Projects per year
Personal profile
Expertise
Sophie Hernot obtained her Master of Science in Bio-engineering from the Vrije Universiteit of Brussels. She completed her PhD thesis in Medical Sciences in 2011 on the use of microbubbles (ultrasound contrast agents) as well as Nanobodies for molecular imaging and drug delivery applications. As post-doctoral researcher, and since 2016 as assistant professor in the Laboratory of In vivo Cellular and Molecular Imaging (ICMI, VUB), her research interests are two-fold: 1) design and validation of nanobodies for optical imaging applications, and in particular towards a clinical translation for image-guided surgery, and 2) validation of nanobody-based molecular probes for identification and characterization of high-risk atherosclerotic lesions. In both cases, particular attention is given to the effects of the nanobody-structure and radioactive or fluorescence labeling of nanobodies on their pharmacokinetics.
Expertise:
- Nanobody labelling
- Non-invasive molecular imaging (optical and nuclear imaging)
- Intra-operative imaging
- Preclinical animal models
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Collaborations and top research areas from the last five years
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FWOSB194: NAIROBI: iNjectable suprAmolecular peptIde hydRogels for cOntrolled release of BioactIves
Robberechts, I., Martin, C., Ballet, S. & Hernot, S.
1/11/24 → 31/10/28
Project: Fundamental
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HERC66: 3D-CELLMAP: Unveiling complex cellular interactions in tissues through 3D super-resolution protein multiplex imaging
Movahedi, K., Rooman, I., Sermon, K., De Bundel, D., Fioravanti, A., Staels, W., Magez, S., Breckpot, K., De Kock, J., Laoui, D., Goyvaerts, C., Smolders, I., Van Ginderachter, J., Marcelino Rodrigues, R., De Leu, N., van Grunsven, L., Hernot, S., Peeters, E., Vanhaecke, T., De Veirman, K., Ruytinx, J., Van Schependom, J., Kortekaas, I. & Goossens, E.
1/05/24 → 31/05/28
Project: Fundamental
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OZR4288: Financiering MZW OZR: RAPTOR: Rapid Analysis and production of Proteins for clinical Translation using biacORe and bioreactOR systems.
Devoogdt, N., Hernot, S., De Groof, T., Ballet, S., Stijlemans, B., Massie, A., Rooman, I., Keyaerts, M., Raes, G., De Kock, J., Breckpot, K., De Veirman, K. & Caveliers, V.
24/04/24 → 24/04/28
Project: Fundamental
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SRP95: Exploiting Peptides as Protein Binders, Modulators, Inhibitors and Biomaterials for Imaging and Therapy [Exploit-PeptIT]
Ballet, S., Caveliers, V., Hernot, S., Versées, W., Devoogdt, N. & Covens, P.
1/03/24 → 28/02/29
Project: Fundamental
Research output
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64 × 64-Pixel Current-Assisted Photonic Sampler Image Sensor and Camera System for Real-time Fluorescence Lifetime Imaging
Van Den Dries, T., Lapauw, T., Janssen, S., Sahakian, S., Lepoutte, T., Stroet, M., Hernot, S., Kuijk, M. & Ingelberts, H., 10 Jun 2024, In: IEEE Sensors Journal. 24, 15, p. 23729-23737 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile35 Downloads (Pure) -
Comparison of trivalent platforms for bimodal PET/NIR fluorescence imaging with Nanobody tracers
Saliën, J., Vizier, R., Floru, S., Bridoux, J., Stroet, M., Goncalves, V., Denat, F. & Hernot, S., 15 Mar 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Contact immunofluorescence: a novel methodology for intraoperative ex vivo margin assessment using fluorescent EGFR-targeting nanobodies
Debacker, J., Herreira do Valle, N. C., Creytens, D., Göker, M., Janssen, S., Struys, M., Henrotte, M., Huvenne, W., Van de Vijver, K., Vergauwen, G., de Rooster, H. & Hernot, S., 2 Oct 2024.Research output: Unpublished contribution to conference › Poster
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Effect of fluorescent dye on the localization of labeled Nanobodies in the kidneys at sub-organ and cellular level
Chigoho, D. M., Mateusiak, L., Bridoux, J. & Hernot, S., 15 Mar 2024.Research output: Unpublished contribution to conference › Poster
File10 Downloads (Pure) -
Fluorinated Peptide Hydrogels Result in Longer In Vivo Residence Time after Subcutaneous Administration
Honfroy, A., Bertouille, J. (ed.), Turea, A-M., Cauwenbergh, T., Bridoux, J., Lensen, N., Mangialetto, J., Van den Brande, N., White, J. F., Gardiner, J., Brigaud, T., Ballet, S., Hernot, S., Chaume, G. & Martin, C., 4 Sep 2024, In: Biomacromolecules. 25, 10, p. 6666-6680 15 p., 39230056.Research output: Contribution to journal › Article › peer-review
Open Access
Prizes
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Best Poster in Category
Bala, Gezim (Recipient) & Hernot, Sophie (Recipient), 28 May 2013
Prize: Prize (including medals and awards)
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Best Poster in Category, World Molecular Imaging Congress
Hernot, Sophie (Recipient), 11 Aug 2011
Prize: Prize (including medals and awards)
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Finalist Young Investigator Award
Tierens, S. (Recipient) & Hernot, Sophie (Recipient), 5 Jun 2014
Prize: Prize (including medals and awards)
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Nomination Marie Curie Award
Varasteh, Z. (Recipient) & Hernot, Sophie (Recipient), 24 Oct 2017
Prize: Prize (including medals and awards)
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Nomination Marie Curie Award
Varasteh, Z. (Recipient) & Hernot, Sophie (Recipient), 24 Oct 2017
Prize: Prize (including medals and awards)
Activities
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In vivo and ex vivo differentiation between tumor and healthy tissue with a novel macroscale time-domain fluorescence lifetime imaging system: preclinical results
Simone Janssen (Speaker), Thomas Van Den Dries (Contributor), Marcus Stroet (Contributor), Sevada Sahakian (Contributor), Thomas Lapauw (Contributor), Maarten Kuijk (Contributor), Hilde de Rooster (Contributor), Hans Ingelberts (Contributor) & Sophie Hernot (Contributor)
28 Jan 2024Activity: Talk or presentation › Talk or presentation at a conference
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Fluorescently labeled nanobodies targeting EGFR for tumor delineation in head and neck cancer, a canine dose-escalation study
Jens Debacker (Speaker), Nayra Cristina Herreira do Valle (Contributor), Sofie Pollenus (Contributor), Hilde De Cock (Contributor), David Creytens (Contributor), Simone Janssen (Contributor), Ingeborgh Polis (Contributor), Sophie Hernot (Contributor) & Hilde de Rooster (Contributor)
3 Oct 2024Activity: Talk or presentation › Talk or presentation at a conference
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In vitro and in vivo validation of a fluorescently-labeled anti-CEA Nanobody for fluorescence guided surgery of colorectal cancer.
