IOF PoC “MOTIF: MOdification of T cells In situ for altered Functionality”

Project Details

Description

In the MOTIF research project we aim to develop new nanobodies against a T-cell-specific membrane protein. These nanobodies will be conjugated on the envelope of viral vector, hereby selectively infecting and transducting the T-cells. We will additionally employ genetically-modified mice to test these engineered viral vectors in an optimal manner..
AcronymIOFPOC42
StatusActive
Effective start/end date1/01/2131/12/22

Flemish discipline codes

  • Molecular and cell biology not elsewhere classified

Keywords

  • T cells
  • in situ
  • Nanobodies
  • Viral transduction
  • Genetically-engineered mice