Projects per year
Personal profile
Expertise
Basic research related to the development of in vitro alternative methods:
- Human liver-based in vitro models
- Adult human skin-derived progenitor cells and their hepatic derivatives
- DILI screening, including steatosis, phospholipidosis and acute liver failure
- Flow cytometry-based high throughput screening of various hepatic cell models, for live/dead cell analysis, lipid and phospholipid accumulation
- Microscopy-based high content analysis for lipid and mitochondrial deregulation analysis
- Genotoxicant-specific qPCR array
- Transcriptomics and metabolomics readouts and analysis
- Risk assessment of consumer products
Education/Academic qualification
European Registered Toxicologist, BelTox
Doctor in Pharmaceutical Sciences, Vrije Universiteit Brussel
1994 → 2000
Certificate of successful pass of the exam of the Safety Assessment of Cosmetics in the EU - Training Course, Vrije Universiteit Brussel
2004
External positions
Member, Scientific Committee on Consumer Safety (SCCS) - DG SANCO
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Recent external collaboration on country level. Dive into details by clicking on the dots or
Projects
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EUAR35: H2020: CSA: TWINALT: Twinning towards excellence in alternative methods for toxicity assessment
1/09/20 → 31/08/23
Project: Applied
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OZR3687: H2020: CSA: TWINALT: Twinning towards excellence in alternative methods for toxicity assessment (OZR EU BONUS)
1/09/20 → 31/08/23
Project: Fundamental
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VLOV105: GENOMARK: Validatie van een nieuwe in vitro genotoxiciteitstest
11/05/20 → 10/05/21
Project: Fundamental
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OZR3588: Financiering FWO hercules: ERA platform: Extended RNA Analysis platform - version 2.0
Rooman, I., Bouwens, L., Heimberg, H., Neyns, B., Vranken, W., Vanhaecke, T., Massie, A., van Grunsven, L., De Bruyne, E., De Bundel, D., Forsyth, R., Breckpot, K., Van Dooren, S., De Kock, J., Njemini, R. & Laoui, D.
1/05/20 → 30/04/24
Project: Fundamental
Research output
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An exploratory approach for an oriented development of an untargeted hydrophilic interaction liquid chromatography-mass spectrometry platform for polar metabolites in biological matrices
Iturrospe, E., Da Silva, K. M., Talavera Andújar, B., Cuykx, M., Boeckmans, J., Vanhaecke, T., Covaci, A. & van Nuijs, A. L. N., 25 Jan 2021, In : Journal of Chromatography. A. 1637, 14 p., 461807.Research output: Contribution to journal › Article
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Corrigendum to: Impact of the Revised European Tobacco Product Directive on the Quality of E-cigarette Refill Liquids in Belgium
Barhdadi, S., Moens, G., Canfyn, M., Vanhee, C., Desmedt, B., Courselle, P., Rogiers, V., Vanhaecke, T. & Deconinck, E., 7 Jan 2021, In : Nicotine & tobacco research. 23, 1, p. 322-323 2 p.Research output: Contribution to journal › Article
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Identification of flavouring substances of genotoxic concern present in e-cigarette refills
Barhdadi, S., Mertens, B., Van Bossuyt, M., Maele, J. V. D., Anthonissen, R., Canfyn, M., Courselle, P., Rogiers, V., Deconinck, E. & Vanhaecke, T., Jan 2021, In : Food and Chemical Toxicology. 147, 111864.Research output: Contribution to journal › Article
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Corrigendum to "Hepatic cells derived from human skin progenitors show a typical phospholipidotic response upon exposure to amiodarone" [Toxicol. Lett. 284 (2018) 184-194]
Natale, A., Boeckmans, J., Desmae, T., De Boe, V., De Kock, J., Vanhaecke, T., Rogiers, V. & Rodrigues, R. M., 2020, In : Toxicology Letters. 333, p. 322-323 2 p.Research output: Contribution to journal › Article
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COVID-19 and drug-induced liver injury: a problem of plenty or a petty point?
