Projects per year
Personal profile
Expertise
My main expertise is situated in the field of structural biology, enzymology, steady state and pre-steady state enzyme kinetics and biophysics. Hereby I focus on the elucidation of the structure and function of enzymes and enzyme complexes involved in human disease and neurological disorders in particular. In recent years my group has mainly been investigating enzymes belonging the family of the large multi-domain GTPase and their biological interaction networks. Topics include, among others, Roco proteins such as LRRK2 involved in Parkinson’s disease, the hypothetical Rab GTPase activating protein TBC1D24 implicated in epilepsy and Obg involved in bacterial persistence. Within all these projects we also strive to translate our novel insights into new strategies to fight human diseases.
External positions
Staff Scientist, Flanders Institute for Biotechnology
1 Oct 2007 → …Postdoctoral Researcher, Max Planck Institute for Molecular Physiology
1 Oct 2007 → 30 Sep 2008Fingerprint
Dive into the research topics where Wim Versées is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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FWOAL901: Unravelling and modulating the complex conformational cycle of the Roco protein family
1/01/19 → 31/12/22
Project: Fundamental
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FWOTM913: Understanding the role of Obg and its interactome in bacterial cell death and survival at the atomic scale
1/10/18 → 30/09/22
Project: Fundamental
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Allosteric Inhibition of Parkinson's-Linked LRRK2 by Constrained Peptides
Helton, L. G., Soliman, A., von Zweydorf, F., Kentros, M., Manschwetus, J. T., Hall, S., Gilsbach, B., Ho, F. Y., Athanasopoulos, P. S., Singh, R. K., LeClair, T. J., Versées, W., Raimondi, F., Herberg, F. W., Gloeckner, C. J., Rideout, H., Kortholt, A. & Kennedy, E. J., 8 Sep 2021, In : ACS Chemical Biology. xxx, xxx, p. xxx-xxx 13 p.Research output: Contribution to journal › Article
Open AccessFile7 Downloads (Pure) -
Entropic pressure controls olgomerization of Vibrio cholerae ParD2 antitoxin
Garcia Rodriguez, G., Girardin, Y., Volkov, O., Singh, R. K., Muruganandam, G., Van Dyck, J., Sobott, F., Versées, W., Charlier, D. & Loris, R., 18 Jun 2021, In : Acta Crystallographica Section D: Structural Biology (2016- ). 77, Pt 7, p. 904-920 17 p.Research output: Contribution to journal › Article
Open AccessFile7 Downloads (Pure) -
Nanobodies to allosterically modulate the GTPase activity of a LRRK2 homolog.
Galicia Diaz Santana, C., Leemans, M., Deyaert, E., Singh, R. K. & Versées, W., 21 May 2021.Research output: Unpublished contribution to conference › Poster
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New structural and functional insights in Synj1 and its implication in disease.
Martin, E., Paesmans, J., Galicia Diaz Santana, C. & Versées, W., 21 May 2021.Research output: Unpublished contribution to conference › Poster
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Structure-Activity Relationship (SAR) Study of Spautin-1 to Entail the Discovery of Novel NEK4 Inhibitors. IF (2020) 5.923
Elsocht, M., Giron, P., Maes, L., Versées, W., Gutierrez, G. J., De Grève, J. & Ballet, S., 2 Jan 2021, In : International Journal of Molecular Sciences. 22, 2, p. 1-40 40 p., 635.Research output: Contribution to journal › Article
Open AccessFile5 Downloads (Pure)
Activities
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Medical Research Council (External organisation)
Wim Versées (Reviewer)9 Aug 2021Activity: Membership › Work on advisory panel to industry or government or non-government organisation
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GBA1 stabilization through nanobodies: a versatile tool to improve wild-type and mutant enzyme function
Wim Versées (Speaker)18 May 2021Activity: Talk or presentation › Talk or presentation at a conference
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eLife (Journal)
Wim Versées (Peer reviewer)8 Jan 2021Activity: Publication peer-review and editorial work › Editorial activity
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Biochemical and structural characterization of LRRK2‐specific Nanobodies
Wim Versées (Speaker)28 Aug 2021Activity: Talk or presentation › Talk or presentation at a conference
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EMBO Reports (Journal)
Wim Versées (Peer reviewer)2 Apr 2021Activity: Publication peer-review and editorial work › Editorial activity
Press / Media
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Article in May issue of Parkoers, the 4-montly magazine of the Flemish Parkinson Liga
1/05/21
1 Media contribution
Press/Media: Other
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Article in Knack magazine "Synaptojanin1 is een breinbreker "
17/02/21
1 item of Media coverage
Press/Media: Other
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Coverage of results published in Peeters et al. Nat Commun. 2017 in printed National newspaper “Gazet van Antwerpen” (p11) – 19/10/2017
19/10/17
1 item of Media coverage
Press/Media: Other
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Coverage of results published in Peeters et al. Nat Commun. 2017 in printed National newspaper “La Dernière Heure” – 19/10/2017
19/10/17
1 item of Media coverage
Press/Media: Other
Thesis
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Adaptation of Pseudomonas aeruginosa to the cystic fibrosis lung and the role of shear stress in disrupting alginate matrix biofilms.
Author: Dingemans, J., 28 Oct 2015Supervisor: Cornelis, P. (Promotor), Charlier, D. (Promotor), Angenon, G. (Jury), Versees, W. (Jury), Van Ginderachter, J. (Jury), Verniest, G. (Promotor), Roelants, K. (Jury), Van Houdt, R. (External person) (Co-promotor), Malfroot, A. (Co-promotor), De Mot, R. (External person) (Jury), Chevalier, S. (External person) (Jury) & Winstanley, C. (External person) (Jury)
Student thesis: Doctoral Thesis
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Analysis of the structure-function relation of trypanosoma vivax nucleoside hydrolase
Author: Versees, W. & Steyaert, J., 1998Supervisor: Steyaert, J. (Promotor)
Student thesis: Master's Thesis
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Bifidogenic and butyrogenic effects of arabinoxylan-oligosaccharides, a kinetic and molecular approach
Author: Rivière, A., De Vuyst, L., Desmet, G., Van Driessche, E., Remaut, H. K., Versees, W., Eeltink, S., Vande Wiele, T. & Van Sinderen, D., 25 Sep 2015Student thesis: Doctoral Thesis
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Bijdrage van het folaat-bindend domein van MnmE aand de MnmE/GidA-gekatalyseerde tRNA-modificatierectie
Author: Hubin, E., Versees, W. & Loris, R., Sep 2010Supervisor: Versees, W. (Promotor) & Loris, R. (Jury)
Student thesis: Master's Thesis
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Biochemical and structural characterization of TBC1D24, a human protein implicated in neurological diseases
Author: Janssens, J., 26 Jun 2016Supervisor: Versees, W. (Promotor)
Student thesis: Master's Thesis