Project Details
Description
Prolongation:n order to increase the physiological duration and the selectivity of peptides, the conformation of the backbone and of the side-chains has been restricted by cyclization and by incorporation of pseudo-peptides. Synthetic isosteres of the peptide bond such as CH=CH, C(CH3)=CH, CH2NH, COCH2 were prepared. Combined with cyclization this results in peptidomimetics. The design of these analogues is based on a thourough conformational study by 2D-NMR of the natural structures as well as of the analogues. The mass spectrometry plays an important role to monitor the synthetic processes. This general approach is applied to a number of peptide targets : somatostatin, enkephalin, casomorphin, oxytocin, vasopressin, substance P, endothelin.
Acronym | OZR24 |
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Status | Finished |
Effective start/end date | 1/01/97 → 31/12/98 |
Keywords
- chemistry
Flemish discipline codes in use since 2023
- Chemical sciences
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