Projects per year
Personal profile
Expertise
Sophie Hernot obtained her Master of Science in Bio-engineering from the Vrije Universiteit of Brussels. She completed her PhD thesis in Medical Sciences in 2011 on the use of microbubbles (ultrasound contrast agents) as well as Nanobodies for molecular imaging and drug delivery applications. As post-doctoral researcher, and since 2016 as assistant professor in the Laboratory of In vivo Cellular and Molecular Imaging (ICMI, VUB), her research interests are two-fold: 1) design and validation of nanobodies for optical imaging applications, and in particular towards a clinical translation for image-guided surgery, and 2) validation of nanobody-based molecular probes for identification and characterization of high-risk atherosclerotic lesions. In both cases, particular attention is given to the effects of the nanobody-structure and radioactive or fluorescence labeling of nanobodies on their pharmacokinetics.
Expertise:
- Nanobody labelling
- Non-invasive molecular imaging (optical and nuclear imaging)
- Intra-operative imaging
- Preclinical animal models
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Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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FWOSB135: Imaging with Hybrid Nanobody-Tracer for Improved Clinical DecisionMaking in Colorectal Cancer (IN
1/11/22 → 31/10/26
Project: Fundamental
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EUAR96: CoDaFlight : Colouring the Dark in Fluorescence Light
Kuijk, M., Van Heijningen, R., Ingelberts, H., Hernot, S., Van Den Dries, T. & Lapauw, T.
1/10/22 → 30/09/26
Project: Applied
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OZR3984: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - UGent, JANSSEN Simone
15/06/22 → 14/06/26
Project: Fundamental
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HERC56: Intravital imaging as tool to bridge the gap between macroscopic in vivo imaging and microscopic tissue analysis
Hernot, S., Staels, W., Hellemans, K., Smolders, I., Rooman, I., Devoogdt, N., Menu, E., De Bundel, D., Breckpot, K., De Leu, N., Movahedi, K., D'Huyvetter, M. & De Kock, J.
1/05/22 → 30/04/26
Project: Fundamental
Research output
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A convenient labeling strategy for the preparation of fluorescent/radioactive sdab-based tracers carrying 99mTc and IRDye800CW for intra-operative decision making
Declerck, N., Huygen, C. M., Mateusiak, L., Stroet, M. & Hernot, S., 18 Jan 2023, (Unpublished).Research output: Unpublished contribution to conference › Unpublished abstract
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Dual-labelling of an anti-CEA Nanobody for PET and fluorescence imaging via a chemically synthesised trivalent platform
Saliën, J., Vizier, R., Stroet, M., Claron, M., Vivier, D., Bridoux, J., Floru, S., Hernot, S., Goncalves, V. & Denat, F., 15 Mar 2023, (Unpublished).Research output: Unpublished contribution to conference › Poster
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In vivo optical imaging of glioma using a novel uPAR-targeting fluorescent single-domain antibody
Mateusiak, L., Floru, S. (ed.), De Groof, T. (ed.), Declerck, N. (ed.), Wouters, J. (ed.), Janssen, S. (ed.), Debie, P. (ed.), Zeven, K. (ed.), Vincke, C. (ed.), Puttemans, J. (ed.), Stroet, M. (ed.), Breckpot, K. (ed.), Devoogdt, N. (ed.) & Hernot, S. (ed.), 17 Mar 2023.Research output: Unpublished contribution to conference › Unpublished abstract
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In vivo optical imaging using a novel fluorescently-labeled single-domain antibody targeting a universal tumor marker
Mateusiak, L., Floru, S., Wouters, J., De Groof, T., Declerck, N., Janssen, S., Debie, P., Zeven, K., Puttemans, J., Breckpot, K., Devoogdt, N. & Hernot, S., 28 Jan 2023.Research output: Unpublished contribution to conference › Unpublished abstract
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Safety assessment of fluorescence-labeled anti-EGFR Nanobody in healthy dogs
Herreira do Valle, N. C., Janssen, S., Stroet, M., Pollenus, S., Van den Block, S., Devoogdt, N., Debacker, J., Hernot, S. & de Rooster, H., 2023.Research output: Unpublished contribution to conference › Unpublished abstract
Prizes
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Best Poster in Category
Bala, Gezim (Recipient) & Hernot, Sophie (Recipient), 28 May 2013
Prize: Prize (including medals and awards)
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Best Poster in Category, World Molecular Imaging Congress
Hernot, Sophie (Recipient), 11 Aug 2011
Prize: Prize (including medals and awards)
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Finalist Young Investigator Award
Tierens, S. (Recipient) & Hernot, Sophie (Recipient), 5 Jun 2014
Prize: Prize (including medals and awards)
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Nomination Marie Curie Award
Varasteh, Z. (Recipient) & Hernot, Sophie (Recipient), 24 Oct 2017
