Projects per year
Personal profile
Expertise
My main expertise is situated in the field of structural biology, enzymology, steady state and pre-steady state enzyme kinetics and biophysics. Hereby I focus on the elucidation of the structure and function of enzymes and enzyme complexes involved in human disease and neurological disorders in particular. In recent years my group has mainly been investigating enzymes belonging the family of the large multi-domain GTPase and their biological interaction networks. Topics include, among others, Roco proteins such as LRRK2 involved in Parkinson’s disease, the hypothetical Rab GTPase activating protein TBC1D24 implicated in epilepsy and Obg involved in bacterial persistence. Within all these projects we also strive to translate our novel insights into new strategies to fight human diseases.
External positions
Staff Scientist, Flanders Institute for Biotechnology
1 Oct 2007 → …Postdoctoral Researcher, Max Planck Institute of Molecular Physiology
1 Oct 2007 → 30 Sep 2008Fingerprint
Dive into the research topics where Wim Versées is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Network
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FWOAL1054: Understanding the structure, function and mechanism of Synaptojanin1 in the context of neurological disease
1/01/22 → 31/12/25
Project: Fundamental
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FWOEOS16: deCiphering bacterial peRsIsTence of Individual Cells down to Atomic Level
1/01/22 → 31/12/25
Project: Fundamental
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AIIFUND83: GBA I stabilization through nanobodies:a versatile tool to improve wild type and mutant enzyme function
30/06/21 → 31/12/23
Project: Fundamental
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Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2
Singh, R. K., Soliman, A., Guaitoli, G., Störmer, E., von Zweydorf, F., Dal Maso, T., Oun, A., Van Rillaer, L., Schmidt, S. H., Chatterjee, D., David, J. A., Pardon, E., Schwartz, T. U., Knapp, S., Kennedy, E. J., Steyaert, J., Herberg, F. W., Kortholt, A., Gloeckner, C. J. & Versées, W., 1 Mar 2022, In : Proceedings of the National Academy of Sciences of the United States of America. 119, 9, p. 1-12 12 p., e2112712119.Research output: Contribution to journal › Article
Open AccessFile46 Downloads (Pure) -
Allosteric Inhibition of Parkinson's-Linked LRRK2 by Constrained Peptides
Helton, L. G., Soliman, A., von Zweydorf, F., Kentros, M., Manschwetus, J. T., Hall, S., Gilsbach, B., Ho, F. Y., Athanasopoulos, P. S., Singh, R. K., LeClair, T. J., Versées, W., Raimondi, F., Herberg, F. W., Gloeckner, C. J., Rideout, H., Kortholt, A. & Kennedy, E. J., 19 Nov 2021, In : ACS Chemical Biology. 16, 11, p. 2326-2338 13 p.Research output: Contribution to journal › Article
Open AccessFile3 Citations (Scopus)36 Downloads (Pure) -
Entropic pressure controls olgomerization of Vibrio cholerae ParD2 antitoxin
Garcia Rodriguez, G., Girardin, Y., Volkov, O., Singh, R. K., Muruganandam, G., Van Dyck, J., Sobott, F., Versées, W., Charlier, D. & Loris, R., 18 Jun 2021, In : Acta Crystallographica Section D: Structural Biology (2016- ). 77, Pt 7, p. 904-920 17 p.Research output: Contribution to journal › Article
Open AccessFile2 Citations (Scopus)52 Downloads (Pure) -
Nanobodies to allosterically modulate the GTPase activity of a LRRK2 homolog.
Galicia Diaz Santana, C., Leemans, M., Deyaert, E., Singh, R. K. & Versées, W., 21 May 2021.Research output: Unpublished contribution to conference › Poster
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New structural and functional insights in Synj1 and its implication in disease.
Martin, E., Paesmans, J., Galicia Diaz Santana, C. & Versées, W., 21 May 2021.Research output: Unpublished contribution to conference › Poster
Activities
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Trends in Biochemical Sciences (Journal)
Wim Versées (Peer reviewer)4 Jun 2022Activity: Publication peer-review and editorial work › Editorial activity
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From fundamental mechanistic insights toward therapeutic targeting of LRRK2 in Parkinson’s disease
Wim Versées (Speaker)31 Mar 2022Activity: Talk or presentation › Talk or presentation at a conference
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Université libre de Bruxelles (External organisation)
Wim Versées (Jury), François Ancien (Presenter), Wim Vranken (Supervisor), Marianne Rooman (Supervisor), Ann Nowe (Chair)14 Jan 2022Activity: Membership › Member of PhD committee
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Nature Webcasts series: Llama-derived nanobodies in the fight against Parkinson’s disease
Wim Versées (Invited speaker)31 May 2022Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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Nanobodies as Allosteric Modulators of LRRK2 Activity
Wim Versées (Speaker)12 May 2022Activity: Talk or presentation › Talk or presentation at a conference
Press / Media
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VUB/VIB-onderzoek met lama antilichamen kan weg effenen naar nieuwe Parkinson behandelingen
1/05/22
1 Media contribution
Press/Media: Other
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Parkinson’s: Llama antibodies may help design treatments
8/03/22
1 Media contribution
Press/Media: Other
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Article in the newspaper "De Morgen" (Zeno) "Parkinson bestrijden met antilichamen van Lama"
5/03/22
1 item of Media coverage
Press/Media: Other
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Article in May issue of Parkoers, the 4-montly magazine of the Flemish Parkinson Liga
1/05/21
1 Media contribution
Press/Media: Other
Thesis
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Adaptation of Pseudomonas aeruginosa to the cystic fibrosis lung and the role of shear stress in disrupting alginate matrix biofilms.
Author: Dingemans, J., 28 Oct 2015Supervisor: Cornelis, P. (Promotor), Charlier, D. (Promotor), Angenon, G. (Jury), Versees, W. (Jury), Van Ginderachter, J. (Jury), Verniest, G. (Promotor), Roelants, K. (Jury), Van Houdt, R. (External person) (Co-promotor), Malfroot, A. (Co-promotor), De Mot, R. (External person) (Jury), Chevalier, S. (External person) (Jury) & Winstanley, C. (External person) (Jury)
Student thesis: Doctoral Thesis
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Analysis of the structure-function relation of trypanosoma vivax nucleoside hydrolase
Author: Versees, W. & Steyaert, J., 1998Supervisor: Steyaert, J. (Promotor)
Student thesis: Master's Thesis
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Bifidogenic and butyrogenic effects of arabinoxylan-oligosaccharides, a kinetic and molecular approach
Author: Rivière, A., De Vuyst, L., Desmet, G., Van Driessche, E., Remaut, H. K., Versees, W., Eeltink, S., Vande Wiele, T. & Van Sinderen, D., 25 Sep 2015Student thesis: Doctoral Thesis
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Bijdrage van het folaat-bindend domein van MnmE aand de MnmE/GidA-gekatalyseerde tRNA-modificatierectie
Author: Hubin, E., Versees, W. & Loris, R., Sep 2010Supervisor: Versees, W. (Promotor) & Loris, R. (Jury)
Student thesis: Master's Thesis
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Biochemical and structural characterization of TBC1D24, a human protein implicated in neurological diseases
Author: Janssens, J., 26 Jun 2016Supervisor: Versees, W. (Promotor)
Student thesis: Master's Thesis