Genotypic and phenotypic variability, individual susceptibility factors and industrial genotoxicants/neurotoxicants in occupational medicine

Project Details

Description

The fascinating progress made in genome analysis and the recent
identification of several classes of genes involved in disease
susceptibility, point to the possibility of identifying carriers of
specific allelic combinations or polymorphisms who should be at increased
risk for environmentally and occupationally induced illnesses. The purpose
of this project is to confront, where they already exist, candidate
biomarkers of susceptibility with biomarkers of exposure and of effect
which are sensitive, specific and predictive enough to perform reliable
assessments.
For this purpose, the research project will aim at addressing sequentially
three major questions:
1) Are we CAPABLE of measuring variability parameters? Are the diagnostic
tools available and sufficiently validated to perform reliable and robust
measurements, possibly on a large scale? 2) Is it sceintifically USEFUL to
implement these tests? Assuming that technical aspects are sufficiently
mastered, which is the biological significance of these tests? Which is
their public health relevance. 3) If these tests are potentially useful,
are they APPLICABLE in occupational medicine? Within the network of this
programme specific attention will be paid to the legal aspects through the
direct association with experts in occupational law.
AcronymOZR581
StatusFinished
Effective start/end date1/01/0131/12/03

Keywords

  • response of the organism
  • external dose
  • occupational medicine
  • individual susceptibility - polymorphism
  • internal dose

Flemish discipline codes

  • Basic sciences
  • Law and legal studies
  • Health sciences
  • Biological sciences