Projects per year
Personal profile
Expertise
Sophie Hernot obtained her Master of Science in Bio-engineering from the Vrije Universiteit of Brussels. She completed her PhD thesis in Medical Sciences in 2011 on the use of microbubbles (ultrasound contrast agents) as well as Nanobodies for molecular imaging and drug delivery applications. As post-doctoral researcher, and since 2016 as assistant professor in the Laboratory of In vivo Cellular and Molecular Imaging (ICMI, VUB), her research interests are two-fold: 1) design and validation of nanobodies for optical imaging applications, and in particular towards a clinical translation for image-guided surgery, and 2) validation of nanobody-based molecular probes for identification and characterization of high-risk atherosclerotic lesions. In both cases, particular attention is given to the effects of the nanobody-structure and radioactive or fluorescence labeling of nanobodies on their pharmacokinetics.
Expertise:
- Nanobody labelling
- Non-invasive molecular imaging (optical and nuclear imaging)
- Intra-operative imaging
- Preclinical animal models
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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HERC73: Upgrade of confocal FLIM microscope with two-photon excitation and detection modules
1/01/25 → 31/01/28
Project: Fundamental
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FWOSB194: NAIROBI: iNjectable suprAmolecular peptIde hydRogels for cOntrolled release of BioactIves
Robberechts, I., Martin, C., Ballet, S. & Hernot, S.
1/11/24 → 31/10/28
Project: Fundamental
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HERC66: 3D-CELLMAP: Unveiling complex cellular interactions in tissues through 3D super-resolution protein multiplex imaging
Movahedi, K., Rooman, I., Sermon, K., De Bundel, D., Fioravanti, A., Staels, W., Magez, S., Breckpot, K., De Kock, J., Laoui, D., Goyvaerts, C., Smolders, I., Van Ginderachter, J., Marcelino Rodrigues, R., De Leu, N., van Grunsven, L., Hernot, S., Peeters, E., Vanhaecke, T., De Veirman, K., Ruytinx, J., Van Schependom, J., Kortekaas, I. & Goossens, E.
1/05/24 → 31/05/28
Project: Fundamental
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OZR4288: Financiering MZW OZR: RAPTOR: Rapid Analysis and production of Proteins for clinical Translation using biacORe and bioreactOR systems.
Devoogdt, N., Hernot, S., De Groof, T., Ballet, S., Stijlemans, B., Massie, A., Rooman, I., Keyaerts, M., Raes, G., De Kock, J., Breckpot, K., De Veirman, K. & Caveliers, V.
24/04/24 → 24/04/28
Project: Fundamental
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SRP95: Exploiting Peptides as Protein Binders, Modulators, Inhibitors and Biomaterials for Imaging and Therapy [Exploit-PeptIT]
Ballet, S., Caveliers, V., Hernot, S., Versées, W., Devoogdt, N., Covens, P. & Martin, C.
1/03/24 → 28/02/29
Project: Fundamental
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Bimodal PET/fluorescence imaging with Nanobody tracers: comparison of MOMIP platforms
Saliën, J., Floru, S., Vizier, R., Delalieux, S., Bridoux, J., Goncalves, V., Denat, F. & Hernot, S., 14 Mar 2025.Research output: Unpublished contribution to conference › Poster
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Breaking the Nanosecond Barrier: Antibody-Based Tumor Imaging with Extended-Lifetime Fluorescent Tracers – A Promise for Enhanced Multiplexing
Mateusiak, L., Chazeau, E., Al-Sabea, H., Samuelsen Fosse, V., Kleinmanns, K., Goze, C., McCormack, E., Lapauw, T., Van Den Dries, T., Ingelberts, H., Denat, F. & Hernot, S., 12 Mar 2025.Research output: Unpublished contribution to conference › Poster
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Cetuximab enhances tumor-to-background ratio during Nanobody-based fluorescence guided surgery in dogs with EGFR-expressing tumors
Herreira do Valle, N. C., Debacker, J., De Cock, H., Pollenus, S., Hernot, S. & de Rooster, H., 14 Mar 2025.Research output: Unpublished contribution to conference › Poster
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Comparison of NOTA-derivatives for Nanobody PET imaging
Saliën, J., Floru, S., Van Hove, M., De Pauw, T., Vizier, R., Bridoux, J., Goncalves, V., Denat, F. & Hernot, S., Jun 2025, (Unpublished).Research output: Unpublished contribution to conference › Unpublished abstract
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Evaluation of a single domain antibody targeting uPAR for molecular imaging of atherosclerosis in ApoE-/-mice
Dumas, L., Raes, F., Adoumou-Limoune, B., André, C., Bezot, M., Bacot, S., Ahmadi, M., N'guessan, E., Mateusiak, L., Ghezzi, C., Hernot, S. & Broisat, A., 2025.Research output: Unpublished contribution to conference › Poster
Datasets
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Generation and Characterization of Novel Pan-Cancer Anti-uPAR Fluorescent Nanobodies as Tools for Image-Guided Surgery
Mateusiak, L. (Creator), Floru, S. (Researcher), De Groof, T. (Researcher), Wouters, J. (Researcher), Declerck, N. (Researcher), Debie, P. (Researcher), Janssen, S. (Researcher), Zeven, K. (Researcher), Puttemans, J. (Researcher), Vincke, C. (Researcher), Breckpot, K. (Project Member), Devoogdt, N. (Project Member) & Hernot, S. (Supervisor), Zenodo, 26 Mar 2025
DOI: https://zenodo.org/records/15089920
Dataset
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Fluorescent Nanobodies for enhanced guidance in digestive tumors and liver metastasis surgery
Mateusiak, L. (Creator), Hakuno, S. (Researcher), de Jonge-Muller, E. (Researcher), Floru, S. (Researcher), Sier, C. F. M. (Supervisor), Hawinkels, L. J. (Supervisor) & Hernot, S. (Supervisor), Zenodo, 27 Mar 2025
