recombinant antibody fragments derived from camelidae
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Collaborations and top research areas from the last five years
Projects
- 51 Finished
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IOFPOC51: IOF POC Project SYNALI : Development and application of a Synthetic Nanobody Library
Devoogdt, N. (Administrative Promotor), Muyldermans, S. (Co-Promotor), Sterckx, Y. (Co-Promotor) & Caljon, G. (Co-Promotor)
1/01/22 → 25/04/25
Project: Applied
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SRP50: SRP-Onderzoekszwaartepunt: Exploiting Peptides: Protein Binders, Modulators and Inhibitors for Imaging and Therapy [Exploit-PeptIT]
Ballet, S. (Administrative Promotor), Caveliers, V. (Co-Promotor), Hernot, S. (Co-Promotor), Versées, W. (Co-Promotor), Vinken, M. (Co-Promotor), Muyldermans, S. (Co-Promotor), Devoogdt, N. (Co-Promotor), Bridoux, J. (Collaborator) & Martin, C. (Collaborator)
1/03/19 → 30/09/25
Project: Fundamental
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FWOAL879: Nanobody-based inhibitors of connexin hemichannels and pannexin channels as novel therapeutics for the treatment of inflammatory hepatic and cardiovascular diseases.
Vinken, M. (Administrative Promotor), Muyldermans, S. (Co-Promotor) & Kwak, B. R. (Co-Promotor)
1/01/18 → 31/12/21
Project: Fundamental
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ANI192: Evaluation of the theranostic potential of Nanobodies against Acute Myeloid Leukemia Stem Cell Markers
Muyldermans, S. (Administrative Promotor), Romao, E. (Collaborator) & Devoogdt, N. (Co-Promotor)
1/10/17 → 14/11/18
Project: Fundamental
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FWOAL856: ERA-NET NEURON cofund JTC 2016: 'Spinal cord repair by endogenous stem cells from the spinal niche'
Muyldermans, S. (Administrative Promotor)
1/07/17 → 30/06/19
Project: Fundamental
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Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody
Pinto Torres, J. E., Claes, M., Hendrickx, R., Yuan, M., Smiejkowska, N., Van Wielendaele, P., Hacisuleyman, A., De Winter, H., Muyldermans, S., Michels, P. A. M., Walkinshaw, M. D., Versées, W., Caljon, G., Magez, S. & Sterckx, Y.G.-J., 31 Mar 2025, In: eLife. 13, 27 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile41 Downloads (Pure) -
DEVELOPMENT OF NANOBODIES AS FIRST-IN-CLASS INHIBITORS FOR THE DENEDDYLATING ENZYME NEDP1
XIRODIMAS , D. (Inventor), Abidi-Azzouz, N. (Inventor) & Muyldermans, S. (Inventor), 2025, Patent No. US2025101133A1Research output: Patent
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Evidence for a model of conformational change by the Plasmodium falciparum circumsporozoite protein during sporozoite development in the mosquito host through the use of camelid single-domain antibodies.
Geens, R., De Vocht, L., Aguirre-Botero, M. C., Vincke, C., Romão, E., Magez, S., Muyldermans, S., Amino, R. & Sterckx, Y.G.-J., Jun 2025, In: Infection and Immunity. 93, 6, 20 p., e0008125.Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Downloads (Pure) -
Integrating in vitro screening in drug development to reduce animal use: a case approach
Van Campenhout, R., De Groof, T., Kadam, P., Kwak, B. R., Muyldermans, S., Devoogdt, N. & Vinken, M., 15 Sept 2025. 1 p.Research output: Unpublished contribution to conference › Poster
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Nanobody-based Pannexin1 channel inhibitors increase survival after cardiac ischemia/reperfusion
Rusiecka, O. M., Molica, F., Clochard, L., Van Campenhout, R., De Groof, T., Bes, V., Devoogdt, N., Muyldermans, S., Vinken, M. & Kwak, B. R., 2025, In: Cell and Tissue Research. 402, 1, p. 121-137 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)3 Downloads (Pure)
Datasets
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Nanobody-based pannexin1 channel inhibitors reduce inflammation in acute liver injury
Van Campenhout, R. (Creator), De Groof, T. (Creator), Kadam, P. (Researcher), Muyldermans, S. (Supervisor), Devoogdt, N. (Supervisor) & Vinken, M. (Supervisor), Journal of Nanobiotechnology, 2023
DOI: 10.1186/s12951-023-02137-1
Dataset
Prizes
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ESMI presentation award for best oral presentation
