Conformational restricted peptide analogues with potential hormonal activity - Synthesis, analysis(MS) and conformation study (NMR)

Project Details

Description

Prolongation:n order to increase the physiological duration and the selectivity of peptides, the conformation of the backbone and of the side-chains has been restricted by cyclization and by incorporation of pseudo-peptides. Synthetic isosteres of the peptide bond such as CH=CH, C(CH3)=CH, CH2NH, COCH2 were prepared. Combined with cyclization this results in peptidomimetics. The design of these analogues is based on a thourough conformational study by 2D-NMR of the natural structures as well as of the analogues. The mass spectrometry plays an important role to monitor the synthetic processes. This general approach is applied to a number of peptide targets : somatostatin, enkephalin, casomorphin, oxytocin, vasopressin, substance P, endothelin.
AcronymOZR24
StatusFinished
Effective start/end date1/01/9731/12/98

Keywords

  • chemistry

Flemish discipline codes in use since 2023

  • Chemical sciences

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