Sam Floru (Speaker), Lukasz Mateusiak (Contributor), Jelena Saliën (Contributor), Marcus Stroet (Contributor) & Sophie Hernot (Contributor)
13 Mar 2024Activity: Talk or presentation › Talk or presentation at a conference
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Fluorescence-guided surgery using an anti-EGFR Nanobody in dogs with spontaneous carcinomas: translational prospects for head and neck cancer
Nayra Cristina Herreira do Valle (Speaker), Jens Debacker (Contributor), David Creytens (Contributor), Simone Janssen (Contributor), Marcus Stroet (Contributor), Sofie Pollenus (Contributor), Mathieu Struys (Contributor), Michaël Henrotte (Contributor), Hilde De Cock (Contributor), Wouter Huvenne (Contributor), Sophie Hernot (Contributor) & Hilde de Rooster (Contributor)
14 Mar 2024Activity: Talk or presentation › Talk or presentation at a conference
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Macroscale fluorescence lifetime imaging with novel time-gated camera complemented with high-resolution color image registration
Sevada Sahakian (Speaker), Simone Janssen (Contributor), Thomas Van Den Dries (Contributor), Thomas Lapauw (Contributor), Marcus Stroet (Contributor), Theo Lepoutte (Contributor), Pooria Iranian (Contributor), Maarten Kuijk (Contributor), Sophie Hernot (Contributor) & Hans Ingelberts (Contributor)
7 Apr 2024Activity: Talk or presentation › Talk or presentation at a conference
Press/Media
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VUB-onderzoekers ontwikkelen gel met natuurlijke pijnstillers
Steven Ballet, Charlotte Martin & Sophie Hernot
6/12/18
2 Media contributions
Press/Media: Research
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Presentation of data acquired with a novel high-resolution PET imaging system and radiolabeled nanobodies in the context of atherosclerosis
C. Vanhove, Sophie Hernot & Jessica Bridoux
18/04/18
1 Media contribution
Press/Media: Research
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Grotere overlevingskansen bij kankeroperaties door fluorescente vloeistof
22/12/17
2 Media contributions
Press/Media: Research
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Kikkers gebruiken moleculen als micro-giftanden om roofdieren te vergiftigen
Kim Roelants, Vicky Caveliers, Sophie Hernot & Cindy Peleman
16/11/17
1 Media contribution
Press/Media: Research
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Publication of results on the use of the Cellvizio system for in vivo microscopic imaging tumor targeting of fluorescent nanobodies
14/04/14
1 Media contribution
Press/Media: Research
Thesis
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Bijdrage tot de ontwikkeling van een in vitro ziektemodel voor rhepatische steatose door gebruik te maken van huidafgeleide stamcellen
Author: Declerck, E., Vanhaecke, T., Marcelino Rodrigues, R. & Hernot, S., 7 Sep 2017Student thesis: Master's Thesis
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Conception d’agents d’imagerie moléculaire et théranostiques pour la détection et la thérapie ciblée de cancers
Author: Renard, E. & Hernot, S., Dec 2020Student thesis: Doctoral Thesis
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Confirming the applicability of the anti-EGFR Nanobodies for fluorescence-guided surgery in canine and human head and neck cancer
Author: Hernot, S. & de Rooster, H., 2025Student thesis: Doctoral Thesis
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Development of Improved Adeno-Asociated Viral Vector Designs for Gene Therapy of Duchenne Muscular Dystrophy
Author: Claeys, L., VandenDriessche, T., Chuah, M. & Hernot, S., 7 Sep 2017Supervisor: Chai, Y. C. (Advisor) & Boon, D. (Advisor)
Student thesis: Master's Thesis
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Enhancing brain tumor visualization for surgical resection using fluorescent labeled nanobodies.
Author: Floru, S. & Hernot, S., 2022Supervisor: Mateusiak, L. (Co-promotor)
Student thesis: Master's Thesis