Projects per year
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Expertise
Thomas Ertveldt is a junior postdoc at the VUB’s Molecular Imaging and Therapy (MITH) research group. He recently concluded his doctoral studies revolving the immunogenic properties of targeted radionuclide therapy (TRT) mediated by single domain antibodies (sdAb’s) and immune imaging upon immune intervention. With his research, he aspires to improve knowledge and tools to increase patients response as well as reduce adverse effects to novel therapies such as TRT and immunotherapy.
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Projects
- 1 Finished
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FWOSB80: Combining targeted radionuclide therapy and cancer immunotherapy to advance precision medicine through innovation.
Breckpot, K. (Administrative Promotor), Devoogdt, N. (Co-Promotor), D'Huyvetter, M. (Co-Promotor), Keyaerts, M. (Co-Promotor) & Ertveldt, T. (Mandate)
1/11/19 → 31/10/23
Project: Fundamental
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Efficient α and β- radionuclide therapy targeting fibroblast activation protein-α in an aggressive preclinical mouse tumour model
Ceuppens, H., Pombo Antunes, A. R., Navarro, L., Ertveldt, T., Berdal, M., Nagachinta, S., De Ridder, K., Lahoutte, T., Keyaerts, M., Devoogdt, N., Goyvaerts, C., D'Huyvetter, M. & Breckpot, K., Jan 2025, In: European Journal of Nuclear Medicine and Molecular Imaging. 52, 2, p. 444-457 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)8 Downloads (Pure) -
Immune modulation following α and β- radionuclide therapy targeting fibroblast activation protein-α in a preclinical tumor model
Ceuppens, H., De Ridder, K., Ertveldt, T., Zeven, K., de Mey, W., Pombo Antunes, A. R., Navarro, L., Dumauthioz, N., Lahoutte, T., Debacker, J., Devoogdt, N., Keyaerts, M., D'Huyvetter, M., Goyvaerts, C. & Breckpot, K., 1 Dec 2025, In: Oncoimmunology. 14, 1, 16 p., 2540054.Research output: Contribution to journal › Article › peer-review
Open Access -
Novel Resin-Based Recovery of Astatine-211 : A Breakthrough for Efficient Radiolabeling
Navarro, L., Sevenois, M., Ertveldt, T., Zeven, K., Jensen, H. J., Haddad, F., D'Huyvetter, M. & Covens, P., 12 May 2025. 1 p.Research output: Unpublished contribution to conference › Poster
File4 Downloads (Pure) -
Generic semi-automated radiofluorination strategy for single domain antibodies: [18F]FB-labelled single domain antibodies for PET imaging of fibroblast activation protein-α or folate receptor-α overexpression in cancer
Dierick, H., Navarro, L., Ceuppens, H., Ertveldt, T., Pombo Antunes, A. R., Keyaerts, M., Devoogdt, N., Breckpot, K., D'Huyvetter, M., Lahoutte, T., Caveliers, V. & Bridoux, J., Dec 2024, In: EJNMMI Radiopharmacy and Chemistry. 9, 1, 14 p., 54.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)55 Downloads (Pure) -
Sustained release of a human pd-l1 single-domain antibody using peptide-based hydrogels
Heremans, J., Maximilian Awad, R., Bridoux, J., Ertveldt, T., Caveliers, V., Madder, A., Hoogenboom, R., Devoogdt, N., Ballet, S., Hernot, S., Breckpot, K. & Martin, C., Mar 2024, In: European Journal of Pharmaceutics and Biopharmaceutics. 196, 196, 21 p., 114183.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)224 Downloads (Pure)
Datasets
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DataSet-Targeted Radionuclide Therapy with Low and High-Dose Lutetium-177-Labeled Single Domain Antibodies Induces Distinct Immune Signatures in a Mouse Melanoma Model
Ertveldt, T. (Creator), De Beck, L. (Creator), De Ridder, K. (Creator), Locy, H. (Creator), de Mey, W. (Creator), Goyvaerts, C. (Creator), Lecocq, Q. (Creator), Ceuppens, H. (Creator), De Vlaeminck, Y. (Creator), Awad, R. M. (Creator), Keyaerts, M. (Creator), Devoogdt, N. (Creator), D'Huyvetter, M. (Creator), Breckpot, K. (Creator) & Krasniqi, A. (Creator), Zenodo, 16 Dec 2024
Dataset
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Nanobody-mediated SPECT/CT imaging reveals the spatiotemporal expression of programmed death-ligand 1 in response to a CD8+ T cell and iNKT cell activating mRNA vaccine
Breckpot, K. (Creator) & Ertveldt, T. (Creator), Theranostics, 16 Dec 2024
Dataset
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Dataset of Development and evaluation of nanobody tracers for noninvasive nuclear imaging of the immune-checkpoint TIGIT
De Groof, T. (Creator), Zeven, K. (Creator), Ceuppens, H. (Creator), Awad, R. M. (Creator), Ertveldt, T. (Creator), de Mey, W. (Creator), Meeus, F. (Creator), Raes, G. (Creator), Breckpot, K. (Creator) & Devoogdt, N. (Creator), Zenodo, 24 Mar 2025
Dataset
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B16-huCD20 tumors treated with 177Lu-TRT were subjected to multiplex analysis to study the tumor immune signature.
