Projects per year
Personal profile
Expertise
My main expertise is situated in the field of structural biology, enzymology, steady state and pre-steady state enzyme kinetics and biophysics. Hereby I focus on the elucidation of the structure and function of enzymes and enzyme complexes involved in human disease and neurological disorders in particular. In recent years my group has mainly been investigating enzymes belonging the family of the large multi-domain GTPase and their biological interaction networks. Topics include, among others, Roco proteins such as LRRK2 involved in Parkinson’s disease, the hypothetical Rab GTPase activating protein TBC1D24 implicated in epilepsy and Obg involved in bacterial persistence. Within all these projects we also strive to translate our novel insights into new strategies to fight human diseases.
External positions
Staff Scientist, Flanders Institute for Biotechnology
1 Oct 2007 → …Postdoctoral Researcher, Max Planck Institute of Molecular Physiology
1 Oct 2007 → 30 Sep 2008Fingerprint
Dive into the research topics where Wim Versées is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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FWOTM1139: Unravelling the structure, mechanism and cellular function of the Parkinson’s disease protein DNAJC13
1/11/22 → 31/10/26
Project: Fundamental
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FWOTM1123: Unraveling the structure and mechanism of the Rab3GAP1- Rab3GAP2 enzyme complex and its implication in disease.
Versées, W., Verstreken, P. & Berghmans, M.
1/11/22 → 31/10/26
Project: Fundamental
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FWOEOS16: deCiphering bacterial peRsIsTence of Individual Cells down to Atomic Level
1/01/22 → 31/12/25
Project: Fundamental
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FWOAL1054: Understanding the structure, function and mechanism of Synaptojanin1 in the context of neurological disease
1/01/22 → 31/12/25
Project: Fundamental
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AIIFUND83: GBA I stabilization through nanobodies:a versatile tool to improve wild type and mutant enzyme function
30/06/21 → 31/12/23
Project: Fundamental
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Deep mutational scanning of essential bacterial proteins can guide antibiotic development
Dewachter, L., Brooks, A. N., Noon, K., Cialek, C., Clark-ElSayed, A., Schalck, T., Krishnamurthy, N., Versées, W., Vranken, W. & Michiels, J., 16 Jan 2023, In: Nature Communications. 14, 1, 16 p., 241.Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Downloads (Pure) -
EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation
Bademosi, A. T., Decet, M., Kuenen, S., Calatayud, C., Swerts, J., Gallego, S. F., Schoovaerts, N., Karamanou, S., Louros, N., Martin, E., Sibarita, J-B., Vints, K., Gounko, N. V., Meunier, F. A., Economou, A., Versées, W., Rousseau, F., Schymkowitz, J., Soukup, S-F. & Verstreken, P., 15 Feb 2023, In: Neuron. 111, p. 1-21 21 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
YbiB: a novel interactor of the GTPase ObgE
Deckers, B., Vercauteren, S., De Kock, V., Martin, C., Lazar, T., Herpels, P., Dewachter, L., Verstraeten, N., Peeters, E., Ballet, S., Michiels, J., Galicia, C. & Versées, W., 2 Mar 2023, In: Nucleic Acids Research. 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
Downsizing Nanobodies: Towards CDR3 Loop Mimetics Modulating Intracellular Protein-Protein Interactions
Van Holsbeeck, K., Fischer, B., Gonzalez, S., Gadais, C., Versées, W., Martins, J. C., Martin, C., Wohlkönig, A., Steyaert, J. & Ballet, S., 4 Nov 2022, Proceedings of the 36th European and the 12th International Peptide Symposium.Research output: Chapter in Book/Report/Conference proceeding › Conference paper
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Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2
Singh, R. K., Soliman, A., Guaitoli, G., Störmer, E., von Zweydorf, F., Dal Maso, T., Oun, A., Van Rillaer, L., Schmidt, S. H., Chatterjee, D., David, J. A., Pardon, E., Schwartz, T. U., Knapp, S., Kennedy, E. J., Steyaert, J., Herberg, F. W., Kortholt, A., Gloeckner, C. J. & Versées, W., 1 Mar 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 9, p. 1-12 12 p., e2112712119.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)134 Downloads (Pure)
Datasets
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YbiB: a Novel Interactor of the GTPase ObgE
Deckers, B. (Creator), Peeters, E. (Creator), Ballet, S. (Creator), Galicia Diaz Santana, C. (Creator) & Versées, W. (Creator), Zenodo, 8 Nov 2022
Dataset
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Crystal Structure of dual specific Trm10 construct from Thermococcus kodakaraensis (PDB 6EMS).
