Research output per year
Research output per year
Personal profile
Expertise
Liver fibrosis, cirrhosis and cancer are an increasing problem worldwide with a substantial global burden of disease. Liver fibrosis consists of a pathological deposition of extra-cellular matrix, which is produced by hepatic stellate cells who activate upon liver damage. When the liver injury is stopped, reversal of fibrosis is accompanied by inactivation of the HSCs. However, there is only limited knowledge on the mechanisms behind HSC inactivation. My PhD project focusses on sinusoidal cell communication to discover novel mechanisms of fibrosis development and reversal both in mice and human. Novel information gained from my PhD will fuel new treatment strategies for liver fibrosis.
Education/Academic qualification
Medicine, Master, Vrije Universiteit Brussel
20 Sep 2013 → 29 Jun 2017
Medicine, United States Medical Licensing Examination ® (USMLE®) Step 1
28 Sep 2016
Medicine, Bachelor, Vrije Universiteit Brussel
20 Sep 2010 → 5 Jul 2013
External positions
Arts-Specialist in Opleiding, Universitair Ziekenhuis Brussel
1 Aug 2017 → 30 Sep 2017Fingerprint
Dive into the research topics where Vincent De Smet is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Gene Signatures Detect Damaged Liver Sinusoidal Endothelial Cells in Chronic Liver Diseases
Verhulst, S., van Os, E. A., De Smet, V., Eysackers, N., Mannaerts, I. & van Grunsven, L. A., 20 Oct 2021, In : Frontiers in Medicine. 8, 14 p., 750044.Research output: Contribution to journal › Article
Open AccessFile2 Downloads (Pure) -
Initiation of hepatic stellate cell activation extends into chronic liver disease
De Smet, V., Eysackers, N., Merens, V., Kazemzadeh Dastjerd, M., Halder, G., Verhulst, S., Mannaerts, I. & van Grunsven, L. A., 27 Nov 2021, In : Cell & Death Disease. 12, 12, 10 p., 1110.Research output: Contribution to journal › Article
Open AccessFile15 Downloads (Pure) -
Single cell RNA sequencing analysis did not predict hepatocyte infection by SARS-CoV-2
De Smet, V., Verhulst, S. & van Grunsven, L. A., Oct 2020, In : Journal of Hepatology. 73, 4, p. 993-995 3 p.Research output: Contribution to journal › Letter
Open AccessFile13 Citations (Scopus)6 Downloads (Pure)
Prizes
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BASL best basic abstract award
Vincent De Smet (Recipient), 4 Mar 2021
Prize: Prize (including medals and awards)
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PhD Fellowship (Research Foundation - Flanders)
Vincent De Smet (Recipient), 28 Jun 2017
Prize: Fellowship awarded competitively
Activities
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A profibrotic role for the orphan G-protein coupled receptor 176 during hepatic stellate cell activation
Vincent De Smet (Speaker)23 Jun 2021Activity: Talk or presentation › Talk or presentation at a conference
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BASL Wintermeeting & Livercourse 2021
Vincent De Smet (Participant)3 Dec 2021 → 4 Dec 2021Activity: Participating in or organising an event › Participation in conference
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XXXIIIth Belgian Week of Gastroenterology
Vincent De Smet (Participant)4 Mar 2021 → 5 Mar 2021Activity: Participating in or organising an event › Participation in conference
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A profibrotic role for the orphan G-protein coupled receptor 176 during hepatic stellate cell activation
Vincent De Smet (Speaker)4 Mar 2021Activity: Talk or presentation › Talk or presentation at a conference
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International Liver Congress 2021 - EASL
Vincent De Smet (Participant)23 Jun 2021 → 26 Jun 2021Activity: Participating in or organising an event › Participation in conference
Press / Media
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VUB-onderzoekers waarschuwen voor gevaar van foute conclusies in Covid-19 levercelonderzoek
20/07/20
1 Media contribution
Press/Media: Research
Thesis
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Hepatic sinusoidal cell cross-talk is key to liver fibrosis resolution
Author: De Smet, V., Mannaerts, I. & Reynaert, H., Jun 2017Supervisor: Mannaerts, I. (Co-promotor) & Reynaert, H. (Promotor)
Student thesis: Master's Thesis
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Inhibition of CDK7 reduces YAP downstream signaling in hepatic stellate cell activation
Author: Gürbüz, E., 15 Jun 2021Supervisor: van Grunsven, L. (Promotor) & De Smet, V. (Co-promotor)
Student thesis: Master's Thesis
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The role of Gpr176 in hepatic stellate cell activation.
Author: Kazemzadeh Dastjerd, M., 2020Supervisor: van Grunsven, L. (Promotor) & De Smet, V. (Co-promotor)
Student thesis: Master's Thesis