Projects per year
Personal profile
Expertise
"Decoding the brain enigma" is what currently drives me during my PhD in neurosciences. Studying the marriage between artificial intelligence and medical sciences, I am trying to create predictive models on MRI and clinical parameters for disease progression in Multiple Sclerosis; The creation of a guiding compass for the future.
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Collaborations and top research areas from the last five years
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FWOTM1215: Leveraging recent advances in explainable AI to decode cognitive functioning from T1/FLAIR weighted MR images in MS - An international federated learning approach
Denissen, S. (Mandate), Nagels, G. (Administrative Promotor) & Van Schependom, J. (CoI (Co-Promotor))
1/10/24 → 30/09/27
Project: Fundamental
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VLAOO2: Baekeland mandate: Creating the MS compass of the future: imaging AI to predict disease progression
Nagels, G. (Administrative Promotor), Van Schependom, J. (Co-Promotor) & Denissen, S. (Collaborator)
1/02/20 → 31/01/24
Project: Applied
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Federated Adversarial Network (FAN): A Generative Proxy-Based, Defense-Enhanced, and Non-IID-Robust Federated Learning Method
Wang, X., Nagels, G., Van Schependom, J., Denissen, S., Doan, Q. M., Nguyen, L. T., Chen, O. Y., Vargas Guerrero, A. J. & Hu, T., 27 Jan 2026, SSRN, 27 p.Research output: Working paper › Preprint
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Incorporating Measures of Cognitive Processing Speed and Brain Volume in Clinical Management of Pediatric Onset Multiple Sclerosis
Sosa, A., O'Neill, K. A., Billiet, T., Chen, J., Couvreur, L., Denissen, S., Lustberg, M., Pehel, S., Ribbens, A. & Krupp, L., Feb 2026, In: Pediatric Neurology. 175, p. 50-57 8 p.Research output: Contribution to journal › Article › peer-review
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PDD-FANs: Personalized Decentralized Federated Adversarial Networks with Defense Mechanism in Non-IID Setting
Wang, X., Nguyen, L. T., Chen, O. Y., Van Schependom, J., Denissen, S. & Nagels, G., 2 Feb 2026, 2025 IEEE 24th International Conference on Trust, Security and Privacy in Computing and Communications (TrustCom). IEEE, p. 1317-1326 10 p. (2025 IEEE 24th International Conference on Trust, Security and Privacy in Computing and Communications (TrustCom)).Research output: Chapter in Book/Report/Conference proceeding › Conference paper
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Real-world federated learning for brain imaging scientists
Denissen, S., Laton, J., Grothe, M., Vaneckova, M., Uher, T., Kudrna, M., Horáková, D., Baijot, J., Penner, I.-K., Kirsch, M., Motýl, J., De Vos, M., Chén, O. Y., Van Schependom, J., Sima, D. M. & Nagels, G., 13 Mar 2026, In: Frontiers in digital health. 8, p. 1-13 13 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
The relationship between objective and subjective cognitive performance and clinical and MRI disease burden in early multiple sclerosis
Van Laethem, D., Costers, L., Miravalle, A., Alvarez, E., Myers, B., Boster, A., Al Halawani, H., Dewil, M., Cambron, M., Grothe, M., Denissen, S., Bartz, R., Sima, D. M., Ribbens, A., Smeets, D. & Nagels, G., 16 May 2026, In: Scientific Reports. 16, 1, 11 p., 22224.Research output: Contribution to journal › Article › peer-review
Open Access
Prizes
Activities
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From Paradox to Power: Practical Guidelines for Sample Size Estimation in Neuroimaging Studies of Multiple Sclerosis
Vandermeulen, S. (Participant), Van Schependom, J. (Supervisor), Nagels, G. (Supervisor) & Denissen, S. (Supervisor)
2 Mar 2026Activity: Other › Written proposal
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Surfing the smartphone wave to support clinical practice
Van Laethem, D. (Speaker) & Denissen, S. (Speaker)
14 May 2025Activity: Talk or presentation › Talk or presentation at a conference
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Live performance at the Vlaamse Scriptieprijs 2022
Denissen, S. (Participant)
20 Dec 2022Activity: Other
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Icognition: Test je cognitieve functies op je smartphone
Denissen, S. (Speaker) & Van Laethem, D. (Speaker)
22 Sept 2022Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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Brain age as a surrogate marker for IPS in MS
Denissen, S. (Speaker)
18 May 2022Activity: Talk or presentation › Talk or presentation at a conference
Press/Media
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De hersenleeftijd als bevattelijke klinische parameter bij MS
31/03/21
1 item of Media coverage
Press/Media: Research
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Brain age serves as sensitive marker for information processing speed in MS
25/02/21
1 item of Media coverage
Press/Media: Research
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How to compare cognitive scores in MS?
Denissen, S., Costers, L., Laton, J. & Baijot, J.
12/11/20
1 Media contribution
Press/Media: Research
Thesis
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Applying a microbiome-age model to a subfertile population: An AI-based approach
Derua, J. ((PhD) Student), Demuyser, T. (Promotor), Nagels, G. (Promotor) & Denissen, S. (Co-promotor), 2024Student thesis: Master's Thesis
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Characterising neurophysiological processes behind Information Processing Speed in Multiple Sclerosis
Burta, O. D. ((PhD) Student), Van Schependom, J. (Promotor), Nagels, G. (Jury) & Denissen, S. (Jury), Akbarian, F. (Advisor), Jul 2024Student thesis: Master's Thesis
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Deep learning for brain age prediction from T1-weighted magnetic resonance images
Vital Serafim Silva, A. ((PhD) Student), Van Schependom, J. (Promotor), Nagels, G. (Promotor) & Denissen, S. (Advisor), 2023Student thesis: Master's Thesis