Projects per year
Personal profile
Expertise
Timo De Groof studied Biochemistry and Biotechnology at the University of Ghent where he graduated in 2015. During his master studies, he specialized both in Biomedical Biotechnology and Structural Biology and Biochemistry. During his last year of studies, De Groof performed research in the biopharmaceutical company Argenx and gained experience on the identification and characterization of llama-derived antibodies in inflammatory diseases and oncology.
From 2015 to 2019, De Groof worked as a PhD student in the Medicinal Chemistry group at VU University Amsterdam under the supervision of prof. dr. Martine Smit where he focused on development and characterization of nanobodies targeting viral G protein-coupled receptors while also focusing on different applications of these nanobodies as therapeutics and research tools.
Starting from September 2019, De Groof started working as a postdoctoral researcher in the In Vivo Cellular and Molecular Imaging (ICMI) group under the supervision of prof. dr. Nick Devoogdt. His research focuses on the non-invasive clinical imaging of immune cells using nanobodies (as part of the Horizon 2020 Innovative Medicine Initiative “Immune Image project”).
Starting from November 2022, De Groof has obtained a personal FWO junior postdoctoral grant to further investigate the role of viral G protein-coupled receptors in viral immune evasion in oncology using modulatory nanobodies.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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OZR4288: Financiering MZW OZR: RAPTOR: Rapid Analysis and production of Proteins for clinical Translation using biacORe and bioreactOR systems.
Devoogdt, N., Hernot, S., De Groof, T., Ballet, S., Stijlemans, B., Massie, A., Rooman, I., Keyaerts, M., Raes, G., De Kock, J., Breckpot, K., De Veirman, K. & Caveliers, V.
24/04/24 → 24/04/28
Project: Fundamental
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OZR4286: Financiering MZW OZR: DELI-SORT: MACSQuant® Tyto for sterile DELicate Immune cells SORTing
Laoui, D., Vanginderachter, J. A., Magez, S., Tuyaerts, S., Fioravanti, A., Devoogdt, N., Van der Henst, C., Raes, G., Stijlemans, B., Hadadi, E., De Trez, C., Ruytinx, J., Brunner, J., De Groof, T. & De Veirman, K.
24/04/24 → 24/04/28
Project: Fundamental
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FWOTM1119: INVISIBLE: Investigation and inhibition of Epstein-Barr Virus immune evasion by BILF1-modulating nanobodies
1/11/22 → 31/10/25
Project: Fundamental
Research output
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Advancements in Nuclear Imaging Using radiolabeled Nanobody tracers to support Cancer Immunotherapy
Zeven, K., Lauwers, Y., De Mey, L., Debacker, J., De Pauw, T., De Groof, T. & Devoogdt, N., 26 Aug 2024, In: Immunotherapy Advances. 4, 1, 11 p., Itae006.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
AXL-specific single domain antibodies show diagnostic potential and anti-tumor activity in Acute Myeloid Leukemia
Vandewalle, N., Satilmis, H., Verheye, E., Fan, R., Wang, Y., De Groof, T., Bridoux, J., kerre, T., De Beule, N., De Becker, A., De Bruyne, E., Menu, E., Vanderkerken, K., Breckpot, K., Devoogdt, N. & De Veirman, K., 15 Apr 2024, In: Theranostics. 14, 7, p. 2656-2674 19 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Generation and Characterization of Novel Pan-Cancer Anti-uPAR Fluorescent Nanobodies as Tools for Image-Guided Surgery
Mateusiak, Ł., Floru, S., De Groof, T. W. M., Wouters, J., Declerck, N. B., Debie, P., Janssen, S., Zeven, K., Breckpot, K., Puttemans, J., Vincke, C., Devoogdt, N. & Hernot, S., Aug 2024, In: Advanced Science. 11, 30, 11 p., e2400700.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Noninvasive nuclear imaging of the immune checkpoint TIGIT using different nanobody-scaffolds and radionuclides
Zeven, K., Dierick, H., Sevenois, M., Baudhuin, H. V., Bridoux, J., Navarro, L., De Groof, T., Raes, G., Breckpot, K. & Devoogdt, N., 13 Mar 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Scrutiny of chimeric antigen receptor activation by the extracellular domain: experience with single domain antibodies targeting multiple myeloma cells highlights the need for case-by-case optimization