Prize: Prize (including medals and awards)
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Nomination Marie Curie Award
Varasteh, Z. (Recipient) & Hernot, Sophie (Recipient), 24 Oct 2017
Prize: Prize (including medals and awards)
Activities
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SPIE Photonics West 2023
Sophie Hernot (Participant)
Jan 2023Activity: Participating in or organising an event › Participation in conference
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In vivo optical imaging using a novel fluorescently-labeled single-domain antibody targeting a universal tumor marker
Lukasz Mateusiak (Speaker), Sam Floru (Contributor), Janne Wouters (Contributor), Timo De Groof (Contributor), Noemi Declerck (Contributor), Simone Janssen (Contributor), Pieterjan Debie (Contributor), Katty Zeven (Contributor), Janik Puttemans (Contributor), Karine Breckpot (Contributor), Nick Devoogdt (Contributor) & Sophie Hernot (Contributor)
28 Jan 2023Activity: Talk or presentation › Talk or presentation at a conference
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First in vivo results for a novel macroscale time-domain fluorescence imaging system
Hans Ingelberts (Speaker), Simone Janssen (Speaker), Thomas Lapauw (Contributor), Thomas Van Den Dries (Contributor), Sevada Sahakian (Contributor), Pooria Iranian (Contributor), Maarten Kuijk (Contributor), Marcus Stroet (Contributor), Laurens Albert J Raes (Contributor), Sophie Hernot (Contributor) & Hilde de Rooster (Contributor)
16 Mar 2023Activity: Talk or presentation › Talk or presentation at a conference
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In vivo optical imaging of glioma using a novel uPAR-targeting fluorescent single-domain antibody
Lukasz Mateusiak (Speaker), Sam Floru (Contributor), Timo De Groof (Contributor), Noemi Declerck (Contributor), Janne Wouters (Contributor), Simone Janssen (Contributor), Pieterjan Debie (Contributor), Katty Zeven (Contributor), Cecile Vincke (Contributor), Janik Puttemans (Contributor), Marcus Stroet (Contributor), Karine Breckpot (Contributor), Nick Devoogdt (Contributor) & Sophie Hernot (Contributor)
16 Mar 2023Activity: Talk or presentation › Talk or presentation at a conference
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World Molecular Imaging Congress
Sophie Hernot (Participant)
Sep 2022Activity: Participating in or organising an event › Participation in conference
Press/Media
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VUB-onderzoekers ontwikkelen gel met natuurlijke pijnstillers
Steven Ballet, Charlotte Martin & Sophie Hernot
6/12/18
2 Media contributions
Press/Media: Research
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Presentation of data acquired with a novel high-resolution PET imaging system and radiolabeled nanobodies in the context of atherosclerosis
C. Vanhove, Sophie Hernot & Jessica Bridoux
18/04/18
1 Media contribution
Press/Media: Research
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Grotere overlevingskansen bij kankeroperaties door fluorescente vloeistof
22/12/17
2 Media contributions
Press/Media: Research
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Kikkers gebruiken moleculen als micro-giftanden om roofdieren te vergiftigen
Kim Roelants, Vicky Caveliers, Sophie Hernot & Cindy Peleman
16/11/17
1 Media contribution
Press/Media: Research
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Publication of results on the use of the Cellvizio system for in vivo microscopic imaging tumor targeting of fluorescent nanobodies
14/04/14
1 Media contribution
Press/Media: Research
Thesis
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Bijdrage tot de ontwikkeling van een in vitro ziektemodel voor rhepatische steatose door gebruik te maken van huidafgeleide stamcellen
Author: Declerck, E., Vanhaecke, T., Marcelino Rodrigues, R. & Hernot, S., 7 Sep 2017Student thesis: Master's Thesis
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Conception d’agents d’imagerie moléculaire et théranostiques pour la détection et la thérapie ciblée de cancers
Author: Renard, E. & Hernot, S., Dec 2020Student thesis: Doctoral Thesis
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Confirming the applicability of the anti-EGFR Nanobodies for fluorescence-guided surgery in canine and human head and neck cancer
Author: Hernot, S. & de Rooster, H., 2025Student thesis: Doctoral Thesis
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Development of Improved Adeno-Asociated Viral Vector Designs for Gene Therapy of Duchenne Muscular Dystrophy
Author: Claeys, L., VandenDriessche, T., Chuah, M. & Hernot, S., 7 Sep 2017Supervisor: Chai, Y. C. (Advisor) & Boon, D. (Advisor)
Student thesis: Master's Thesis
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Development of new Recombinase Polymerase Amplification (RPA) and antigen-based diagnostic tools for the detection of Trypanosoma evansi infections
Author: Zeng, L., Magez, S., Sterckx, Y., Versées, W. & Hernot, S., Dec 2020Student thesis: Doctoral Thesis