Cancerresearch 'New directions in the therapy of cancer'.

Project Details

Description

Study of neovasular mechanisms in multiple myeloma as a target for the therapeutical intervention.

Allthough the importance of neovascularisation in solid tumors is well established, its role in haematopoietic malignancies remains unclear. With this project, we would like to gain more insight in the underlying mechanisms that mediate neovascularisation in MM. In a first part, we will determine whether MM cell lines (human and mouse origin) can stimulate metalloproteinase (MMP) production, migration, proliferation and lumenformation in endothelial cells. Next, the production of specific angiogenic factors by MM cells will be analyzed. We will also determine whether endothelial cells can stimulate the proliferation of MM cells. In a second part, an in vivo mouse model (5T2 MM) will be used to study the effect of anti-angiogenesis therapy in MM. We will not only evaluate the effect of specific MMP-inhibitors, but also therapeutical effect of angiogenesis inhibitors (TNP-470, Thalidomide, e.o)
AcronymANI16
StatusFinished
Effective start/end date1/01/0131/12/03

Flemish discipline codes

  • Basic sciences

Keywords

  • transplantation
  • cancer