Serotonin (5-HT) is known to play a major role in various neuroendocrine and behavioural functions, eg activation of the Hypothalamus-Pituitary-Adrenal (HPA) axis, feeding and locomotion. In our previous study we found that neither a metabolic precursor of DA nor a specific centrally acting 5-HT(2A/2C) antagonist did influence the time to exhaustion on a bicycle trial at 65% Watt max. Until now only two research projects appaered in which a 5-HT reuptake inhibitor was used, these studies used a "time to xhaustion" design, in which possible other interfering factors could have influenced "fatigue". Clearly much more research is needed to examine the possible role of 5-HT in this so-called "central-fatigue" hypothesis. Therefore, the purpose of this study is to examine the effect of a single dose of a 5-HT reuptake inhibitor (Fluoxetine-HCL) on exercise performance during a 90 min time trial at 65% Watt max.
|Effective start/end date||1/01/99 → 31/12/99|
- central fatigue
Flemish discipline codes
- Basic sciences