Cognitive-motor telerehabilitation in multiple sclerosis and its effects on cognition.

Project Details


Multiple sclerosis (MS) is the most common neurodegenerative and
inflammatory disease in young adults. One in two patients has
cognitive impairments, which have a profound impact on the their
daily lives. The treatment of cognitive impairment remains an
important unmet need, and while cognitive rehabilitation has proven
to be effective in improving cognitive performance, research in elderly
indicates a higher effectiveness of a combined cognitive-motor
intervention. Furthermore, the COVID-19 pandemic has emphasized
the need for, but also the possibilities of, telemedicine and
The primary goal of this project is to provide evidence that a homebased combined cognitive-motor training program using telemedicine
improves cognition in persons with MS (PwMS). To achieve this, we
will carry out a high-quality randomized controlled clinical trial in a
group of cognitively impaired PwMS. We hypothesize that our
intensive combined rehabilitation program will increase the score on
the symbol digit modalities test with a clinically relevant improvement
of 10% compared to single cognitive and single motor training. A
secondary goal is to identify the mechanisms of improvement and
predictors of treatment response by monitoring neurophysiological
and neuroanatomical changes.
Providing evidence for this type of intervention could pave the way
towards reimbursement of cognitive-motor rehabilitation and
telerehabilitation, both in PwMS and other patients groups.
Effective start/end date1/11/2131/10/23

Flemish discipline codes

  • Cognitive neuroscience
  • Rehabilitation


  • Multiple sclerosis
  • Cognitive-motor rehabilitation
  • Telerehabilitation