Detection of novel genome disorders in mental retardation. Detection of novel genome disorders in mental retardation.

This project aims to detect novel genome disorders in mental retardation by performing SNP arrays on a series of selected patients with a mental handicap. It can be anticipated that novel deletions will be discovered. The size of the deletions will be determined and analysis of breakpoints will increase our insights in the mechanisms causing the rearrangements. Candidate genes in the deletions will be identified and analyzed using mouse models.