Projects per year
Personal profile
Expertise
My main expertise is situated in the field of structural biology, enzymology, steady state and pre-steady state enzyme kinetics and biophysics. Hereby I focus on the elucidation of the structure and function of enzymes and enzyme complexes involved in human disease and neurological disorders in particular. In recent years my group has mainly been investigating enzymes belonging the family of the large multi-domain GTPase and their biological interaction networks. Topics include, among others, Roco proteins such as LRRK2 involved in Parkinson’s disease, the hypothetical Rab GTPase activating protein TBC1D24 implicated in epilepsy and Obg involved in bacterial persistence. Within all these projects we also strive to translate our novel insights into new strategies to fight human diseases.
External positions
Staff Scientist, Flanders Institute for Biotechnology
1 Oct 2007 → …
Postdoctoral Researcher, Max Planck Institute of Molecular Physiology
1 Oct 2007 → 30 Sept 2008
Fingerprint
Dive into the research topics where Wim Versées is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
ANI443: Nanobody-enabled discovery of pharmaceutical chaperones to restore the function of the Parkinson’s-associated protein glucocerebrosidase
Versées, W. (Administrative Promotor)
16/02/26 → 16/02/29
Project: Fundamental
-
FWOAL1206: Putting bacteria to sleep: GTPase ObgE as a nucleator of protein aggregation in bacterial dormancy
Versées, W. (Administrative Promotor)
1/01/26 → 31/12/29
Project: Fundamental
-
ANI425: Nanobodies as allosteric modifiers of the LRRK2 protein in the fight against Parkinson's disease
Versées, W. (Administrative Promotor)
22/05/25 → 15/12/27
Project: Fundamental
-
FWOSB191: Exploring novel ways to target LRRK2 in Parkinson’s disease: in-depth characterization and optimization of allosteric Nanobodies
Van Mele, F. (Mandate) & Versées, W. (Administrative Promotor)
1/11/24 → 31/10/28
Project: Fundamental
-
HERC68: High-resolution low-cost 100 kV electron cryogenic microscope for near-atomic protein structure determination
Efremov, R. (Administrative Promotor), Messens, J. (CoI (Co-Promotor)), Vorobieva, A. A. (CoI (Co-Promotor)), Remaut, H. K. (CoI (Co-Promotor)), Van der Henst, C. (CoI (Co-Promotor)), Steyaert, J. (CoI (Co-Promotor)), Versées, W. (CoI (Co-Promotor)), Loris, R. (CoI (Co-Promotor)) & Brunner, J. (CoI (Co-Promotor))
1/05/24 → 30/04/28
Project: Fundamental
-
Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody
Pinto Torres, J. E., Claes, M., Hendrickx, R., Yuan, M., Smiejkowska, N., Van Wielendaele, P., Hacisuleyman, A., De Winter, H., Muyldermans, S., Michels, P. A. M., Walkinshaw, M. D., Versées, W., Caljon, G., Magez, S. & Sterckx, Y.G.-J., 31 Mar 2025, In: eLife. 13, 27 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile45 Downloads (Pure) -
Characterization of nanobodies as tools for the elucidation of the structure and function of the Rab3GAP1 protein
Denayer, L., Berghmans, M. & Versées, W., 2025, (Unpublished). 1 p.Research output: Unpublished contribution to conference › Poster
-
Cryo-EM structures of the MnmE-MnmG complex reveal large conformational changes and provide new insights into the mechanism of tRNA modification
Maes, L., Mares-Mejía, I., Martin, E., Bickel, D., Claeys, S., Vranken, W., Fislage, M., Galicia, C. & Versées, W., 9 Sept 2025, In: Nucleic Acids Research. 53, 16, 17 p., gkaf824.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)7 Downloads (Pure) -
Cryo-TEM structure of β-glucocerebrosidase in complex with its transporter LIMP-2
