Projects per year
Personal profile
Expertise
Timo De Groof studied Biochemistry and Biotechnology at the University of Ghent where he graduated in 2015. During his master studies, he specialized both in Biomedical Biotechnology and Structural Biology and Biochemistry. During his last year of studies, De Groof performed research in the biopharmaceutical company Argenx and gained experience on the identification and characterization of llama-derived antibodies in inflammatory diseases and oncology.
From 2015 to 2019, De Groof worked as a PhD student in the Medicinal Chemistry group at VU University Amsterdam under the supervision of prof. dr. Martine Smit where he focused on development and characterization of nanobodies targeting viral G protein-coupled receptors while also focusing on different applications of these nanobodies as therapeutics and research tools.
Starting from September 2019, De Groof started working as a postdoctoral researcher in the In Vivo Cellular and Molecular Imaging (ICMI) group under the supervision of prof. dr. Nick Devoogdt. His research focuses on the non-invasive clinical imaging of immune cells using nanobodies (as part of the Horizon 2020 Innovative Medicine Initiative “Immune Image project”).
Starting from November 2022, De Groof has obtained a personal FWO junior postdoctoral grant to further investigate the role of viral G protein-coupled receptors in viral immune evasion in oncology using modulatory nanobodies.
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Collaborations and top research areas from the last five years
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FWOTM1119: INVISIBLE: Investigation and inhibition of Epstein-Barr Virus immune evasion by BILF1-modulating nanobodies
1/11/22 → 31/10/25
Project: Fundamental
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IOFPOC42: IOF PoC “MOTIF: MOdification of T cells In situ for altered Functionality”
Devoogdt, N., Breckpot, K., Meeus, F., De Groof, T. & De Vlaeminck, Y.
1/01/21 → 31/12/22
Project: Applied
Research output
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A few good reasons to use nanobodies for cancer treatment
Jumapili, N. A., Zivalj, M., Barthelmess, R. M., Raes, G., De Groof, T. W. M., Devoogdt, N., Stijlemans, B., Vincke, C. & Van Ginderachter, J. A., Sep 2023, In: European Journal of Immunology. 53, 9, p. e2250024 2250024.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)2 Downloads (Pure) -
Characterization of CD163-specific nanobody-based immunotracers for non-invasive imaging of immunosuppressive macrophages
Lauwers, Y., De Groof, T., Emami, M., Vincke, C., Van Craenenbroeck, J., Raes, G., Van Ginderachter, J. & Devoogdt, N., 16 Oct 2023.Research output: Unpublished contribution to conference › Poster
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Characterization of CD163-specific nanobody-based immunotracers for non-invasive imaging of immunosuppressive macrophages.
Lauwers, Y., De Groof, T., Emami, M., Vincke, C., Van Craenenbroeck, J., Raes, G., Van Ginderachter, J. & Devoogdt, N., 2023.Research output: Unpublished contribution to conference › Poster
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Current status and future expectations of nanobodies in oncology trials
De Pauw, T., De Mey, L., Debacker, J., Raes, G., Van Ginderachter, J., De Groof, T. & Devoogdt, N., Sep 2023, In: Expert Opinion on Investigational Drugs. 32, 8, p. 705-721 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Downloads (Pure) -
Development and evaluation of nanobody tracers for noninvasive nuclear imaging of the immune-checkpoint TIGIT
Zeven, K., De Groof, T. W. M., Ceuppens, H., Awad, R. M., Ertveldt, T., de Mey, W., Meeus, F., Raes, G., Breckpot, K. & Devoogdt, N., 20 Sep 2023, In: Frontiers in Immunology. 14, 1, 16 p., 1268900.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure)
Prizes
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AIMMS annual meeting PhD oral presentation competition 2018
De Groof, Timo (Recipient), Apr 2018
Prize: Prize (including medals and awards)
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AIMMS annual meeting poster prize award 2016
De Groof, Timo (Recipient), Apr 2016
Prize: Prize (including medals and awards)
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FIGON DMD Medicinal Chemistry PhD poster prize award 2017
De Groof, Timo (Recipient), Oct 2017
Prize: Prize (including medals and awards)
Activities
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The use of a CD163-specific nanobody-based immunotracer as a clinical imaging agent to study immunosuppressive tumor-associated macrophages
Yoline Lauwers (Contributor), Timo De Groof (Contributor), Maral Emami (Contributor), Cecile Vincke (Speaker), Jolien Van Craenenbroeck (Contributor), Geert Raes (Contributor), Jo Van Ginderachter (Contributor) & Nick Devoogdt (Contributor)
16 Oct 2023Activity: Talk or presentation › Talk or presentation at a conference
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Characterization of CD163-specific nanobody-based immunotracers for non-invasive imaging of immunosuppressive macrophages
Yoline Lauwers (Speaker), Timo De Groof (Contributor), Nick Devoogdt (Contributor), Jo Van Ginderachter (Contributor), Maral Emami (Contributor), Cecile Vincke (Contributor) & Geert Raes (Contributor)
14 Mar 2023 → 17 Mar 2023Activity: Talk or presentation › Talk or presentation at a conference
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Development and evaluation of Nanobody tracers for non-invasive nuclear imaging of the next generation immune checkpoint TIGIT
Katty Zeven (Speaker), Timo De Groof (Contributor), Hannelore Ceuppens (Contributor), Robin Maximilian Awad (Contributor), Thomas Ertveldt (Contributor), Geert Raes (Contributor), Karine Breckpot (Contributor) & Nick Devoogdt (Contributor)
18 Sep 2023 → 20 Sep 2023Activity: Talk or presentation › Talk or presentation at a conference
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In vivo optical imaging of glioma using a novel uPAR-targeting fluorescent single-domain antibody
Lukasz Mateusiak (Speaker), Sam Floru (Contributor), Timo De Groof (Contributor), Noemi Declerck (Contributor), Janne Wouters (Contributor), Simone Janssen (Contributor), Pieterjan Debie (Contributor), Katty Zeven (Contributor), Cecile Vincke (Contributor), Janik Puttemans (Contributor), Marcus Stroet (Contributor), Karine Breckpot (Contributor), Nick Devoogdt (Contributor) & Sophie Hernot (Contributor)
16 Mar 2023Activity: Talk or presentation › Talk or presentation at a conference
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The use of a CD163-specific nanobody-based immunotracer as a clinical imaging agent to study immunosuppressive tumor-associated macrophages
Yoline Lauwers (Speaker), Timo De Groof (Contributor), Cecile Vincke (Contributor), Jolien Van Craenenbroeck (Contributor), Nick Devoogdt (Contributor), Geert Raes (Contributor) & Jo Van Ginderachter (Contributor)
19 Sep 2023Activity: Talk or presentation › Talk or presentation at a conference
Thesis
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Characterization of CD69-targeting nanobodies as immunotracers
Author: Ndini, T., Van Ginderachter, J., Devoogdt, N., Vincke, C. & De Groof, T., Sep 2021Student thesis: Master's Thesis
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Development of a CD8-targeting immunotracer for non-invasive imaging of cytotoxic T-cells
Author: Aziz Ouazzani, W., Van Ginderachter, J., Devoogdt, N., Vincke, C. & De Groof, T., 2 Sep 2021Supervisor: Lauwers, Y. (Promotor)
Student thesis: Master's Thesis