Projects per year
Personal profile
Expertise
Timo De Groof studied Biochemistry and Biotechnology at the University of Ghent where he graduated in 2015. During his master studies, he specialized both in Biomedical Biotechnology and Structural Biology and Biochemistry. During his last year of studies, De Groof performed research in the biopharmaceutical company Argenx and gained experience on the identification and characterization of llama-derived antibodies in inflammatory diseases and oncology.
From 2015 to 2019, De Groof worked as a PhD student in the Medicinal Chemistry group at VU University Amsterdam under the supervision of prof. dr. Martine Smit where he focused on development and characterization of nanobodies targeting viral G protein-coupled receptors while also focusing on different applications of these nanobodies as therapeutics and research tools.
Starting from September 2019, De Groof started working as a postdoctoral researcher in the In Vivo Cellular and Molecular Imaging (ICMI) group under the supervision of prof. dr. Nick Devoogdt where he will be focusing on the development of nanobodies targeting immune cells as part of the Immune Image project.
Fingerprint
- 1 Similar Profiles
Network
Projects
- 1 Active
-
IOFPOC42: IOF PoC “MOTIF: MOdification of T cells In situ for altered Functionality”
Devoogdt, N., Breckpot, K., Meeus, F., De Groof, T. & De Vlaeminck, Y.
1/01/21 → 31/12/22
Project: Applied
Research output
-
Therapeutic Nanobodies Targeting Cell Plasma Membrane Transport Proteins: A High-Risk/High-Gain Endeavor
Van Campenhout, R., Muyldermans, S., Vinken, M., Devoogdt, N. & De Groof, T., 6 Jan 2021, In : Biomolecules. 11, 1, p. 1-19 19 p., 63.Research output: Contribution to journal › Article
Open AccessFile7 Downloads (Pure) -
The Therapeutic and Diagnostic Potential of Nanobodies
Devoogdt, N. (Guest ed.), De Groof, T. (Guest ed.), Muyldermans, S. (Guest ed.) & Hernot, S. (Guest ed.), 2021, In : Biomolecules.Research output: Contribution to journal › Special issue
-
Targeting the latent human cytomegalovirus reservoir with virus specific nanobodies
De Groof, T., Elder, E., Heukers, R., Lim, E., Wills, M., Sinclair, J. & Smit, M., 13 May 2020, In : BIORXIV. 2020, 29 p.Research output: Contribution to journal › Article
File -
Antibodies targeting chemokine receptors CXCR4 and ACKR3
Bobkov, V., Arimont, M., Zarca, A., De Groof, T., van der Woning, B., de Haard, H. & Smit, M. J., Dec 2019, In : Molecular Pharmacology. 96, 6, p. 753-764 12 p.Research output: Contribution to journal › Article
10 Citations (Scopus) -
Nanobodies: New avenues for imaging, stabilizing and modulating GPCRs
De Groof, T. W. M., Bobkov, V., Heukers, R. & Smit, M. J., 15 Mar 2019, In : Molecular and Cellular Endocrinology. 484, p. 15-24 10 p.Research output: Contribution to journal › Scientific review
16 Citations (Scopus)
Prizes
-
AIMMS annual meeting PhD oral presentation competition 2018
Timo De Groof (Recipient), Apr 2018
Prize: Prize (including medals and awards)
-
AIMMS annual meeting poster prize award 2016
Timo De Groof (Recipient), Apr 2016
Prize: Prize (including medals and awards)
-
-
-
FIGON DMD Medicinal Chemistry PhD poster prize award 2017
Timo De Groof (Recipient), Oct 2017
Prize: Prize (including medals and awards)
Activities
-
2021-80
Nick Devoogdt (Supervisor), Timo De Groof (Contributor), Fien Meeus (Contributor), Karine Breckpot (Contributor), Yannick De Vlaeminck (Contributor)2021 → …Activity: Other
-
Nanobodies targeting HCMV-encoded receptor US28 as modulators of US28 function and means to eradicate US28-expressing cells.
Timo De Groof (Speaker)Jul 2018Activity: Talk or presentation › Talk or presentation at a conference
-
Nanobodies targeting and modulating the oncogenic viral GPCR US28
Timo De Groof (Speaker)5 Oct 2018Activity: Talk or presentation › Talk or presentation at a conference
-
Nanobodies targeting and modulating the oncogenic viral GPCR US28
Timo De Groof (Speaker)2 Oct 2018Activity: Talk or presentation › Talk or presentation at a conference
-
Nanobodies targeting and modulating the oncogenic viral GPCR US28
Timo De Groof (Speaker)12 Apr 2018Activity: Talk or presentation › Talk or presentation at a conference
Thesis
-
US28 nanobodies: A ‘VUN' example of targeting viral GPCRs
Author: Devoogdt, N., De Groof, T. & Smit, M. J., 8 May 2020Student thesis: Doctoral Thesis