Dynamic studies of allosteric modulator antibodies.

  • Steyaert, Jan (Administrative Promotor)
  • Oyen, David, (Co-Promotor)

Project Details

Description

Allosteric Modulator Antibodies as Therapeutic Molecules. Antibodies are an increasingly important therapeutic class of molecule (1). Current clinical therapeutic antibodies kill cells, inhibit cellular interactions, or prevent effector molecules from binding their targets. In comparison to small molecule inhibitors, antibodies are generally poor at inhibiting active site processes (for example, in enzymes) but better at inhibiting proteinprotein interactions. Antibodies also display the ability to induce long range effects, at a distance from the binding epitope, which can lead to modulation of protein function. Such antibodies are referred to as allosteric modulators and their effects on a variety of proteins have been studied, including G-protein coupled receptors (2), integrin adhesion receptors (3) and enzymes (4).
AcronymFWOTM493
StatusFinished
Effective start/end date1/10/0830/09/12

Flemish discipline codes

  • Biological sciences

Keywords

  • Applied Biology