Dendritic cells (DC) are the bridge between innate and adaptive immunity. They are responsible for the uptake and sensing of potentially harmfull pathogens. The recognition of pathogens sarts a cascade of events that will transform the DC from an immature to a mature stage. It is this latter stage that is detremintal for the induction of T cell immunity or tolerance. In this project, we wish to get a better insight in the factors that determine whether a given DC will induce immunity or tolerance.