Ertveldt, T. (Creator), De Ridder, K. (Creator), Locy, H. (Creator) & Breckpot, K. (Creator), Gene Expression Omnibus (GEO), 2 Apr 2022
Dataset
Prizes
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File
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Marie-Louise Lottin Award
Ertveldt, T. (Recipient), Nov 2024
Prize: Prize (including medals and awards)
File
Activities
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Efficient α and β- radionuclide therapy targeting fibroblast activation protein-α in an aggressive preclinical mouse tumour model.
Ceuppens, H. (Speaker), Pombo Antunes, A. R. (Contributor), Navarro, L. (Contributor), Ertveldt, T. (Contributor), Berdal, M. (Contributor), Nagachinta, S. (Contributor), De Ridder, K. (Contributor), Keyaerts, M. (Contributor), Devoogdt, N. (Contributor), Goyvaerts, C. (Contributor), D'Huyvetter, M. (Contributor) & Breckpot, K. (Contributor)
23 Oct 2024Activity: Talk or presentation › Talk or presentation at a conference
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Cancer Biotherapy and Radiopharmaceuticals (Journal)
Ertveldt, T. (Peer reviewer)
1 Oct 2023 → 31 Oct 2023Activity: Publication peer-review and editorial work › Publication peer-review
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SCK NMA-talk
Ertveldt, T. (Presenter), Devoogdt, N. (Invited speaker) & D'Huyvetter, M. (Contributor)
14 Nov 2023Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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Development and evaluation of Nanobody tracers for non-invasive nuclear imaging of the next generation immune checkpoint TIGIT
Zeven, K. (Speaker), De Groof, T. (Contributor), Ceuppens, H. (Contributor), Awad, R. M. (Contributor), Ertveldt, T. (Contributor), Raes, G. (Contributor), Breckpot, K. (Contributor) & Devoogdt, N. (Contributor)
18 Sept 2023 → 20 Sept 2023Activity: Talk or presentation › Talk or presentation at a conference
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The development of radiolabeled nanobodies against the next-generation immune checkpoint TIGIT for non-invasive immune phenotyping of tumors
Zeven, K. (Speaker), De Groof, T. (Contributor), Awad, R. M. (Contributor), De Mey, W. (Contributor), Ertveldt, T. (Contributor), Ceuppens, H. (Contributor), De Jonghe, K. (Contributor), Raes, G. (Contributor), Keyaerts, M. (Contributor), Breckpot, K. (Contributor) & Devoogdt, N. (Contributor)
16 Mar 2023Activity: Talk or presentation › Talk or presentation at a conference
Thesis
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Immunogenic effect of targeted radionuclide therapy-induced tumor cell death
Ertveldt, T. ((PhD) Student), Breckpot, K. (Promotor), Keyaerts, M. (Co-promotor), D'Huyvetter, M. (Co-promotor) & Krasniqi, A. (Advisor), Krasniqi, A. (Promotor), 15 Jun 2019Student thesis: Master's Thesis