Projects per year
Personal profile
Expertise
Basic research related to the development of in vitro alternative methods:
- Human liver-based in vitro models
- Adult human skin-derived progenitor cells and their hepatic derivatives
- DILI screening, including steatosis, phospholipidosis and acute liver failure
- Flow cytometry-based high throughput screening of various hepatic cell models, for live/dead cell analysis, lipid and phospholipid accumulation
- Microscopy-based high content analysis for lipid and mitochondrial deregulation analysis
- Genotoxicant-specific qPCR array
- Transcriptomics and metabolomics readouts and analysis
- Risk assessment of consumer products
Education/Academic qualification
European Registered Toxicologist, Belgian Society of Toxicology
Award Date: 1 Jan 2010
Doctor in Pharmaceutical Sciences, Vrije Universiteit Brussel
1994 → 2000
Award Date: 30 Sep 2000
Certificate of successful pass of the exam of the Safety Assessment of Cosmetics in the EU - Training Course, Vrije Universiteit Brussel
2004
External positions
Member, Scientific Committee on Consumer Safety (SCCS) - DG SANCO
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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BASGO40: OZR Basisfinanciering voor Grote Onderzoeksgroepen - In Vitro Toxicology and Dermato-Cosmetology (IVTD)
1/01/25 → 31/12/25
Project: Fundamental
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HERC66: 3D-CELLMAP: Unveiling complex cellular interactions in tissues through 3D super-resolution protein multiplex imaging
Movahedi, K., Rooman, I., Sermon, K., De Bundel, D., Fioravanti, A., Staels, W., Magez, S., Breckpot, K., De Kock, J., Laoui, D., Goyvaerts, C., Smolders, I., Van Ginderachter, J., Marcelino Rodrigues, R., De Leu, N., van Grunsven, L., Hernot, S., Peeters, E., Vanhaecke, T., De Veirman, K., Ruytinx, J., Van Schependom, J., Kortekaas, I. & Goossens, E.
1/05/24 → 31/05/28
Project: Fundamental
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IOFPOC61: EVOStAR: a strategic applicability and business plan roadmap for EVOZymes-based therapeutics.
1/01/24 → 30/06/25
Project: Applied
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VLAIM5: Innovation mandate Spin-off: EVOZymes Development Platform
Neuckermans, J., De Kock, J. & Vanhaecke, T.
1/08/23 → 31/07/25
Project: Applied
Research output
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Mapping physiology: a systems biology approach for the development of alternative methods in toxicology
Staumont, B., Ladeira, L. C. M., Gamba, A., Heusinkveld, H. J., Piersma, A., Fritsche, E., Masereeuw, R., Vanhaecke, T., Teunis, M., Luechtefeld, T. H., Hartung, T., Jover, R., Vinken, M. & Geris, L., 13 Jan 2025, (Accepted/In press) In: ALTEX.Research output: Contribution to journal › Article › peer-review
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Analysis of preservatives and fragrances in topical medical devices: The need for more stringent regulation
Stras, A., Grassmann, A., Van Campenhout, P., Vanhaecke, T., Desmedt, B. & Deconinck, E., Apr 2024, In: Contact Dermatitis. 90, 6, p. 594-606 13 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
A quantitative weight-of-evidence method for confidence assessment of adverse outcome pathway networks: a case study on chemical-induced liver steatosis
Verhoeven, A., van Ertvelde, J., Boeckmans, J., Gatzios, A., Rover, R., Lindeman, B., Lopze Soop, G., Rodrigues, R., Rapisarda, A., Sanz-Serrano, J., Stinckens, M., Sepehri, S., Teunis, M., Vinken, M., Jiang, J. & Vanhaecke, T., Jun 2024, In: Toxicology. 505, 11 p., 153814.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus)18 Downloads (Pure) -
Building disease ontology maps: in silico tools for applications in toxicology
Staumont, B., Ladeira, L. C. M., Gamba, A., Verhoeven, A., Sanz-Serrano, J., Kuchovska, E., Berkhout, J., Barnes, D. A., Teunis, M., Luechtefeld, T., Hartung, T., Jover, R., Vanhaecke, T., Fritsche, E., Heusinkveld, H. J., Piersma, A., Masereeuw, R., Vinken, M. & Geris, L., 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Carriage of multiple genetic risk factors for MASH stimulates an altered inflammatory secretome in a human stem cell-based in vitro model
Gatzios, A., Rombaut, M., De Kock, J., De Win, D., Heymans, A., Rogiers, V., Rodrigues, R., Boeckmans, J. & Vanhaecke, T., 1 Oct 2024, The Liver Meeting: 2024 Abstracts. S1 ed. Wolters Kluwer Health, Vol. 80. p. S35-S35 1 p. 53. (Hepatology (Baltimore, Md.)).Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book)
Datasets
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Gene expression profiling of Fah- and Hgd-deficient mouse livers upon short-term nitisinone discontinuation
Neuckermans, J. (Creator), Claes, P. (Researcher), Heymans, A. (Researcher), Colemonts-Vroninks, H. (Project Member), Martens, G. (Project Member), Vanhaecke, T. (Supervisor) & De Kock, J. (Supervisor), NCBI Gene Expression Omnibus, 4 Apr 2023
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE225001
Dataset
Prizes
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33. Forschungspreises zur Förderung methodischer Arbeiten mit dem Ziel der Einschränkung und des Ersatzes von Tierversuchen
