Projects per year
Personal profile
Expertise
Yannick De Vlaeminck finished his Bachelor as a Medical Lab Technician in 2008 at the Erasmus Hogeschool Brussels and started to work in the field of neurogenetics, cardiogentics and mitochondrial diseases (Centre of Medical Genetics, UZBrussel). As he expanded his practical skills, he gradually started to participate more and more in research projects. This enabled him to develop a scientific and critical way of thinking. This experience motivated him to obtain a Master degree in Biomedical Sciences and as such pursue a research career.
During his internship of the final year Master in Biomedical Sciences (VUB, 2014-2015) at the LMCT, he was in charge of setting up a novel project in which he used state-of-the-art tools such as lentiviral vectors and nanobodies to target tumor-associated macrophages (TAMs). The insights he gained on how lentiviral vectors and nanobodies marriage together as a successful couple for cell targeting, and how the function of TAMs can be manipulated through lentiviral-mediated delivery of a SMAC mimetic, laid the foundation for his VLK/ORC/FWO-SB funded PhD project (VUB, 2015-2020) at LMCT.
During his PhD he gained experience in molecular cloning, single domain antibody production/purification, gene therapy approaches using lentiviral vectors and macrophage biology.
Fingerprint
Dive into the research topics where Yannick De Vlaeminck is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
ANI324: A new adoptive T-cell therapy targeting B7-H3 and HMGB1: towards a cure for multiple myeloma
Breckpot, K. & De Vlaeminck, Y.
26/07/22 → 1/06/24
Project: Fundamental
-
IOFPOC42: IOF PoC “MOTIF: MOdification of T cells In situ for altered Functionality”
Devoogdt, N., Breckpot, K., Meeus, F., De Groof, T. & De Vlaeminck, Y.
1/01/21 → 31/12/22
Project: Applied
-
FWOSB36: Development of an innovative gene-based technology platform to modulate immune cells in the tumor microenvironment
Breckpot, K. & De Vlaeminck, Y.
1/01/17 → 31/12/20
Project: Fundamental
-
ANI146: Targeting Tumor-Associated Macrophages using lentiviral vectors and nanobodies.
Breckpot, K. & De Vlaeminck, Y.
1/10/15 → 30/09/16
Project: Fundamental
Research output
-
Accepted poster session at ImmunoRad 2023: Targeted alpha therapy using Actinium-225 radiolabeled single domain antibodies induces antigen-specific immune responses and instills immunomodulation both systemically and at the tumor microenvironment
Ertveldt, T., Krasniqi, A., Ceuppens, H., Puttemans, J., Dekempeneer, Y., De Jonghe, K., de Mey, W., Lecocq, Q., De Vlaeminck, Y., Awad, R. M., Goyvaerts, C., De Veirman, K., Morgenstern, A., Bruchertseifer, F., Keyaerts, M., Devoogdt, N., D'Huyvetter, M. & Breckpot, K., 27 Sep 2023.Research output: Unpublished contribution to conference › Poster
-
In vitro modelling of local gene therapy with IL-15/IL-15Rα and a PD-L1 antagonist in melanoma reveals an interplay between NK cells and CD4+ T cells
Awad, R. M., De Vlaeminck, Y., Meeus, F., Ertveldt, T., Zeven, K., Ceuppens, H., Goyvaerts, C., Verdonck, M., Salguero, G., Raes, G., Devoogdt, N. & Breckpot, K., Dec 2023, In: Scientific reports. 13, 1, p. 1-13 13 p., 18995.Research output: Contribution to journal › Article › peer-review
Open Access -
Nanobody-mediated SPECT/CT imaging reveals the spatiotemporal expression of programmed death-ligand 1 in response to a CD8+ T cell and iNKT cell activating mRNA vaccine
Ertveldt, T., Meulewaeter, S., De Vlaeminck, Y., Olarte, O., Broos, K., Van Calenbergh, S., Bourgeois, S., Deprez, J., Heremans, Y., Goyvaerts, C., Staels, W., De Smedt, S., Dewitte, H., Devoogdt, N., Keyaerts, M., Verbeke, R., Barbé, K., Lentacker, I. & Breckpot, K., 9 Oct 2023, In: Theranostics. 13, 15, p. 5483-5500 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Downloads (Pure) -
Targeted α-Therapy Using 225Ac Radiolabeled Single-Domain Antibodies Induces Antigen-Specific Immune Responses and Instills Immunomodulation Both Systemically and at the Tumor Microenvironment
Ertveldt, T., Krasniqi, A., Ceuppens, H., Puttemans, J., Dekempeneer, Y., De Jonghe, K., de Mey, W., Lecocq, Q., De Vlaeminck, Y., Awad, R. M., Goyvaerts, C., De Veirman, K., Morgenstern, A., Bruchertseifer, F., Keyaerts, M., Devoogdt, N., D'Huyvetter, M. & Breckpot, K., 1 May 2023, In: Journal of Nuclear Medicine. 64, 5, p. 751-758 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus) -
Validation of anti-PD-1 monocolonal antibody binding to novel Immune checkpoint based Chimeric Antigen Receptors for better anti-tumor activity in glioblastoma patients.
