Connexin and pannexin channels: function, regulation and applications

Project Details

Description

The main research of the VUB-FAFY team is situated in the field of experimental in vitro toxicology. Special attention is being paid to the development of liver based in vitro models for pharmacotoxicological purposes that are applicable at an early stage during the development of new chemical and biological entities. A first approach implies the stabilisation of the phenotype of cultured primary hepatocytes by epigenetically modifying gene expression patterns. The second strategy that has been initiated involves the use of stem cell technology to produce functional human hepatocytes. Recently, a third strategy has been launched in the VUB-FAFY group, namely the development of a differentiated primary hepatocyte cell line. The overall relevance of connexin-based signalling, especially related to connexin species Cx32 an Cx43, in the control of hepatocyte proliferation, differentiation and cell death represents a major research topic in the VUB-FAFY team.
AcronymOZR2275
StatusActive
Effective start/end date1/09/11 → …

Keywords

  • Cultures And Co-Cultures
  • Apoptosis
  • apoptosis
  • Hepatocytes
  • Cosmetics
  • Isobutene
  • Toxicity
  • Saponins
  • Dermato-Cosmetics
  • Anti-Epileptic Drugs
  • Phytochemistry
  • Dermato-Cosmetic Sciences
  • Drug Metabolism
  • In Vitro Toxicology
  • Liver Cells
  • Pharmacognosy
  • Human Skin
  • Keratinocytes