Research output per year
Research output per year
Personal profile
Research interests
Liver diseases, including liver fibrosis, cirrhosis, and cancer, present a significant global health challenge with a major burden of disease. Liver fibrosis, characterized by abnormal scar tissue accumulation in the liver, is primarily induced by activated hepatic stellate cells following liver damage. Currently, treatment options for liver fibrosis are limited to addressing the underlying cause or liver transplantation. However, these options are often not possible. My research focuses on investigating hepatic stellate cells using techniques such as transcriptomics to uncover novel insights into their role in liver fibrosis. Through this, we aim to develop innovative treatment strategies to combat liver fibrosis.
Education/Academic qualification
medical sciences, Doctoral degree , Hepatic Stellate Cell Transcriptional Dynamics in Liver Fibrosis, Vrije Universiteit Brussel
1 Oct 2017 → 20 Jun 2022
Award Date: 20 Jun 2022
Medicine, Master, Vrije Universiteit Brussel
20 Sept 2013 → 29 Jun 2017
Award Date: 29 Jun 2017
Medicine, United States Medical Licensing Examination ® (USMLE®) Step 1
28 Sept 2016
Award Date: 28 Sept 2016
Medicine, Bachelor, Vrije Universiteit Brussel
20 Sept 2010 → 5 Jul 2013
Award Date: 5 Jul 2013
Specialistische Geneeskunde - Gastroenterologie, Master-na-master, Vrije Universiteit Brussel
1 Aug 2017 → …
External positions
Arts-Specialist in Opleiding, Universitair Ziekenhuis Brussel
1 Aug 2017 → …
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Drug-induced liver injury in biopsy-scaled Precision-Cut Liver Slices
Lobo, M., Eysackers, N., Smout, A., Verhulst, S., Messaoudi, N., De Smet, V. & van Grunsven, L. A., 9 May 2025.Research output: Unpublished contribution to conference › Poster
Open Access -
Hepatic stellate cell single cell atlas reveals a highly similar activation process across liver disease aetiologies
Merens, V., Knetemann, E., Gürbüz, E., De Smet, V., Messaoudi, N., Reynaert, H., Verhulst, S. & van Grunsven, L. A., Jan 2025, In: JHEP reports. 7, 1, p. 1-12 12 p., 101223.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)15 Downloads (Pure) -
GPR176 Expression Correlates With Hepatic Stellate Cell Activation In Metabolic Dysfunction-Associated Steatotic Liver Disease And Chronic Viral Hepatitis
De Smet, V., Gürbüz, E., Eysackers, N., Smout, A., Lefesvre, P., Messaoudi, N., Mannaerts, I., Verhulst, S. & van Grunsven, L. A., 2024, In: Acta Gastro-Enterologica Belgica. Vol 87 (S1), 1 p., A04.Research output: Contribution to journal › Meeting abstract (Journal)
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Hemorrhagic Shock In Upper GI Bleeding
Bourgeois, A., Attar, A., Abdessalami, M., De Smet, V., Carini, A. & Eisendrath, P., 2024, In: Acta Gastro-Enterologica Belgica. Vol 87 (S1), 1 p., G33.Research output: Contribution to journal › Meeting abstract (Journal)
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Human iPSC-derived liver co-culture spheroids to model liver fibrosis
Cools, L., Kazemzadeh Dastjerd, M., Smout, A., Merens, V., Yang, Y., Reynaert, H., Messaoudi, N., De Smet, V., Kumar, M., Verhulst, S., Verfaillie, C. & van Grunsven, L. A., 28 Jun 2024, In: Biofabrication. 16, 3, p. 1-18 18 p., 035032.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)81 Downloads (Pure)
Datasets
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Transcriptional dynamics of hepatic stellate cells during first hours of in vitro activation
De Smet, V. (Creator), Gene Expression Omnibus (GEO), 5 May 2021
DOI: 10.1038/s41419-021-04377-1, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE173920
Dataset
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The orphan receptor GPR176 in hepatic stellate cells exerts a profibrotic role during chronic liver diseases
De Smet, V. (Creator), Zenodo, 18 Dec 2023
DOI: 10.5281/zenodo.10401819, https://zenodo.org/records/10528667
Dataset
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Transcriptional dynamics of hepatic stellate cells in experimental acute liver injury, liver fibrosis and liver fibrosis reversal.
De Smet, V. (Creator), Gene Expression Omnibus (GEO), 2 Jun 2021
DOI: 10.1038/s41419-021-04377-1, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE176042
Dataset
Prizes
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BASL best basic abstract award
De Smet, Vincent (Recipient), 4 Mar 2021
Prize: Prize (including medals and awards)
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PhD Fellowship (Research Foundation - Flanders)
De Smet, Vincent (Recipient), 28 Jun 2017
Prize: Fellowship awarded competitively
Activities
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Hemorrhagic shock in Upper GI bleeding.
Amelie BOURGEOIS (Speaker), Aicha ATTAR (Contributor), Mohamed ABDESSALAMI (Contributor), Vincent De Smet (Contributor), A CARINI (Contributor) & Pierre Eisendrath (Contributor)
2 Feb 2024Activity: Talk or presentation › Talk or presentation at a conference
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GPR176 Expression Correlates with Hepatic Stellate Cell Activation in Metabolic Dysfunction-Associated Steatotic Liver Disease and Chronic Viral Hepatitis
Vincent De Smet (Speaker) & Elif Gürbüz (Speaker)
1 Feb 2024Activity: Talk or presentation › Talk or presentation at a conference
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International Critical Care Conference
Vincent De Smet (Participant)
9 Sept 2023Activity: Participating in or organising an event › Participation in conference
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BASL Winter Meeting & Liver course 2023
Vincent De Smet (Participant)
1 Dec 2023Activity: Participating in or organising an event › Participation in conference
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Masterclass Jong VVGE - Hepatobiliaire pathologie
Vincent De Smet (Participant)
23 Sept 2023Activity: Participating in or organising an event › Participation in conference
Press/Media
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VUB onderzoeksteam ontdekt essentieel eiwit dat bijdraagt aan leverfibrose
23/02/24
1 Media contribution
Press/Media: Research
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VUB-onderzoekers waarschuwen voor gevaar van foute conclusies in Covid-19 levercelonderzoek
20/07/20
1 Media contribution
Press/Media: Research
Thesis
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Hepatic sinusoidal cell cross-talk is key to liver fibrosis resolution
Author: De Smet, V., Mannaerts, I. & Reynaert, H., Jun 2017Supervisor: Mannaerts, I. (Co-promotor) & Reynaert, H. (Promotor)
Student thesis: Master's Thesis