Boeckmans, J., Rodrigues, R., Demuyser, T., Pierard, D., Vanhaecke, T. & Rogiers, V., 8 Apr 2020, In : Archives of dairy research and technology. 94, 4, p. 1367-1369 3 p., 21.Research output: Contribution to journal › Article
27 Citations (Scopus)
Prizes
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33. Forschungspreise zur Förderung methodischer Arbeiten mit dem Ziel der Einschränkung und des Ersatzes von Tierversuchen
Tamara Vanhaecke (Recipient), 2014
Prize: National/international honour
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33. Forschungspreise zur Förderung methodischer Arbeiten mit dem Ziel der Einschränkung und des Ersatzes von Tierversuchen
Tamara Vanhaecke (Recipient), 4 Dec 2014
Prize: Prize (including medals and awards)
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Best Paper Award 2007 from the Toxicological Society
Tamara Vanhaecke (Recipient), 2007
Prize: Prize (including medals and awards)
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Establishment of an in vitro model of liver cell death
Tamara Vanhaecke (Recipient), 2008
Prize: Prize (including medals and awards)
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Poster Competition Award of the EPAA 2008 Conference
Tamara Vanhaecke (Recipient), 3 Nov 2008
Prize: Prize (including medals and awards)
Activities
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A human hepatocyte-like cell based In Vitro model for hepatic insulin-driven De Novo Lipogenesis
Karolien Buyl (Speaker), Martine Vrints (Speaker), Ruani Fernando (Speaker), Thomas Van Eeckhoute (Speaker), Mia Jans (Speaker), Joost Boeckmans (Speaker), Robim Marcelino Rodrigues (Speaker), Vera Rogiers (Speaker), Jan Van Der Schueren (Speaker), Joery De Kock (Speaker), Tamara Vanhaecke (Speaker), Filip Beirinckx (Speaker)2020 → …Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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In vitro investigation of the anti-NASH properties of elafibranor and lanifibranor using a human stem cell-derived disease model
Joost Boeckmans (Speaker), Vera Rogiers (Contributor), Tamara Vanhaecke (Contributor), Robim Marcelino Rodrigues (Contributor)25 Feb 2019 → 26 Feb 2019Activity: Talk or presentation › Talk or presentation at a conference
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The investigation of drug-induced cholestasis in HepaRG cells using untargeted LC-MS metabolomics
Matthias Cuykx (Speaker), C Beirnaert (Speaker), Robim Marcelino Rodrigues (Speaker), K Laukens (Speaker), Tamara Vanhaecke (Speaker), A Covaci (Speaker)2 Sep 2018 → 5 Sep 2018Activity: Talk or presentation › Talk or presentation at a conference
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Untargeted in vitro metabololics to identify hepatotoxic modes of action
Matthias Cuykx (Speaker), C Beirnaert (Speaker), Robim Marcelino Rodrigues (Speaker), K Laukens (Speaker), Tamara Vanhaecke (Speaker), Adrian Covaci (Speaker)19 Sep 2018 → 20 Sep 2018Activity: Talk or presentation › Talk or presentation at a conference
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The investigation of drug-induced cholestasis in HepaRG cells using untargeted LC-MS cholestasis
Matthias Cuykx (Speaker), C Beirnaert (Speaker), Robim Marcelino Rodrigues (Speaker), K Laukens (Speaker), Tamara Vanhaecke (Speaker), Adrian Covaci (Speaker)2 Sep 2018 → 5 Sep 2018Activity: Talk or presentation › Talk at an external academic organisation
Press / Media
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Antitumorale farmaca dragen bij tot minder proefdiergebruik.
20/01/05
1 Media contribution
Press/Media: Other
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Thesis
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Alternative approaches to build quantitative structure-retention relationships
Author: Put, R., Vander Heyden, Y., Vanhaecke, T., Foriers, A., Smolders, I. J., Adams, E. & Kaliszan, R., 17 Sep 2008Supervisor: Vander Heyden, Y. (Promotor), Vanhaecke, T. (Jury), Foriers, A. (Jury), Smolders, I. (Jury), Adams, E. (External person) (Jury) & Kaliszan, R. (External person) (Jury)
Student thesis: Doctoral Thesis
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Bepaling van de blootstelling aan een actief farmacon tijdens de productie ervan
Author: De Grande, F. & Vanhaecke, T., 2007Supervisor: Vanhaecke, T. (Promotor)
Student thesis: Master-after-master
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Bepaling van het optimale mRNA elektroporatieprotocol voor humane huidafgeleide stamcellen.
Author: Neuckermans, J. & Vanhaecke, T., 2016Student thesis: Master's Thesis
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Bepaling van nicotine en alkaloïden onzuiverheden in e-liquids beschikbaar op de Belgische markt.
Author: Sintobin, M. & Vanhaecke, T., 2017Student thesis: Master's Thesis
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Beroepsmatige blootstelling aan mangaa bij lassers. Persoonlijke luchtbemonstering en biologische monitoring van mangaan in plasma, rode bloedcellen en urine
Author: Vanmarcke, E., Vanhaecke, T. & Hoet, P., 2009Supervisor: Vanhaecke, T. (Promotor) & Hoet, P. (External person) (Promotor)
Student thesis: Master-after-master