Free radical production and exercise - implications for cardiac rehabilitation - how much exercise is "enough"

Project Details


Free radical reactions cause damage to cell membranes, prtoeins, DNA and other cellular compartements. The damage caused by free radicals is inhibited partly by endogenous anti oxidative enzymes and partly by exogenous intake of anti oxidants. There is an unstable equilibrium between the production and neutralisation of free radical reactions. Exercise may promote free radical production in a number of ways. This study has two objectives: A) to adjust an existing technique, by which the DNA damage in human lymphocytes - caused by axidative stress can be measured in a reproducable and quantitative way, in order to be able to use this technique to evaluate the effect of oxidative stredd on exercise therapy. B) with the data obtained in A, to study oxidative stress in different types of exercise therapy, to come to a consensus concerning optimal exercise therapy in cardiac rehabilitation. An additional question that can be asked is: is it necessary to give anti oxidants systematically to patients with coronary heart diseae who follow a cardiac rehabilitation program?
Effective start/end date1/01/9731/12/97

Flemish discipline codes

  • Health sciences


  • free radical production
  • implications for cardiac