Research output per year
Research output per year
Personal profile
Expertise
In 2015, I obtained my Bachelor's degree in Pharmaceutical and Biological Laboratory Technologies (Hogent). In order to obtain this degree, I have performed an internship at the University of Coimbra, Portugal, in the field of aquatic ecotoxicology at the Centre for Functional Ecology (CFE). During this stay, I investigated the short-term toxicity effects of nanomaterials on the ecosystem by evaluating the ecologically meaningful feeding response in aquatic organisms.
In June 2019, I obtained my Master's degree in Pharmaceutical Sciences at the Vrije Unversiteit Brussel. In the context of my Master Thesis, I performed a study stay abroad at the University of Oslo, Norway at the Department Biosciences. The purpose of this project was to develop protein quantification methods for therapeutic proteins and their modifications in combination with liquid chromatography and mass spectrometry.
Currently, I am doing my PhD at the Vrije Universiteit Brussel. During this project, I am focussing on the orphan disease Alkaptonuria with the aim to develop a gene therapy.
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Collaborations and top research areas from the last five years
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A robust high-throughput screening system to assess bacterial tyrosine ammonia lyase activity in the context of tyrosine inherited metabolic disorders
Nulmans, I., Laga, C. A., Salvi, N. S., Desmet, L., Lequeue, S., Neuckermans, J., Schwaneberg, U. & De Kock, J., 27 Sep 2024, In: Scientific reports. 14, 1, 1 p., 22175.Research output: Contribution to journal › Article › peer-review
Open Access -
An AAV-mediated liver-directed gene therapy metabolically corrects alkaptonuria in an Hgd deficient mouse model
Lequeue, S., Norman, B. P., Neuckermans, J., Colemonts-Vroninks, H., Hughes, J. H., Claes, P., Heymans, A., Ranganath, L., Gallagher, J., Vanhaecke, T., Bou-Gharios, G. & De Kock, J., 14 Aug 2023.Research output: Unpublished contribution to conference › Poster
Open Access -
Development of a robust high-throughput screenings system for the evaluation of tyrosine ammonia lyases in the context of inborn errors of tyrosine metabolism
Nulmans, I., Laga, C. A., Salvi, N. S., Desmet, L., Lequeue, S., Neuckermans, J. & De Kock, J., 19 Sep 2023.Research output: Unpublished contribution to conference › Poster
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Hereditary Tyrosinemia Type 1 Mice under Continuous Nitisinone Treatment Display Remnants of an Uncorrected Liver Disease Phenotype
Neuckermans, J., Lequeue, S., Claes, P., Heymans, A., Hughes, J. H., Colemonts-Vroninks, H., Marcélis, L., Casimir, G., Goyens, P., Martens, G. A., Gallagher, J. A., Vanhaecke, T., Bou-Gharios, G. & De Kock, J., 11 Mar 2023, In: Genes. 14, 3, 15 p., 693.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)43 Downloads (Pure) -
A robust bacterial high-throughput screening system to evaluate single nucleotide polymorphisms of human homogentisate 1,2-dioxygenase in the context of alkaptonuria
Lequeue, S., Neuckermans, J., Nulmans, I., Schwaneberg, U., Vanhaecke, T. & De Kock, J., 14 Nov 2022, In: Scientific Reports. 12, 1, p. 1-15 15 p., 19452.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)38 Downloads (Pure)
Prizes
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FixAKUre: High-throughput screening of a chemical compound library with the aim to identify restabilizing compounds for homogentisate 1,2-dioxygenase enzyme variants in the context of rare disease alkaptonuria
De Kock, Joery (Recipient) & Lequeue, Sien (Recipient), 2022
Prize: Prize (including medals and awards)
Activities
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Society for The Study of Inborn Errors of Metabolism Annual Symposium 2023
Sien Lequeue (Participant)
29 Aug 2023 → 1 Sep 2023Activity: Participating in or organising an event › Participation in conference
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Liver-directed AAV gene therapy metabolically corrects AKU in Hgd tm1a-/- mice
Sien Lequeue (Speaker)
20 Apr 2023Activity: Talk or presentation › Talk at an external academic organisation
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Liver-directed AAV gene therapy metabolically corrects AKU in Hgd tm1a-/- mice
Sien Lequeue (Invited speaker)
27 Jul 2023 → 28 Jul 2023Activity: Talk or presentation › Talk or presentation at a conference
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The 13th International Conference on AKU
Sien Lequeue (Participant)
27 Jul 2023 → 28 Jul 2023Activity: Participating in or organising an event › Participation in conference
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Development of robust screening assays for the evaluation of AKU mutations
Sien Lequeue (Invited speaker)
14 May 2022 → 15 May 2022Activity: Talk or presentation › Talk or presentation at a conference
Thesis
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Development of a protein quantification assay for filgrastim using liquid chromatography-mass spectrometry
Author: Lequeue, S., Thiede, B. & Van Eeckhaut, A., 2019Student thesis: Master's Thesis