Image-guided stereotactic radiotherapy for dose escalation in inoperable stage I/II non-small cell lung cancer with selective application of breathing synchronisation with audiovisual feedback.

Our hypothesis is that a further improvement of the LC in stage I/II inoperable NSCLC can be achieved by a dose-escalation without increment of the toxicity profile when breathing synchronization is selectively applied and optimized with audiovisual feedback.

Purposes:
1. To increase of the actuarial LC in stage I/II NSCLC by dose escalation of the BED in a prospective study.
2. To evaluate the feasibility of breathing synchronization with audiovisual feedback in stereotactic radiotherapy.
3. To maintain the toxicity profile by the application of personalized PTV margins and continuous intrafraction analysis of the breathing signal.