Research output per year
Research output per year
- 22 results
Search results
-
2024
Characterization of the long-term effects of lethal total body irradiation followed by bone marrow transplantation on the brain of C57BL/6 mice
Janssen, P., De Pauw, L., Mambretti, M., Lara, O., Walckiers, J., Mackens, L., Rooman, I., Guillaume, B., De Ridder, M., Ates, G. & Massie, A., 3 Mar 2024, In: International Journal of Radiation Biology. 100, 3, p. 385-398 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Downloads (Pure) -
Compartmentalized role of xCT in supporting pancreatic tumor growth, inflammation and mood disturbance in mice
Lara, O., Janssen, P., Mambretti, M., De Pauw, L., Ates, G., Mackens, L., De Munck, J., Walckiers, J., Pan, Z., Beckers, P., Espinet, E., Sato, H., De Ridder, M., Marks, D. L., Barbé, K., Aerts, J., Hermans, E., Rooman, I. & Massie, A., May 2024, In: Brain, Behavior, and Immunity. 118, p. 275-286 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
High-resolution and quantitative spatial analysis reveal intra-ductal phenotypic and functional diversification in pancreatic cancer
Michiels, E., Madhloum, H., Van Lint, S., Messaoudi, N., Kunda, R., Martens, S., Giron, P., Olsen, C., Lefesvre, P., Dusetti, N., El Mohajer, L., Tomasini, R., Hawinkels, L. J., Ahsayni, F., Nicolle, R., Arsenijevic, T., Bouchart, C., Van Laethem, J-L. & Rooman, I., Jan 2024, In: Journal of pathology. 262, 1, p. 76-89 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Downloads (Pure) -
2023
Axon guidance genes control hepatic artery development
Gannoun, L., De Schrevel, C., Belle, M., Dauguet, N., Achouri, Y., Loriot, A., Vanderaa, C., Cordi, S., Dili, A., Heremans, Y., Rooman, I., Leclercq, I. A., Jacquemin, P., Gatto, L. & Lemaigre, F. P., 15 Aug 2023, In: Development. 150, 16, 15 p., dev201642.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Heterotopia of salivary gland tissue in the pancreas
Martens, S., Coolens, K., Olsen, C., Lefesvre, P. & Rooman, I., Dec 2023, In: Diagnostic pathology. 18, 1, 6 p., 98.Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Downloads (Pure) -
Pancreatic acinar cell fate relies on system xC- to prevent ferroptosis during stress
Pan, Z., Van den Bossche, J-L., Rodriguez-Aznar, E., Janssen, P., Lara, O., Ates, G., Massie, A., De Paep, D. L., Houbracken, I., Mambretti, M. & Rooman, I., 21 Aug 2023, In: Cell & Death Disease. 14, 8, 10 p., 536.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Downloads (Pure) -
2022
Discovery and 3D imaging of a novel ΔNp63-expressing basal cell type in human pancreatic ducts with implications in disease
Martens, S., Coolens, K., Van Bulck, M., Arsenijevic, T., Casamitjana, J., Fernandez Ruiz, A., El Kaoutari, A., Martinez de Villareal, J., Madhloum, H., Esni, F., Heremans, Y., Leuckx, G., Heimberg, H., Bouwens, L., Jacquemin, P., De Paep, D. L., In't Veld, P., D'Haene, N., Bouchart, C., Dusetti, N. & 6 others, , 1 Oct 2022, In: Gut. 71, 10, p. 2030-2042 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)32 Downloads (Pure) -
2021
Aggressive PDACs show hypomethylation of repetitive elements and the execution of an intrinsic IFN program linked to a ductal cell-of-origin
Espinet, E., Gu, Z., Imbusch, C. D., Giese, N. A., Buscher, M., Safavi, M., Weisenburger, S., Klein, C., Vogel, V., Falcone, M., Insua-Rodriguez, J., Reitberger, M., Thiel, V., Kossi, S. O., Muckenhuber, A., Sarai, K., Lee, A. Y., Backx, E., Zarei, S., Gaida, M. M. & 18 others, , Mar 2021, In: Cancer discovery. 11, 3, p. 638-659 22 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile63 Citations (Scopus)121 Downloads (Pure) -
Cystine-glutamate antiporter deletion accelerates motor recovery and improves histological outcomes following spinal cord injury in mice
Sprimont, L., Janssen, P., De Swert, K., Van Bulck, M., Rooman, I., Gilloteaux, J., Massie, A. & Nicaise, C., 9 Jun 2021, In: Scientific Reports. 11, 1, 15 p., 12227.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)52 Downloads (Pure) -
MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions
Backx, E., Wauters, E., Baldan, J., Van Bulck, M., Michiels, E., Heremans, Y., De Paep, D. L., Kurokawa, M., Goyama, S., Bouwens, L., Jacquemin, P., Houbracken, I. & Rooman, I., Sep 2021, In: Cell Death and Differentiation. 28, 9, p. 2601-2615 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Citations (Scopus)70 Downloads (Pure) -