Dobert, J. P., Schäfer, J.-H., Dal Maso, T., Ravindran, P., Huard, D. J. E., Socher, E., Schildmeyer, L. A., Lieberman, R. L., Versées, W., Moeller, A., Zunke, F. & Arnold, P., 30 Mar 2025, In: Nature communications. 16, 1, p. 1-14 14 p., 3074.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)93 Downloads (Pure) -
Developing nanobodies as allosteric molecular chaperones of glucocerebrosidase function
Dal Maso, T., Sinisgalli, C., Zilio, G., Franzin, E., Tessari, I., Pardon, E., Steyaert, J., Ballet, S., Greggio, E., Versées, W. & Plotegher, N., 27 May 2025, In: Nature communications. 16, 1, 19 p., 4890.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)20 Downloads (Pure)
Datasets
-
Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2
Kortholt, A. (Creator), Versées, W. (Creator), Singh, R. (Creator) & Soliman, A. (Creator), Zenodo, 9 Feb 2022
DOI: 10.5281/zenodo.6028265, https://zenodo.org/record/6028265
Dataset
-
YbiB: a Novel Interactor of the GTPase ObgE
Deckers, B. (Creator), Vercauteren, S. (Creator), De Kock, V. (Creator), Martin, C. (Creator), Lazar, T. (Creator), Herpels, P. (Creator), Dewachter, L. (Creator), Verstraeten, N. (Creator), Peeters, E. (Creator), Ballet, S. (Creator), Michiels, J. (Creator), Galicia Diaz Santana, C. (Creator) & Versées, W. (Creator), Zenodo, 8 Nov 2022
Dataset
-
Crystal structure of the E. coli TrpD2 protein YbiB at 1.3 A resolution
Deckers, B. (Creator), Galicia Diaz Santana, C. (Creator) & Versées, W. (Creator), Protein Data Bank, 22 Feb 2023
Dataset
-
Crystal structure of the E. coli TrpD2 protein in complex with a C-terminal peptide from ObgE
Deckers, B. (Creator), Galicia Diaz Santana, C. (Creator) & Versées, W. (Creator), Protein Data Bank, 22 Feb 2023
Dataset
-
Roco protein from C. tepidum in the GTP state bound to the activating Nanobodies NbRoco1 and NbRoco2
Versées, W. (Creator) & Galicia Diaz Santana, C. (Creator), Protein Data Bank, 1 May 2024
DOI: 10.2210/pdb8R4B/pdb
Dataset
Prizes
-
-
Wetenschappelijk Fonds Willy Gepts 2022-2026: SPARTAN: SLIT-ROBO Library screening for PAncReaTic cANcer
Rooman, I. (Recipient), Ballet, S. (Recipient) & Versées, W. (Recipient), 2022
Prize: Prize (including medals and awards)
Activities
-
Member of PhD committee of Silke Vercauteren “The genetic landscape underlying persistence in Escherichia coli” (Event)
Versées, W. (Jury)
22 Jan 2025Activity: Membership › Member of PhD committee
-
National Science Center (External organisation)
Versées, W. (Reviewer)
12 Sept 2025Activity: Membership › Membership of peer-review panel or committee
-
PhD Defence Ayse Kilic (Event)
Kilic, A. (Presenter), Versées, W. (Jury) & Verstreken, P. (Supervisor)
30 Sept 2025Activity: Membership › Member of PhD committee
-
Synaptojanin1: From Structural Insights to Therapeutic Targeting
Martin, E. (Speaker) & Versées, W. (Contributor)
14 Nov 2025Activity: Talk or presentation › Talk or presentation at a conference
-
PhD Defence Ella Martin (Event)
Martin, E. (Presenter), Versées, W. (Supervisor), Laoui, D. (Chair), Hennecke, U. (Jury), Vorobieva, A. A. (Jury), Greggio, E. (Jury) & Ismail, S. (Jury)
29 Sept 2025Activity: Membership › Member of PhD committee
Press/Media
-
VUB/VIB-onderzoek met lama antilichamen kan weg effenen naar nieuwe Parkinson behandelingen
1/05/22
1 Media contribution
Press/Media: Other
-
-
Parkinson’s: Llama antibodies may help design treatments
8/03/22
1 Media contribution
Press/Media: Other
-
Article in the newspaper "De Morgen" (Zeno) "Parkinson bestrijden met antilichamen van Lama"
5/03/22
1 item of Media coverage
Press/Media: Other
-
Article in May issue of Parkoers, the 4-montly magazine of the Flemish Parkinson Liga
1/05/21
1 Media contribution
Press/Media: Other
Thesis
-
Analysis of the structure-function relation of trypanosoma vivax nucleoside hydrolase
Versees, W. ((PhD) Student), Steyaert, J. (Promotor), 1998Student thesis: Master's Thesis