Versées, W. (Project Leader) & Singh, R. K. (Creator), Protein Data Bank in Europe, 13 Jun 2018
DOI: 10.2210/pdb6EMS/pdb
Dataset
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Crystal Structure of dual specific Trm10 construct from Thermococcus kodakaraensis (PDB 6EMT).
Versées, W. (Project Leader) & Singh, R. K. (Creator), Protein Data Bank in Europe, 13 Jun 2018
DOI: 10.2210/pdb6EMT/pdb
Dataset
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Crystal Structure of dual specific Trm10 construct from Thermococcus kodakaraensis (PDB 6EMU)
Versées, W. (Project Leader) & Singh, R. K. (Creator), Protein Data Bank in Europe, 13 Jun 2018
DOI: 10.2210/pdb6EMU/pdb
Dataset
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Crystal structure of the 5-phosphatase domain of Synaptojanin1 bound to its substrate diC8-PI(3,4,5)P3 in complex with a nanobody.
Paesmans, J. (Creator), Versées, W. (Supervisor), Galicia Diaz Santana, C. (Creator) & Martin, E. (Creator), Protein Data Bank in Europe, 30 Dec 2020
DOI: 10.2210/pdb7A17/pdb
Dataset
Activities
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Llama-derived nanobodies in the fight against Parkinson’s disease-associated neurodegeneration
Wim Versées (Speaker)
13 Feb 2023Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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Optimized AAV systems for the treatment of CNS-related diseases (Event)
Wim Versées (Jury), Marika Marino (Presenter), Patrick Callaerts (Supervisor), Matthew Holt (Supervisor) & Inge Depoortere (Chair)
1 Sep 2022Activity: Membership › Member of PhD committee
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Trends in Biochemical Sciences (Journal)
Wim Versées (Peer reviewer)
4 Jun 2022Activity: Publication peer-review and editorial work › Editorial activity
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From fundamental mechanistic insights toward therapeutic targeting of LRRK2 in Parkinson’s disease
Wim Versées (Speaker)
31 Mar 2022Activity: Talk or presentation › Talk or presentation at a conference
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Nature Webcasts series: Llama-derived nanobodies in the fight against Parkinson’s disease
Wim Versées (Invited speaker)
31 May 2022Activity: Talk or presentation › Talk or presentation at a workshop/seminar
Press/Media
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VUB/VIB-onderzoek met lama antilichamen kan weg effenen naar nieuwe Parkinson behandelingen
1/05/22
1 Media contribution
Press/Media: Other
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Parkinson’s: Llama antibodies may help design treatments
8/03/22
1 Media contribution
Press/Media: Other
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Article in the newspaper "De Morgen" (Zeno) "Parkinson bestrijden met antilichamen van Lama"
5/03/22
1 item of Media coverage
Press/Media: Other
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Article in May issue of Parkoers, the 4-montly magazine of the Flemish Parkinson Liga
1/05/21
1 Media contribution
Press/Media: Other
Thesis
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Analysis of the structure-function relation of trypanosoma vivax nucleoside hydrolase
Author: Versees, W. & Steyaert, J., 1998Supervisor: Steyaert, J. (Promotor)
Student thesis: Master's Thesis
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Bifidogenic and butyrogenic effects of arabinoxylan-oligosaccharides, a kinetic and molecular approach
Author: Rivière, A., De Vuyst, L., Desmet, G., Van Driessche, E., Remaut, H. K., Versees, W., Eeltink, S., Vande Wiele, T. & Van Sinderen, D., 25 Sep 2015Student thesis: Doctoral Thesis
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Biochemical characterization of interactors of the bacterial GTPase ObgE
Author: Versées, W. & Ghaemi, M., 2 Sep 2021Student thesis: Master's Thesis
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Biochemical characterization of nanobodies modulating the Chlorobium tepidum Roco proteins’ GTPase activity
Author: Janssens, A. & Versees, W., 2 Jul 2018Student thesis: Master's Thesis
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Biochemical characterization of the interaction between ObgE and a novel interaction partner relevant for bacterial persistence
Author: Versées, W. & Van Rillaer, L., 29 Jun 2020Student thesis: Master's Thesis