De Kock, Joery (Recipient), Marcelino Rodrigues, Robim (Recipient), Vanhaecke, Tamara (Recipient) & Rogiers, Vera (Recipient), 2014
Prize: Prize (including medals and awards)
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33. Forschungspreise zur Förderung methodischer Arbeiten mit dem Ziel der Einschränkung und des Ersatzes von Tierversuchen
Vanhaecke, Tamara (Recipient), 4 Dec 2014
Prize: Prize (including medals and awards)
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33. Forschungspreise zur Förderung methodischer Arbeiten mit dem Ziel der Einschränkung und des Ersatzes von Tierversuchen
Vanhaecke, Tamara (Recipient), 2014
Prize: National/international honour
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Best Paper Award 2007 from the Toxicological Society
Vanhaecke, Tamara (Recipient), 2007
Prize: Prize (including medals and awards)
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Best Poster Award
Maushagen, Jan (Recipient), Sepehri, Sara (Recipient), Sanctorum, Audrey (Recipient), Vanhaecke, Tamara (Recipient), De Troyer, Olga (Recipient) & Debruyne, C. (Recipient), Sep 2024
Prize: National/international honour
Activities
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The development of a human liver-based in vitro test battery to detect liver steatotic potential of chemicals from various applicability domains
Anouk Verhoeven (Invited speaker), Annika Hanna Drees (Contributor), Alexandra Gatzios (Contributor), Robim Marcelino Rodrigues (Contributor), Julen Sanz Serrano (Contributor), Andres Tabernilla Garcia (Contributor), Tamara Vanhaecke (Contributor) & Mathieu Vinken (Contributor)
9 Sep 2024Activity: Talk or presentation › Talk or presentation at a conference
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Genetic predisposition for anti-MASH drug response: a population-based in vitro study
Alexandra Gatzios (Speaker), Matthias Rombaut (Contributor), Joery De Kock (Contributor), Dinja De Win (Contributor), Anja Heymans (Contributor), Vera Rogiers (Contributor), Robim Marcelino Rodrigues (Contributor), Joost Boeckmans (Contributor) & Tamara Vanhaecke (Contributor)
5 Jun 2024Activity: Talk or presentation › Talk or presentation at a conference
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A Next Generation Risk Assessment Case Study For The Hair Dye HC Yellow 13 Focused On Liver Steatosis
Sara Sepehri (Speaker) & Tamara Vanhaecke (Speaker)
3 Jun 2024 → 6 Jun 2024Activity: Talk or presentation › Talk or presentation at a conference
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Genetic predisposition for anti-MASH drug response: a population-based in vitro study
Alexandra Gatzios (Speaker), Matthias Rombaut (Contributor), Joery De Kock (Contributor), Dinja De Win (Contributor), Anja Heymans (Contributor), Vera Rogiers (Contributor), Robim Marcelino Rodrigues (Contributor), Joost Boeckmans (Contributor) & Tamara Vanhaecke (Contributor)
25 Jun 2024Activity: Talk or presentation › Talk or presentation at a conference
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A stem cell-based in vitro test battery to predict liver steatotic potential of diverse chemicals
Anouk Verhoeven (Speaker), Alexandra Gatzios (Contributor), Robim Marcelino Rodrigues (Contributor), Julen Sanz Serrano (Contributor), Andres Tabernilla Garcia (Contributor), Joery De Kock (Contributor), Mathieu Vinken (Contributor) & Tamara Vanhaecke (Contributor)
4 Jun 2024Activity: Talk or presentation › Talk or presentation at a conference
Press/Media
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Allergenen in geparfumeerde menstruatieproducten
Quinten Marcelis, Tamara Vanhaecke, Bart Desmedt, Eric Deconinck & Vera Rogiers
1/05/21
1 Media contribution
Press/Media: Research
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Antitumorale farmaca dragen bij tot minder proefdiergebruik.
20/01/05
1 Media contribution
Press/Media: Other
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Thesis
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Applicability of the KeratinoSensTM on mixtures
Author: Lee, K. A. & Vanhaecke, T., 2024Supervisor: Desmedt, B. (External person) (Advisor) & Marcelis, Q. (Advisor)
Student thesis: Master's Thesis
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Application of a Human stem cell-based in vitro model to investigate the impact of genetic determinants on response to ANTI-MASLD drug candidates
Author: Waegeman, L., Vanhaecke, T. & Boeckmans, J., 2024Supervisor: Gatzios, A. (Advisor)
Student thesis: Master's Thesis
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Bepaling van het optimale mRNA elektroporatieprotocol voor humane huidafgeleide stamcellen.
Author: Neuckermans, J. & Vanhaecke, T., 2016Student thesis: Master's Thesis
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Bepaling van nicotine en alkaloïden onzuiverheden in e-liquids beschikbaar op de Belgische markt.
Author: Sintobin, M. & Vanhaecke, T., 2017Student thesis: Master's Thesis
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Bijdrage tot de ontwikkeling van een in vitro ziektemodel voor rhepatische steatose door gebruik te maken van huidafgeleide stamcellen
Author: Declerck, E., Vanhaecke, T., Marcelino Rodrigues, R. & Hernot, S., 7 Sep 2017Student thesis: Master's Thesis