Research output per year
Research output per year
Project Details
Description
Multiple myeloma (MM) treatment with T cells engineered to express antigen receptors (CARs) shown promising responses yet with room for improvement. Therefore, we propose to develop B7-H3 nano CAR-T cells that produce HMGB1-blocking peptides allowing us to study simultaneously the novel B7-H3 target and recently identified immune suppressor HMGB1, thereby enhancing the functionality of the CAR-T therapy. If successful, the results of this project can be translated to the clinic.
Project result
Multiple myeloma (MM) treatment with T cells engineered to express antigen receptors (CARs) shown promising responses yet with room for improvement. Therefore, we propose to develop B7-H3 nano CAR-T cells that produce HMGB1-blocking peptides allowing us to study simultaneously the novel B7-H3 target and recently identified immune suppressor HMGB1, thereby enhancing the functionality of the CAR-T therapy. If successful, the results of this project can be translated to the clinic.
| Acronym | ANI324 |
|---|---|
| Status | Finished |
| Effective start/end date | 26/07/22 → 1/06/24 |
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Research output
- 1 Article
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Preclinical evaluation of antigen-sensitive B7-H3-targeting nanobody-based CAR-T cells in glioblastoma cautions for on-target, off-tumor toxicity
Meeus, F., Funeh, C. N., Awad, R. M., Zeven, K., Autaers, D., De Becker, A., Van Riet, I., Goyvaerts, C., Tuyaerts, S., Neyns, B., Devoogdt, N., De Vlaeminck, Y. & Breckpot, K., 19 Nov 2024, In: Journal for ImmunoTherapy of Cancer. 12, 11, 16 p., e009110.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)9 Downloads (Pure)