Hanssens, H., Meeus, F., De Vlaeminck, Y., Lecocq, Q., Puttemans, J., Debie, P., De Groof, T. W. M., Goyvaerts, C., De Veirman, K., Breckpot, K. & Devoogdt, N., 2024, In: Frontiers in Immunology. 15, 15 p., 1389018.Research output: Contribution to journal › Article › peer-review
Open Access
Prizes
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AIMMS annual meeting PhD oral presentation competition 2018
De Groof, Timo (Recipient), Apr 2018
Prize: Prize (including medals and awards)
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AIMMS annual meeting poster prize award 2016
De Groof, Timo (Recipient), Apr 2016
Prize: Prize (including medals and awards)
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FIGON DMD Medicinal Chemistry PhD poster prize award 2017
De Groof, Timo (Recipient), Oct 2017
Prize: Prize (including medals and awards)
Activities
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Nanobody-based pannexin1 channel inhibitors reduce inflammation in acute liver injury
Raf Van Campenhout (Speaker), Timo De Groof (Contributor), Prashant Kadam (Contributor), Brenda R. Kwak (Contributor), Serge Muyldermans (Contributor), Nick Devoogdt (Contributor) & Mathieu Vinken (Contributor)
24 Jul 2024 → 31 Jul 2024Activity: Talk or presentation › Talk or presentation at a conference
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The use of a CD163-specific nanobody-based immunotracer as an imaging agent to study tumor-associated macrophages.
Yoline Lauwers (Speaker), Timo De Groof (Contributor), Cecile Vincke (Contributor), Jolien Van Craenenbroeck (Contributor), Geert Raes (Contributor), Nick Devoogdt (Contributor) & Jo Van Ginderachter (Contributor)
18 Apr 2024Activity: Talk or presentation › Talk or presentation at a conference
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AXL-specific single domain antibodies show diagnostic potential and anti-tumor activity in Acute Myeloid Leukemia
Niels Vandewalle (Presenter), Hatice Satilmis (Contributor), Emma Verheye (Contributor), Yanmeng Wang (Contributor), Timo De Groof (Contributor), Nathan De Beule (Contributor), Tessa kerre (Contributor), Nathan De Beule (Contributor), Ann De Becker (Contributor), Elke De Bruyne (Contributor), Eline Menu (Contributor), Karin Vanderkerken (Contributor), Karine Breckpot (Contributor), Nick Devoogdt (Contributor) & Kim De Veirman (Contributor)
12 Mar 2024Activity: Talk or presentation › Talk or presentation at a conference
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The use of a CD163-specific nanobody-based immunotracer as a clinical imaging agent to study immunosuppressive tumor-associated macrophages
Yoline Lauwers (Contributor), Timo De Groof (Contributor), Maral Emami (Contributor), Cecile Vincke (Speaker), Jolien Van Craenenbroeck (Contributor), Geert Raes (Contributor), Jo Van Ginderachter (Contributor) & Nick Devoogdt (Contributor)
11 Mar 2024 → 13 Mar 2024Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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Evaluation of nanobody-scaffolds as nuclear imaging tracers for noninvasive detection of the next generation immune checkpoint TIGIT
Katty Zeven (Speaker), Herlinde Dierick (Contributor), Matthijs Sevenois (Contributor), Henri Vincent Baudhuin (Contributor), Jessica Bridoux (Contributor), Laurent Navarro (Contributor), Timo De Groof (Contributor), Geert Raes (Contributor), Karine Breckpot (Contributor) & Nick Devoogdt (Contributor)
26 Aug 2024 → 30 Aug 2024Activity: Talk or presentation › Talk or presentation at a conference
Press/Media
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VUB team develops breakthrough nanobody technology against liver inflammation
Raf Van Campenhout, Mathieu Vinken, Nick Devoogdt & Timo De Groof
8/12/23
1 item of Media coverage
Press/Media: Other
Thesis
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Characterization of CD69-targeting nanobodies as immunotracers
Author: Ndini, T., Van Ginderachter, J., Devoogdt, N., Vincke, C. & De Groof, T., Sep 2021Student thesis: Master's Thesis
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Development of a CD8-targeting immunotracer for non-invasive imaging of cytotoxic T-cells
Author: Aziz Ouazzani, W., Van Ginderachter, J., Devoogdt, N., Vincke, C. & De Groof, T., 2 Sep 2021Supervisor: Lauwers, Y. (Promotor)
Student thesis: Master's Thesis