DOI: https://zenodo.org/records/15096527
Dataset
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Dataset related to article "Size-advantage of monovalent nanobodies against the macrophage mannose receptor for deep tumor penetration and tumor-associated macrophage targeting"
Movahedi, K. (Creator), Allavena, P. (Creator), Erreni, M. (Creator), Debie, P. (Creator), Mantovani, A. (Creator), D'Autilia, F. (Creator), Doni, A. (Creator), van Leeuwen, F. W. B. (Creator), Avigni, R. (Creator), Arnouk, S. (Creator), Vincke, C. (Creator), Van Ginderachter, J. (Creator), Anselmo, A. (Creator), Parente, R. (Creator), Hernot, S. (Creator), Garlanda, C. (Creator) & Bolli, E. (Creator), Zenodo, 4 Dec 2023
DOI: 10.5281/zenodo.10254683, https://zenodo.org/records/10254683
Dataset
Prizes
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Best Poster in Category
Bala, Gezim (Recipient) & Hernot, Sophie (Recipient), 28 May 2013
Prize: Prize (including medals and awards)
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Best Poster in Category, World Molecular Imaging Congress
Hernot, Sophie (Recipient), 11 Aug 2011
Prize: Prize (including medals and awards)
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Finalist Young Investigator Award
Tierens, Simon (Recipient) & Hernot, Sophie (Recipient), 5 Jun 2014
Prize: Prize (including medals and awards)
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Nomination Marie Curie Award
Varasteh, Zohreh (Recipient) & Hernot, Sophie (Recipient), 24 Oct 2017
Prize: Prize (including medals and awards)
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Nomination Marie Curie Award
Varasteh, Zohreh (Recipient) & Hernot, Sophie (Recipient), 24 Oct 2017
Prize: Prize (including medals and awards)
Activities
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Nanobody-based Fluorescent Contrast Agents for Rapid and Specific Intra-Operative Tumor Visualization.
Sophie Hernot (Invited speaker)
30 Sept 2025Activity: Talk or presentation › Talk or presentation at a conference
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Nanobody-based tracers in image-guided surgery applications
Marleen Keyaerts (Speaker), Jens Debacker (Speaker) & Sophie Hernot (Contributor)
17 May 2025Activity: Talk or presentation › Talk or presentation at a conference
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Educational talk: Tracer Design: Enhancing Intraoperative Imaging for Precision Surgery.
Sophie Hernot (Speaker)
11 Mar 2025Activity: Talk or presentation › Talk or presentation at a conference
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Ontwikkeling en preklinische validatie van fluorescente tracers
Sophie Hernot (Keynote speaker)
17 May 2025Activity: Talk or presentation › Talk or presentation at a conference
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Enhancing Fluorescence-Guided Surgery with Nanobodies and Fluorescence Lifetime Imaging.
Sophie Hernot (Keynote speaker)
21 Apr 2025Activity: Talk or presentation › Talk or presentation at a conference
Press/Media
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VUB-onderzoekers ontwikkelen gel met natuurlijke pijnstillers
Steven Ballet, Charlotte Martin & Sophie Hernot
6/12/18
2 Media contributions
Press/Media: Research
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Presentation of data acquired with a novel high-resolution PET imaging system and radiolabeled nanobodies in the context of atherosclerosis
C. Vanhove, Sophie Hernot & Jessica Bridoux
18/04/18
1 Media contribution
Press/Media: Research
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Grotere overlevingskansen bij kankeroperaties door fluorescente vloeistof
22/12/17
2 Media contributions
Press/Media: Research
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Kikkers gebruiken moleculen als micro-giftanden om roofdieren te vergiftigen
Kim Roelants, Vicky Caveliers, Sophie Hernot & Cindy Peleman
16/11/17
1 Media contribution
Press/Media: Research
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Publication of results on the use of the Cellvizio system for in vivo microscopic imaging tumor targeting of fluorescent nanobodies
14/04/14
1 Media contribution
Press/Media: Research
Thesis
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Bijdrage tot de ontwikkeling van een in vitro ziektemodel voor rhepatische steatose door gebruik te maken van huidafgeleide stamcellen
Author: Declerck, E., Vanhaecke, T., Marcelino Rodrigues, R. & Hernot, S., 7 Sept 2017Student thesis: Master's Thesis
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Conception d’agents d’imagerie moléculaire et théranostiques pour la détection et la thérapie ciblée de cancers
Author: Renard, E. & Hernot, S., Dec 2020Student thesis: Doctoral Thesis
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Confirming the applicability of the anti-EGFR Nanobodies for fluorescence-guided surgery in canine and human head and neck cancer
Author: Hernot, S. & de Rooster, H., 2025Student thesis: Doctoral Thesis
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Development of Improved Adeno-Asociated Viral Vector Designs for Gene Therapy of Duchenne Muscular Dystrophy
Author: Claeys, L., VandenDriessche, T., Chuah, M. & Hernot, S., 7 Sept 2017Supervisor: Chai, Y. C. (Advisor) & Boon, D. (Advisor)
Student thesis: Master's Thesis
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Enhancing brain tumor visualization for surgical resection using fluorescent labeled nanobodies.
Author: Floru, S. & Hernot, S., 2022Supervisor: Mateusiak, L. (Co-promotor)
Student thesis: Master's Thesis