Research output per year
Research output per year
Personal profile
Expertise
Liver fibrosis, cirrhosis and cancer are an increasing problem worldwide with a substantial global burden of disease. Liver fibrosis consists of a pathological deposition of extra-cellular matrix, which is produced by hepatic stellate cells who activate upon liver damage. When the liver injury is stopped, reversal of fibrosis is accompanied by inactivation of the HSCs. However, there is only limited knowledge on the mechanisms behind HSC inactivation. My PhD project focusses on sinusoidal cell communication to discover novel mechanisms of fibrosis development and reversal both in mice and human. Novel information gained from my PhD will fuel new treatment strategies for liver fibrosis.
Education/Academic qualification
Medicine, Master, Vrije Universiteit Brussel
20 Sep 2013 → 29 Jun 2017
Award Date: 29 Jun 2017
Medicine, United States Medical Licensing Examination ® (USMLE®) Step 1
28 Sep 2016
Award Date: 28 Sep 2016
Medicine, Bachelor, Vrije Universiteit Brussel
20 Sep 2010 → 5 Jul 2013
Award Date: 5 Jul 2013
External positions
Arts-Specialist in Opleiding, Universitair Ziekenhuis Brussel
1 Aug 2017 → 30 Sep 2017Fingerprint
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Network
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Research output
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AP-1 and YAP1-TEAD drive independent transcriptional programs to activate hepatic stellate cells
De Smet, V., 2022, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Financial implications of the renewed reimbursement system of total hip arthroplasty in Belgium
Rabbachin, N., Lieten, S., De Smet, V., Pien, K. & Scheerlinck, T., 2022, In: Acta Orthopædica Belgica.Research output: Contribution to journal › Article › peer-review
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Hepatic stellate cell transcriptional dynamics in liver fibrosis
De Smet, V., 2022, 204 p.Research output: Thesis › PhD Thesis
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Improved Precision-Cut Liver Slice Cultures for Testing Drug-Induced Liver Fibrosis
Dewyse, L., De Smet, V., Verhulst, S., Eysackers, N., Kunda, R., Messaoudi, N., Reynaert, H. & van Grunsven, L. A., 30 Mar 2022, In: Frontiers in Medicine. 9, 11 p., 862185.Research output: Contribution to journal › Article › peer-review
Open Access -
A profibrotic role for the orphan G-protein coupled receptor 176 during hepatic stellate cell activation
De Smet, V., Verhulst, S., Dewyse, L., Dastjerd, M. K., Reynaert, H., Halder, G., Mannaerts, I. & van Grunsven, L. A., Jul 2021, In: Journal of Hepatology. 75, S2, p. S527-S527Research output: Contribution to journal › Meeting abstract (Journal)
Prizes
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BASL best basic abstract award
De Smet, Vincent (Recipient), 4 Mar 2021
Prize: Prize (including medals and awards)
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PhD Fellowship (Research Foundation - Flanders)
De Smet, Vincent (Recipient), 28 Jun 2017
Prize: Fellowship awarded competitively
Activities
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AP-1 and YAP1-TEAD drive independent transcriptional programs to activate hepatic stellate cells
Vincent De Smet (Speaker)
9 Feb 2022 → 11 Feb 2022Activity: Talk or presentation › Talk or presentation at a conference
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XXXIVth Belgian Week of Gastroenterology
Vincent De Smet (Organiser)
11 Feb 2022Activity: Participating in or organising an event › Participation in conference
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BASL Wintermeeting & Livercourse 2021
Vincent De Smet (Participant)
3 Dec 2021 → 4 Dec 2021Activity: Participating in or organising an event › Participation in conference
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International Liver Congress 2021 - EASL
Vincent De Smet (Participant)
23 Jun 2021 → 26 Jun 2021Activity: Participating in or organising an event › Participation in conference
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Young Belgian Assocation for Study of the Liver (External organisation)
Vincent De Smet (Member)
1 Oct 2021 → …Activity: Membership › Membership of external research organisation
Press / Media
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VUB-onderzoekers waarschuwen voor gevaar van foute conclusies in Covid-19 levercelonderzoek
20/07/20
1 Media contribution
Press/Media: Research
Thesis
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Hepatic sinusoidal cell cross-talk is key to liver fibrosis resolution
Author: De Smet, V., Mannaerts, I. & Reynaert, H., Jun 2017Supervisor: Mannaerts, I. (Co-promotor) & Reynaert, H. (Promotor)
Student thesis: Master's Thesis