Schaukens, J., De Vlaeminck, Y., Geeraerts, X., Stevens, L., Breckpot, K., Neyns, B. & Tuyaerts, S., 27 Oct 2023.Research output: Unpublished contribution to conference › Poster
File
Prizes
-
Awarded 1000 € by the ‘Stichting tegen Kanker’ as first prize winner in the category (bio-)medical sciences for my master thesis entitled ‘Dissecting the biology of tumor-associated macrophages using lentiviral vectors and nanobodies’
De Vlaeminck, Yannick (Recipient), 31 Dec 2015
Prize: Prize (including medals and awards)
-
Granted FWO fellowship
De Vlaeminck, Yannick (Recipient), 1 Jan 2017
Prize: Fellowship awarded competitively
-
International Students Research Conference on Health (MOSA conference 2018)
Awad, Robin Maximilian (Recipient), De Vlaeminck, Yannick (Recipient), Goyvaerts, Cleo (Recipient), Bonelli, S. (Recipient), Van Ginderachter, Jo (Recipient) & Breckpot, Karine (Recipient), 20 Jun 2018
Prize: Prize (including medals and awards)
-
One-year fellowship grant from the 'Vlaamse Liga tegen Kanker'
De Vlaeminck, Yannick (Recipient), 15 Nov 2015
Prize: Prize (including medals and awards)
-
Activities
-
Development of an in vitro hot tumor model for immunotherapeutic drug screening
Robin Maximilian Awad (Presenter), Fien Meeus (Contributor), Yannick De Vlaeminck (Contributor), Nick Devoogdt (Contributor) & Karine Breckpot (Contributor)
21 Sep 2022Activity: Talk or presentation › Talk or presentation at a conference
-
Human relevant models for drug research and development
Fien Meeus (Speaker), Robin Maximilian Awad (Contributor), Nick Devoogdt (Contributor), Sandra Tuyaerts (Contributor), Cleo Goyvaerts (Contributor), Yannick De Vlaeminck (Contributor), Bart Neyns (Contributor) & Karine Breckpot (Contributor)
8 Oct 2021Activity: Talk or presentation › Talk or presentation at a workshop/seminar
-
Combining dual G9a/DNMTs epigenetic inhibition and immunotherapy to treat metastatic melanoma
Lien De Beck (Speaker), Robin Maximilian Awad (Contributor), Yannick De Vlaeminck (Contributor), Veronica Basso (Contributor), Noelia Casares (Contributor), Stefaan Verhulst (Contributor), Edurne San José-Enériz (Contributor), Kirsten De Ridder (Contributor), Cleo Goyvaerts (Contributor), Ken Maes (Contributor), Karin Vanderkerken (Contributor), Xabier Agirre (Contributor), Filipe Prosper (Contributor), Juan José Lasarte (Contributor), Anna Mondino (Contributor) & Karine Breckpot (Contributor)
11 Feb 2021Activity: Talk or presentation › Talk or presentation at a conference
-
Noninvasive imaging and inhibition of human programmed death ligand 1 (PD-L1) using nanobody K2 to improve cancer immunotherapy
Robin Maximilian Awad (Contributor), Dora Mugoli Chigoho (Contributor), Katrijn Broos (Contributor), Quentin Lecocq (Contributor), Katty Zeven (Contributor), Thomas Ertveldt (Contributor), Lien De Beck (Contributor), Hannelore Ceuppens (Contributor), Yannick De Vlaeminck (Contributor), Cleo Goyvaerts (Contributor), Steve Schoonooghe (Contributor), Vicky Caveliers (Contributor), Catarina Xavier (Contributor), Jessica Bridoux (Contributor), Geert Raes (Contributor), Marleen Keyaerts (Contributor), Nick Devoogdt (Contributor) & Karine Breckpot (Speaker)
25 Oct 2021 → 26 Oct 2021Activity: Talk or presentation › Talk or presentation at a conference
File -
2021-80
Nick Devoogdt (Supervisor), Timo De Groof (Contributor), Fien Meeus (Contributor), Karine Breckpot (Contributor) & Yannick De Vlaeminck (Contributor)
2021 → …Activity: Other
Press/Media
-
Betaalbare kankerimmunotherapie
Karine Breckpot, Nick Devoogdt, Yannick De Vlaeminck & Fien Meeus
8/02/22
1 item of Media coverage
Press/Media: Research
-
VUB-onderzoek naar gedeeltelijk falen immuuntherapie
Karine Breckpot, Fien Meeus & Yannick De Vlaeminck
3/02/22
1 Media contribution
Press/Media: Research
-
VUB-onderzoekers en start-up Esobiotec streven naar betaalbare kankerimmunotherapie
Karine Breckpot, Nick Devoogdt, Yannick De Vlaeminck & Fien Meeus
31/01/22
1 Media contribution
Press/Media: Research
-
VUB-onderzoekers en start-up Esobiotec willen kankerimmunotherapie betaalbaarder maken
Karine Breckpot, Nick Devoogdt, Fien Meeus & Yannick De Vlaeminck
31/01/22
1 item of Media coverage
Press/Media: Research
Thesis
-
Dissecting the biology of tumor-associated macrophages using lentiviral vectors and nanobodies
Author: De Vlaeminck, Y., 18 Jun 2015Supervisor: Breckpot, K. (Promotor) & Goyvaerts, C. (Promotor)
Student thesis: Master's Thesis
-
TAMING cancer:TArgeting Myeloid cells using INnovative. Gene-based technologies
Author: De Vlaeminck, Y., Breckpot, K., Goyvaerts, C., Van Ginderachter, J., Emeagi, P., Mazzone, M., Movahedi, K., Menu, E. & VandenDriessche, T., 3 Mar 2021Supervisor: Breckpot, K. (Promotor), Goyvaerts, C. (Co-promotor), Van Ginderachter, J. (Co-promotor), Emeagi, P. (External person) (Jury), Mazzone, M. (External person) (Jury), Movahedi, K. (Jury), Menu, E. (Jury) & VandenDriessche, T. (Jury)
Student thesis: Doctoral Thesis