Combining targeted radionuclide therapy and cancer immunotherapy to advance precision medicine through innovation.

Breckpot, Karine (Administrative Promotor)
Devoogdt, Nick (Co-Promotor)
D'Huyvetter, Matthias (Co-Promotor)
Keyaerts, Marleen (Co-Promotor)
Ertveldt, Thomas (Mandate)

4 Poster
4 Article
1 PhD Thesis

4 results

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2023
Nanobody-mediated SPECT/CT imaging reveals the spatiotemporal expression of programmed death-ligand 1 in response to a CD8+ T cell and iNKT cell activating mRNA vaccine
Ertveldt, T., Meulewaeter, S., De Vlaeminck, Y., Olarte, O., Broos, K., Van Calenbergh, S., Bourgeois, S., Deprez, J., Heremans, Y., Goyvaerts, C., Staels, W., De Smedt, S., Dewitte, H., Devoogdt, N., Keyaerts, M., Verbeke, R., Barbé, K., Lentacker, I. & Breckpot, K., 9 Oct 2023, In: Theranostics. 13, 15, p. 5483-5500 18 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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7 Citations (Scopus)

48 Downloads (Pure)
Targeted α-Therapy Using 225Ac Radiolabeled Single-Domain Antibodies Induces Antigen-Specific Immune Responses and Instills Immunomodulation Both Systemically and at the Tumor Microenvironment
Ertveldt, T., Krasniqi, A., Ceuppens, H., Puttemans, J., Dekempeneer, Y., De Jonghe, K., de Mey, W., Lecocq, Q., De Vlaeminck, Y., Awad, R. M., Goyvaerts, C., De Veirman, K., Morgenstern, A., Bruchertseifer, F., Keyaerts, M., Devoogdt, N., D'Huyvetter, M. & Breckpot, K., 1 May 2023, In: Journal of Nuclear Medicine. 64, 5, p. 751-758 8 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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13 Citations (Scopus)

39 Downloads (Pure)
2022
Targeted radionuclide therapy with low and high-dose Lutetium-177 labeled single domain antibodies induces distinct immune signatures in a mouse melanoma model
Ertveldt, T., De Beck, L., De Ridder, K., Locy, H., De Mey, W., Goyvaerts, C., Lecocq, Q., Ceuppens, H., De Vlaeminck, Y., Awad, R. M., Keyaerts, M., Devoogdt, N., D'Huyvetter, M., Breckpot, K. & Krasniqi, A., Jul 2022, In: Molecular Cancer Therapeutics. 21, 7, p. 1136-1148 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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12 Citations (Scopus)

75 Downloads (Pure)
2021
CS1-specific single-domain antibodies labeled with Actinium-225 prolong survival and increase CD8+ T cells and PD-L1 expression in Multiple Myeloma
De Veirman, K., Puttemans, J., Krasniqi, A., Ertveldt, T., Hanssens, H., Romao, E., Hose, D., Goyvaert, C., Vlummens, P., Muyldermans, S., Breckpot, K., Bruchertseifer, F., Morgenstern, A., D'Huyvetter, M. & Devoogdt, N., 2021, In: Oncoimmunology. 10, 1, 11 p., 2000699.
Research output: Contribution to journal › Article › peer-review

Open Access
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15 Citations (Scopus)

31 Downloads (Pure)