On the origin of pancreatic cancer: Molecular Tumor Subtypes in Perspective of Exocrine Cell Plasticity
Backx, E., Coolens, K., Van den Bossche, J-L., Houbracken, I., Espinet, E. & Rooman, I., 4 Dec 2021, In: Cellular and molecular gastroenterology and hepatology. 13, 4, p. 1243-1253 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)216 Downloads (Pure) -
Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer
Glasgow Precision Oncology Laboratory, & Rooman, I., Jan 2021, In: Gastroenterology. 160, 1, p. 362-377.e13 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile75 Citations (Scopus)49 Downloads (Pure) -
2020
HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer
Glasgow Precision Oncology Laboratory, Brunton, H., Caligiuri, G., Cunningham, R., Upstill-Goddard, R., Bailey, U-M., Garner, I. M., Nourse, C., Dreyer, S., Jones, M., Moran-Jones, K., Wright, D. W., Paulus-Hock, V., Nixon, C., Thomson, G., Jamieson, N. B., McGregor, G. A., Evers, L., McKay, C. J., Gulati, A. & 25 others, , 12 May 2020, In: Cell Reports. 31, 6, 28 p., 107625.Research output: Contribution to journal › Article › peer-review
Open AccessFile78 Citations (Scopus)94 Downloads (Pure) -
Nicotinamide combined with gemcitabine is an immunomodulatory therapy that restrains pancreatic cancer in mice
Chellakkan Selvanesan, B., Meena, K., Beck, A., Meheus, L., Lara, O., Rooman, I. & Gravekamp, C., 5 Nov 2020, In: Journal for immunotherapy of cancer. 8, 2, 14 p., e001250.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)105 Downloads (Pure) -
On-Label or Off-Label? Overcoming Regulatory and Financial Barriers to Bring Repurposed Medicines to Cancer Patients
Verbaanderd, C., Rooman, I., Meheus, L. & Huys, I., 1 Jan 2020, In: Frontiers in Pharmacology. 10, 01664.Research output: Contribution to journal › Article › peer-review
Open AccessFile46 Citations (Scopus)79 Downloads (Pure) -
Pan-cancer analysis of whole genomes
ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, Feb 2020, In: Nature. 578, 7793, p. 82-93 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1646 Citations (Scopus)23 Downloads (Pure) -
Sex differences in oncogenic mutational processes
PCAWG Tumour Subtypes and Clinical Translation & Li, C. H., 28 Aug 2020, In: Nature Communications. 11, 1, 24 p., 4330.Research output: Contribution to journal › Article › peer-review
Open AccessFile56 Citations (Scopus)31 Downloads (Pure) -
2019
Adult human pancreatic acinar cells dedifferentiate into an embryonic progenitor-like state in 3D suspension culture
Baldan, J., Houbracken, I., Rooman, I. & Bouwens, L., 11 Mar 2019, In: Scientific Reports - Nature. 9, 1, p. 1-12 12 p., 4040.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)32 Downloads (Pure) -
Different shades of pancreatic ductal adenocarcinoma, different paths towards precision therapeutic applications
Martens, S., Lefesvre, P., Nicolle, R., Biankin, A. V., Puleo, F., Van Laethem, J-L. & Rooman, I., Sep 2019, In: Annals of Oncology. 30, 9, p. 1428-1436 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile42 Citations (Scopus)183 Downloads (Pure) -
2018
ReDO_DB: the repurposing drugs in oncology database
Pantziarka, P., Verbaanderd, C., Sukhatme, V., Rica Capistrano, I., Crispino, S., Gyawali, B., Rooman, I., Van Nuffel, A. M., Meheus, L., Sukhatme, V. P. & Bouche, G., 6 Dec 2018, In: ecancermedicalscience. 12, 19 p., 886.Research output: Contribution to journal › Article › peer-review
Open AccessFile92 Citations (Scopus)44 Downloads (Pure) -
ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling
Pinho, A. V., Van Bulck, M., Chantrill, L., Arshi, M., Sklyarova, T., Herrmann, D., Vennin, C., Gallego-Ortega, D., Mawson, A., Giry-Laterriere, M., Magenau, A., Leuckx, G., Baeyens, L., Gill, A. J., Phillips, P., Timpson, P., Biankin, A. V., Wu, J. & Rooman, I., 1 Dec 2018, In: Nature Communications. 9, 1, 14 p., 5083.Research output: Contribution to journal › Article › peer-review
Open AccessFile43 Citations (Scopus)33 Downloads (Pure) -
2017
Hypermutation In Pancreatic Cancer
Humphris, J. L., Patch, A-M., Nones, K., Bailey, P. J., Johns, A. L., McKay, S., Chang, D. K., Miller, D. K., Pajic, M., Kassahn, K. S., Quinn, M. C. J., Bruxner, T. J. C., Christ, A. N., Harliwong, I., Idrisoglu, S., Manning, S., Nourse, C., Nourbakhsh, E., Stone, A., Wilson, P. J. & 31 others, , Jan 2017, In: GASTROENTEROLOGY. 152, 1, p. 68-74.e2 7 p.Research output: Contribution to journal › Article › peer-review
171 Citations (Scopus)