Projects per year
Personal profile
Expertise
Development of radiopharmaceuticals for PET and radionuclide therapy applications based on camelid single domain antibody fragments (also called VHH or Nanobodies).
Optimization of (automated) radiolabeling procedures, purification methods and formulation. In vitro and in vivo evaluation of new radiopharmaceutical probes in terms of biodistribution, in vivo stability and targeting potential. Translation of preclinically validated tracers to early phase clinical trials, including fulfilling all regulatory requirements.
GMP manufacturing of radiopharmaceuticals.
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Collaborations and top research areas from the last five years
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FWOIRI10: Research on radioactive nuclei at ISOLDE-CERN, SPIRAL2- GANIL and MEDICIS-CERN
Caveliers, V. & D'Huyvetter, M.
1/01/23 → 31/12/26
Project: Fundamental
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HERC59: CASA PETIt: CAmera for Small Animal PET-Imaging
Devoogdt, N., Raes, G., Lahoutte, T., Van Ginderachter, J., Caveliers, V., Keyaerts, M., Hernot, S. & D'Huyvetter, M.
1/05/22 → 30/04/26
Project: Fundamental
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FWOSB114: Development of a novel chemoenzymatic technology to generate radiofluorinated PET tracers
Declercq, S., Devoogdt, N., Bridoux, J. & Caveliers, V.
1/11/21 → 31/10/26
Project: Fundamental
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IOF3018: GEAR: TOPGUN: Peptidomimetic TheranOstics develoPment and GMP prodUctioN platform
Ballet, S., Caveliers, V., Martin, C., Barlow, T. & Bridoux, J.
1/01/21 → 31/12/25
Project: Applied
Research output
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A comparison of [68Ga]Ga-NOTA-anti-HER2-sdAb PET/CT with [18F]FDG-PET/CT in breast carcinoma patients.
Gondry, O., Xavier, C., Heemskerk, J., Raes, L. A. J., Debacker, J., De Geeter, F., Fontaine, C., Vanhoeij, M., Aspeslagh, S., Joris, S., De Grève, J., Verfaillie, G., Luyten, I., De Mey, L., Vandenbroucke, F., Waelput, W., Glorieus, K., Bourgeois, S., Cousaert, J., Vaneycken, I. & 5 others, , 2023.Research output: Unpublished contribution to conference › Unpublished abstract
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A realistic multiregion mouse kidney dosimetry model to support the preclinical evaluation of potential nephrotoxicity of radiopharmaceutical therapy
Vargas, C. S., Struelens, L., D'Huyvetter, M., Caveliers, V. & Covens, P., 1 Mar 2023, In: Journal of Nuclear Medicine. 64, 3, p. 493-499 7 p., 264453.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Phase I Study of [68Ga]Ga-Anti-CD206-sdAb for PET/CT Assessment of Protumorigenic Macrophage Presence in Solid Tumors (MMR Phase I)
Gondry, O., Xavier, C., Raes, L., Heemskerk, J., Devoogdt, N., Everaert, H., Breckpot, K., Lecocq, Q., Decoster, L., Fontaine, C., Schallier, D., Aspeslagh, S., Vaneycken, I., Raes, G., Van Ginderachter, J. A., Lahoutte, T., Caveliers, V. & Keyaerts, M., Sep 2023, In: Journal of Nuclear Medicine. 64, 9, p. 1378-1384 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)1 Downloads (Pure) -
Site-specifically versus randomly THP-functionalized hPD-L1 single domain antibody; preliminary data toward kit development
Dierick, H., Baudhuin, H. V., Caveliers, V. & Bridoux, J., 2023, (Unpublished).Research output: Unpublished contribution to conference › Unpublished abstract
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A multi-region model of a mouse kidney for preclinical internal dosimetry of beta- and alpha-particle emitting radionuclides
Saldarriaga Vargas, C., Struelens, L., D'Huyvetter, M., Caveliers, V. & Covens, P., 22 Sep 2022, In: European Journal of Nuclear Medicine and Molecular Imaging. 49, SUPPL 1, p. 208-208 1 p., OP-623.Research output: Contribution to journal › Meeting abstract (Journal)
Prizes
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ESMI presentation award for best oral presentation
Bridoux, Jessica (Recipient), Broos, K. (Recipient), Lecocq, Quentin (Recipient), Crauwels, M. (Recipient), Martin, Charlotte (Recipient), Cleeren, F. (Recipient), Kondrashov, M. (Recipient), Ballet, Steven (Recipient), Bormans, G. (Recipient), Schou, M. (Recipient), Elmore, C. (Recipient), Raes, Geert (Recipient), Breckpot, Karine (Recipient), Muyldermans, Serge (Recipient), Devoogdt, Nick (Recipient), Keyaerts, Marleen (Recipient), Caveliers, Vicky (Recipient) & Xavier, Catarina (Recipient), 17 Jan 2020
Prize: Prize (including medals and awards)
Activities
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The future Radiopharmacy: challenge and/or opportunity?