Bridoux, J. (Recipient), Broos, K. (Recipient), Lecocq, Q. (Recipient), Crauwels, M. (Recipient), Martin, C. (Recipient), Cleeren, F. (Recipient), Kondrashov, M. (Recipient), Ballet, S. (Recipient), Bormans, G. (Recipient), Schou, M. (Recipient), Elmore, C. (Recipient), Raes, G. (Recipient), Breckpot, K. (Recipient), Muyldermans, S. (Recipient), Devoogdt, N. (Recipient), Keyaerts, M. (Recipient), Caveliers, V. (Recipient) & Xavier, C. (Recipient), 17 Jan 2020
Prize: Prize (including medals and awards)
Activities
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Development and testing of nanobody-based drug candidates for the treatment of liver inflammation
Peeters, D. (Presenter), De Groof, T. (Contributor), Kadam, P. (Contributor), Kwak, B. R. (Contributor), Muyldermans, S. (Contributor), Devoogdt, N. (Contributor), Vinken, M. (Contributor) & Van Campenhout, R. (Contributor)
15 May 2025Activity: Talk or presentation › Talk or presentation at a conference
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Nanobody-based Panx1 channel inhibitors reduce inflammation in acute liver injury
Peeters, D. (Presenter), De Groof, T. (Contributor), Kadam, P. (Contributor), Kwak, B. R. (Contributor), Muyldermans, S. (Contributor), Devoogdt, N. (Contributor), Van Campenhout, R. (Contributor) & Vinken, M. (Contributor)
7 Oct 2024Activity: Talk or presentation › Talk or presentation at a conference
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Nanobody-based pannexin1 channel inhibitors reduce inflammation in acute liver injury
Van Campenhout, R. (Speaker), De Groof, T. (Contributor), Kadam, P. (Contributor), Kwak, B. R. (Contributor), Muyldermans, S. (Contributor), Devoogdt, N. (Contributor) & Vinken, M. (Contributor)
24 Jul 2024 → 31 Jul 2024Activity: Talk or presentation › Talk or presentation at a conference
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Biomolecules (Journal)
Devoogdt, N. (Editor), Muyldermans, S. (Editor), De Groof, T. (Editor) & Hernot, S. (Editor)
2021 → …Activity: Publication peer-review and editorial work › Editorial activity
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Immuno-PET imaging using the hPD-L1 Nanobody: Radiolabelling strategies
Bridoux, J. (Speaker), Broos, K. (Contributor), Lecocq, Q. (Contributor), Crauwels, M. (Contributor), Martin, C. (Contributor), Cleeren, F. (Contributor), Krivoshapov, M. (Speaker), Ballet, S. (Speaker), Bormans, G. (Speaker), Raes, G. (Speaker), Breckpot, K. (Speaker), Muyldermans, S. (Speaker), Schou, M. (Speaker), Elmore, C. (Speaker), Devoogdt, N. (Speaker), Caveliers, V. (Speaker), Keyaerts, M. (Speaker) & Xavier, C. (Speaker)
14 Jan 2020Activity: Talk or presentation › Talk or presentation at a conference
Thesis
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Bead based immunoassay of HER2 ECD domain using nanobodies
Adaga, E. ((PhD) Student), Muyldermans, S. (Promotor), De Pauw, P. (Co-promotor) & Devoogdt, N. (Jury), 1 Sept 2015Student thesis: Master's Thesis
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Conversion of Nanobodies to Fluorescent probes with conserved size and functionality
Nguyen, T. N. H. ((PhD) Student), Xavier, C. (Jury), Muyldermans, S. (Promotor) & Pauw, De, P. (Advisor), 5 Sept 2014Student thesis: Master's Thesis
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Development of novel fluorescent reporters for Sulfolobus acidocaldarius and their application to build a biosensor strain
Linussio, J. ((PhD) Student), Peeters, E. (Promotor), Willaert, R. (Jury) & Muyldermans, S. (Jury), Sybers, D. (Advisor), 27 Jun 2016Student thesis: Master's Thesis
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Diagnostic potential of a Nanobody directed against Trypanosoma congolense fructose-1,6-bisphosphate aldolase
Lee, F. ((PhD) Student), Muyldermans, S. (Jury), Van Ginderachter, J. (Jury), Sterckx, Y. (Co-promotor) & Magez, S. (Promotor), Jun 2016Student thesis: Master's Thesis
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Effect of different characteristics of radiometal labelled nanobodies on the kidney retention
Crauwels, M. ((PhD) Student), Xavier, C. (Promotor), Muyldermans, S. (Promotor) & Devoogdt, N. (Co-promotor), 26 Oct 2020Student thesis: Doctoral Thesis