Dendritic cell immunobiology and dentritic cell-based immunotherapy of HIV and cancer.

Project Details

Description

The aim of the present project is to combine fundamental insights into the immunobiology of dentritic cells and the development of an optimized dendritic cell-based vaccine for anti-cancer and anti-HIV immunotherapies.

Hereto we will:

- Develop the tools to study the immunobiology of mouse and human dendritic cells and to evaluate the immune responses.
- Optimize the use of dendritic cells to induce cellular immune responses by developing strategies to optimize the expression of the entire antigenic polypeptides and the presentation of multiple HLA class I and class II epitopes.
- Further evaluate and extend ongoing phase I-II pilot studies to assess the safety and toxicity of dendritic cell-based vaccination in melanoma patients.
- Develop dendritic cell-based therapeutic vaccination pilot studies in HIV-1 infected individuals
AcronymGOA32
StatusFinished
Effective start/end date1/01/0431/12/08

Keywords

  • medicine

Flemish discipline codes

  • Basic sciences