Endurence training effects on striatal neurotransmitter release

Peripheral adaptions to exercise training are well documented. In contrast, studies relating chronic exercise to brain neurotransmitter levels especially neurotransmitter release are scarce. Clearly, biochemical changes are associated with movement disorders such as Parkinson's disease, and with mental disorders such as anxiety and depression, and exercise produces biochemical changes. It is of interest to examine the effect of an exercise training programme on striatal neurotransmitter release, since movement initiation and control of locomotion have been shown to be related to striatal neurotransmitter function, and one of the possible therapeutic modalities in movement, and mental disorders is exercise theraphy. Therefore the purpose of this study is to examine the effect of an exercise training programme on striatal neurotransmitter release, and to investigate if an acute bout of exercise differently influence striatal neurotransmitters in trained and sedentary rats.