Vicky Caveliers (Speaker)
22 Apr 2023Activity: Talk or presentation › Talk or presentation at a conference
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Site-specifically THP-functionalized hPD-L1 single domain antibody; preliminary data toward kit development
Herlinde Dierick (Speaker), Henri Vincent Baudhuin (Contributor), Vicky Caveliers (Contributor) & Jessica Bridoux (Contributor)
26 May 2023Activity: Talk or presentation › Talk or presentation at a conference
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EXPLORING THE POTENTIAL OF [18F]ALF-PSMA-11 FOR PROSTATE CANCER IMAGING (Event)
Sarah Piron (Presenter) & Vicky Caveliers (Jury)
13 Jan 2023Activity: Membership › Member of PhD committee
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Using the site-specific radiolabeling of a PD-L1 nanobody via maleimide–cysteine chemistry to develop a PET-tracer as screening tool for personalized oncology treatment
Dora Mugoli Chigoho (Speaker), Jessica Bridoux (Speaker), Catarina Xavier (Speaker), Vicky Caveliers (Speaker), Marleen Keyaerts (Speaker), Nick Devoogdt (Speaker), Karine Breckpot (Speaker), Robin Maximilian Awad (Speaker) & Quentin Lecocq (Speaker)
7 May 2022Activity: Talk or presentation › Talk or presentation at a conference
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A multi-region model of a mouse kidney for preclinical internal dosimetry of beta- and alpha-particle emitting radionuclides
Clarita Saldarriaga Vargas (Speaker), Lara Struelens (Contributor), Matthias D'Huyvetter (Contributor), Vicky Caveliers (Contributor) & Peter Covens (Contributor)
18 Oct 2022Activity: Talk or presentation › Talk or presentation at a conference
Press/Media
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Ontwikkeling van nanobodies voor de visualisatie van tumoren.
11/12/17
1 Media contribution
Press/Media: Research
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Kikkers gebruiken moleculen als micro-giftanden om roofdieren te vergiftigen
Kim Roelants, Vicky Caveliers, Sophie Hernot & Cindy Peleman
16/11/17
1 Media contribution
Press/Media: Research
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Tackling a shortage of PET scientists and improving healthcare
Jessica Bridoux, Vicky Caveliers & Catarina Xavier
1/10/17
1 Media contribution
Press/Media: Research
Thesis
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Amino acids in oncology diagnostics: Development of new PET probes targeting the glutamine transporter ASCT-2
Author: Baguet, T., De Vos, F., Van Calenbergh, S. & Caveliers, V., 3 Jul 2020Student thesis: Doctoral Thesis
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A multistep manufacturing protocol for the site-specific radiolabeling of a nanobody with [18F]Al.
Author: Vanmarcke, S. G., Caveliers, V. & Bridoux, J., 13 Jun 2018Student thesis: Master's Thesis
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Analysis of glutamate transporter expression in post mortem tissue of depressed patients
Author: Rubbens, N., Demuyser, T., Massie, A., Smolders, I. & Caveliers, V., 2016Supervisor: Demuyser, T. (Promotor)
Student thesis: Master's Thesis
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Analytical method validation of radiopharmaceutical [18F]PSMA-7 in a GMP environment
Author: ten Haaf, M. & Caveliers, V., 17 Jun 2022Student thesis: Master's Thesis
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Bepaling van de plasmastabiliteit van een synthetisch peptide en preliminair onderzoek naar het minimaliseren van peptide-adsorptie tijdens microdialyse
Author: Van den Borre, L., Van Eeckhaut, A., Caveliers, V. & Doktorova, T., 10 Jun 2015Student thesis: Master's Thesis