Genetic susceptibility of premature children for oxidative damage.

Project Details


The process of birth itself is accompagnied by an increase in oxidative stress: the foetus transfers from a
hypoxic (intra-uterus) to a normoxic, relatively hyperoxic (extra-uterus), environment. Efficient defense
mechanisms, such as antioxidants, protect against oxidative damage. Premature born children on the other
hand have lower concentrations of antioxidants and antioxidant enzymes and, besides birth itself, are also
exposed to other types of increased oxidative stress, like receiving additional oxygen. The aim of this
project is 1 ) to investigate the efficacy of the DNA-repair enzymes involved in the repair of oxidative
DNA damage and to compare it with adults and full term babies; 2) to follow-up these prematures during
1 year after birth in close collaboration with pediatricians to evaluate further development of their DNA
repair system. Therefore the DNA repair phenotype and genotoxic effects of H²O² will be studied, taking
into account the genotype of important genes from the enzymatic antioxidant and DNA repair systems,
age, and weight at bil-tli. This project is part of an EU-Intergrated project (FOOD-CT-2005-016320-2.
"NewGeneris") and aims at additional financial support (matching fund).
Effective start/end date1/01/0931/12/09

Flemish discipline codes

  • Biological sciences


  • Biology