Projects per year
Personal profile
Expertise
Timo De Groof studied Biochemistry and Biotechnology at the University of Ghent where he graduated in 2015. During his master studies, he specialized both in Biomedical Biotechnology and Structural Biology and Biochemistry. During his last year of studies, De Groof performed research in the biopharmaceutical company Argenx and gained experience on the identification and characterization of llama-derived antibodies in inflammatory diseases and oncology.
From 2015 to 2019, De Groof worked as a PhD student in the Medicinal Chemistry group at VU University Amsterdam under the supervision of prof. dr. Martine Smit where he focused on development and characterization of nanobodies targeting viral G protein-coupled receptors while also focusing on different applications of these nanobodies as therapeutics and research tools.
Starting from September 2019, De Groof started working as a postdoctoral researcher in the In Vivo Cellular and Molecular Imaging (ICMI) group under the supervision of prof. dr. Nick Devoogdt where he will be focusing on the development of nanobodies targeting immune cells as part of the Immune Image project.
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Projects
- 1 Active
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IOFPOC42: IOF PoC “MOTIF: MOdification of T cells In situ for altered Functionality”
Devoogdt, N., Breckpot, K., Meeus, F., De Groof, T. & De Vlaeminck, Y.
1/01/21 → 31/12/22
Project: Applied
Research output
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Emerging applications of nanobodies in cancer therapy
Awad, R. M., Meeus, F., Ceuppens, H., Ertveldt, T., Hanssens, H., Lecocq, Q., Mateusiak, L., Zeven, K., Valenta, H., De Groof, T. W. M., De Vlaeminck, Y., Krasniqi, A., De Veirman, K., Goyvaerts, C., D'Huyvetter, M., Hernot, S., Devoogdt, N. & Breckpot, K., 2022, In : International review of cell and molecular biology. 369, p. 143-199 57 p.Research output: Contribution to journal › Article
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Imaging and therapeutic targeting of the tumor immune microenvironment with biologics
Arnouk, S., De Groof, T. & Van Ginderachter, J., May 2022, In : Advanced Drug Delivery Reviews. 184, 114239.Research output: Contribution to journal › Scientific review
Open Access -
In Vitro Assessment of Binding Affinity, Selectivity, Uptake, Intracellular Degradation, and Toxicity of Nanobody-Photosensitizer Conjugates
De Groof, T., Beltrán Hernández, I., Heukers, R. & Oliveira, S., 4 May 2022, Photodynamic Therapy. Springer, p. 505-520 16 p. (Methods in Molecular Biology; vol. 2451).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Mechanisms underlying connexin hemichannel activation in disease
Van Campenhout, R., Coelho Gomes, A. R., De Groof, T., Muyldermans, S., Devoogdt, N. & Vinken, M., 1 Apr 2021, In : International Journal of Molecular Sciences. 22, 7, p. 1-13 13 p., 3503.Research output: Contribution to journal › Article
Open AccessFile7 Citations (Scopus)174 Downloads (Pure) -
Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies
De Groof, T., Bergkamp, N. D., Heukers, R., Giap, T., Bebelman, M. P., Goeij-de Haas, R., Piersma, S., Jimenez, C., Garcia, K. C., Ploegh, H., Siderius, M. & Smit, M. J., 1 Dec 2021, In : Nature Communications. 12, 1, p. 4357 17 p., 4357.Research output: Contribution to journal › Article
Open AccessFile2 Citations (Scopus)59 Downloads (Pure)
Prizes
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AIMMS annual meeting PhD oral presentation competition 2018
Timo De Groof (Recipient), Apr 2018
Prize: Prize (including medals and awards)
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AIMMS annual meeting poster prize award 2016
Timo De Groof (Recipient), Apr 2016
Prize: Prize (including medals and awards)
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FIGON DMD Medicinal Chemistry PhD poster prize award 2017
Timo De Groof (Recipient), Oct 2017
Prize: Prize (including medals and awards)
Activities
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Biomolecules (Journal)
Nick Devoogdt (Editor), Serge Muyldermans (Editor), Timo De Groof (Editor), Sophie Hernot (Editor)2021 → …Activity: Publication peer-review and editorial work › Editorial activity
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2021-80
Nick Devoogdt (Supervisor), Timo De Groof (Contributor), Fien Meeus (Contributor), Karine Breckpot (Contributor), Yannick De Vlaeminck (Contributor)2021 → …Activity: Other
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Nanobodies in Drug Discovery Research
Timo De Groof (Speaker)3 Dec 2021Activity: Talk or presentation › Talk at an external academic organisation
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Nanobody discovery and biotechnological applications
Timo De Groof (Speaker)20 Apr 2021Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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Nanobodies targeting and modulating the oncogenic viral GPCR US28
Timo De Groof (Speaker)5 Oct 2018Activity: Talk or presentation › Talk or presentation at a conference
Thesis
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Characterization of CD69-targeting nanobodies as immunotracers
Author: Ndini, T., Van Ginderachter, J., Devoogdt, N., Vincke, C. & De Groof, T., Sep 2021Student thesis: Master's Thesis
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Development of a CD8-targeting immunotracer for non-invasive imaging of cytotoxic T-cells
Author: Aziz Ouazzani, W., Van Ginderachter, J., Devoogdt, N., Vincke, C. & De Groof, T., 2 Sep 2021Supervisor: Lauwers, Y. (Promotor)
Student thesis: Master's Thesis
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US28 nanobodies: A ‘VUN' example of targeting viral GPCRs
Author: Devoogdt, N., De Groof, T. & Smit, M. J., 8 May 2020Student thesis: Doctoral Thesis