Biophysical characterisation of the conserved bacterial GTPase Obg, a novel target for drug development against bacterial persisters

Project Details


The Obg protein family belongs to the TRAFAC (translation factor) class of P-loop GTPases and is conserved from bacteria to eukaryotes. Essential roles in many different cellular processes have been suggested for the Obg protein from Escherichia coli (ObgE), and we recently showed that it is a central regulator of bacterial persistence.
Effective start/end date1/01/1331/12/16

Flemish discipline codes

  • Medical biophysics
  • Structural biology


  • Applied Biology